524 research outputs found
Relativistic nuclear structure effects in quasielastic neutrino scattering
Charged-current cross sections are calculated for quasielastic neutrino and
antineutrino scattering using a relativistic meson-nucleon model. We examine
how nuclear-structure effects, such as relativistic random-phase-approximation
(RPA) corrections and momentum-dependent nucleon self-energies, influence the
extraction of the axial form factor of the nucleon. RPA corrections are
important only at low-momentum transfers. In contrast, the momentum dependence
of the relativistic self-energies changes appreciably the value of the
axial-mass parameter, , extracted from dipole fits to the axial form
factor. Using Brookhaven's experimental neutrino spectrum we estimate the
sensitivity of M to various relativistic nuclear-structure effects.Comment: 26 pages, revtex, 6 postscript figures (available upon request
Constraints on Decaying Dark Matter from Fermi Observations of Nearby Galaxies and Clusters
We analyze the impact of Fermi gamma-ray observations (primarily
non-detections) of selected nearby galaxies, including dwarf spheroidals, and
of clusters of galaxies on decaying dark matter models. We show that the fact
that galaxy clusters do not shine in gamma rays puts the most stringent limits
available to-date on the lifetime of dark matter particles for a wide range of
particle masses and decay final states. In particular, our results put strong
constraints on the possibility of ascribing to decaying dark matter both the
increasing positron fraction reported by PAMELA and the high-energy feature in
the electron-positron spectrum measured by Fermi. Observations of nearby dwarf
galaxies and of the Andromeda Galaxy (M31) do not provide as strong limits as
those from galaxy clusters, while still improving on previous constraints in
some cases.Comment: 27 pages, 5 figures, submitted to JCAP, revised version with some
additions and correction
Pyrrolidine nucleoside bisphosphonates as antituberculosis agents targeting hypoxanthine-guanine phosphoribosyltransferase
Therapeutic treatment of tuberculosis (TB) is becoming increasingly problematic due to the emergence of drug resistant Mycobacterium tuberculosis (Mt). Thus, new targets for anti-TB drug discovery need to be identified to combat and eradicate this disease. One such target is hypoxanthine-guanine phosphoribosyltransferase (HGPRT) which synthesises the 6-oxopurine nucleoside monophosphates essential for DNA/RNA production. [3R,4R]-4-Hypoxanthin-9-yl-3-( (S)-2-hydroxy-2-phosphonoethyl)oxy-1-N-(phosphonopropionyl)pyrrolidine and [3R,4R-4-guanin-9-yl-3-((S)-2-hydroxy-2-phosphonoethyl)oxy-1-N-(phosphonopropionyl)pyrrolidine (compound 6) are the most potent inhibitors of MtHGPRT yet discovered having K-i values of 60 nM. The crystal structure of the MtHGPRT.6 complex was obtained and compared with that of human HGPRT in complex with the same inhibitor. These structures provide explanations for the 60-fold difference in the inhibition constants between these two enzymes and a foundation for the design of next generation inhibitors. In addition, crystal structures of MtHGPRT in complex with two pyrrolidine nucleoside phosphosphonate inhibitors plus pyrophosphate provide insights into the final stage of the catalytic reaction. As the first step in ascertaining if such compounds have the potential to be developed as anti-TB therapeutics, the tetra-(ethyl L-phenylalanine) tetraamide prodrug of 6 was tested in cell based assays. This compound arrested the growth of virulent Mt not only in its replicating phase (IC50 of 14 mu M) but also in its latent phase (IC50 of 29 mu M). Furthermore, it arrested the growth of Mt in infected macrophages (MIC50 of 85 mu M) and has a low cytotoxicity in mammalian cells (CC50 of 132 +/- 20 mu M). These inhibitors are therefore viewed as forerunners of new anti-TB chemotherapeutics. (C) 2018 Elsevier Masson SAS. All rights reserved
Gamma-ray Observations Under Bright Moonlight with VERITAS
Imaging atmospheric Cherenkov telescopes (IACTs) are equipped with sensitive
photomultiplier tube (PMT) cameras. Exposure to high levels of background
illumination degrades the efficiency of and potentially destroys these
photo-detectors over time, so IACTs cannot be operated in the same
configuration in the presence of bright moonlight as under dark skies. Since
September 2012, observations have been carried out with the VERITAS IACTs under
bright moonlight (defined as about three times the night-sky-background (NSB)
of a dark extragalactic field, typically occurring when Moon illumination >
35%) in two observing modes, firstly by reducing the voltage applied to the
PMTs and, secondly, with the addition of ultra-violet (UV) bandpass filters to
the cameras. This has allowed observations at up to about 30 times previous NSB
levels (around 80% Moon illumination), resulting in 30% more observing time
between the two modes over the course of a year. These additional observations
have already allowed for the detection of a flare from the 1ES 1727+502 and for
an observing program targeting a measurement of the cosmic-ray positron
fraction. We provide details of these new observing modes and their performance
relative to the standard VERITAS observations
VERITAS: the Very Energetic Radiation Imaging Telescope Array System
The Very Energetic Radiation Imaging Telescope Array System (VERITAS)
represents an important step forward in the study of extreme astrophysical
processes in the universe. It combines the power of the atmospheric Cherenkov
imaging technique using a large optical reflector with the power of
stereoscopic observatories using arrays of separated telescopes looking at the
same shower. The seven identical telescopes in VERITAS, each of aperture 10 m,
will be deployed in a filled hexagonal pattern of side 80 m; each telescope
will have a camera consisting of 499 pixels with a field of view of 3.5 deg
VERITAS will substantially increase the catalog of very high energy (E >
100GeV) gamma-ray sources and greatly improve measurements of established
sources.Comment: 44 pages, 16 figure
The First VERITAS Telescope
The first atmospheric Cherenkov telescope of VERITAS (the Very Energetic
Radiation Imaging Telescope Array System) has been in operation since February
2005. We present here a technical description of the instrument and a summary
of its performance. The calibration methods are described, along with the
results of Monte Carlo simulations of the telescope and comparisons between
real and simulated data. The analysis of TeV -ray observations of the
Crab Nebula, including the reconstructed energy spectrum, is shown to give
results consistent with earlier measurements. The telescope is operating as
expected and has met or exceeded all design specifications.Comment: Accepted by Astroparticle Physic
Magnetic fields in cosmic particle acceleration sources
We review here some magnetic phenomena in astrophysical particle accelerators
associated with collisionless shocks in supernova remnants, radio galaxies and
clusters of galaxies. A specific feature is that the accelerated particles can
play an important role in magnetic field evolution in the objects. We discuss a
number of CR-driven, magnetic field amplification processes that are likely to
operate when diffusive shock acceleration (DSA) becomes efficient and
nonlinear. The turbulent magnetic fields produced by these processes determine
the maximum energies of accelerated particles and result in specific features
in the observed photon radiation of the sources. Equally important, magnetic
field amplification by the CR currents and pressure anisotropies may affect the
shocked gas temperatures and compression, both in the shock precursor and in
the downstream flow, if the shock is an efficient CR accelerator. Strong
fluctuations of the magnetic field on scales above the radiation formation
length in the shock vicinity result in intermittent structures observable in
synchrotron emission images. Resonant and non-resonant CR streaming
instabilities in the shock precursor can generate mesoscale magnetic fields
with scale-sizes comparable to supernova remnants and even superbubbles. This
opens the possibility that magnetic fields in the earliest galaxies were
produced by the first generation Population III supernova remnants and by
clustered supernovae in star forming regions.Comment: 30 pages, Space Science Review
Magnetic fields in supernova remnants and pulsar-wind nebulae
We review the observations of supernova remnants (SNRs) and pulsar-wind
nebulae (PWNe) that give information on the strength and orientation of
magnetic fields. Radio polarimetry gives the degree of order of magnetic
fields, and the orientation of the ordered component. Many young shell
supernova remnants show evidence for synchrotron X-ray emission. The spatial
analysis of this emission suggests that magnetic fields are amplified by one to
two orders of magnitude in strong shocks. Detection of several remnants in TeV
gamma rays implies a lower limit on the magnetic-field strength (or a
measurement, if the emission process is inverse-Compton upscattering of cosmic
microwave background photons). Upper limits to GeV emission similarly provide
lower limits on magnetic-field strengths. In the historical shell remnants,
lower limits on B range from 25 to 1000 microGauss. Two remnants show
variability of synchrotron X-ray emission with a timescale of years. If this
timescale is the electron-acceleration or radiative loss timescale, magnetic
fields of order 1 mG are also implied. In pulsar-wind nebulae, equipartition
arguments and dynamical modeling can be used to infer magnetic-field strengths
anywhere from about 5 microGauss to 1 mG. Polarized fractions are considerably
higher than in SNRs, ranging to 50 or 60% in some cases; magnetic-field
geometries often suggest a toroidal structure around the pulsar, but this is
not universal. Viewing-angle effects undoubtedly play a role. MHD models of
radio emission in shell SNRs show that different orientations of upstream
magnetic field, and different assumptions about electron acceleration, predict
different radio morphology. In the remnant of SN 1006, such comparisons imply a
magnetic-field orientation connecting the bright limbs, with a non-negligible
gradient of its strength across the remnant.Comment: 20 pages, 24 figures; to be published in SpSciRev. Minor wording
change in Abstrac
Highly Charged Ions in Rare Earth Permanent Magnet Penning Traps
A newly constructed apparatus at the National Institute of Standards and
Technology (NIST) is designed for the isolation, manipulation, and study of
highly charged ions. Highly charged ions are produced in the NIST electron-beam
ion trap (EBIT), extracted through a beamline that selects a single mass/charge
species, then captured in a compact Penning trap. The magnetic field of the
trap is generated by cylindrical NdFeB permanent magnets integrated into its
electrodes. In a room-temperature prototype trap with a single NdFeB magnet,
species including Ne10+ and N7+ were confined with storage times of order 1
second, showing the potential of this setup for manipulation and spectroscopy
of highly charged ions in a controlled environment. Ion capture has since been
demonstrated with similar storage times in a more-elaborate Penning trap that
integrates two coaxial NdFeB magnets for improved B-field homogeneity. Ongoing
experiments utilize a second-generation apparatus that incorporates this
two-magnet Penning trap along with a fast time-of-flight MCP detector capable
of resolving the charge-state evolution of trapped ions. Holes in the
two-magnet Penning trap ring electrode allow for optical and atomic beam
access. Possible applications include spectroscopic studies of one-electron
ions in Rydberg states, as well as highly charged ions of interest in atomic
physics, metrology, astrophysics, and plasma diagnostics.Comment: Proceedings of CDAMOP-2011, 13-16 Dec 2011, Delhi, India. To be
published by Springer Verla
A Study of Cosmic Ray Secondaries Induced by the Mir Space Station Using AMS-01
The Alpha Magnetic Spectrometer (AMS-02) is a high energy particle physics
experiment that will study cosmic rays in the to range and will be installed on the International Space Station
(ISS) for at least 3 years. A first version of AMS-02, AMS-01, flew aboard the
space shuttle \emph{Discovery} from June 2 to June 12, 1998, and collected
cosmic ray triggers. Part of the \emph{Mir} space station was within the
AMS-01 field of view during the four day \emph{Mir} docking phase of this
flight. We have reconstructed an image of this part of the \emph{Mir} space
station using secondary and emissions from primary cosmic rays
interacting with \emph{Mir}. This is the first time this reconstruction was
performed in AMS-01, and it is important for understanding potential
backgrounds during the 3 year AMS-02 mission.Comment: To be submitted to NIM B Added material requested by referee. Minor
stylistic and grammer change
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