Cosmological Family Asymmetry and CP violation

We discuss how the cosmological baryon asymmetry can be achieved by the lepton family asymmetries of heavy Majorana neutrino decays and they are related to CP violation in neutrino oscillation, in the minimal seesaw model with two heavy Majorana neutrinos. We derive the most general formula for CP violation in neutrino oscillation in terms of the heavy Majorana masses and Yukawa mass term. It is shown that the formula is very useful to classify several models in which $e-$, $\mu-$ and $\tau-$leptogenesis can be separately realized and to see how they are connected with low energy CP violaton. To make the models predictive, we take texture with two zeros in the Dirac neutrino Yukawa matrix. In particular, we find some interesting cases in which CP violation in neutrino oscillation can happen while lepton family asymmetries do not exist at all. On the contrary, we can find $e-$, $\mu-$ and $\tau-$leptogenesis scenarios in which the cosmological CP violation and low energy CP violation measurable via neutrino oscillations are very closely related to each other. By determining the allowed ranges of the parameters in the models, we predict the sizes of CP violation in neutrino oscillation and $|V_{e3}^{MNS}|$. Finally, the leptonic unitarity triangles are reconstructed.Comment: 22 pages, 9 figures A figure caption correcte

Production of manganese peroxidase by white rot fungi from potato-processing wastewater: Role of amino acids on biosynthesis

The production of manganese peroxidase (MnP) by white rot fungus strain L-25 was carried out using potato-processing wastewater and the effects of amino acids in the potato-processing wastewater was investigated. The MnP was efficiently produced from the wastewater by the addition of glucose and the maximum MnP activity linearly increased with an increase in the glucose concentration. The initial pH affected the cell growth and also the production rate of the MnP. The maximum activity and theproduction rate of the MnP using the potato-processing wastewater-based medium were higher (ca. 2.5- fold) than that of the basal medium. Moreover, amino acids in the wastewater had significant effects onthe MnP production. L-Glutamic acid, L-aspartic acid and L-serine induced the MnP secretion, on the other hand, L-phenylalanine, L-tyrosine, L-leucine and L-lysine inhibited it. The addition of L-leucine and L-lysine caused growth inhibition, while, L-phenylalanine and L-tyrosine blocked the MnP biosynthetic pathway. Ammonium ion released from the L-phenylalanine by the L-phenylalanine ammonia-lyase participated in the repression of the MnP biosynthetic pathway of the strain L-25

Asymptotic analysis of the model for distribution of high-tax payers

The z-transform technique is used to investigate the model for distribution of high-tax payers, which is proposed by two of the authors (K. Y and S. M) and others. Our analysis shows an asymptotic power-law of this model with the exponent -5/2 when a total ``mass'' has a certain critical value. Below the critical value, the system exhibits an ordinary critical behavior, and scaling relations hold. Above the threshold, numerical simulations show that a power-law distribution coexists with a huge ``monopolized'' member. It is argued that these behaviors are observed universally in conserved aggregation processes, by analizing an extended model.Comment: 5pages, 3figure

Functional analysis of recombinant B beta 15C and B beta 15A fibrinogens demonstrates that B beta 15G residue plays important roles in FPB release and in lateral aggregation of protofibrils

The definitive version is available at www.blackwell-synergy.com.ArticleJOURNAL OF THROMBOSIS AND HAEMOSTASIS. 3(5): 983-990 (2005)journal articl

Complex Relationship of Body Mass Index with Mortality in Patients with Critical Limb Ischemia Undergoing Endovascular Treatment

ObjectiveTo investigate the relationship between body mass index (BMI) and long-term outcomes of patients with CLI after endovascular treatment (EVT).DesignRetrospective multicenter study.Subjects1088 consecutive patients (1306 limbs, mean age 72 ± 10 years) with CLI who underwent EVT for isolated infrapopliteal artery lesions were evaluated. These subjects were identified in the J-BEAT III registry.MethodsThe patients were divided into groups based on BMI <18.5 kg/m2 (underweight, n = 188; 219 limbs), 18.5 to 24.9 kg/m2 (normal weight, n = 718; 868 limbs), and >25.0 kg/m2 (overweight/obese, n = 182; 219 limbs). The endpoints were overall survival and freedom from major adverse limb events (MALE).ResultsThe median follow up period was 1.5 years (range: 1 month–8.7 years). The 3 year overall survival rates were 33.3%, 61.2%, and 69.8% in underweight, normal, and overweight/obese patients, respectively. The survival rate was significantly lower in underweight patients and significantly higher in overweight/obese patients compared with patients of normal weight (both p < .0001). The 3 year rates of freedom from MALE did not differ significantly among the three groups (36.4%, 45.4%, and 52.3%, respectively, p = .32). Age, BMI <18.5 kg/m2, heart failure, aortic valve stenosis, renal failure, triglyceride levels, serum albumin <3.0 g/dL, anticoagulant treatment, non-ambulatory status, and Rutherford 6 classification all were significantly associated with overall survival.ConclusionsBMI has a complex correlation with mortality in patients with CLI after EVT for isolated infrapopliteal artery lesions. Underweight patients with CLI have an extremely poor prognosis. Such patients have many other factors associated with mortality, but low BMI was identified as an independent predictor of a poor prognosis in patients with CLI. Similarly, normal weight patients had a small but significant increase in mortality compared with overweight/obese patients

Sperm proteins SOF1, TMEM95, and SPACA6 are required for sperm-oocyte fusion in mice

Noda, T., Lu, Y., Fujihara, Y., Oura, S., Koyano, T., Kobayashi, S., . . . Ikawa, M. (2020). Sperm proteins SOF1, TMEM95, and SPACA6 are required for sperm-oocyte fusion in mice. Proceedings of the National Academy of Sciences of the United States of America, 117(21) doi:10.1073/pnas.192265011

B : b interactions are essential for polymerization of variant fibrinogens with impaired holes 'a'

This is an electronic version of an Article published in Journal of Thrombosis and Haemostasis 2007; 5(12): 2352-2359.ArticleJOURNAL OF THROMBOSIS AND HAEMOSTASIS. 5(12): 2352-2359 (2007)journal articl

Development of Time- and Energy-Resolved Synchrotron-Radiation-Based Mössbauer Spectroscopy

14th International Conference on Synchrotron Radiation Instrumentation (SRI 2021) 28.03.2022 - 01.04.2022 OnlineSynchrotron-radiation based Mössbauer spectroscopy has become a useful technique capable for investigating various Mössbauer isotopes. For a typical experimental setup, the information associated with the pulse height (that is, energy) in an avalanche photodiode (APD) detector has not been used effectively. By using a system for simultaneous measurement system of time and energy associated with the APD signal, a system for the time- and energy-resolved Mössbauer spectroscopy has been developed. In this system, the pulse height information was converted to the time information through an amplitude-to-time converter applied to one of the divided signals from the APD. The corresponding time information was processed separately from another one of the divided signals. Both signals are recorded by a multi-channel scaler in an event-by-event data acquisition process. The velocity information from the Mössbauer transducer was also recorded as a tag for each signal event. Thus, the Mössbauer spectra with any time- and energy-window can be reconstructed after the data collection process. This system can be used for many purposes in time- and energy-resolved Mössbauer spectroscopy, and shows significant promise for use with other fast detectors and for various types of experiments

Spermatozoa lacking Fertilization Influencing Membrane Protein (FIMP) fail to fuse with oocytes in mice

Fujihara, Y., Lu, Y., Noda, T., Oji, A., Larasati, T., Kojima-Kita, K., . . . Ikawa, M. (2020). Spermatozoa lacking fertilization influencing membrane protein (FIMP) fail to fuse with oocytes in mice. Proceedings of the National Academy of Sciences of the United States of America, 117(17), 9393-9400. doi:10.1073/pnas.191706011