Creating an Antibacterial with in Vivo Efficacy: Synthesis and Characterization of Potent Inhibitors of the Bacterial Cell Division Protein FtsZ with Improved Pharmaceutical Properties

3-Methoxybenzamide (1) is a weak inhibitor of the essential bacterial cell division protein FtsZ. Alkyl derivatives of 1 are potent antistaphylococcal compounds with suboptimal drug-like properties. Exploration of the structure-activity relationships of analogues of these inhibitors led to the identification of potent antistaphylococcal compounds with improved pharmaceutical properties

Writing Toward Readers\u27 Better Health: A Case Study Examining the Development of Online Health Information

Each year, more people search the Internet for health information. Through a case study conducted at a prominent health information company, I will show that technical communicators are well suited to contribute to the development of online health information. Like other technical communicators, online health information developers must make rhetorical choices based on audience needs, function within specific social contexts, and work through challenges of writing, editing, and project management

A nomogram for deconvolution of single exponential fluorescence decays.

An extremely rapid technique for deconvolving single exponential luminescence decay data is described that involves essentially no mathematical manipulation of the experimental data. The method permits "real time" measurement of deconvolved luminescence lifetimes with conventional pulsed, lifetime-fluorometers and phosphorimeters. The method assumes that the true luminescence decay of the chromophore is accurately represented by a single exponential decay function

Similarity-Based Support for Text Reuse in Technical Writing

Technical writing in professional environments, such as user manual authoring for new products, is a task that relies heavily on reuse of content. Therefore, technical content is typically created following a strategy where modular units of text have references to each other. One of the main challenges faced by technical authors is to avoid duplicating existing content, as this adds unnecessary effort, generates undesirable inconsistencies, and dramatically increases maintenance and translation costs. However, there are few computational tools available to support this activity. This paper investigates the use of different similarity methods for the task of identification of reuse opportunities in technical writing. We evaluated our results using existing ground truth as well as feedback from technical authors. Finally, we also propose a tool that combines text similarity algorithms with interactive visualizations to aid authors in understanding differences in a collection of topics and identifying reuse opportunities.International Development Research Centre (grant 2013- LACREG-07)CALDO-FAPESP (grant Proc. 2013/50380-0)CNPq (grant 205291/2014-7)FAPESP (grant 2011/22749- 8)NSERCInnovatia Inc