1,640 research outputs found
Practical application and clinical impact of the WHO histopathological criteria on bone marrow biopsy for the diagnosis of essential thrombocythemia versus prefibrotic primary myelofibrosis
Aims: To evaluate the feasibility of the histopathological diagnosis of prefibrotic–early primary myelofibrosis (PM) as described in the World Health Organization (WHO) classification and to evaluate the clinical implications of prefibrotic–early PM in a series of patients previously diagnosed as having essential thrombocythemia (ET) according to the Polycythemia Vera Study Group criteria.
Methods and results: WHO criteria were applied to bone marrow biopsy specimens by two pathologists who then reclassified 127 cases as 102 ET (80.3%), 18 prefibrotic–early PM (14.2%) and seven fibrotic PM (5.5%). In 45 cases (35%), the final diagnosis was only reached by consensus. The megakaryocytic criteria that best discriminated between ET and prefibrotic–early PM were an increased nucleo–cytoplasmic ratio, presence of cloudlike nuclei, hyperchromatic-dysplastic nuclei, paratrabecular megakaryocytes and tight clusters. A histological score discriminated between ET (score ≤3) and PM (score ≥6), but 21 cases showed an intermediate ambiguous score. No significant differences were observed at diagnosis and at follow-up (median time 93 months) for thrombosis, major haemorrhage, laboratory data, transformation into overt myeloid metaplasia and survival.
Conclusions: The distinction between ET and prefibrotic–early PM is impaired by subjectivity in pathological practice and is of questionable clinical relevance, at least when considering individual patients
Nuclear dependence coefficient for the Drell-Yan and J/ production
Define the nuclear dependence coefficient in terms of ratio
of transverse momentum spectrum in hadron-nucleus and in hadron-nucleon
collisions: . We argue that in small region, the
for the Drell-Yan and J/ production is given by a universal function:\
, where parameters a and b are completely determined by either
calculable quantities or independently measurable physical observables. We
demonstrate that this universal function is insensitive to the
A for normal nuclear targets. For a color deconfined nuclear medium, the
becomes strongly dependent on the A. We also show that our
for the Drell-Yan process is naturally linked to perturbatively
calculated at large without any free parameters, and the
is consistent with E772 data for all .Comment: latex, 28 pages, 10 figures, updated two figures, and add more
discussion
Barkhausen Noise and Critical Scaling in the Demagnetization Curve
The demagnetization curve, or initial magnetization curve, is studied by
examining the embedded Barkhausen noise using the non-equilibrium, zero
temperature random-field Ising model. The demagnetization curve is found to
reflect the critical point seen as the system's disorder is changed. Critical
scaling is found for avalanche sizes and the size and number of spanning
avalanches. The critical exponents are derived from those related to the
saturation loop and subloops. Finally, the behavior in the presence of long
range demagnetizing fields is discussed. Results are presented for simulations
of up to one million spins.Comment: 4 pages, 4 figures, submitted to Physical Review Letter
LES of non-Newtonian physiological blood flow in a model of arterial stenosis
Large Eddy Simulation (LES) is performed to study the physiological pulsatile transition-to-turbulent non-Newtonian blood flow through a 3D model of arterial stenosis by using five different blood viscosity models: (i) Power-law, (ii) Carreau, (iii) Quemada, (iv) Cross and (v) modified-Casson. The computational domain has been chosen is a simple channel with a biological type stenosis formed eccentrically on the top wall. The physiological pulsation is generated at the inlet of the model using the first four harmonic series of the physiological pressure pulse (Loudon and Tordesillas [1]). The effects of the various viscosity models are investigated in terms of the global maximum shear rate, post-stenotic re-circulation zone, mean shear stress, mean pressure, and turbulent kinetic energy. We find that the non-Newtonian viscosity models enlarge the length of the post-stenotic re-circulation region by moving the reattachment point of the shear layer separating from the upper wall further downstream. But the turbulent kinetic energy at the immediate post-lip of the stenosis drops due to the effects of the non-Newtonian viscosity. The importance of using LES in modelling the non-Newtonian physiological pulsatile blood flow is also assessed for the different viscosity models in terms of the results of the dynamic subgrid-scale (SGS) stress Smagorinsky model constant, C<sub>s</sub>, and the corresponding SGS normalised viscosity
Leptogenesis and Low-energy Observables
We relate leptogenesis in a class of theories to low-energy experimental
observables: quark and lepton masses and mixings. With reasonable assumptions
motivated by grand unification, one can show that the CP-asymmetry parameter
takes a universal form. Furthermore the dilution mass is related to the light
neutrino masses. Overall, these models offer a natural explanation for a lepton
asymmetry in the early universe.Comment: 10 pages, revised discussion on light neutrino masse
Thickness Estimation of Epitaxial Graphene on SiC using Attenuation of Substrate Raman Intensity
A simple, non-invasive method using Raman spectroscopy for the estimation of
the thickness of graphene layers grown epitaxially on silicon carbide (SiC) is
presented, enabling simultaneous determination of thickness, grain size and
disorder using the spectra. The attenuation of the substrate Raman signal due
to the graphene overlayer is found to be dependent on the graphene film
thickness deduced from X-ray photoelectron spectroscopy and transmission
electron microscopy of the surfaces. We explain this dependence using an
absorbing overlayer model. This method can be used for mapping graphene
thickness over a region and is capable of estimating thickness of multilayer
graphene films beyond that possible by XPS and Auger electron spectroscopy
(AES).Comment: 14 pages, 9 figure
Crackling Noise, Power Spectra and Disorder Induced Critical Scaling
Crackling noise is observed in many disordered non-equilibrium systems in
response to slowly changing external conditions. Examples range from Barkhausen
noise in magnets to acoustic emission in martensites to earthquakes. Using the
non-equilibrium random field Ising model, we derive universal scaling
predictions for the dependence of the associated power spectra on the disorder
and field sweep rate, near an underlying disorder-induced non-equilibrium
critical point. Our theory applies to certain systems in which the crackling
noise results from avalanche-like response to a (slowly) increasing external
driving force, and is characterized by a broad power law scaling regime of the
power spectra. We compute the critical exponents and discuss the relevance of
the results to experiments.Comment: 27 Latex Pages, 14 eps figure
A systematic study of J/psi suppression in cold nuclear matter
Based on a Glauber model, a statistical analysis of all mid-rapidity J/psi
hadroproduction and leptoproduction data on nuclear targets is carried out.
This allows us to determine the J/psi-nucleon inelastic cross section, whose
knowledge is crucial to interpret the J/psi suppression observed in heavy-ion
collisions, at SPS and at RHIC. The values of sigma are extracted from each
experiment. A clear tension between the different data sets is reported. The
global fit of all data gives sigma=3.4+/-0.2 mb, which is significantly smaller
than previous estimates. A similar value, sigma=3.5+/-0.2 mb, is obtained when
the nDS nuclear parton densities are included in the analysis, although we
emphasize that the present uncertainties on gluon (anti)shadowing do not allow
for a precise determination of sigma. Finally, no significant energy dependence
of the J/psi-N interaction is observed, unless strong nuclear modifications of
the parton densities are assumed.Comment: 25 pages, 5 figure
Leptogenesis and low energy observables in left-right symmetric models
In the context of left-right symmetric models we study the connection of
leptogenesis and low energy parameters such as neutrinoless double beta decay
and leptonic CP violation. Upon imposition of a unitarity constraint, the
neutrino parameters are significantly restricted and the Majorana phases are
determined within a narrow range, depending on the kind of solar solution. One
of the Majorana phases gets determined to a good accuracy and thereby the
second phase can be probed from the results of neutrinoless double beta decay
experiments. We examine the contributions of the solar and atmospheric mass
squared differences to the asymmetry and find that in general the solar scale
dominates. In order to let the atmospheric scale dominate, some finetuning
between one of the Majorana phases and the Dirac CP phase is required. In this
case, one of the Majorana phases is determined by the amount of CP violation in
oscillation experiments.Comment: 18 pages, 6 figures. Matches version to appear in PR
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