Retinoprotective Effect of 2‐Ethyl‐3‐hydroxy‐6‐methylpyridine Nicotinate

An important task of pharmacology is to find effective agents to improve retinal microcirculation and resistance to ischemia. The purpose of the study is to pharmacologically evaluate the retinoprotective effect of 2-3-hydroxy-6-methylpyridine nicotinate in a rat model of retinal ischemia-reperfusio

Disorder-driven superconductor-normal metal phase transition in quasi-one-dimensional organic conductors

Effects of non-magnetic disorder on the critical temperature T_c and on diamagnetism of quasi-one-dimensional superconductors are reported. The energy of Josephson-coupling between wires is considered to be random, which is typical for dirty organic superconductors. We show that this randomness destroys phase coherence between wires and that T_c vanishes discontinuously at a critical disorder-strength. The parallel and transverse components of the penetration-depth are evaluated. They diverge at different critical temperatures T_c^{(1)} and T_c, which correspond to pair-breaking and phase-coherence breaking respectively. The interplay between disorder and quantum phase fluctuations is shown to result in quantum critical behavior at T=0, which manifests itself as a superconducting-normal metal phase transition of first-order at a critical disorder strength.Comment: 12 pages, 3 figure

Correction of Experimental Retinal Ischemia by L-Isomer of Ethylmethylhydroxypyridine Malate

An important task of pharmacology and ophtalmology is to find specific and highly effective agents for correcting retinal ischemia. The objective of this study is to increase the effectiveness of pharmacological correction of retinal ischemia by using new 3-hydroxypyridine derivative-L-isomer of ethylmethylhydroxypyridine malat

Human recombinant erythropoietin gradient dosage influence on ischemic and reperfusion liver injury

We investigate influence of human recombinant erythropoietin different dosage on blood flow velocity and morphological changes in liver during ischemic and reperfusion injury. It was proved what optimal preconditioning dosage is 50 IU/k

Contributions of spontaneous phase slippage to linear and non-linear conduction near the Peierls transition in thin samples of o-TaS_3

In the Peierls state very thin samples of TaS_3 (cross-section area \sim 10^{-3} mkm^2) are found to demonstrate smearing of the I-V curves near the threshold field. With approaching the Peierls transition temperature, T_P, the smearing evolves into smooth growth of conductance from zero voltage interpreted by us as the contribution of fluctuations to the non--linear conductance. We identify independently the fluctuation contribution to the linear conductance near T_P. Both linear and non-linear contributions depend on temperature with close activation energies \sim (2 - 4) x 10^3 K and apparently reveal the same process. We reject creep of the {\it continuous} charge-density waves (CDWs) as the origin of this effect and show that it is spontaneous phase slippage that results in creep of the CDW. A model is proposed accounting for both the linear and non-linear parts of the fluctuation conduction up to T_P.Comment: 6 pages, 5 Postscript figure, RevTeX, accepted for publication in PR

The 3d-to-4s-by-2p highway to superconductivity in cuprates

High-temperature superconductors are nowadays found in great variety and hold technological promise. It is still an unsolved mystery that the critical temperature T_c of the basic cuprates is so high. The answer might well be hidden in a conventional corner of theoretical physics, overlooked in the recent hunt for exotic explanations of new effects in these materials. A forgotten intra-atomic s-d two-electron exchange in the Cu atom is found to provide a strong (~eV) electron pairing interaction. A Bardeen-Cooper-Schrieffer approach can explain the main experimental observations and predict the correct d_{x^2-y^2} symmetry of the gap.Comment: 4 pages, 3 figures, LaTeX2

Pharmacokinetic studies of new antiparkinsonian drug Rapitalam

The aim of this study was to investigate the pharmacokinetic parameters of the mGluR4 receptor blocker Rapitalam on rabbits. There was developed the method of the quantitative determination of Rapitalam in the blood plasma of rabbits using high performance liquid chromatography with tandem mass spectrometric detection. The study was performed on 12 rabbits (males, weighing between 3,300 to 3,500 g). In intragastric dosing of the substance was administered using a gastric tube in the form of suspension in water 0.9 mg/ml, 9 mg/ml, and 90 mg/ml at a dose of 0.3 mg/kg, 3 mg/kg and 30 mg/kg. The main pharmacokinetic parameters of the substance was established on rabbits that allow you to optimize the future use of it's as a potential drug for the treatment of Parkinson's diseas

Pharmacological correction of retinal ischemia/reperfusion by minoxidil

The objective of this paper was to increase the effectiveness of pharmacological correction of retinal ischemia-reperfusion by using minoxidil. Minoxidil at a dose of 0.5 mg/kg of rat mass protects the retina from ischemic-reperfusion injury. Protective effects of minoxidil are carried out by a preconditioning action, as evidenced by the lack of positive effects with the administration of glibenclamid

Fermion Analogy for Layered Superconducting Films in Parallel Magnetic Field

The equivalence between the Lawrence-Doniach model for films of extreme type-II layered superconductors and a generalization of the back-scattering model for spin-1/2 electrons in one dimension is demonstrated. This fermion analogy is then exploited to obtain an anomalous $H_{\parallel}^{-1}$ tail for the parallel equilibrium magnetization of the minimal double layer case in the limit of high parallel magnetic fields $H_{\parallel}$ for temperatures in the critical regime.Comment: 11 pages of plain TeX, 1 postscript figur