Orpheu et al.: Modernism, Women, and the War

The article takes off from Orpheu, the little magazine at the origin of Portuguese modernism, to reflect, from a comparative perspective, on the development of modernist poetry in the context of the Great War and the social changes evolving during the first decades of the twentieth century on both sides of the Atlantic.O artigo parte de Orpheu, a revista que dá origem ao modernismo português, para reflectir, numa perspectiva comparada, sobre o desenvolvimento da poesia modernista no contexto da Grande Guerra e das mudanças sociais emergentes nas primeiras décadas do século XX dos dois lados do Atlântico

Adaptação à gravidez : um estudo biopsicossocial

Este estudo explorou a relação entre o Relacionamento Conjugal, Suporte Social, estilo de Coping e a saúde física e psicológica da grávida. Além disso, pretendeu avaliar se o Sentido de Coerência (Antonovsky, 1974) era capaz de medir o impacto dos factores de risco para a saúde. A discussão dos resultados, implicações, bem como limitações do estudo são analisados em função desses objectivos.This study explored the relationship between the Couple’s Adjustment, Social Support, Coping and physical/psychological health in pregnant women. The study also evaluated whether the Sense of Coherence (Antonovsky, 1974) was able to mediate the impact of risk factors on health. A discussion of the results, implications and limitations of the study were analised having these goals in mind

Tet2 Rescues Age-Related Regenerative Decline and Enhances Cognitive Function in the Adult Mouse Brain.

Restoring adult stem cell function provides an exciting approach for rejuvenating the aging brain. However, molecular mechanisms mediating neurogenic rejuvenation remain elusive. Here we report that the enzyme ten eleven translocation methylcytosine dioxygenase 2 (Tet2), which catalyzes the production of 5-hydroxymethylcytosine (5hmC), rescues age-related decline in adult neurogenesis and enhances cognition in mice. We detected a decrease in Tet2 expression and 5hmC levels in the aged hippocampus associated with adult neurogenesis. Mimicking an aged condition in young adults by abrogating Tet2 expression within the hippocampal neurogenic niche, or adult neural stem cells, decreased neurogenesis and impaired learning and memory. In a heterochronic parabiosis rejuvenation model, hippocampal Tet2 expression was restored. Overexpressing Tet2 in the hippocampal neurogenic niche of mature adults increased 5hmC associated with neurogenic processes, offset the precipitous age-related decline in neurogenesis, and enhanced learning and memory. Our data identify Tet2 as a key molecular mediator of neurogenic rejuvenation

Anti-inflammatory effect of the antidepressant fluvoxamine – a systematic review

Neuroinflammation corresponds to the immune response of the nervous system to an injury, infection or neurodegenerative disease characterized by the activation of resident glial cells, including microglia and astrocytes, the release of cytokines and chemokines and the activation and migration of leukocytes. Evidence suggests that inflammatory cytokines may be a central factor, affecting multiple neuronal pathways and contributing to the development of depression. Supporting this neuroinflammatory theory, several studies have demonstrated the anti-inflammatory effect of various antidepressant drugs [1]. Fluvoxamine is a selective serotonin uptake inhibitor (SSRIs) used manly in the treatment of depression and anxiety disorders. Recent evidence pointed that a fluvoxamine early treatment on SARS-CoV-2-infected subjets fully prevented COVID-19 symptoms [2]. Thus, it seems relevant to explore the anti-inflammatory mechanism of fluvoxamine.info:eu-repo/semantics/publishedVersio

Optical Coherence Tomography-Guided Full Plastic Jacket in Spontaneous Coronary Artery Dissection

info:eu-repo/semantics/publishedVersio

Rendimento de grãos de três cultivares de milho (Zea mays L.) de diferentes ciclos em diversas épocas de semeadura, em duas localidades do Estado de Mato Grosso do Sul.

Com o objetivo de verificar o ciclo da cultivar de milho mais adequado para as diversas opcoes de epocas de semeadura, foram conduzidos experimentos em Sao Gabriel d'Oeste e Sidrolandia, no Mato Grosso do Sul, utilizando as cultivares Cargill 606 (super precoce), Hata 1000 (precoce) e Agroceres 106 (normal) em diversas epocas de semeadura, no periodo de outubro a janeiro dos anos 1988/89 e 1989/90. Utilizou-se o delineamento de blocos casualizados em esquema de parcelas subdivididas, onde as parcelas foram as epocas e as subparcelas as cultivares, com quatro repeticoes. Atraves dos resultados obtidos verificou-se: uma diminuicao no rendimento de graos de 47,78 kg/ha para cada dia de atraso na semeadura, independentemente da cultivar, do ano e do local onde foram conduzidos os experimentos; a partir do mes de outubro, quando mais cedo for realizado a semeadura, melhor sera a desempenho da cultura do milho; a desvantagem das cultivares de ciclo mais precoce em relacao as mais tardias diminuiu a medida que se retardou a semeadura; considerando que os dois locais se mostraram semelhantes, a recomendacao de cultivares de milho se tornaria mais eficiente se os ensaios de avaliacao fossem conduzidos em um maior numero de epocas de semeadura, em apenas um desses dois locais

Interação cultivares de milho X épocas de semeadura em diferentes ambientes do Estado de Minas Gerais.

Foram utilizados 20 cultivares, sendo cinco de cada grupo: hibridos simples, triplos, duplos e variedade de polinizacao livre, os quais foram avaliados em tres epocas de semeaduras e em tres municipios do Estado de Minas Gerais. Em cada um dos locais foram conduzidos tres experimentos. No primeiro, a semeadura foi realizada em outubro; no segundo e terceiro, 30 e 60 dias apos. O delineamento experimental foi o de blocos ao acaso com tres repeticoes. As parcelas foram constituidas de duas fileiras de 4 m de comprimento. Constatou-se efeito significativo (P< 0.01) na fonte de variacao epoca de semeadura, em todos os caracteres. Observaram-se diferencas entre e dentro dos grupos, e o grupo dos hibridos triplos foi o mais produtivo. O atraso na epoca de semeadura reduziu a expressao dos caracteres dias para o florescimento masculino, altura de plantas e peso de espigas despalhadas. O decrescimo na producao de espigas despalhadas, como conseqüência do atraso na semeadura, foi semelhante nos diferentes grupos de cultivares. O atraso na semeadura, a partir da segunda quinzena de outubro, ocasionou reducao de 28 kg/ha/dia na produtividade de espigas despalhadas, e ate 15 de dezembro isso causou uma reducao de 20% na expressao desse carater

Selection of common bean segregating populations using genetic and phenotypic parameters and RAPD markers.

In an attempt to identify strategies for choosing common bean segregating populations, the diallel parameters, the contribution of homozygous (m+a?) and heterozygous (d) loci, the heritability (h2a), the genetic distance (RAPD), and the selection potential (Z) were estimated in a study carried out in two stages. In the first, 30 hybrid combinations (partial diallel) were assessed in the F2 and F3 generations. Increasing grain yield was due dominance effect (d) although, both GCA and SCA were significant. d varied greatly and gave an information like SCA, however h2a alone was not indicative of success in a breeding program. In the second stage, five populations with lesser d and five with higher were selected, and twenty-seven families were taken from each, which were assessed with the parents and seven controls. The estimated parameters were used to check those from the first stage. There was partial agreement among the estimates and the percentages of lines superior to Pérola cultivar, which suggests that two or more estimates are needed to identify the promising segregating populations

Choice of parents for dry bean (Phaseolus vulgaris L.) breeding. I. Interactions of mean components by generation and by location.

Four dry bean cultivars (Phaseolus vulgaris L.) adapted to the southern region of the state of Minas Gerais, Brazil, were crossed with five exotic cultivars according to a partial diallel design. The nine parents and twenty hybrid population, were tested in six experiment in fully randomized blocks. In one of the experiments, the segregation populations were in the F2 generation. Trials were held at two locations in the state of Minas Gerais and at one location in the state of Goias in 1986. All twenty nine-genetic materials showed heterogeneity concerning grain yield in all trials, with cultivars having a greater effect (additive gene effect) than heterosis (dominance effect), especially in the more advanced generations. No interactions between cultivar x generation effects and cultivar heterosis x generation effects were observed at any location. However, cultivar and cultivar heterosis x locations were significant, suggesting that the choice of segregating populations for genetic improvement of commons beans should be based on the performance of the populations at the locations where they will be used, but disregarding generation. In this way, because of larger quantities of seed, the material can be evaluated in the F4 generation. Despite components of means x location interactions, the population ESAL 501 x A 354 was the most promissing for selection based on grain yield because of the general combining ability of its parents and of grain quality