207 research outputs found
Nanophotonic and hydrogel-based diagnostic system for the monitoring of chronic wounds
Chronic wounds present a major healthcare burden, yet most wounds are only assessed superficially, and treatment is rarely based on the analysis of wound biomarkers. This lack of analysis is based on the fact that sampling of wound biomarkers is typically invasive, leading to a disruption of the wound bed while biomarker detection and quantification is performed in a remote laboratory, away from the point of care. Here, we introduce the diagnostic element of a novel theranostic system that can non-invasively sample biomarkers without disrupting the wound and that can perform biomarker quantification at the point of care, on a short timescale. The system is based on a thermally switchable hydrogel scaffold that enhances wound healing through regeneration of the wound tissue and allows the extraction of wound biomarkers non-destructively. We demonstrate the detection of two major biomarkers of wound health, i.e., IL-6 and TNF-α, in human matrix absorbed into the hydrogel dressing. Quantification of the biomarkers directly in the hydrogel is achieved using a chirped guided mode resonant biosensor and we demonstrate biomarker detection within the clinically relevant range of pg/mL to μg/mL concentrations. We also demonstrate the detection of IL-6 and TNF-α at concentration 1 ng/mL in hydrogel dressing absorbed with clinical wound exudate samples. The high sensitivity and the wide dynamic range we demonstrate are both essential for the clinical relevance of our system. Our test makes a major contribution towards the development of a wound theranostic for guided treatment and management of chronic wounds
Dynamics of tachyonic preheating after hybrid inflation
We study the instability of a scalar field at the end of hybrid inflation,
using both analytical techniques and numerical simulations. We improve previous
studies by taking the inflaton field fully into account, and show that the
range of unstable modes depends sensitively on the velocity of the inflaton
field, and thereby on the Hubble rate, at the end of inflation. If topological
defects are formed, their number density is determined by the shortest unstable
wavelength. Finally, we show that the oscillations of the inflaton field
amplify the inhomogeneities in the energy density, leading to local symmetry
restoration and faster thermalization. We believe this explains why tachyonic
preheating is so effective in transferring energy away from the inflaton zero
mode.Comment: 12 pages, 10 figures, REVTeX. Minor changes, some references added.
To appear in PR
The calibration of the Sudbury Neutrino Observatory using uniformly distributed radioactive sources
The production and analysis of distributed sources of 24Na and 222Rn in the
Sudbury Neutrino Observatory (SNO) are described. These unique sources provided
accurate calibrations of the response to neutrons, produced through
photodisintegration of the deuterons in the heavy water target, and to low
energy betas and gammas. The application of these sources in determining the
neutron detection efficiency and response of the 3He proportional counter
array, and the characteristics of background Cherenkov light from trace amounts
of natural radioactivity is described.Comment: 24 pages, 13 figure
p-wave phase shift and scattering length of Li
We have calculated the p-wave phase shifts and scattering length of Li.
For this we solve the partial wave Schr\"odinger equation and analyze the
validity of adopting the semiclassical solution to evaluate the constant
factors in the solution. Unlike in the wave case, the semiclassical
solution does not provide unique value of the constants. We suggest an
approximate analytic solution, which provides reliable results in special
cases. Further more, we also use the variable phase method to evaluate the
phase shifts. The p-wave scattering lengths of Cs and Cs are
calculated to validate the schemes followed. Based on our calculations, the
value of the wave scattering length of Li is .Comment: 10 figure
Neutrino Interferometry In Curved Spacetime
Gravitational lensing introduces the possibility of multiple (macroscopic)
paths from an astrophysical neutrino source to a detector. Such a multiplicity
of paths can allow for quantum mechanical interference to take place that is
qualitatively different to neutrino oscillations in flat space. After an
illustrative example clarifying some under-appreciated subtleties of the phase
calculation, we derive the form of the quantum mechanical phase for a neutrino
mass eigenstate propagating non-radially through a Schwarzschild metric. We
subsequently determine the form of the interference pattern seen at a detector.
We show that the neutrino signal from a supernova could exhibit the
interference effects we discuss were it lensed by an object in a suitable mass
range. We finally conclude, however, that -- given current neutrino detector
technology -- the probability of such lensing occurring for a
(neutrino-detectable) supernova is tiny in the immediate future.Comment: 25 pages, 1 .eps figure. Updated version -- with simplified notation
-- accepted for publication in Phys.Rev.D. Extra author adde
Is the evidence for dark energy secure?
Several kinds of astronomical observations, interpreted in the framework of
the standard Friedmann-Robertson-Walker cosmology, have indicated that our
universe is dominated by a Cosmological Constant. The dimming of distant Type
Ia supernovae suggests that the expansion rate is accelerating, as if driven by
vacuum energy, and this has been indirectly substantiated through studies of
angular anisotropies in the cosmic microwave background (CMB) and of spatial
correlations in the large-scale structure (LSS) of galaxies. However there is
no compelling direct evidence yet for (the dynamical effects of) dark energy.
The precision CMB data can be equally well fitted without dark energy if the
spectrum of primordial density fluctuations is not quite scale-free and if the
Hubble constant is lower globally than its locally measured value. The LSS data
can also be satisfactorily fitted if there is a small component of hot dark
matter, as would be provided by neutrinos of mass 0.5 eV. Although such an
Einstein-de Sitter model cannot explain the SNe Ia Hubble diagram or the
position of the `baryon acoustic oscillation' peak in the autocorrelation
function of galaxies, it may be possible to do so e.g. in an inhomogeneous
Lemaitre-Tolman-Bondi cosmology where we are located in a void which is
expanding faster than the average. Such alternatives may seem contrived but
this must be weighed against our lack of any fundamental understanding of the
inferred tiny energy scale of the dark energy. It may well be an artifact of an
oversimplified cosmological model, rather than having physical reality.Comment: 12 pages, 5 figures; to appear in a special issue of General
Relativity and Gravitation, eds. G.F.R. Ellis et al; Changes: references
reformatted in journal style - text unchange
Solar Neutrinos and the Principle of Equivalence
We study the proposed solution of the solar neutrino problem which requires a
flavor nondiagonal coupling of neutrinos to gravity. We adopt a
phenomenological point of view and investigate the consequences of the
hypothesis that the neutrino weak interaction eigenstates are linear
combinations of the gravitational eigenstates which have slightly different
couplings to gravity, and , , corresponding to a
difference in red-shift between electron and muon neutrinos, . We perform a analysis of the latest available solar
neutrino data and obtain the allowed regions in the space of the relevant
parameters. The existing data rule out most of the parameter space which can be
probed in solar neutrino experiments, allowing only for small values of the mixing angle () and for large mixing (). Measurements of the -neutrino energy spectrum in the SNO and
Super-Kamiokande experiments will provide stronger constraints independent of
all considerations related to solar models. We show that these measurements
will be able to exclude part of the allowed region as well as to distinguish
between conventional oscillations and oscillations due to the violation of the
equivalence principle.Comment: 20 pages + 4 figures, IASSNS-AST 94/5
Recent Advances in Understanding Particle Acceleration Processes in Solar Flares
We review basic theoretical concepts in particle acceleration, with
particular emphasis on processes likely to occur in regions of magnetic
reconnection. Several new developments are discussed, including detailed
studies of reconnection in three-dimensional magnetic field configurations
(e.g., current sheets, collapsing traps, separatrix regions) and stochastic
acceleration in a turbulent environment. Fluid, test-particle, and
particle-in-cell approaches are used and results compared. While these studies
show considerable promise in accounting for the various observational
manifestations of solar flares, they are limited by a number of factors, mostly
relating to available computational power. Not the least of these issues is the
need to explicitly incorporate the electrodynamic feedback of the accelerated
particles themselves on the environment in which they are accelerated. A brief
prognosis for future advancement is offered.Comment: This is a chapter in a monograph on the physics of solar flares,
inspired by RHESSI observations. The individual articles are to appear in
Space Science Reviews (2011
Dimensionless cosmology
Although it is well known that any consideration of the variations of
fundamental constants should be restricted to their dimensionless combinations,
the literature on variations of the gravitational constant is entirely
dimensionful. To illustrate applications of this to cosmology, we explicitly
give a dimensionless version of the parameters of the standard cosmological
model, and describe the physics of Big Bang Neucleosynthesis and recombination
in a dimensionless manner. The issue that appears to have been missed in many
studies is that in cosmology the strength of gravity is bound up in the
cosmological equations, and the epoch at which we live is a crucial part of the
model. We argue that it is useful to consider the hypothetical situation of
communicating with another civilization (with entirely different units),
comparing only dimensionless constants, in order to decide if we live in a
Universe governed by precisely the same physical laws. In this thought
experiment, we would also have to compare epochs, which can be defined by
giving the value of any {\it one} of the evolving cosmological parameters. By
setting things up carefully in this way one can avoid inconsistent results when
considering variable constants, caused by effectively fixing more than one
parameter today. We show examples of this effect by considering microwave
background anisotropies, being careful to maintain dimensionlessness
throughout. We present Fisher matrix calculations to estimate how well the fine
structure constants for electromagnetism and gravity can be determined with
future microwave background experiments. We highlight how one can be misled by
simply adding to the usual cosmological parameter set
Out-of-equilibrium evolution of quantum fields in the hybrid model with quantum back reaction
The hybrid model with a scalar "inflaton" field coupled to a "Higgs" field
with a broken symmetry potential is one of the promising models for inflation
and (p)reheating after inflation. We consider the nonequilibrium evolution of
the quantum fields of this model with quantum back reaction in the Hartree
approximation, in particular the transition of the Higgs field from the
metastable "false vacuum" to the broken symmetry phase. We have performed the
renormalization of the equations of motion, of the gap equations and of the
energy density, using dimensional regularization. We study the influence of the
back reaction on the evolution of the classical fields and of the quantum
fluctuations. We observe that back reaction plays an important role over a wide
range of parameters. Some implications of our investigation for the preheating
stage after cosmic inflation are presented.Comment: 35 pages, 16 eps figures, revtex4; v2: typos corrected and references
added, accepted for publication in Physical Review
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