12 research outputs found
Ciprofloxacin Causes Persister Formation by Inducing the TisB toxin in Escherichia coli
Persisters are specialized survivor cells that arise in populations of E. coli after antibiotic-mediated DNA damage induces the production of a small membrane-acting peptide TisB, which causes reversible dormancy. The TisB-dependent persisters are tolerant to multiple antibiotics