Co-segregation of recombinant inbred lines of the common bean to races 65 and 73 Colletotrichum lindemuthianum.

The common bean (Phaseolus vulgaris L.) is one of the most important legumes for direct human consumption (Lin et al. 2008). Anthracnose, caused by Colletotrichum lindemuthianum is the most widespread, recurrent and devastating disease of the common bean in Latin America and Africa (Pastor-Corrales and Tu 1989). The genetic mapping is carried out using segregating populations. Obtaining segregating populations for genetic mapping have been standard practice in the common bean research (Gepts et al. 1993; Blair et al. 2006). These populations have led to detailed studies and promising to greater efficiency in the genetic breeding of the crop worldwide, but have as limitation, the small size (Sanglard et al. 2013). Thus, the objective of this research was to phenotype the recombinant inbred lines (RIL?s) population from AND 277 × Rudá cross with the 65 and 73 races of Colletotrichum lindemuthianum

Intrafollicular immature oocyte transfer (IFIOT) for in vivo maturation of vitrified bovine oocytes.

Edição dos resumos da 37ª Annual Meeting of the Brazilian Embryo Technology Society, 2024, Atibaia, SP

Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19

Background: We previously reported that impaired type I IFN activity, due to inborn errors of TLR3- and TLR7-dependent type I interferon (IFN) immunity or to autoantibodies against type I IFN, account for 15–20% of cases of life-threatening COVID-19 in unvaccinated patients. Therefore, the determinants of life-threatening COVID-19 remain to be identified in ~ 80% of cases. Methods: We report here a genome-wide rare variant burden association analysis in 3269 unvaccinated patients with life-threatening COVID-19, and 1373 unvaccinated SARS-CoV-2-infected individuals without pneumonia. Among the 928 patients tested for autoantibodies against type I IFN, a quarter (234) were positive and were excluded. Results: No gene reached genome-wide significance. Under a recessive model, the most significant gene with at-risk variants was TLR7, with an OR of 27.68 (95%CI 1.5–528.7, P = 1.1 × 10−4) for biochemically loss-of-function (bLOF) variants. We replicated the enrichment in rare predicted LOF (pLOF) variants at 13 influenza susceptibility loci involved in TLR3-dependent type I IFN immunity (OR = 3.70[95%CI 1.3–8.2], P = 2.1 × 10−4). This enrichment was further strengthened by (1) adding the recently reported TYK2 and TLR7 COVID-19 loci, particularly under a recessive model (OR = 19.65[95%CI 2.1–2635.4], P = 3.4 × 10−3), and (2) considering as pLOF branchpoint variants with potentially strong impacts on splicing among the 15 loci (OR = 4.40[9%CI 2.3–8.4], P = 7.7 × 10−8). Finally, the patients with pLOF/bLOF variants at these 15 loci were significantly younger (mean age [SD] = 43.3 [20.3] years) than the other patients (56.0 [17.3] years; P = 1.68 × 10−5). Conclusions: Rare variants of TLR3- and TLR7-dependent type I IFN immunity genes can underlie life-threatening COVID-19, particularly with recessive inheritance, in patients under 60 years old

Educomunicação e suas áreas de intervenção: Novos paradigmas para o diálogo intercultural

oai:omp.abpeducom.org.br:publicationFormat/1O material aqui divulgado representa, em essência, a contribuição do VII Encontro Brasileiro de Educomunicação ao V Global MIL Week, da UNESCO, ocorrido na ECA/USP, entre 3 e 5 de novembro de 2016. Estamos diante de um conjunto de 104 papers executivos, com uma média de entre 7 e 10 páginas, cada um. Com este rico e abundante material, chegamos ao sétimo e-book publicado pela ABPEducom, em seus seis primeiros anos de existência. A especificidade desta obra é a de trazer as “Áreas de Intervenção” do campo da Educomunicação, colocando-as a serviço de uma meta essencial ao agir educomunicativo: o diálogo intercultural, trabalhado na linha do tema geral do evento internacional: Media and Information Literacy: New Paradigms for Intercultural Dialogue

Co-segregation of recombinant inbred lines of the common bean to races 65 and 73 Colletotrichum lindemuthianum.

The common bean (Phaseolus vulgaris L.) is one of the most important legumes for direct human consumption (Lin et al. 2008). Anthracnose, caused by Colletotrichum lindemuthianum is the most widespread, recurrent and devastating disease of the common bean in Latin America and Africa (Pastor-Corrales and Tu 1989). The genetic mapping is carried out using segregating populations. Obtaining segregating populations for genetic mapping have been standard practice in the common bean research (Gepts et al. 1993; Blair et al. 2006). These populations have led to detailed studies and promising to greater efficiency in the genetic breeding of the crop worldwide, but have as limitation, the small size (Sanglard et al. 2013). Thus, the objective of this research was to phenotype the recombinant inbred lines (RIL?s) population from AND 277 × Rudá cross with the 65 and 73 races of Colletotrichum lindemuthianum.Made available in DSpace on 2017-12-14T23:19:35Z (GMT). No. of bitstreams: 1 CNPAF2017BICp27.pdf: 251482 bytes, checksum: af359830ccf0cbf9b13884e81b02cce7 (MD5) Previous issue date: 2017-12-13bitstream/item/169077/1/CNPAF-2017-BICp27.pd