Exposing the evidence gap for complementary and alternative medicine to be integrated into science-based medicine.

When people who advocate integrating conventional science-based medicine with complementary and alternative medicine (CAM) are confronted with the lack of evidence to support CAM they counter by calling for more research, diverting attention to the 'package of care' and its non-specific effects, and recommending unblinded 'pragmatic trials'. We explain why these responses cannot close the evidence gap, and focus on the risk of biased results from open (unblinded) pragmatic trials. These are clinical trials which compare a treatment with 'usual care' or no additional care. Their risk of bias has been overlooked because the components of outcome measurements have not been taken into account. The components of an outcome measure are the specific effect of the intervention and non-specific effects such as true placebo effects, cognitive measurement biases, and other effects (which tend to cancel out when similar groups are compared). Negative true placebo effects ('frustrebo effects') in the comparison group, and cognitive measurement biases in the comparison group and the experimental group make the non-specific effect look like a benefit for the intervention group. However, the clinical importance of these effects is often dismissed or ignored without justification. The bottom line is that, for results from open pragmatic trials to be trusted, research is required to measure the clinical importance of true placebo effects, cognitive bias effects, and specific effects of treatments

Cognitive psychopathology: The role of emotion

This paper examines the role of emotion in the understanding of psychopathology. The influential Cognitive Therapy model of Beck is briefly reviewed and a number of limitations are considered. Two particular weaknesses are highlighted in the understanding of cognitive psychopathology; namely, the importance of multi-level processing systems and the importance of emotion. The Power and Dalgleish (1997, 2008) SPAARS model is presented to show the advantages that arise from the inclusion of multilevel processes combined with a theoretical account of emotion. In order to illustrate the application of the SPAARS model to cognitive psychopathology, findings from a recent emotion profile analysis of clinical depression and anxiety are summarised. The analyses also illustrate the importance of shamerelated emotions in depression in contrast to the guiltrelated emotions that are highlighted in classification systems such as DSM-IV. ------ RESUMO ------ Neste artigo fazemos uma reflexão sobre o papel da emoção na compreensão da psicopatologia. Fazemos uma breve revisão e apontamos uma série de limitações. do influente modelo da Psicoterapia Cognitiva preconizado por Beck. Dois pontos particularmente fracos são destacados na compreensão da psicopatologia cognitiva; nomeadamente, a importância dos sistemas de processamento multi-nível e a importância das emoções. Apresentamos o modelo SPAARS de Power e Dalgleish (1997, 2008), para mostrar as vantagens que resultam da inclusão de processos de multi-nível combinados com uma teoria relacionada com as emoções. Com o objectivo de ilustrar a aplicação do modelo SPAARS à psicopatologia cognitiva. Referimos, de forma sucinta, o que foi observado numa recente analise sobre o perfil da depressão e ansiedade clínicas. Estas analises ilustram também a importância das emoções relacionadas com a vergonha na depressão, em contraste com as emoções relacionadas com a culpa que são destacadas em sistemas de classificação como o DSM-IV

Controlled Natural Language Processing as Answer Set Programming: an Experiment

Most controlled natural languages (CNLs) are processed with the help of a pipeline architecture that relies on different software components. We investigate in this paper in an experimental way how well answer set programming (ASP) is suited as a unifying framework for parsing a CNL, deriving a formal representation for the resulting syntax trees, and for reasoning with that representation. We start from a list of input tokens in ASP notation and show how this input can be transformed into a syntax tree using an ASP grammar and then into reified ASP rules in form of a set of facts. These facts are then processed by an ASP meta-interpreter that allows us to infer new knowledge

Dynamics and Asymptotics of Correlations in a Many-Body Localized System

We examine the dynamics of nearest-neighbor bipartite concurrence and total correlations in the spin-1/2 $XXZ$ model with random fields. We show, starting from factorized random initial states, that the concurrence can suffer entanglement sudden death in the long time limit and therefore may not be a useful indicator of the properties of the system. In contrast, we show that the total correlations capture the dynamics more succinctly, and further reveal a fundamental difference in the dynamics governed by the ergodic versus many-body localized phases, with the latter exhibiting dynamical oscillations. Finally, we consider an initial state composed of several singlet pairs and show that by fixing the correlation properties, while the dynamics do not reveal noticeable differences between the phases, the long-time values of the correlation measures appear to indicate the critical region.Comment: 5 pages, 5 figures. Close to published versio

Nonclassicality and criticality in symmetry-protected magnetic phases

Quantum and global discord in a spin-1 Heisenberg chain subject to single-ion anisotropy (uniaxial field) are studied using exact diagonalisation and the density matrix renormalisation group (DMRG). We find that these measures of quantum nonclassicality are able to detect the quantum phase transitions confining the symmetry protected Haldane phase and show critical scaling with universal exponents. Moreover, in the case of thermal states, we find that quantum discord can increase with increasing temperature.Comment: 7 pages, 6 figures, Close to published version. Includes a link to data used for the figure

Duplicated membrane estrogen receptors in the European sea bass (Dicentrarchus labrax): Phylogeny, expression and regulation throughout the reproductive cycle

The numerous estrogen functions reported across vertebrates have been classically explained by their binding to specific transcription factors, the nuclear estrogen receptors (ERs). Rapid non-genomic estrogenic responses have also been recently identified in vertebrates including fish, which can be mediated by membrane receptors such as the G protein-coupled estrogen receptor (Gper). In this study, two genes for Gper, namely gpera and gperb, were identified in the genome of a teleost fish, the European sea bass. Phylogenetic analysis indicated they were most likely retained after the 3R teleost-specific whole genome duplication and raises questions about their function in male and female sea bass. Gpera expression was mainly restricted to brain and pituitary in both sexes while gperb had a widespread tissue distribution with higher expression levels in gill filaments, kidney and head kidney. Both receptors were detected in the hypothalamus and pituitary of both sexes and significant changes in gpers expression were observed throughout the annual reproductive season. In female pituitaries, gpera showed an overall increase in expression throughout the reproductive season while gperb levels remained constant. In the hypothalamus, gpera had a higher expression during vitellogenesis and decreased in fish entering the ovary maturation and ovulation stage, while gperb expression increased at the final atresia stage. In males, gpers expression was constant in the hypothalamus and pituitary throughout the reproductive cycle apart from the mid- to late testicular development stage transition when a significant up-regulation of gpera occurred in the pituitary. The differential sex, seasonal and subtype-specific expression patterns detected for the two novel gper genes in sea bass suggests they may have acquired different and/or complementary roles in mediating estrogens actions in fish, namely on the neuroendocrine control of reproduction.info:eu-repo/semantics/publishedVersio

Water calcium concentration modifies whole-body calcium uptake in sea bream larvae during short-term adaptation to altered salinities

Whole-body calcium uptake was studied in gilthead sea bream larvae (9–83·mg) in response to changing environmental salinity and [Ca2+]. Calcium uptake increased with increased fish size and salinity. Fish exposed to calcium-enriched, diluted seawater showed increased calcium uptake compared with fish in diluted seawater alone. Calcium uptake was unchanged in Na+- enriched, diluted seawater. Overall, [Ca2+], and not salinity/osmolarity per se, appears to be the main factor contributing to calcium uptake. By contrast, drinking was reduced by a decrease in salinity/osmolarity but was little affected by external [Ca2+]. Calculations of the maximum contribution from drinking-associated calcium uptake showed that it became almost insignificant (less than 10%) through a strong decrease in drinking rate at low salinities (0–8‰). Diluted seawater enriched in calcium to the concentration present in full-strength seawater (i.e. constant calcium, decreasing salinity) restored intestinal calcium uptake to normal. Extra-intestinal calcium uptake also benefited from calcium addition but to a lesser extent

The SKA as a Doorway to Angular Momentum

Angular momentum is one of the most fundamental physical quantities governing galactic evolution. Differences in the colours, morphologies, star formation rates and gas fractions amongst galaxies of equal stellar/baryon mass M are potentially widely explained by variations in their specific stellar/baryon angular momentum j. The enormous potential of angular momentum science is only just being realised, thanks to the emergence of the first simulations of galaxies with converged spins, paralleled by a dramatic increase in kinematic observations. Such observations are still challenged by the fact that most of the stellar/baryon angular momentum resides at large radii. In fact, the radius that maximally contributes to the angular momentum of an exponential disk (3Re-4Re) is twice as large as the radius that maximally contributes to the disk mass; thus converged measurements of angular momentum require either extremely deep IFS data or, alternatively, kinematic measurements of neutral atomic hydrogen (HI), which naturally resides at the large disk radii that dominate the angular momentum. The SKA has a unique opportunity to become the world-leading facility for angular momentum studies due to its ability to measure the resolved and/or global HI kinematics in very large and well-characterised galaxy samples. These measurements will allow, for example, (1) a very robust determination of the two-dimensional distribution of galaxies in the (M,j)-plane, (2) the largest, systematic measurement of the relationship between M, j, and tertiary galaxy properties, and (3) the most accurate measurement of the large-scale distribution and environmental dependence of angular momentum vectors, both in terms of norm and orientation. All these measurements will represent exquisite tools to build a next generation of galaxy evolution models.Comment: 13 pages, 5 figures, 3 table