6 research outputs found
Atypical antipsychotic drugs and the risk of sudden cardiac death
- Author
- Publication venue
- Publication date
- 01/01/2009
- Field of study
Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure
- Author
- Abecasis G. (Goncalo)
- Almgren P. (Peter)
- Andersson C. (Charlotte)
- Aragam K.G. (Krishna G.)
- Asselbergs F.W. (Folkert)
- Backman J. (Joshua)
- Backman J.D. (Joshua D.)
- Bai X. (Xiaodong)
- Balasubramanian S. (Suganthi)
- Banerjee N. (Nilanjana)
- Baras A. (Aris)
- Barnard L. (Leland)
- Beechert C. (Christina)
- Biggs M.L. (Mary L.)
- Bloom H.L. (Heather L.)
- Blumenfeld A. (Andrew)
- Brandimarto J. (Jeffrey)
- Brown M.R. (Michael R.)
- Buckbinder L. (Leonard)
- Cantor M. (Michael)
- Cappola T.P. (Thomas P.)
- Carey D.J. (David J.)
- Chaffin M.D. (Mark D.)
- Chai Y. (Yating)
- Chasman D.I. (Daniel I.)
- Chen X. (Xing)
- Chen X. (Xu)
- Chung J. (Jonathan)
- Chung J. (Jonathan)
- Chutkow W. (William)
- Cook J.P. (James P.)
- Coppola G. (Giovanni)
- Damask A. (Amy)
- Dehghan A. (Abbas)
- Delgado G.
- Denaxas S. (Spiros)
- Dewey F. (Frederick)
- Doney A.S.F. (Alex)
- Dudley S.C. (Samuel C.)
- Dunn M.E. (Michael E.)
- Dörr M. (Marcus)
- Economides A. (Aris)
- Ellinor P.T. (Patrick)
- Engström G.
- Eom G. (Gisu)
- Esko T. (Tõnu)
- Fatemifar G. (Ghazaleh)
- Felix S.B. (Stephan B.)
- Finan C. (Chris)
- Ford I. (Ian)
- Forsythe C. (Caitlin)
- Fuller E.D. (Erin D.)
- Ghanbari M. (Mohsen)
- Ghasemi S. (Sahar)
- Giedraitis V. (Vilmantas)
- Giulianini F. (Franco)
- Gottdiener J.S. (John)
- Gross S. (Stefan)
- Gu Z. (Zhenhua)
- Gurski L. (Lauren)
- Gutmann R. (Rebecca)
- Guzzardo P.M. (Paloma M.)
- Guðbjartsson D.F. (Daníel F.)
- Habegger L. (Lukas)
- Haggerty C.M. (Christopher M.)
- Hahn Y. (Young)
- Harst P. (Pim) van der
- Hawes A. (Alicia)
- Hedman A.K. (Asa)
- Helgadottir H.T. (Hafdis)
- Hemingway H.
- Henry A. (Albert)
- Hingorani A. (Aroon)
- Holm H. (Hilma)
- Holmes M.V. (Michael)
- Hyde C.L. (Craig L.)
- Ingelsson E. (Erik)
- Jones M.B. (Marcus B.)
- Jukema J.W. (Jan Wouter)
- Kao W.H.L. (Wen)
- Kavousi M. (Maryam)
- Khalid S. (Shareef)
- Khaw K.-T. (Kay-Tee)
- Kleber M.E. (Marcus)
- Koekemoer A. (Andrea)
- Kuchenbaecker K.B. (Karoline)
- Køber L. (Lars)
- Lang C.C. (Chim C.)
- Langenberg C. (Claudia)
- Lattari M. (Michael)
- Li A. (Alexander)
- Lin H. (Honghuang)
- Lin N. (Nan)
- Lindgren C.M. (Cecilia M.)
- Liu D. (Daren)
- London B. (Barry)
- Lopez A. (Alexander)
- Lotta L.A. (Luca A.)
- Lovering R.C. (Ruth C.)
- Luan J.
- Lubitz S.A. (Steven)
- Lumbers R.T. (R. Thomas)
- Magnusson P.K. (Patrik)
- Mahajan A. (Anubha)
- Manoochehri K. (Kia)
- Marchini J. (Jonathan)
- Marcketta A. (Anthony)
- Margulies K.B. (Kenneth B.)
- Maxwell E.K. (Evan K.)
- McCarthy S. (Shane)
- McMurray J.J.V. (John J. V.)
- Melander O. (Olle)
- Mitnaul L.J. (Lyndon)
- Mordi I.R. (Ify R.)
- Morgan T. (Thomas)
- Morley M.P. (Michael P.)
- Morris A.D. (Andrew D.)
- Morris A.P. (Andrew)
- Morrison A.C. (Alanna C.)
- Mälarstig A. (Anders)
- Nagle M.W. (Michael W.)
- Nelson C.P. (Christopher P.)
- Newton-Cheh C. (Christopher)
- Niessner A. (Alexander)
- Niiranen T. (Teemu)
- Overton J.D. (John D.)
- Owens A.T. (Anjali T.)
- O’Donoghue M.L. (Michelle L.)
- O’Dushlaine C. (Colm)
- Padilla M.S. (Maria Sotiropoulos)
- Palmer C.N.A. (Colin N. A.)
- Parry H.M. (Helen M.)
- Paulding C. (Charles)
- Penn J. (John)
- Perola M. (Markus)
- Portilla-Fernandez E. (Eliana)
- Pradhan M. (Manasi)
- Psaty B.M. (Bruce M.)
- Reid J.G. (Jeffrey G.)
- Rice K.M. (Kenneth)
- Ridker P.M. (Paul M.)
- Romaine S.P.R. (Simon P. R.)
- Roselli C. (Carolina)
- Rotter J.I. (Jerome I.)
- Salo P. (Perttu)
- Salomaa V. (Veikko)
- Samani N.J. (Nilesh J.)
- Sattar N. (Naveed)
- Schleicher T.D. (Thomas D.)
- Schurmann C. (Claudia)
- Setten J. (Jessica) van
- Shah S. (Sonia)
- Shalaby A.A. (Alaa A.)
- Shuldiner A. (Alan)
- Smelser D.T. (Diane T.)
- Smith J.G. (J Gustav)
- Smith N.L. (Nicholas L.)
- Staples J.C. (Jeffrey C.)
- Stefansson K. (Kari)
- Stender S. (Steen)
- Stott D.J. (David. J.)
- Sun D. (Dylan)
- Sveinbjörnsson G. (Garðar)
- Svensson P. (Per)
- Swerdlow D.I. (Daniel)
- Tammesoo M.L.
- Taylor K.D. (Kent D.)
- Teder-Laving M. (Maris)
- Teumer A. (Alexander)
- Thorgeirsson G. (Guðmundur)
- Thorsteinsdottir U. (Unnur)
- Toledo K. (Karina)
- Torp-Pedersen C. (Christian Tobias)
- Trompet S. (Stella)
- Tyl B. (Benoit)
- Uitterlinden A.G. (Andre G.)
- Ulloa R.H. (Ricardo H.)
- van Hout C. (Cristopher)
- Vasan R.S. (Ramachandran Srini)
- Veluchamy A. (Abirami)
- Verweij N. (Niek)
- Visscher P.M. (Peter M.)
- Voors A.A. (Adriaan A.)
- Völker U. (Uwe)
- Wang X. (Xiaosong)
- Wareham N.J. (Nick)
- Waterworth D. (Dawn)
- Weeke P.E. (Peter E.)
- Weiss R. (Ram)
- Widom L. (Louis)
- Wiggins K.L. (Kerri L.)
- Wilk J.B. (Jemma)
- Wolf S.E. (Sarah E.)
- Xing H. (Heming)
- Yadav A. (Ashish)
- Yang J. (Jian)
- Ye B. (Bin)
- Ye S. (Shu)
- Yerges-Armstrong L.M. (Laura)
- Yu B. (Bing)
- Zannad F. (Faiez)
- Zhao J.H. (Jing Hua)
- Ärnlöv J. (Johan)
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 09/01/2020
- Field of study
Heart failure (HF) is a leading cause of morbidity and mortality worldwide. A small proportion of HF cases are attributable to monogenic cardiomyopathies and existing genome-wide association studies (GWAS) have yielded only limited insights, leaving the observed heritability of HF largely unexplained. We report results from a GWAS meta-analysis of HF comprising 47,309 cases and 930,014 controls. Twelve independent variants at 11 genomic loci are associated with HF, all of which demonstrate one or more associations with coronary artery disease (CAD), atrial fibrillation, or reduced left ventricular function, suggesting shared genetic aetiology. Functional analysis of non-CAD-associated loci implicate genes involved in cardiac development (MYOZ1, SYNPO2L), protein homoeostasis (BAG3), and cellular senescence (CDKN1A). Mendelian randomisation analysis supports causal roles for several HF risk factors, and demonstrates CAD-independent effects for atrial fibrillation, body mass index, and hypertension. These findings extend our knowledge of the pathways underlying HF and may inform new therapeutic strategies
Multiancestry analysis of the HLA locus in Alzheimer’s and Parkinson’s diseases uncovers a shared adaptive immune response mediated by HLA-DRB1*04 subtypes
- Author
- Aarsland Dag
- Aarsland Dag
- Abdelnour Carla
- Abraham Richard
- Abraham Richard
- Adarmes-Gómez A.D.
- Adarmes-Gómez Ad
- Aguilera N.
- Aguilera Nuria
- Ahmad Shahzad
- Al-Chalabi Ammar
- Al-Chalabi Ammar
- Alarcon E.
- Alarcón-Martín E.
- Alarcón-Martín Emilio
- Alcolea Daniel
- Alegret M.
- Alegret Montserrat
- Alonso M.D.
- Alvarez Ignacio
- Alvarez Victoria
- Ambati Aditya
- Amer-Ferrer G.
- Amin Najaf
- Amouyel Philippe
- Amouyel Philippe
- Amouyel Phillippe
- Anastasiou Anna
- Anastasiou Costas
- Andrade Victor
- Andreassen Ole A.
- Andreassen Ole A.
- Andreassen Ole A.
- Andreoni Simona
- Annuar Azlina Ahmad
- Antequera M.
- Anthoula Tsolaki
- Antikainen Riitta
- Antonell Anna
- Antúnez C.
- Appollonio Ildebrando
- Arcaro Marina
- Archetti Silvana
- Arfan Ikram M.
- Arias Pastor Alfonso
- Ariel Prestia Federico
- Armstrong Nicola J.
- Arosio Beatrice
- Arosio Beatrice
- Assogna Francesca
- Athanasiu Lavinia
- Athanasiu Lavinia
- Au Wing-Lok
- Bahrami Shahram
- Bailly Henri
- Banaj Nerisa
- Baquero M.
- Baquero Miquel
- Bass Nicholas J.
- Bass Nick
- Bastiani Patrizia
- Bayer Anthony
- Becker Tim
- Belezhanska Diyana
- Bellenguez Céline
- Bellenguez Céline
- Bellenguez Céline
- Belloy Michael E.
- Belén Pastor Ana
- Ben-Shlomo Yoav
- Benussi Alberto
- Benussi Luisa
- Benussi Luisa
- Bergh Sverre
- Bernal M.
- Bernardo-Harrington Mateus
- Berr Claudine
- Berr Claudine
- Besse Céline
- Bessi Valentina
- Binetti Giuliano
- Bizarro Alessandra
- Bjerke Maria
- Blennow Kaj
- Blesa R.
- Blesa Rafael
- Boada M.
- Boada M.
- Boada Mercè
- Boada Mercè
- Boecker Henning
- Boland Anne
- Boland Anne
- Borroni Barbara
- Borroni Barbara
- Boschi Silvia
- Bosnes Ingunn
- Bossù Paola
- Brayne Carol
- Brayne Carol
- Bresner Catherine
- Brice Alexis
- Brodaty Henry
- Brookes Keeley J.
- Brown Kristelle
- Brown Kristelle S.
- Bråthen Geir
- Bråthen Geir
- Buendia M.
- Buendia Mar
- Buiza-Rueda D.
- Buiza-Rueda Dolores
- Bullido M.J.
- Bullido María J.
- Bullido María J.
- Burguera J.A.
- Burholt Vanessa
- BÛrger Katharina
- Caffarra Paolo
- Calero M.
- Calero Miguel
- campion Dominique
- Campos-Martin Rafael
- Cano A.
- Carracedo A.
- Carracedo Ángel
- Carrillo F.
- Carrillo F.
- Carrion-Claro M.
- Carrión-Claro M.
- Casajeros M.J.
- Castaño Eduardo M.
- Castillo Morales Atahualpa
- Cañabate P.
- Cañabate Pilar
- Cecchetti Roberta
- Cervera-Carles Laura
- Chan Anne Y.Y.
- Chao Yinxia
- Chapuis Julien
- Charbonnier Camille
- Chen Ling
- Chen Yongping
- Chene Geneviève
- Chew Elaine Guo Yan
- Chillotti Caterina
- Chipi Elena
- Chung Sun Ju
- Ciccone Simona
- Ciullo Valentina
- Claassen Jurgen A.H.R.
- Clarimon Jordi
- Clarimon Jordi
- Clarimon Jordi
- Clarimón J.
- Clark Christopher
- Clarke Robert
- Collinge John
- Collinge John
- Conti Elisa
- Corbatón-Anchuelo A.
- Cores Valeria
- Corma-Gómez Anaïs
- Costa Marcos R
- Costantini Emanuele
- Craig David
- Craig David
- Cruz-Gamero J.M.
- Cuesta Carolina
- Custodero Carlo
- Daian Delphine
- Dalmasso Maria Carolina
- Damotte Vincent
- Damotte Vincent
- Daniele Antonio
- Daniele Antonio
- Dardiotis Efthimios
- Darling Daniel
- Dartigues Jean-Francois
- Dartigues Jean-François
- David Smith A.
- David Smith A.
- Davies Chloe
- de Deyn Peter Paul
- de Mendonça Alexandre
- de Mendonça Alexandre
- de Munain Adolfo Lopez
- de Pancorbo M.M.
- De Roeck Ellen
- de Rojas I.
- de Rojas I.
- de Rojas Itziar
- de Rojas Itziar
- Debette Stéphanie
- Debette Stéphanie
- Deckert Jürgen
- del Ser T.
- del Ser Teodoro
- Del Zompo Maria
- Deleuze Jean-François
- Deleuze Jean-François
- Deloukas Panagiotis
- Deloukas Pangiotis
- den Bussche Hendrik
- Denning Nicola
- Denning Nicola
- Deramecourt Vincent
- Dermecourt Vincent
- Dichgans Martin
- Dichgans Martin
- Dichgans Martin
- Diego S.
- Diego Susana
- Diehl-Schmid Janine
- Diez-Fairen M.
- Diez-Fairen Mónica
- Dionigi Rossi Paolo
- Djurovic Srdjan
- Djurovic Srdjan
- Dolores Alonso María
- Dowzell Kimberley
- Drichel Dmitriy
- Dubois Bruno
- Dufouil Carole
- Dufouil Carole
- Dufouil Carole
- During Emmanuel
- Duron Emmanuelle
- Düzel Emrah
- Düzel Emrah
- Engelborghs Sebastiaan
- Epelbaum Jacques
- Escott-Price Valentina
- Escott-Price Valentina
- Escuela R.
- Escuela R.
- Espinosa A.
- Espinosa Ana
- Etchepareborda Ignacio
- Eugenia Sáez María
- Ewers Michael
- Fabrizio Tagliavini
- Fallgaard Nielsen Sune
- Farotti Lucia
- Fenoglio Chiara
- Fernández-Fuertes Marta
- Ferrarese Carlo
- Ferreira Catarina B
- Ferri Evelyn
- Feulner Thomas
- Fievet Nathalie
- Fievet Nathalie
- Fin Bertrand
- Fischer Peter
- Fisher Elizabeth
- Fladby Tormod
- Fladby Tormod
- Fließbach Klaus
- Foo Jia Nee
- Foo Jia Nee
- Forsell Charlotte
- Fortea J.
- Fortea Juan
- Fostinelli Silvia
- Fox Nick
- Fox Nick C.
- Fox Nick C.
- Franco E.
- Franco-Macías Emlio
- Frank-García A.
- Frank-García Ana
- Frikke-Schmidt Ruth
- Frikke-Schmidt Ruth
- Froelich Lutz
- Frölich Lutz
- Gailhajenet A.
- Gailhajenet Anna
- Galeano Pablo
- Galimberti Daniela
- Galimberti Daniela
- Gan-Or Ziv
- Garcia Madrona S.
- Garcia-Gonzalez Pablo
- Garcia-Madrona Sebastian
- Garcia-Ribas G.
- Garcia-Ribas Guillermo
- Garcia-Ribas Guillermo
- García-Alberca J.M.
- García-Alberca José María
- García-González P.
- García-González Pablo
- García-González Pablo
- Garrote-Espina L.
- Garrote-Espina L.
- Germani Sandra
- Gerrish Amy
- Gerrish Amy
- Ghanbari Mohsen
- Ghidoni Roberta
- Giedraitis Vilmantas
- Giedraitis Vilmantas
- Giegling Ina
- Giegling Ina
- Gill Michael
- Gill Michael
- Gill Michael
- Gim Jungsoo
- Giorgio Giaccone
- Goldhardt Oliver
- Goldhardt Oliver
- González-Péerez A.
- González-Pérez Antonio
- Graff Caroline
- Graff Caroline
- Grande Giulia
- Green Emma
- Greicius Michael D.
- Grenier-Boley Benjamin
- Grenier-Boley Benjamin
- Grenier-Boley Benjamin
- Grimmer Timo
- Grünblatt Edna
- Grünblatt Edna
- Gu Wei
- Guerreiro Rita
- Guetta-Baranes Tamar
- Guitart M.
- Guitart Marina
- Gurling Hugh
- Gwilliam Rhian
- Gwilliam Rhian
- Gómez-Garre P.
- Gómez-Garre P.
- Haapasalo Annakaisa
- Hadjigeorgiou Georgios
- Hampel Harald
- Hampel Harald
- Hannequin Didier
- Hanon Olivier
- Hanon Olivier
- Hanon Olivier
- Hardy John
- Hardy John
- Hardy John
- Harold Denise
- Harold Denise
- Hartmann Annette M.
- Hartmann Annette M.
- Harwood Janet
- Hausner Lucrezia
- Hausner Lucrezia
- He Zihuai
- Heilmann-Heimbach Stefanie
- Heilmann-Heimbach Stefanie
- Helisalmi Seppo
- Heneka Michael T.
- Hernández Isabel
- Herold Christine
- Herrmann Martin J.
- Heun Reinhard
- Heuser Isabella
- Hevilla S.
- Hiltunen Mikko
- Hiltunen Mikko
- Hodges Angela
- Hoffmann Per
- Hoffmann Per
- Hollingworth Paul
- Hollingworth Paul
- Holmans Peter
- Holmans Peter A.
- Holmes Clive
- Holmes Clive
- Holstege Henne
- Holstege Henne
- Hooper Nigel M.
- Hort Jakub
- Hort Jakub
- Huerto Vilas Raquel
- Hulsman Marc
- Hüll Michael
- Ibarria M.
- Ibarria Marta
- Ignacio Bacha Juan
- Ignacio Brusco Luis
- Ikeuchi Takeshi
- Ingelsson Martin
- Ingelsson Martin
- Ingino Carlos
- Jan Biessels Geert
- Janowitz Daniel
- Jansen Iris
- Jansen Iris
- Jeon Beom S.
- Jessen Frank
- Jessen Frank
- Jessen Frank
- Jesús S.
- Jesús S.
- Jiang Lulu
- Johansson Charlotte
- Johnston Janet A.
- Johnston Jarret A.
- Jones Lesley
- Jones Lesley
- Jung Yoo Jin
- Jöckel Karl-Heinz
- Jürgen Deckert
- Kauwe John
- Kehoe Patrick
- Kehoe Patrick G.
- Kehoe Patrick G.
- Kern Silke
- Khor Chiea Chuen
- Kilander Lena
- Kinhult Ståhlbom Anne
- Kivipelto Miia
- Kleineidam Luca
- Klopp Norman
- Kochen Silvia
- Koh Woon-Puay
- Kohler Eduardo
- Kohler Matias
- Koivisto Anne
- Kornhuber Johannes
- Kornhuber Johannes
- Kosmidis Mary H.
- Kuulasmaa Teemu
- Kuulasmaa Teemu
- Kölsch Heike
- Küçükali Fahri
- Küçükali Fahri
- Laatikainen Tiina
- Labrador Espinosa M.A.
- Labrador Ma
- Lacidogna Giordano
- Lacour ndré
- Laczo Jan
- Lafuente A.
- Lafuente Asunción
- Lage C.
- Lage Carmen
- Lage Carmen
- Lambert Jean-Charles
- Lambert Jean-Charles
- Lambert Jean-Charles
- Laske Christoph
- Laukka Erika J
- Lauria Alessandra
- Lawlor Brian
- Lawlor Brian
- Le Guen Yann
- Lee Kun Ho
- Legaz A.
- Lehtisalo Jenni
- Lerch Ondrej
- Lian Michelle M.
- Lian Michelle Mulan
- Lim Jia Lun
- Lim Shen-Yang
- Lin Juei-Jueng
- Lin Ling
- Lindström Jaana
- Lis Palacio Dana
- Lisso Julieta
- Liu Chunfeng
- Liu Jianjun
- Livingston Gill
- Livingston Gill
- Lleó Alberto
- Lleóo A.
- Lord Jenny
- Love Seth
- Love Seth
- Lovestone Simon
- Lovestone Simon
- Luckcuck Lauren
- Luckcuck Lauren
- Luis Royo Jose
- Luo Guo
- Lupton Michelle
- Lupton Michelle
- Luís Royo Jose
- Lynch Aoibhinn
- Lynch Aoibhinn
- Lóopez de Munáin A.
- López-García S.
- López-García Sara
- Löwemark Malin
- Macias J.
- Macias-García D.
- Macias-García D.
- MacLeod Catherine A.
- Macías Juan
- Magda Tsolaki
- Maier Wolfgang
- Maier Wolfgang
- Malik Rainer
- Mangialasche Francesca
- Mangone Carlos
- Mann David
- Mann David
- Manzanares S.
- Mao Chengjie
- Marco Spallazzi
- Maria García-Alberca Jose
- Maroñas O.
- Marquié M.
- Marquié M.
- Marquié Marta
- Marshall Rachel
- Marshall Rachel
- Martín Montes A.
- Martín Montes Angel
- Martín E.
- Martín Elvira
- Martínez Rodríguez Carmen
- Martínez B.
- Martínez C.
- Martínez M.T.
- Martínez V.
- Martínez-Lage Álvarez A.
- Marín M.
- Marín M.
- Marín T.
- Marín-Muñoz J.
- Masullo Carlo
- Masullo Carlo
- Mata Ignacio
- Mather Karen
- Matoska Vaclav
- Mauleón Ana
- Mayhaus Manuel
- Mayo Kevin
- McGuinness Bernadette
- McGuinness Bernadette
- McQuillin Andrew
- McQuillin Andrew
- Mead Simon
- Mead Simon
- Meah Wee-Yang
- Mecocci Patrizia
- Mecocci Patrizia
- Medel Nancy
- Medina M.
- Medina Miguel
- Meggy Alun
- Meggy Alun
- Mehrabian Shima
- Mehrabian Shima
- Mendioroz Iriarte M.
- Mendoza Silvia
- Menéndez-González M.
- Menéndez-González Manuel
- Mignot Emmanuel
- Mir P.
- Mir Pablo
- Mir Pablo
- Miyashita Akinori
- Moebus Susanne
- Moebus Susanne
- Moebus Susanne
- Mok Shi Qi
- Mok Vincent
- Mol Merel
- Molina-Porcel Laura
- Montrreal L.
- Montrreal L.
- Montrreal Laura
- Morelli Laura
- Moreno Fermin
- Moreno Fermin
- Moreno M.
- Moreno Mariona
- Moreno-Grau S.
- Moreno-Grau Sonia
- Morgan Kevin
- Morgan Kevin
- Morizono Takashi
- Morris John
- Muchnik Carolina
- Mummery Catherine
- Möthen Markus M
- Nacmias Benedetta
- Nacmias Benedetta
- Naito Tatsuhiko
- Nash William
- Natunen Teemu
- Ng Ebonne Y.
- Ngandu Tiia
- Nicolas Aude
- Nicolas Gael
- Nicolas Gael
- Niida Shumpei
- Nordestgaard Børge G.
- Nordestgaard Børge G.
- Novack Gisela
- Nuñez-Llaves R.
- Nöthen Markus M.
- O'Donovan Michael
- O'Donovan Michael C.
- Okada Yukinori
- Olaso Robert
- Olivar Natividad
- Olivé C.
- Orellana A.
- Orellana A.
- Orellana Adelina
- Orsini Michela
- Ortega G.
- Ortega Gemma
- Ortiz Cecilia
- Owen Michael
- Owen Michael J.
- Ozaki Kouichi
- Pablo Tartan Juan
- Padovani Alessandro
- Pancho A.
- Pancho Ana
- Paola Zoia Chiara
- Paolo Caffarra
- Papenberg Goran
- Papenberg Goran
- Papma Janne
- Park Hyeonseul
- Parnetti Lucilla
- Parnetti Lucilla
- Parveen Kayenat
- Parveen Kayenat
- Pasquier Florence
- Pasquier Florence
- Pasquier Florence
- Passmore Peter
- Passmore Peter
- Pastor P.
- Pastor Pau
- Pastor Pau
- Patel Yogen
- Pei Zhong
- Peixoto Leal Thiago
- Pelejà E.
- Pelejà Esther
- Peltonen Markku
- Peng Rong
- Pericard Pierre
- Periñán Mt
- Periñán-Tocino T.
- Perneczky Robert
- Peters Oliver
- Peters Oliver
- Pickering-Brown Stuart
- Pijnenburg Yolande A. L.
- Pijnenburg Yolande A.L.
- Pinchler Sabrina
- Pineda J.A.
- Pineda Juan A.
- Pineda-Sánchez R.
- Pineda-Sánchez R.
- Piras Fabrizio
- Piras Federica
- Pisanu Claudia
- Piñol Ripoll G.
- Piñol-Ripoll Gerard
- Piñol-Ripoll Gerard
- Polak Thomas
- Politis Daniel G.
- Popp Julius
- Popp Julius
- Porcel Laura Molina
- Posthuma Danielle
- Powell John
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- Prakash Kumar-M.
- Preckler S.
- Preckler Silvia
- Priller Josef
- Proitsi Petra
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- Puerta R.
- Puerta Raquel
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- Pérez-Cordon A.
- Pérez-Cordón Alba
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- Pérez-Tur Jordi
- Quenez Olivier
- Quintela I.
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- Rainero Innocenzo
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- Ramakers Inez
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- Ramirez Alfredo
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- Real de Asúa D.
- Real L.M.
- Real Luis M.
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- Reinders Marcel J.T.
- Reyes Toso Carlos
- Riedel-Heller Steffi
- Riedel-Heller Steffi
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- Riemenschneider Matthias
- Rios Mario
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- Rodriguez-Rodriguez Eloy
- Rodriguez-Rodriguez Eloy
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- Rosende-Roca M.
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- Sastre I.
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- Scheltens Philip
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- Scherbaum Norbert
- Scherbaum Norbert
- Scherer Martin
- Scherer Martin
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- Shadrin Alexey A.
- Shang Hui-Fang
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- Sims Rebecca
- Sims Rebecca
- Sims Rebecca
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- Sleegers Kristel
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- Solfrizzi Vincenzo
- Solfrizzi Vincenzo
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- Song Kyuyoung
- Sorbi Sandro
- Sotolongo-Grau O.
- Sotolongo-Grau O.
- Sotolongo-Grau Oscar
- Spalletta Gianfranco
- Spalletta Gianfranco
- Spottke Annika
- Squassina Alessio
- Squassina Alessio
- Stordal Eystein
- Stordal Eystein
- Strandberg Timo
- Sussams Rebecca
- Sáez M.E.
- Sánchez Juan Pascual
- Sánchez-Arjona María Bernal
- Sánchez-Juan P.
- Sánchez-Juan Pascual
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- Takalo Mari
- Talyansky Seth D.
- Tan Ai Huey
- Tan Eng-King
- Tan Eng-King
- Tan Louis C.S.
- Tandiono Moses
- Tegos Thomas
- Teipel Stefan
- Teresa Martínez-Larrad María
- Tesí Niccolo
- Teunissen Charlotte
- Thalamuthu Anbupalam
- Thomas Charlene
- Thomas Tegos
- Thomassen Jesper Qvist
- Thonberg Håkan
- Toda Tatsushi
- Todd Stephen
- Todd Stephen
- Traykov Latchezar
- Tremolizzo Lucio
- Tremolizzo Lucio
- Tsolaki Magda
- Tsolaki Magda
- Tuomilehto Jaakko
- Turton James
- Tybjærg-Hansen Anne
- Tzourio Christophe
- Táarraga L.
- Tárraga Lluís
- Uitterlinden Andre
- Ullgren Abbe
- Ulstein Ingun
- Ulstein Ingun
- Uphill James
- Vacca Alessandro
- Valero S.
- Valero S.
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- Van Broeckhoven Christine
- van der Flier Wiesje
- van der Flier Wiesje M.
- van der Lee Sven J.
- van der Lugt Aad
- Van Dongen Jasper
- van Duijn Cornelia M.
- Van Duin Cornelia
- van Rooij Jeroen
- van Swieten John
- van Swieten John
- Vandenberghe Rik
- Vardy Emma
- Vargas L.
- Vargas Liliana
- Verhey Frans
- Verhey Frans
- Vicente M.P.
- Vidal Jean-Sébastien
- Vigo-Ortega R.
- Vigo-Ortega R.
- Vivancos L.
- Vogelgsang Jonathan
- Vyhnalek Martin
- Vyhnalek Martin
- Waern Margda
- Wagner Michael
- Wallon David
- Wallon David
- Warden Donald
- Warner Nick
- Warren Jason D.
- Weber Heike
- Weinhold Leonie
- Wichmann H-Erich
- Wilcock Gordon
- Williams Amy
- Williams Julie
- Williams Julie
- Williams Julie
- Wiltfang Jens
- Wiltfang Jens
- Wiltfang Jens
- Windle Gill
- Woods Bob
- Wu Yih-Ru
- Xu Renshi
- Xu Yu-ming
- Yan Yaping
- Yang Jing
- Yannakoulia Mary
- Yaqub Amber
- Yogeshwar Selina Maria
- Yonkova Mihova Kalina
- Yu Eric
- Zetterberg Henrik
- Zettergren Anna
- Zhang Jing
- Zulaica Miren
- Álvarez I.
- Álvarez V.
- Álvarez Victoria
- Publication venue
- National Academy of Sciences
- Publication date
- 29/08/2023
- Field of study
Across multiancestry groups, we analyzed Human Leukocyte Antigen (HLA) associations in over 176,000 individuals with Parkinson’s disease (PD) and Alzheimer’s disease (AD) versus controls. We demonstrate that the two diseases share the same protective association at the HLA locus. HLA-specific fine-mapping showed that hierarchical protective effects of HLA-DRB1*04 subtypes best accounted for the association, strongest with HLA-DRB1*04:04 and HLA-DRB1*04:07, and intermediary with HLA-DRB1*04:01 and HLA-DRB1*04:03. The same signal was associated with decreased neurofibrillary tangles in postmortem brains and was associated with reduced tau levels in cerebrospinal fluid and to a lower extent with increased Aβ42. Protective HLA-DRB1*04 subtypes strongly bound the aggregation-prone tau PHF6 sequence, however only when acetylated at a lysine (K311), a common posttranslational modification central to tau aggregation. An HLA-DRB1*04-mediated adaptive immune response decreases PD and AD risks, potentially by acting against tau, offering the possibility of therapeutic avenues
Atypical antipsychotic drugs and the risk of sudden cardiac death
- Author
- Publication venue
- Publication date
- 01/01/2009
- Field of study
A saturated map of common genetic variants associated with human height
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- 't Hart Leen M
- Abecasis Goncalo
- Adair L.S.
- Adams H.H.H.
- Aguilar-Salinas Carlos Alberto
- Ahluwalia Tarunveer Singh
- Akiyama Masato
- Al-Mulla F.
- Allison Matthew A.
- Andersen Mette korre
- Ani Alireza
- Appadurai Vivek
- Arbeeva Liubov
- Arias Joshua D.
- Arnett D.K.
- Asselbergs F.W.
- Assimes Themistocles
- Attia J.
- Auton Adam
- Banas B.
- Bandinelli S.
- Bartell Eric
- Bennett D.A.
- Bergler T.
- Berndt Sonja I.
- Bharadwaj D.
- Bhaskar Seema
- Bielak Lawrence F.
- Biino G.
- Bin Wei W.
- Bisgaard H.
- Boehnke Michael
- Boerwinkle E.
- Bollepalli Sailalitha
- Bonnycastle Lori L.
- Boomsma D.I.
- Borja J.B.
- Bork-Jensen Jette
- Bouchard C.
- Bowden D.W.
- Bradfield J.P.
- Bradford Y.
- Brandslund I.
- Braund P.S.
- Brody J.A.
- Brumpton B.
- Burgdorf K.S.
- Buring J.E.
- Böger C.A.
- Bønnelykke K.
- Børglum A.D.
- Cade B.E.
- Cai H.
- Cai Q.
- Campbell Archie
- Catamo E.
- Caulfield M.J.
- Cañadas-Garre Marisa
- Chai J.F.
- Chai X.
- Chambers J.C.
- Chandak G.R.
- Chang L.C.
- Chang Y.C.
- Chanock Stephen J.
- Chasman Daniel I.
- Chaturvedi N.
- Chen C.H.
- Chen Shyh-Huei
- Chen Y.D.I.
- Chen Z.
- Cheng C.Y.
- Chesi A.
- Cho Yoon Shin
- Choi S.H.
- Christofidou P.
- Christophersen I.E.
- Chung R.H.
- Ciullo M.
- Cocca M.
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- Danning R.
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- de Borst G.J.
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- Dedoussis G.V.
- Degenhard F.
- Delgado G.E.
- Delitala A.
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- den Hollander A.I.
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- Uitterlinden A.G.
- Universitat Autònoma de Barcelona
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- Publication venue
- Publication date
- 01/01/2022
- Field of study
Common single-nucleotide polymorphisms (SNPs) are predicted to collectively explain 40-50% of phenotypic variation in human height, but identifying the specific variants and associated regions requires huge sample sizes. Here, using data from a genome-wide association study of 5.4 million individuals of diverse ancestries, we show that 12,111 independent SNPs that are significantly associated with height account for nearly all of the common SNP-based heritability. These SNPs are clustered within 7,209 non-overlapping genomic segments with a mean size of around 90 kb, covering about 21% of the genome. The density of independent associations varies across the genome and the regions of increased density are enriched for biologically relevant genes. In out-of-sample estimation and prediction, the 12,111 SNPs (or all SNPs in the HapMap 3 panel) account for 40% (45%) of phenotypic variance in populations of European ancestry but only around 10-20% (14-24%) in populations of other ancestries. Effect sizes, associated regions and gene prioritization are similar across ancestries, indicating that reduced prediction accuracy is likely to be explained by linkage disequilibrium and differences in allele frequency within associated regions. Finally, we show that the relevant biological pathways are detectable with smaller sample sizes than are needed to implicate causal genes and variants. Overall, this study provides a comprehensive map of specific genomic regions that contain the vast majority of common height-associated variants. Although this map is saturated for populations of European ancestry, further research is needed to achieve equivalent saturation in other ancestries