Returning Citizens and Point of Entry: Is There a Match?

The period after incarceration and the influence of neighborhood effects are gaining interest among scholars as a small body of evidence is illustrating the difficulties returning citizens have obtaining basic services and needs, employment, stable housing, and other social and behavioral health supports in the areas where they are being released. Transitional planning efforts to ensure that returning citizens are prepared to engage in society and have necessary supports are often made. However, returning citizens may be in local communities that do not offer needed supports, such as in areas of high poverty and criminal activity, and low employment options. Findings from this study suggest that more attention is needed to where returning citizens are released following their period of incarceration

Returning Citizens and Point of Entry: Is There a Match?

The period after incarceration and the influence of neighborhood effects are gaining interest among scholars as a small body of evidence is illustrating the difficulties returning citizens have obtaining basic services and needs, employment, stable housing, and other social and behavioral health supports in the areas where they are being released. Transitional planning efforts to ensure that returning citizens are prepared to engage in society and have necessary supports are often made. However, returning citizens may be in local communities that do not offer needed supports, such as in areas of high poverty and criminal activity, and low employment options. Findings from this study suggest that more attention is needed to where returning citizens are released following their period of incarceration. </jats:p

Stathmin Regulates Centrosomal Nucleation of Microtubules and Tubulin Dimer/Polymer Partitioning

Stathmin is a microtubule-destabilizing protein ubiquitously expressed in vertebrates and highly expressed in many cancers. In several cell types, stathmin regulates the partitioning of tubulin between unassembled and polymer forms, but the mechanism responsible for partitioning has not been determined. We examined stathmin function in two cell systems: mouse embryonic fibroblasts (MEFs) isolated from embryos +/+, +/−, and −/− for the stathmin gene and porcine kidney epithelial (LLCPK) cells expressing stathmin-cyan fluorescent protein (CFP) or injected with stathmin protein. In MEFs, the relative amount of stathmin corresponded to genotype, where cells heterozygous for stathmin expressed half as much stathmin mRNA and protein as wild-type cells. Reduction or loss of stathmin resulted in increased microtubule polymer but little change to microtubule dynamics at the cell periphery. Increased stathmin level in LLCPK cells, sufficient to reduce microtubule density, but allowing microtubules to remain at the cell periphery, also did not have a major impact on microtubule dynamics. In contrast, stathmin level had a significant effect on microtubule nucleation rate from centrosomes, where lower stathmin levels increased nucleation and higher stathmin levels reduced nucleation. The stathmin-dependent regulation of nucleation is only active in interphase; overexpression of stathmin-CFP did not impact metaphase microtubule nucleation rate in LLCPK cells and the number of astral microtubules was similar in stathmin +/+ and −/− MEFs. These data support a model in which stathmin functions in interphase to control the partitioning of tubulins between dimer and polymer pools by setting the number of microtubules per cell