937 research outputs found
Cut loci and conjugate loci on Liouville surfaces
In the earlier paper (Itoh and Kiyohara, Manuscr Math 114:247–264, 2004), we showed that the cut locus of a general point on two-dimensional ellipsoid is a segment of a curvature line and proved "Jacobi’s last geometric statement" on the singularities of the conjugate locus. In the present paper,we showthat a wider class of Liouville surfaces possess such simple cut loci and conjugate loci. The results include the determination of cut loci and the set of poles on two-sheeted hyperboloids and elliptic paraboloids
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EMP2 regulates angiogenesis in endometrial cancer cells through induction of VEGF.
Understanding tumor-induced angiogenesis is a challenging problem with important consequences for the diagnosis and treatment of cancer. In this study, we define a novel function for epithelial membrane protein-2 (EMP2) in the control of angiogenesis. EMP2 functions as an oncogene in endometrial cancer, and its expression has been linked to decreased survival. Using endometrial cancer xenografts, modulation of EMP2 expression resulted in profound changes to the tumor microvasculature. Under hypoxic conditions, upregulation of EMP2 promoted vascular endothelial growth factors (VEGF) expression through a HIF-1α-dependent pathway and resulted in successful capillary-like tube formation. In contrast, reduction of EMP2 correlated with reduced HIF-1α and VEGF expression with the net consequence of poorly vascularized tumors in vivo. We have previously shown that targeting of EMP2 using diabodies in endometrial cancer resulted in a reduction of tumor load, and since then we have constructed a fully human EMP2 IgG1. Treatment of endometrial cancer cells with EMP2-IgG1 reduced tumor load with a significant improvement in survival. These results support the role of EMP2 in the control of the tumor microenvironment and confirm the cytotoxic effects observed by EMP2 treatment in vivo
Recurrent facial taste neurons of sea catfish Plotosus japonicus : morphology and organization in the ganglion
This study investigated the morphology of the recurrent facial taste neurons and their organization in the recurrent ganglion of the sea catfish Plotosus japonicus. The recurrent ganglion is independent of the anterior ganglion, which consists of trigeminal, facial and anterior lateral line neurons that send peripheral fibres to the head region. The recurrent taste neurons are round or oval and bipolar, with thick peripheral and thin central fibres, and completely wrapped by membranous layers of satellite cells. Two peripheral nerve branches coursing to the trunk or pectoral fin originate from the recurrent ganglion. The results presented here show that the trunk and pectoral-fin neurons are independently distributed to form various sizes of groups, and the groups are intermingled throughout the ganglion. No distinct topographical relationship of the two nerve branches occurs in the ganglion. Centrally, the trunk and pectoral-fin branches project somatotopically in the anterolateral and intermediate medial regions of the trunk tail lobule of the facial lobe, respectively
Magnetic properties of Fe3O4 nanoparticles coated with oleic and dodecanoic acids
Magnetic nanoparticles (NP) of magnetite (Fe3O4) coated with oleic acid (OA)
and dodecanoic acid (DA) were synthesized and investigated through Transmission
Electron Microscopy (TEM),magnetization M, and ac magnetic susceptibility
measurements. The OA coated samples were produced with different magnetic
concentrations (78, 76, and 65%) and the DA sample with 63% of Fe3O4. Images
from TEM indicate that the NP have a nearly spherical geometry and mean
diameter ~ 5.5 nm. Magnetization measurements, performed in zero field cooled
(ZFC) and field cooled (FC) processes under different external magnetic fields
H, exhibited a maximum at a given temperature TB in the ZFC curves, which
depends on the NP coating (OA or DA), magnetite concentration, and H. The
temperature TB decreases monotonically with increasing H and, for a given H,
the increase in the magnetite concentration results in an increase of TB. The
observed behavior is related to the dipolar interaction (DI) between NP which
seems to be an important mechanism in all samples studied. This is supported by
the results of the ac magnetic susceptibility Xac measurements, where the
temperature in which X' peaks for different frequencies follows the
Vogel-Fulcher model, a feature commonly found in systems with dipolar
interactions. Curves of H vs. TB/TB(H=0) for samples with different coatings
and magnetite concentrations collapse into a universal curve, indicating that
the qualitative magnetic behavior of the samples may be described by the NP
themselves, instead of the coating or the strength of the dipolar interaction.
Below TB, M vs. H curves show a coercive field (HC) that increases
monotonically with decreasing temperature. The saturation magnetization (MS)
follows the Bloch's law and values of MS at room temperature as high as 78
emu/g were estimated, a result corresponding to ~80% of the bulk value. The
overlap of M/MS vs. H/T curves for a given sample and the low HC at high
temperatures suggest superparamagnetic behavior in all samples studied. The
overlap of M/MS vs. H curves at constant temperature for different samples
indicates that the NP magnetization behavior is preserved, independently of the
coating and magnetite concentration.Comment: 8 pages and 9 figure
Gallot-Tanno Theorem for closed incomplete pseudo-Riemannian manifolds and applications
We extend the Gallot-Tanno Theorem to closed pseudo-Riemannian manifolds. It
is done by showing that if the cone over a manifold admits a parallel symmetric
tensor then it is Riemannian. Applications of this result to the
existence of metrics with distinct Levi-Civita connections but having the same
unparametrized geodesics and to the projective Obata conjecture are given. We
also apply our result to show that the holonomy group of a closed
-manifold does not preserve any nondegenerate splitting of
.Comment: minor correction
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