18 research outputs found
Naked Singularity Formation In f(R) Gravity
We study the gravitational collapse of a star with barotropic equation of
state in the context of theories of gravity.
Utilizing the metric formalism, we rewrite the field equations as those of
Brans-Dicke theory with vanishing coupling parameter. By choosing the
functionality of Ricci scalar as , we
show that for an appropriate initial value of the energy density, if
and satisfy certain conditions, the resulting singularity would be naked,
violating the cosmic censorship conjecture. These conditions are the ratio of
the mass function to the area radius of the collapsing ball, negativity of the
effective pressure, and the time behavior of the Kretschmann scalar. Also, as
long as parameter obeys certain conditions, the satisfaction of the
weak energy condition is guaranteed by the collapsing configuration.Comment: 15 pages, 4 figures, to appear in GR
Association and spreading of the Drosophila dosage compensation complex from a discrete roX1 chromatin entry site
In Drosophila, dosage compensation is controlled by the male-specific lethal (MSL) complex consisting of MSL proteins and roX RNAs. The MSL complex is specifically localized on the male X chromosome to increase its expression ∼2-fold. We recently proposed a model for the targeted assembly of the MSL complex, in which initial binding occurs at ∼35 dispersed chromatin entry sites, followed by spreading in cis into flanking regions. Here, we analyze one of the chromatin entry sites, the roX1 gene, to determine which sequences are sufficient to recruit the MSL complex. We found association and spreading of the MSL complex from roX1 transgenes in the absence of detectable roX1 RNA synthesis from the transgene. We mapped the recruitment activity to a 217 bp roX1 fragment that shows male-specific DNase hypersensitivity and can be preferentially cross-linked in vivo to the MSL complex. When inserted on autosomes, this small roX1 segment is sufficient to produce an ectopic chromatin entry site that can nucleate binding and spreading of the MSL complex hundreds of kilobases into neighboring regions
Evaluation of antioxidant and antimutagenic activity of herbal teas from native plants used in traditional medicine in Argentina
Synthetic Lethal Analysis Implicates Ste20p, a p21-activated Protein Kinase, in Polarisome Activation
The p21-activated kinases Ste20p and Cla4p carry out undefined functions that are essential for viability during budding in Saccharomyces cerevisiae. To gain insight into the roles of Ste20p, we have used a synthetic lethal mutant screen to identify additional genes that are required in the absence of Cla4p. Altogether, we identified 65 genes, including genes with roles in cell polarity, mitosis, and cell wall maintenance. Herein, we focus on a set that defines a function carried out by Bni1p and several of its interacting proteins. We found that Bni1p and a group of proteins that complex with Bni1p (Bud6p, Spa2p, and Pea2p) are essential in a cla4Δ mutant background. Bni1p, Bud6p, Spa2, and Pea2p are members of a group of polarity determining proteins referred to as the polarisome. Loss of polarisome proteins from a cla4Δ strain causes cells to form elongated buds that have mislocalized septin rings. In contrast, other proteins that interact with or functionally associate with Bni1p and have roles in nuclear migration and cytokinesis, including Num1p and Hof1p, are not essential in the absence of Cla4p. Finally, we have found that Bni1p is phosphorylated in vivo, and a substantial portion of this phosphorylation is dependent on STE20. Together, these results suggest that one function of Ste20p may be to activate the polarisome complex by phosphorylation of Bni1p