8,331 research outputs found
Permutation sampling in Path Integral Monte Carlo
A simple algorithm is described to sample permutations of identical particles
in Path Integral Monte Carlo (PIMC) simulations of continuum many-body systems.
The sampling strategy illustrated here is fairly general, and can be easily
incorporated in any PIMC implementation based on the staging algorithm.
Although it is similar in spirit to an existing prescription, it differs from
it in some key aspects. It allows one to sample permutations efficiently, even
if long paths (e.g., hundreds, or thousands of slices) are needed. We
illustrate its effectiveness by presenting results of a PIMC calculation of
thermodynamic properties of superfluid Helium-four, in which a very simple
approximation for the high-temperature density matrix was utilized
Introduction of CAA into a mathematics course for technology students to address a change in curriculum requirements
The mathematical requirements for engineering, science and technology students has been debated for many years and concern has been expressed about the mathematical preparedness of students entering higher education. This paper considers a mathematics course that has been specifically designed to address some of these issues for technology education students. It briefly chronicles the changes that have taken place over its lifetime and evaluates the introduction of Computer Assisted Assessment (CAA) into a course already being delivered using Computer Aided Learning (CAL).
Benefits of CAA can be categorised into four main areas.
1. Educational – achieved by setting short, topic related, assessments, each of which has to be passed, thereby increasing curriculum coverage.
2. Students – by allowing them to complete assessments at their own pace removing the stress of the final examination.
3. Financial – increased income to the institution, by broadening access to the course. Improved retention rate due to self-paced learning.
4. Time – staff no longer required to set and mark exams.
Most students preferred this method of assessment to traditional exams, because it increased confidence and reduced stress levels. Self-paced working, however, resulted in a minority of students not completing the tests by the deadline
Selecting and implementing overview methods: implications from five exemplar overviews
This is the final version of the article. Available from BioMed Central via the DOI in this record.Background
Overviews of systematic reviews are an increasingly popular method of evidence synthesis; there is a lack of clear guidance for completing overviews and a number of methodological challenges. At the UK Cochrane Symposium 2016, methodological challenges of five overviews were explored. Using data from these five overviews, practical implications to support methodological decision making of authors writing protocols for future overviews are proposed.
Methods
Methods, and their justification, from the five exemplar overviews were tabulated and compared with areas of debate identified within current literature. Key methodological challenges and implications for development of overview protocols were generated and synthesised into a list, discussed and refined until there was consensus.
Results
Methodological features of three Cochrane overviews, one overview of diagnostic test accuracy and one mixed methods overview have been summarised. Methods of selection of reviews and data extraction were similar. Either the AMSTAR or ROBIS tool was used to assess quality of included reviews. The GRADE approach was most commonly used to assess quality of evidence within the reviews.
Eight key methodological challenges were identified from the exemplar overviews. There was good agreement between our findings and emerging areas of debate within a recent published synthesis. Implications for development of protocols for future overviews were identified.
Conclusions
Overviews are a relatively new methodological innovation, and there are currently substantial variations in the methodological approaches used within different overviews. There are considerable methodological challenges for which optimal solutions are not necessarily yet known. Lessons learnt from five exemplar overviews highlight a number of methodological decisions which may be beneficial to consider during the development of an overview protocol.The overview conducted by Pollock [19] was supported by a project grant from the Chief Scientist Office of the Scottish Government. The overview conducted by McClurg [21] was supported by a project grant by the Physiotherapy Research Foundation. The overview by Hunt [22] was supported as part of doctoral programme funding by the National Institute for Health Research (NIHR) Collaboration for Leadership in Applied Health Research and Care South West Peninsula (PenCLAHRC). The overview conducted by Estcourt [20] was supported by an NIHR Cochrane Programme Grant for the Safe and Appropriate Use of Blood Components. The overview conducted by Brunton [23] was commissioned by the Department of Health as part of an ongoing programme of work on health policy research synthesis.
Alex Pollock is employed by the Nursing, Midwifery and Allied Health Professions (NMAHP) Research Unit, which is supported by the Chief Scientist Office of the Scottish Government. Pauline Campbell is supported by the Chief Nurses Office of the Scottish Government
The XMM-Newton EPIC X-ray Light Curve Analysis of WR 6
We obtained four pointings of over 100 ks each of the well-studied Wolf-Rayet
star WR 6 with the XMM-Newton satellite. With a first paper emphasizing the
results of spectral analysis, this follow-up highlights the X-ray variability
clearly detected in all four pointings. However, phased light curves fail to
confirm obvious cyclic behavior on the well-established 3.766 d period widely
found at longer wavelengths. The data are of such quality that we were able to
conduct a search for "event clustering" in the arrival times of X-ray photons.
However, we fail to detect any such clustering. One possibility is that X-rays
are generated in a stationary shock structure. In this context we favor a
co-rotating interaction region (CIR) and present a phenomenological model for
X-rays from a CIR structure. We show that a CIR has the potential to account
simultaneously for the X-ray variability and constraints provided by the
spectral analysis. Ultimately, the viability of the CIR model will require both
intermittent long-term X-ray monitoring of WR 6 and better physical models of
CIR X-ray production at large radii in stellar winds.Comment: to appear in Ap
Lowering of the Kinetic Energy in Interacting Quantum Systems
Interactions never lower the ground state kinetic energy of a quantum system.
However, at nonzero temperature, where the system occupies a thermal
distribution of states, interactions can reduce the kinetic energy below the
noninteracting value. This can be demonstrated from a first order weak coupling
expansion. Simulations (both variational and restricted path integral Monte
Carlo) of the electron gas model and dense hydrogen confirm this and show that
in contrast to the ground state case, at nonzero temperature the population of
low momentum states can be increased relative to the free Fermi distribution.
This effect is not seen in simulations of liquid He-3.Comment: 4 pages, 5 figures, submitted to Phys. Rev. Lett., June, 200
Optimizing outpatient total hip arthroplasty: perspectives of key stakeholders
Background Advances in surgical techniques combined with multimodal analgesia and early rehabilitation have potentiated early mobilization in patients undergoing total hip arthroplasty (THA). Given an increasing push from patients to accelerate recovery and health care budgetary limitations, there has been growing interest in the implementation of outpatient THA in selected patients. Understanding the patient and primary caregiver experience of outpatient THA is important to optimize care. We aimed to gain insight into patient and caregiver perspectives regarding the perceived advantages and disadvantages of same-day discharge to identify areas of care that can be improved. Method Using a qualitative descriptive approach, we conducted in-depth semistructured interviews with patient-primary caregiver dyads who experienced same-day discharge or standard care after primary THA with the direct anterior approach in 2016-2017. Two members of the research team coded the data independently, implementing a thematic and content analysis. Results Twenty-eight participants (16 same-day discharge, 12 standard care) were included. Both groups experienced high levels of satisfaction with their care pathway. Concerns and challenges identified in both groups pertained to mobility, pain, self-care and caregiver support. Challenges and concerns unique to same-day discharge were identified regarding expectations for recovery, medications and their impact on mobility, the timing of postoperative education and the availability of formal care. Conclusion Outpatient THA can be implemented with high patient and caregiver satisfaction. Preoperative education, clarification of recovery processes and expectations, and proactively addressing concerns related to caregiving are important
Antigen depot is not required for alum adjuvanticity
Alum adjuvants have been in continuous clinical use for more than 80 yr. While the prevailing theory has been that depot formation and the associated slow release of antigen and/or inflammation are responsible for alum enhancement of antigen presentation and subsequent T- and B-cell responses, this has never been formally proven. To examine antigen persistence, we used the chimeric fluorescent protein EαGFP, which allows assessment of antigen presentation in situ, using the Y-Ae antibody. We demonstrate that alum and/or CpG adjuvants induced similar uptake of antigen, and in all cases, GFP signal did not persist beyond 24 h in draining lymph node antigen-presenting cells. Antigen presentation was first detectable on B cells within 6–12 h of antigen administration, followed by conventional dendritic cells (DCs) at 12–24 h, then finally plasmacytoid DCs at 48 h or later. Again, alum and/or CpG adjuvants did not have an effect on the magnitude or sequence of this response; furthermore, they induced similar antigen-specific T-cell activation in vivo. Notably, removal of the injection site and associated alum depot, as early as 2 h after administration, had no appreciable effect on antigen-specific T- and B-cell responses. This study clearly rules out a role for depot formation in alum adjuvant activity
Comparison of two non-primitive methods for path integral simulations: Higher-order corrections vs. an effective propagator approach
Two methods are compared that are used in path integral simulations. Both
methods aim to achieve faster convergence to the quantum limit than the
so-called primitive algorithm (PA). One method, originally proposed by
Takahashi and Imada, is based on a higher-order approximation (HOA) of the
quantum mechanical density operator. The other method is based upon an
effective propagator (EPr). This propagator is constructed such that it
produces correctly one and two-particle imaginary time correlation functions in
the limit of small densities even for finite Trotter numbers P. We discuss the
conceptual differences between both methods and compare the convergence rate of
both approaches. While the HOA method converges faster than the EPr approach,
EPr gives surprisingly good estimates of thermal quantities already for P = 1.
Despite a significant improvement with respect to PA, neither HOA nor EPr
overcomes the need to increase P linearly with inverse temperature. We also
derive the proper estimator for radial distribution functions for HOA based
path integral simulations.Comment: 17 pages, latex, 6 postscript figure
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