Braquiópodos neógenos del suroeste de la depresión del Guadalquivir (sur de España)

This paper analyzes the first brachiopod record of three Neogene formations of the southwestern Guadalquivir Basin (Huelva province, SW Spain) with a wide cartographical distribution. Samples obtained in five sections of these formations have allowed to recognize three species belonging to the genera Terebratula, Maltaia and Cryptopora, the latter being the first record of this genus in Spain. In addition, the biostratigraphical distribution and palaeoecological context of these species and others present in upper Neogene sediments (Tortonian-Lower Pliocene) of south Spain are discussed

Braqui�podos ne�genos del suroeste de la depresi�n del Guadalquivir (sur de Espa�a)

This paper analyzes the first brachiopod record of three Neogene formations of the southwestern Guadalquivir Basin (Huelva province, SW Spain) with a wide cartographical distribution. Samples obtained in five sections of these formations have allowed to recognize three species belonging to the genera Terebratula, Maltaia and Cryptopora, the latter being the first record of this genus in Spain. In addition, the biostratigraphical distribution and palaeoecological context of these species and others present in upper Neogene sediments (Tortonian-Lower Pliocene) of south Spain are discussed

The structural assembly switch of cell division protein FtsZ probed with fluorescent allosteric inhibitors

FWN – Publicaties zonder aanstelling Universiteit Leide

Epidemiology of intra-abdominal infection and sepsis in critically ill patients: “AbSeS”, a multinational observational cohort study and ESICM Trials Group Project

Purpose: To describe the epidemiology of intra-abdominal infection in an international cohort of ICU patients according to a new system that classifies cases according to setting of infection acquisition (community-acquired, early onset hospital-acquired, and late-onset hospital-acquired), anatomical disruption (absent or present with localized or diffuse peritonitis), and severity of disease expression (infection, sepsis, and septic shock). Methods: We performed a multicenter (n = 309), observational, epidemiological study including adult ICU patients diagnosed with intra-abdominal infection. Risk factors for mortality were assessed by logistic regression analysis. Results: The cohort included 2621 patients. Setting of infection acquisition was community-acquired in 31.6%, early onset hospital-acquired in 25%, and late-onset hospital-acquired in 43.4% of patients. Overall prevalence of antimicrobial resistance was 26.3% and difficult-to-treat resistant Gram-negative bacteria 4.3%, with great variation according to geographic region. No difference in prevalence of antimicrobial resistance was observed according to setting of infection acquisition. Overall mortality was 29.1%. Independent risk factors for mortality included late-onset hospital-acquired infection, diffuse peritonitis, sepsis, septic shock, older age, malnutrition, liver failure, congestive heart failure, antimicrobial resistance (either methicillin-resistant Staphylococcus aureus, vancomycin-resistant enterococci, extended-spectrum beta-lactamase-producing Gram-negative bacteria, or carbapenem-resistant Gram-negative bacteria) and source control failure evidenced by either the need for surgical revision or persistent inflammation. Conclusion: This multinational, heterogeneous cohort of ICU patients with intra-abdominal infection revealed that setting of infection acquisition, anatomical disruption, and severity of disease expression are disease-specific phenotypic characteristics associated with outcome, irrespective of the type of infection. Antimicrobial resistance is equally common in community-acquired as in hospital-acquired infection. © 2019, The Author(s)