1,633 research outputs found
Measurement of the electron transmission rate of the gating foil for the TPC of the ILC experiment
We have developed a gating foil for the time projection chamber envisaged as
a central tracker for the international linear collider experiment. It has a
structure similar to the Gas Electron Multiplier (GEM) with a higher optical
aperture ratio and functions as an ion gate without gas amplification. The
transmission rate for electrons was measured in a counting mode for a wide
range of the voltages applied across the foil using an Fe source and a
laser in the absence of a magnetic field. The blocking power of the foil
against positive ions was estimated from the electron transmissions.Comment: 25 pages containing 14 figures and 1 tabl
Convergent evidences from human and animal studies implicate angiotensin I-converting enzyme activity in cognitive performance in schizophrenia
In schizophrenia (SCZ), higher angiotensin I-converting enzyme (ACE) levels have been reported in patient's blood and cerebrospinal fluid (CSF). Hereby, we propose to explore whether the ACE activity levels are associated to cognitive performance in SCZ. Seventy-two patients with SCZ or schizoaffective disorder diagnosis, and 69 healthy controls (HCs) underwent a cognitive battery with parallel collection of peripheral blood samples to measure ACE activity. Significant higher ACE activity levels were confirmed in the plasma of SCZ patients compared with HCs (Student's t=−5.216; P<0.001). ACE activity significantly correlated to Hopkins delayed recall measures (r=−0.247; P=0.004) and Hopkins total (r=−0.214; P=0.012). Subjects grouped as high ACE activity (above average) had worse performance compared with low ACE activity level group for Hopkins delayed recall measure, even after correction for clinical condition, age, gender and years of education (P=0.029). The adjusted R squared for this final model was 0.343. This result was evident only comparing extreme groups for ACE activity, when splitting the sample in three groups with similar number of subjects. To clarify this finding, we performed an evaluation of the cognitive performance of transgenic mice with three copies of ACE gene in novel object recognition (NOR) test, which showed that such animals presented impairment in NOR (P<0.05) compared with two copies of wild-type animals. The results observed in SCZ patients and animal model suggest both the association of ACE to cognitive deficits in SCZ. This finding may support the evaluation of novel treatment protocols and/or of innovative drugs for specific intervention of cognitive deficits in SCZ envisioning concomitant ACE activity and behavior evaluations
Cosmic ray tests of a GEM-based TPC prototype operated in Ar-CF4-isobutane gas mixtures
Argon with an admixture of CF4 is expected to be a good candidate for the gas
mixture to be used for a time projection chamber (TPC) in the future linear
collider experiment because of its small transverse diffusion of drift
electrons especially under a strong magnetic field. In order to confirm the
superiority of this gas mixture over conventional TPC gases we carried out
cosmic ray tests using a GEM-based TPC operated mostly in Ar-CF4-isobutane
mixtures under 0 - 1 T axial magnetic fields. The measured gas properties such
as gas gain and transverse diffusion constant as well as the observed spatial
resolution are presented.Comment: 22 pages, 18 figures. Published in Nuclear Instruments and Methods in
Physics Research A. Fig. 3 in the introduction was corrected since it had not
been properly normalized. Minor corrections and no changes in the conclusio
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Measurement of the [Formula: see text] production cross section in the all-jets final state in pp collisions at [Formula: see text][Formula: see text].
The cross section for [Formula: see text] production in the all-jets final state is measured in pp collisions at a centre-of-mass energy of 8 [Formula: see text] at the LHC with the CMS detector, in data corresponding to an integrated luminosity of 18.4 [Formula: see text]. The inclusive cross section is found to be [Formula: see text] [Formula: see text]. The normalized differential cross sections are measured as a function of the top quark transverse momenta, [Formula: see text], and compared to predictions from quantum chromodynamics. The results are reported at detector, parton, and particle levels. In all cases, the measured top quark [Formula: see text] spectra are significantly softer than theoretical predictions
Performance of a Large-Area GEM Detector Prototype for the Upgrade of the CMS Muon Endcap System
Gas Electron Multiplier (GEM) technology is being considered for the forward
muon upgrade of the CMS experiment in Phase 2 of the CERN LHC. Its first
implementation is planned for the GE1/1 system in the region of the muon endcap mainly to control muon level-1 trigger rates
after the second long LHC shutdown. A GE1/1 triple-GEM detector is read out by
3,072 radial strips with 455 rad pitch arranged in eight -sectors.
We assembled a full-size GE1/1 prototype of 1m length at Florida Tech and
tested it in 20-120 GeV hadron beams at Fermilab using Ar/CO 70:30 and
the RD51 scalable readout system. Four small GEM detectors with 2-D readout and
an average measured azimuthal resolution of 36 rad provided precise
reference tracks. Construction of this largest GEM detector built to-date is
described. Strip cluster parameters, detection efficiency, and spatial
resolution are studied with position and high voltage scans. The plateau
detection efficiency is [97.1 0.2 (stat)]\%. The azimuthal resolution is
found to be [123.5 1.6 (stat)] rad when operating in the center of
the efficiency plateau and using full pulse height information. The resolution
can be slightly improved by 10 rad when correcting for the bias due
to discrete readout strips. The CMS upgrade design calls for readout
electronics with binary hit output. When strip clusters are formed
correspondingly without charge-weighting and with fixed hit thresholds, a
position resolution of [136.8 2.5 stat] rad is measured, consistent
with the expected resolution of strip-pitch/ = 131.3 rad. Other
-sectors of the detector show similar response and performance.Comment: 8 pages, 32 figures, submitted to Proc. 2014 IEEE Nucl. Sci.
Symposium, Seattle, WA, reference adde
Anestesia local y Sedación para Intubación con Fibrobroncoscopio de paciente con Vía Aérea Difícil
Presentamos el caso clínico de un varón de 60 años con vía aérea difícil que debía realizarse una tiroidectomía total por el diagnóstico de bocio multinodular tóxico y que, un mes antes, había tenido un intento fallido de intubación con fibrobroncoscopio
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