Properties of nonaqueous electrolytes Quarterly report, 20 Jun. - 19 Sep. 1967

Electrolyte preparation, and physical property and nuclear magnetic resonance structural studies of nonaqueous electrolyte

Surgical Resection in HCC

Hepatocellular carcinoma (HCC) is a deadly disease. Its incidence is rising worldwide without significant improvement in survival in spite of improving therapies. A wide array of treatment options for HCC exist and include surgery, catheter-based therapies, radiation and systemic therapy. These modalities are often used in combination for optimal management in a multidisciplinary approach. Surgical resection remains one of the only curative therapeutic options for HCC, although it is indicated in select patients with localized disease. Herein, we cover the role of surgical resection in the management of HCC, reviewing the perioperative and operative considerations, in addition to highlighting the advances in minimally invasive surgery and novel navigation technologies

Radon--Nikodym representations of Cuntz--Krieger algebras and Lyapunov spectra for KMS states

We study relations between $(H,\beta)$--KMS states on Cuntz--Krieger algebras and the dual of the Perron--Frobenius operator $\mathcal{L}_{-\beta H}^{*}$. Generalising the well--studied purely hyperbolic situation, we obtain under mild conditions that for an expansive dynamical system there is a one--one correspondence between $(H,\beta)$--KMS states and eigenmeasures of $\mathcal{L}_{-\beta H}^{*}$ for the eigenvalue 1. We then consider representations of Cuntz--Krieger algebras which are induced by Markov fibred systems, and show that if the associated incidence matrix is irreducible then these are $\ast$--isomorphic to the given Cuntz--Krieger algebra. Finally, we apply these general results to study multifractal decompositions of limit sets of essentially free Kleinian groups $G$ which may have parabolic elements. We show that for the Cuntz--Krieger algebra arising from $G$ there exists an analytic family of KMS states induced by the Lyapunov spectrum of the analogue of the Bowen--Series map associated with $G$. Furthermore, we obtain a formula for the Hausdorff dimensions of the restrictions of these KMS states to the set of continuous functions on the limit set of $G$. If $G$ has no parabolic elements, then this formula can be interpreted as the singularity spectrum of the measure of maximal entropy associated with $G$.Comment: 30 pages, minor changes in the proofs of Theorem 3.9 and Fact

Measuring Population Transmission Potential for HIV: An Alternative Metric of Transmission Risk in Men who have Sex with Men (MSM) in the US

Background Various metrics for HIV burden and treatment success [e.g. HIV prevalence, community viral load (CVL), population viral load (PVL), percent of HIV-positive persons with undetectable viral load] have important public health limitations for understanding disparities. Methods and Findings Using data from an ongoing HIV incidence cohort of black and white men who have sex with men (MSM), we propose a new metric to measure the prevalence of those at risk of transmitting HIV and illustrate its value. …See full text for complete abstract

Expanding direction of the period doubling operator

We prove that the period doubling operator has an expanding direction at the fixed point. We use the induced operator, a ``Perron-Frobenius type operator'', to study the linearization of the period doubling operator at its fixed point. We then use a sequence of linear operators with finite ranks to study this induced operator. The proof is constructive. One can calculate the expanding direction and the rate of expansion of the period doubling operator at the fixed point

Virtual Meson Cloud of the Nucleon and Intrinsic Strangeness and Charm

We have applied the Meson Cloud Model (MCM) to calculate the charm and strange antiquark distribution in the nucleon. The resulting distribution, in the case of charm, is very similar to the intrinsic charm momentum distribution in the nucleon. This seems to corroborate the hypothesis that the intrinsic charm is in the cloud and, at the same time, explains why other calculations with the MCM involving strange quark distributions fail in reproducing the low x region data. From the intrinsic strange distribution in the nucleon we have extracted the strangeness radius of the nucleon, which is in agreement with other meson cloud calculations.Comment: 9 pages RevTex, 4 figure

Parents' involvement in child care: do parental and work identities matter?

The current study draws on identity theory to explore mothers' and fathers' involvement in childcare. It examined the relationships between the salience and centrality of individuals’ parental and work-related identities and the extent to which they are involved in various forms of childcare. A sample of 148 couples with at least one child aged 6 years or younger completed extensive questionnaires. As hypothesized, the salience and centrality of parental identities were positively related to mothers' and fathers' involvement in childcare. Moreover, maternal identity salience was negatively related to fathers' hours of childcare and share of childcare tasks. Finally, work hours mediated the negative relationships between the centrality of work identities and time invested in childcare, and gender moderated this mediation effect. That is, the more central a mother's work identity, the more hours she worked for pay and the fewer hours she invested in childcare. These findings shed light on the role of parental identities in guiding behavioral choices, and attest to the importance of distinguishing between identity salience and centrality as two components of self-structure

Properties of nonaqueous electrolytes Sixth summary report, 20 Sep. 1967 - 19 Mar. 1968

Physical properties and structural studies on propylene carbonate, dimethyl formamide, and acetonitrile solvent electrolyte

Whole Earth Telescope observations of the hot helium atmosphere pulsating white dwarf EC 20058-5234

We present the analysis of a total of 177h of high-quality optical time-series photometry of the helium atmosphere pulsating white dwarf (DBV) EC 20058-5234. The bulk of the observations (135h) were obtained during a WET campaign (XCOV15) in July 1997 that featured coordinated observing from 4 southern observatory sites over an 8-day period. The remaining data (42h) were obtained in June 2004 at Mt John Observatory in NZ over a one-week observing period. This work significantly extends the discovery observations of this low-amplitude (few percent) pulsator by increasing the number of detected frequencies from 8 to 18, and employs a simulation procedure to confirm the reality of these frequencies to a high level of significance (1 in 1000). The nature of the observed pulsation spectrum precludes identification of unique pulsation mode properties using any clearly discernable trends. However, we have used a global modelling procedure employing genetic algorithm techniques to identify the n, l values of 8 pulsation modes, and thereby obtain asteroseismic measurements of several model parameters, including the stellar mass (0.55 M_sun) and T_eff (~28200 K). These values are consistent with those derived from published spectral fitting: T_eff ~ 28400 K and log g ~ 7.86. We also present persuasive evidence from apparent rotational mode splitting for two of the modes that indicates this compact object is a relatively rapid rotator with a period of 2h. In direct analogy with the corresponding properties of the hydrogen (DAV) atmosphere pulsators, the stable low-amplitude pulsation behaviour of EC 20058 is entirely consistent with its inferred effective temperature, which indicates it is close to the blue edge of the DBV instability strip. (abridged)Comment: 19 pages, 8 figures, 5 tables, MNRAS accepte

Gene co-expression analysis of the human substantia nigra identifies BMP2 as a neurotrophic factor that can promote neurite growth in cells overexpressing wild-type or A53T α-synuclein

Introduction: α-synuclein-induced degeneration of dopaminergic neurons has been proposed to be central to the early progression of Parkinson\u27s disease. This highlights the need to identify factors that are neuroprotective or neuroregenerative against α-synuclein-induced degeneration. Due to their potent neurotrophic effects on nigrostriatal dopaminergic neurons, we hypothesized that members of the bone morphogenetic protein (BMP) family have potential to protect these cells against α-synuclein. Methods: To identify the most relevant BMP ligands, we used unbiased gene co-expression analysis to identify all BMP family members having a significant positive correlation with five markers of dopaminergic neurons in the human substantia nigra (SN). We then tested the ability of lead BMPs to promote neurite growth in SH-SY5Y cells and in primary cultures of ventral mesencephalon (VM) dopaminergic neurons, treated with either 6-OHDA or MPP+, or overexpressing wild-type or A53T α-synuclein. Results: Only the expression of BMP2 was found to be significantly correlated with multiple dopaminergic markers in the SN. We found that BMP2 treatment promoted neurite growth in SH-SY5Y cells and in dopaminergic neurons. Moreover, BMP2 treatment promoted neurite growth in both SH-SY5Y cells and VM neurons, treated with the neurotoxins 6-OHDA or MPP+. Furthermore, BMP2 promoted neurite growth in cells overexpressing wild-type or A53T-α-synuclein. Conclusion: These findings are important given that clinical trials of two neurotrophic factors, GDNF and neurturin, have failed to meet their primary endpoints. Our findings are a key first step in rationalising the further study of BMP2 as a potential neurotrophic factor in α-synuclein-based translational models of Parkinson\u27s disease