550 research outputs found
Three-dimensional physics and the pressure of hot QCD
We update Monte Carlo simulations of the three-dimensional SU(3) + adjoint
Higgs theory, by extrapolating carefully to the infinite volume and continuum
limits, in order to estimate the contribution of the infrared modes to the
pressure of hot QCD. The sum of infrared contributions beyond the known 4-loop
order turns out to be a smooth function, of a reasonable magnitude and specific
sign. Unfortunately, adding this function to the known 4-loop terms does not
improve the match to four-dimensional lattice data, in spite of the fact that
other quantities, such as correlation lengths, spatial string tension, or quark
number susceptibilities, work well within the same setup. We outline possible
ways to reduce the mismatch.Comment: 14 page
Equation of state in 2+1 flavor QCD with improved Wilson quarks by the fixed scale approach
We study the equation of state in 2+1 flavor QCD with nonperturbatively
improved Wilson quarks coupled with the RG-improved Iwasaki glue. We apply the
-integration method to nonperturbatively calculate the equation of state by
the fixed-scale approach. With the fixed-scale approach, we can purely vary the
temperature on a line of constant physics without changing the system size and
renormalization constants. Unlike the conventional fixed- approach, it is
easy to keep scaling violations small at low temperature in the fixed scale
approach. We study 2+1 flavor QCD at light quark mass corresponding to
, while the strange quark mass is chosen around the
physical point. Although the light quark masses are heavier than the physical
values yet, our equation of state is roughly consistent with recent results
with highly improved staggered quarks at large .Comment: 14 pages, 12 figures, v2: Table I and Figure 3 are corrected,
reference updated. Main discussions and conclusions are unchanged, v3:
version to appear in PRD, v4: reference adde
An effective thermodynamic potential from the instanton with Polyakov-loop contributions
We derive an effective thermodynamic potential (Omega_eff) at finite
temperature (T>0) and zero quark-chemical potential (mu_R=0), using the
singular-gauge instanton solution and Matsubara formula for N_c=3 and N_f=2 in
the chiral limit. The momentum-dependent constituent-quark mass is also
obtained as a function of T, employing the Harrington-Shepard caloron solution
in the large-N_c limit. In addition, we take into account the imaginary quark
chemical potential mu_I = A_4, translated as the traced Polayakov-loop (Phi) as
an order parameter for the Z(N_c) symmsetry, characterizing the confinement
(intact) and deconfinement (spontaneously broken) phases. As a result, we
observe the crossover of the chiral (chi) order parameter sigma^2 and Phi. It
also turns out that the critical temperature for the deconfinment phase
transition, T^Z_c is lowered by about (5-10)% in comparison to the case with a
constant constituent-quark mass. This behavior can be understood by
considerable effects from the partial chiral restoration and nontrivial QCD
vacuum on Phi. Numerical calculations show that the crossover transitions occur
at (T^chi_c,T^Z_c) ~ (216,227) MeV.Comment: 15 pages, 7 figure
Molecular Line Observations of Carbon-Chain-Producing Regions L1495B and L1521B
We present the first comprehensive study on physical and chemical properties
of quiescent starless cores L1495B and L1521B, which are known to be rich in
carbon-chain molecules like the cyanopolyyne peak of TMC-1 and L1521E. We have
detected radio spectral lines of various carbon-chain molecules such as CCS,
CS, CH, HCN, and HCN. On the other hand, the NH
lines are weak and the NH lines are not detected. According to our
mapping observations of the HCN, CCS, and CS lines, the dense cores
in L1495B and L1521B are compact with the radius of 0.063 and 0.044 pc,
respectively, and have a simple elliptical structure. The distributions of CCS
seem to be different from those of well-studied starless cores, L1498 and
L1544, where the distribution of CCS shows a shell-like structure. Since the
HCO, HNC, and CS lines are detected in L1495B and
L1521B, the densities of these cores are high enough to excite the NH and
NH lines. Therefore, the abundances of NH and NH
relative to carbon-chain molecules are apparently deficient, as observed in
L1521E. We found that longer carbon-chain molecules such as HCN and
CH are more abundant in TMC-1 than L1495B and L1521B, while those of
sulfur-bearing molecules such as CS, CCS, and CS are comparable.
Both distributions and abundances of the observed molecules of L1495B and
L1521B are quite similar to those of L1521E, strongly suggesting that L1495B
and L1521B is in a very early stage of physical and chemical evolution.Comment: 19 pages, 6 figures, accepted to The Astrophysical Journa
Design and Operation of 1000-fold Voltage Multiplier based on Double-flux-quantum Amplifier
AbstractRapid-single-flux-quantum digital-to-analogue converters (RSFQ-DACs) are now under development for ac voltage standard applications. The voltage multiplier (VM), which precisely amplifies the input voltage, is a key component for RSFQ-DACs. Because the amount of bias current for a conventional VM increases in proportion to its multiplication factor, we have been looking for a VM device which is operated on a different principle. In this paper, we report our design of a 1000-fold VM comprising double flux quantum amplifiers (DFQAs) of which the amount of bias current is independent of its multiplication factor. Test circuits were fabricated using a 2.5 kA/cm2 Nb process. We confirm that the experimental results demonstrate the 1000-fold operation up to 13.2 GHz input SFQ pulse repetition frequency
Self-similar solution of fast magnetic reconnection: Semi-analytic study of inflow region
An evolutionary process of the fast magnetic reconnection in ``free space''
which is free from any influence of outer circumstance has been studied
semi-analytically, and a self-similarly expanding solution has been obtained.
The semi-analytic solution is consistent with the results of our numerical
simulations performed in our previous paper (see Nitta et al. 2001). This
semi-analytic study confirms the existence of self-similar growth. On the other
hand, the numerical study by time dependent computer simulation clarifies the
stability of the self-similar growth with respect to any MHD mode. These
results confirm the stable self-similar evolution of the fast magnetic
reconnection system.Comment: 15 pages, 7 figure
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Repurposing the KCa3.1 inhibitor senicapoc for Alzheimer's disease.
ObjectiveMicroglia play a pivotal role in the initiation and progression of Alzheimer's disease (AD). We here tested the therapeutic hypothesis that the Ca2+-activated potassium channel KCa3.1 constitutes a potential target for treating AD by reducing neuroinflammation.MethodsTo determine if KCa3.1 is relevant to AD, we tested if treating cultured microglia or hippocampal slices with Aβ oligomer (AβO) activated KCa3.1 in microglia, and if microglial KCa3.1 was upregulated in 5xFAD mice and in human AD brains. The expression/activity of KCa3.1 was examined by qPCR, Western blotting, immunohistochemistry, and whole-cell patch-clamp. To investigate the role of KCa3.1 in AD pathology, we resynthesized senicapoc, a clinically tested KCa3.1 blocker, and determined its pharmacokinetic properties and its effect on microglial activation, Aβ deposition and hippocampal long-term potentiation (hLTP) in 5xFAD mice.ResultsWe found markedly enhanced microglial KCa3.1 expression/activity in brains of both 5xFAD mice and AD patients. In hippocampal slices, microglial KCa3.1 expression/activity was increased by AβO treatment, and its inhibition diminished the proinflammatory and hLTP-impairing activities of AβO. Senicapoc exhibited excellent brain penetrance and oral availability, and in 5xFAD mice, reduced neuroinflammation, decreased cerebral amyloid load, and enhanced hippocampal neuronal plasticity.InterpretationOur results prompt us to propose repurposing senicapoc for AD clinical trials, as senicapoc has excellent pharmacological properties and was safe and well-tolerated in a prior phase-3 clinical trial for sickle cell anemia. Such repurposing has the potential to expedite the urgently needed new drug discovery for AD
Magnetic and electric contributions to the energy loss in a dynamical QCD medium
The computation of radiative energy loss in a finite size QCD medium with
dynamical constituents is a key ingredient for obtaining reliable predictions
for jet quenching in ultra-relativistic heavy ion collisions. It was previously
shown that energy loss in dynamical QCD medium is significantly higher compared
to static QCD medium. To understand this difference, we here analyze magnetic
and electric contributions to energy loss in dynamical QCD medium. We find that
the significantly higher energy loss in the dynamical case is entirely due to
appearance of magnetic contribution in the dynamical medium. While for
asymptotically high energies, the energy loss in static and dynamical medium
approach the same value, we find that the physical origin of the energy loss in
these two cases is different.Comment: 6 pages, 4 figure
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