CONTINUOUS BIM ALIGNMENT FOR MIXED REALITY VISUALISATION

Several methods exist that can be used to perform initial alignment of Building information models (BIMs) to the real building for Mixed Reality (MR) applications, such as marker-based or markerless visual methods, but this alignment is susceptible to drift over time. The existing model-based methods that can be used to maintain this alignment have multiple limitations, such as the use of iterative processes and poor performance in environments with either too many or not enough lines. To address these issues, we propose an end-to-end trainable Convolutional Neural Network (CNN) that takes a real and synthetic BIM image pair as input to regress the 6 DoF relative camera pose difference between them directly. By correcting the relative pose error we are able to considerably improve the alignment of the BIM to the real building. Furthermore, the results of our experiments demonstrate good performance in a challenging environment and high resilience to domain shift between synthetic and real images. A high localisation accuracy of approximately 7.0 cm and 0.9° is achieved which indicates the method can be used to reduce the camera tracking drift for MR applications

The Applicability of Provocative Functional Tests in the Diagnosis of Rotator Cuff Muscle Injuries of the Best University Athletes

Rotator cuff disease, external and internal impingement syndromes, low shoulder stability, various types of trauma, and overuse injuries are all related to sports activities. In order to check symptoms in patients with disability and shoulder pain, clinicians use different methods and diagnostic imaging assessment. The research is aimed at evaluating whether there is a difference between provocation function tests (PFT) and ultrasonographic (US) testing of muscles within the rotator cuff in elite collegiate athletes. Patients (n=184) were recruited from university team sports selections and tested with a standardized US examination of the shoulder and five PFTs (Speed's test, Neer's test, Hawkins test, lift-off test, Yergason's test). Based on the VAS pain assessment scale, 60 subjects had some pain, which was taken for further processing in the work (124 subjects did not have the presence of pain and were excluded from further processing). The US examination was conducted using Voluson 730 apparatus, by a linear probe, with the frequency in the range of 6-12 MHz. The chi-square test showed significant differences between PFT and the occurrence of shoulder muscle tendinitis for the following variables: Speed's test and subscapularis tendinitis (p=0.02) and Speed's test and infraspinatus tendinitis (p=0.01); Neer test and biceps brachii caput longum tendinitis (p=0.01), Neer test and supraspinatus tendinitis (p=0.02) and Neer test and infraspinatus tendinitis (p=0.01); lift-off test and subscapularis tendinitis (p=0.05); and Yergason's test and biceps brachii caput longum tendinitis (p=0.03) and Yergason's test and subscapitis tendinitis (p=0.01). The greatest effect of differences was observed in Neer's test and biceps brachii caput longum tendinitis (ϕ=0.60), while the other effects can be described as medium and small in most cases. It can be concluded that functional tests are good predictors of soft tissue changes in the muscles of the rotator cuff of the shoulder. Further monitoring and analysis are needed on a larger number of athletes

A case report: isolation of alysiella filiformis from pig"s lungs

Alysiella filiformis is considered a common resident in the oral cavities of many animals. All reports of Alysiella indicate that it is restricted to the oral cavity of warm-blooded vertebrates, where it apparently is nonpathogenic. However, increased losses of young pigs occured in one farm in Serbia. Spumous content in bronchia and partly clotted blood in blood vesels o f the lungs were present. Characteristic signs of oedema disease were present and E. coli serogroup 0139 was isolated. Furthermore, Alysiella filiformis was the single agent isolated from the lungs of diseased pigs. This is the first isolation of Alysiella filiformis from pig lungs

Integration of healthy volunteers in early phase clinical trials with immuno-oncological compounds

Aim\nMethods\nResults\nDiscussion\nSystematic Review Registration\nTraditionally, early phase clinical trials in oncology have been performed in patients based on safety risk-benefit assessment. Therapeutic transition to immuno-oncology may open new opportunities for studies in healthy volunteers, which are conducted faster and are less susceptible to confounders. Aim of this study was to investigate to what extent this approach is utilized and whether pharmacodynamic endpoints are evaluated in these early phase trials. We conducted a comprehensive review of clinical trials with healthy volunteers using immunotherapies potentially relevant for oncology.\nLiterature searches according to PRISMA guidelines and after registration in PROSPERO were conducted in PubMed, Embase, Web of Science and Cochrane databases with the cut-off date 20 October 2020, using search terms of relevant targets in immuno-oncology. Articles describing clinical trials with immunotherapeutics in healthy volunteers with a mechanism relevant for oncology were included. "Immunotherapeutic" was defined as compounds exhibiting effects through immunological targets. Data including study design and endpoints were extracted, with specific attention to pharmacodynamic endpoints and safety.\nIn total, we found 38 relevant immunotherapeutic compounds tested in HVs, with 86% of studies investigating safety, 82% investigating the pharmacokinetics (PK) and 57% including at least one pharmacodynamic (PD) endpoint. Most of the observed adverse events (AEs) were Grade 1 and 2, consisting mostly of gastrointestinal, cutaneous and flu-like symptoms. Severe AEs were leukopenia, asthenia, syncope, headache, flu-like reaction and liver enzymes increase. PD endpoints investigated comprised of cytokines, immune and inflammatory biomarkers, cell counts, phenotyping circulating immune cells and ex vivo challenge assays.\nHealthy volunteer studies with immuno-oncology compounds have been performed, although not to a large extent. The integration of healthy volunteers in well-designed proof-of-mechanism oriented drug development programs has advantages and could be pursued more in the future, since integrative clinical trial protocols may facilitate early dose selection and prevent cancer patients to be exposed to non-therapeutic dosing regimens.\nhttps://www.crd.york.ac.uk/prospero/display_record.php?RecordID=210861, identifier CRD42020210861.Drug Delivery Technolog

Prirodna radioaktivnost uglja i letećeg pepela u termoelektrani 'Nikola Tesla B'

Serbian thermal power plants (TPPs) produce Siliceous fly ash from lignite in the quantity of approximately 6 million tons per year. The Potential. Market for the use of fly ash is operational, but for the time being, only Used by cement producers. Fly ash radioactivity could be one of the major points of concern When larger use of fly ash is planned, particularly in the Serbian construction industry. Radioactivity measurements have been conducted regularly from 1980. This paper presents the results of a ten-year fly ash radioactivity measurements at the Nikola Tesla B TPP located in Obrenovac. In addition, the paper compares the natural radionuclides coal content data combusted by the Nikola Tesla B TPP boilers coming from the Kolubara Basin and ash created during coal combustion. Fly ash created in the Nikola Tesla TPPs boilers is characterised by the increased concentration of the natural radionuclides content compared to coal. This is the so-called technologically enhanced natural radioactivity (Technologically Enhanced Occurring Radioactive Material - TENORM) of industrial waste, whereas the average specific activities: Th-232 in coal amount to 25.2 Bq/kg, and in fly ash and coal 84.2 Bq/kg and U-238 38.3 Bq/kg, respectively. Following the obtained natural radionuclides content results it may be concluded that the Nikola Tesla B TPP ash may be disposed into the environment. Ash may be used also in the construction industry (civil engineering). In building construction applications, ash share as the additive to other building materials depends from its physical and chemical characteristics, as well as from the radionuclides activity: Ra-226, Th-232 and K-40. Unlike the thermal power plants regularly (once a year) testing the specific natural radionuclides activity in the combusted coal and boiler fly ash, the Electric Power Industry of Serbia has not performed large-scale investigations of the natural radionuclides content in coal within the Kolubara Mining Basin. Natural radionuclides content in fly ash is compared to the combusted coal some 3-4 times higher and may present a limitation for applying ash in the construction industry. In view of the above, and considering the construction industry interests in using the Nikola Tesla B TPP ash, regular investigations of the natural radionuclides content in ash created in the thermal power plants should be carried out, together with the Kolubara Mining Basin coal combusted by the Nikola Tesla B TPP and other PE EPS thermal power plants. The current Kolubara Mining Basin coal characteristics investigation programme should be supplemented by the natural radionuclides content of the uranium (U-238 and Ra-226) and thorium series (Th-232) and potassium 40(K-40).U termoelektranama (TE) Javnog preduzeća 'Elektroprivreda Srbije' (JP EPS) koje u kotlovima sagorevaju lignit, kao nus produkat nastaje godišnje oko 6 miliona tona letećeg pepela. Potencijalno tržište za upotrebu letećeg pepela postoji, ali ga za sada koriste isključivo cementare. Radioaktivnost letećeg pepela može da predstavlja jedan od važnih razloga protiv njegove šire upotrebe u građevinskoj industriji Srbije. Merenje radioaktivnosti u termoelektranama redovno se sprovodi od 1990. godine. U radu su prikazani rezultati dvadesetogodišnjih merenja radioaktivnosti letećeg pepela u termoelektrani Nikola Tesla B (TENT B) u Obrenovcu. Uporedno su prikazani podaci o sadržaju prirodnih radionuklida u uglju koji se sagoreva u kotlovima TENT B poreklom iz kolubarskog basena i pepelu koji nastaje prilikom sagorevanja uglja. Na osnovu dobijenih rezultata o sadržaju prirodnih radionuklida zaključuje se da se pepeo iz termoelektrane Nikola Tesla B može odlagati u životnu sredinu. Pepeo se može koristiti i u građevinarstvu, u niskogradnji. Kod primene u visokoj gradnji udeo pepela kao dodataka drugim građevinskim materijalima zavisi kako od njegovih fizičkih i hemijskih karakteristika, tako i od specifične aktivnosti 226Ra, 232Th i 40K

Target Engagement and Immunogenicity of an Active Immunotherapeutic Targeting Pathological α-Synuclein: A Phase 1 Placebo-Controlled Trial

Investigational therapeutics that target toxic species of α-synuclein (αSyn) aim to slow down or halt disease progression in patients with Parkinson\u27s disease (PD). Here this 44-week, randomized, placebo-controlled, double-blind, single-center phase 1 study investigated safety, tolerability and immunogenicity of UB-312, an active immunotherapeutic targeting pathological αSyn, in patients with PD. The primary outcome measures were adverse event frequency and change in anti-αSyn antibody titers in blood and cerebrospinal fluid (CSF). Exploratory outcomes were changes in clinical scales and biomarker-based target engagement as measured by seed amplification assays. Twenty patients were randomized 7:3 (UB-312:placebo) into 300/100/100 μg or 300/300/300 μg (weeks 1, 5 and 13) intramuscular prime-boost dose groups. Safety was similar across groups; adverse events were mostly mild and transient. Two patients experienced three serious adverse events in total, one possibly treatment related; all resolved without sequalae. Anti-αSyn antibodies in serum from 12/13 and CSF from 5/13 patients who received three UB-312 doses confirmed immunogenicity. Mean serum titers (in log-dilution factor) increased from baseline by 1.398 and 1.354, and peaked at week 29 at 2.520 and 2.133, for 300/100/100 μg and 300/300/300 μg, respectively. CSF titers were 0 at baseline and were 0.182 and 0.032 at week 21, respectively. Exploratory analyses showed no statistical differences in clinical scales but a significant reduction of αSyn seeds in CSF of a subset of UB-312-treated patients. These data support further UB-312 development. ClinicalTrials.gov:NCT04075318.