Resonant control of stochastic spatio-temporal dynamics in a tunnel diode by multiple time delayed feedback

We study the control of noise-induced spatio-temporal current density patterns in a semiconductor nanostructure (double barrier resonant tunnelling diode) by multiple time-delayed feedback. We find much more pronounced resonant features of noise-induced oscillations compared to single time feedback, rendering the system more sensitive to variations in the delay time $\tau$. The coherence of noise-induced oscillations measured by the correlation time exhibits sharp resonances as a function of $\tau$, and can be strongly increased by optimal choices of $\tau$. Similarly, the peaks in the power spectral density are sharpened. We provide analytical insight into the control mechanism by relating the correlation times and mean frequencies of noise-induced breathing oscillations to the stability properties of the deterministic stationary current density filaments under the influence of the control loop. Moreover, we demonstrate that the use of multiple time delays enlarges the regime in which the deterministic dynamical properties of the system are not changed by delay-induced bifurcations

UNC93B1 recruits syntenin-1 to dampen TLR7 signalling and prevent autoimmunity.

At least two members of the Toll-like receptor (TLR) family, TLR7 and TLR9, can recognize self-RNA and self-DNA, respectively. Despite the structural and functional similarities between these receptors, their contributions to autoimmune diseases such as systemic lupus erythematosus can differ. For example, TLR7 and TLR9 have opposing effects in mouse models of systemic lupus erythematosus-disease is exacerbated in TLR9-deficient mice but attenuated in TLR7-deficient mice1. However, the mechanisms of negative regulation that differentiate between TLR7 and TLR9 are unknown. Here we report a function for the TLR trafficking chaperone UNC93B1 that specifically limits signalling of TLR7, but not TLR9, and prevents TLR7-dependent autoimmunity in mice. Mutations in UNC93B1 that lead to enhanced TLR7 signalling also disrupt binding of UNC93B1 to syntenin-1, which has been implicated in the biogenesis of exosomes2. Both UNC93B1 and TLR7 can be detected in exosomes, suggesting that recruitment of syntenin-1 by UNC93B1 facilitates the sorting of TLR7 into intralumenal vesicles of multivesicular bodies, which terminates signalling. Binding of syntenin-1 requires phosphorylation of UNC93B1 and provides a mechanism for dynamic regulation of TLR7 activation and signalling. Thus, UNC93B1 not only enables the proper trafficking of nucleic acid-sensing TLRs, but also sets the activation threshold of potentially self-reactive TLR7

A scalable architecture for quantum computation with molecular nanomagnets

A proposal for a magnetic quantum processor that consists of individual molecular spins coupled to superconducting coplanar resonators and transmission lines is carefully examined. We derive a simple magnetic quantum electrodynamics Hamiltonian to describe the underlying physics. It is shown that these hybrid devices can perform arbitrary operations on each spin qubit and induce tunable interactions between any pair of them. The combination of these two operations ensures that the processor can perform universal quantum computations. The feasibility of this proposal is critically discussed using the results of realistic calculations, based on parameters of existing devices and molecular qubits. These results show that the proposal is feasible, provided that molecules with sufficiently long coherence times can be developed and accurately integrated into specific areas of the device. This architecture has an enormous potential for scaling up quantum computation thanks to the microscopic nature of the individual constituents, the molecules, and the possibility of using their internal spin degrees of freedom.Comment: 27 pages, 6 figure

Experimental and numerical study of local mean age of air

This paper presents the results from the experimental and numerical study of a room with mixing ventilation, focused on the local mean age of air (LMA). The measurements were performed using the tracer gas concentration decay method. The numerical predictions were obtained from the computational fluid dynamics (CFD) module of the latest version of the ESP-r software

Approaching Unit Visibility for Control of a Superconducting Qubit with Dispersive Readout

In a Rabi oscillation experiment with a superconducting qubit we show that a visibility in the qubit excited state population of more than 90 % can be attained. We perform a dispersive measurement of the qubit state by coupling the qubit non-resonantly to a transmission line resonator and probing the resonator transmission spectrum. The measurement process is well characterized and quantitatively understood. The qubit coherence time is determined to be larger than 500 ns in a measurement of Ramsey fringes.Comment: 4 pages, 5 figures, version with high resolution figures available at http://www.eng.yale.edu/rslab/Andreas/content/science/PubsPapers.htm

Multi-band quantum ratchets

We investigate directed motion in non-adiabatically rocked ratchet systems sustaining few bands below the barrier. Upon restricting the dynamics to the lowest M bands, the total system-plus-bath Hamiltonian is mapped onto a discrete tight-binding model containing all the information both on the intra- and inter-well tunneling motion. A closed form for the current in the incoherent tunneling regime is obtained. In effective single-band ratchets, no current rectification occurs. We apply our theory to describe rectification effects in vortex quantum ratchets devices. Current reversals upon variation of the ac-field amplitude or frequency are predicted.Comment: Accepted for publication in Physical Review Letter

Reconstruction of the two-dimensional gravitational potential of galaxy clusters from X-ray and Sunyaev-Zel'dovich measurements

The mass of galaxy clusters is not a direct observable, nonetheless it is commonly used to probe cosmological models. Based on the combination of all main cluster observables, that is, the X-ray emission, the thermal Sunyaev-Zel'dovich (SZ) signal, the velocity dispersion of the cluster galaxies, and gravitational lensing, the gravitational potential of galaxy clusters can be jointly reconstructed. We derive the two main ingredients required for this joint reconstruction: the potentials individually reconstructed from the observables and their covariance matrices, which act as a weight in the joint reconstruction. We show here the method to derive these quantities. The result of the joint reconstruction applied to a real cluster will be discussed in a forthcoming paper. We apply the Richardson-Lucy deprojection algorithm to data on a two-dimensional (2D) grid. We first test the 2D deprojection algorithm on a $\beta$-profile. Assuming hydrostatic equilibrium, we further reconstruct the gravitational potential of a simulated galaxy cluster based on synthetic SZ and X-ray data. We then reconstruct the projected gravitational potential of the massive and dynamically active cluster Abell 2142, based on the X-ray observations collected with XMM-Newton and the SZ observations from the Planck satellite. Finally, we compute the covariance matrix of the projected reconstructed potential of the cluster Abell 2142 based on the X-ray measurements collected with XMM-Newton. The gravitational potentials of the simulated cluster recovered from synthetic X-ray and SZ data are consistent, even though the potential reconstructed from X-rays shows larger deviations from the true potential. Regarding Abell 2142, the projected gravitational cluster potentials recovered from SZ and X-ray data reproduce well the projected potential inferred from gravitational-lensing observations. (abridged)Comment: accepted for publication in the journal A&