167 research outputs found
AFBC of coal with tyre rubber. Influence of the co-combustion variables on the mineral matter of solid by-products and on Zn lixiviation
The study focuses on the generation and distribution of mineral species in fly and bottom ashes. These were formed during a fluidised co-combustion of a fossil fuel (coal) and a non-fossil fuel (tyre rubber) in a small fluidised bed combustor (7cm x 70cm). The pilot plant had continuous fuel feed using varying ratios of coal and rubber. The study also focuses on the lixiviation behaviour of metallic elements with the assessement of zinc recovering
Basic Module Theory over Non-Commutative Rings with Computational Aspects of Operator Algebras
The present text surveys some relevant situations and results where basic
Module Theory interacts with computational aspects of operator algebras. We
tried to keep a balance between constructive and algebraic aspects.Comment: To appear in the Proceedings of the AADIOS 2012 conference, to be
published in Lecture Notes in Computer Scienc
Isobutyryl-CoA dehydrogenase deficiency associated with autism in a girl without an alternative genetic diagnosis by trio whole exome sequencing: A case report
Background: Isobutyryl-CoA dehydrogenase (IBD) is a mitochondrial enzyme catalysing the third step in the degradation of the essential branched-chain amino acid valine and is encoded by ACAD8. ACAD8 mutations lead to isobutyryl-CoA dehydrogenase deficiency (IBDD), which is identified by increased C4-acylcarnitine levels. Affected individuals are either asymptomatic or display a variety of symptoms during infancy, including speech delay, cognitive impairment, failure to thrive, hypotonia, and emesis. Methods: Here, we review all previously published IBDD patients and describe a girl diagnosed with IBDD who was presenting with autism as the main disease feature. Results: To assess whether a phenotype-genotype correlation exists that could explain the development or absence of clinical symptoms in IBDD, we compared CADD scores, in silico mutation predictions, LoF tolerance scores and C4-acylcarnitine levels between symptomatic and asymptomatic individuals. Statistical analysis of these parameters did not establish significant differences amongst both groups. Conclusion: As in our proband, tri
Use of hydrophilic and hydrophobic polymers for the development of controlled release tizanidine matrix tablets
Loss-of-function mutations in UDP-Glucose 6-Dehydrogenase cause recessive developmental epileptic encephalopathy
Developmental epileptic encephalopathies are devastating disorders characterized by intractable epileptic seizures and developmental delay. Here, we report an allelic series of germline recessive mutations in UGDH in 36 cases from 25 families presenting with epileptic encephalopathy with developmental delay and hypotonia. UGDH encodes an oxidoreductase that converts UDP-glucose to UDP-glucuronic acid, a key component of specific proteoglycans and glycolipids. Consistent with being loss-of-function alleles, we show using patientsâ primary fibroblasts and biochemical assays, that these mutations either impair UGDH stability, oligomerization, or enzymatic activity. In vitro, patient-derived cerebral organoids are smaller with a reduced number of proliferating neuronal progenitors while mutant ugdh zebrafish do not phenocopy the human disease. Our study defines UGDH as a key player for the production of extracellular matrix components that are essential for human brain development. Based on the incidence of variants observed, UGDH mutations are likely to be a frequent cause of recessive epileptic encephalopathy
Forecasting the load of electrical power systems in midâ and longâterm horizons: a review
Exercise intervention in people with cancer undergoing adjuvant cancer treatment following surgery: A systematic review
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