Inhibitors of \u3cem\u3eN\u3csup\u3eα\u3c/sup\u3e\u3c/em\u3e-acetyl-l-ornithine Deacetylase: Synthesis, Characterization and Analysis of their Inhibitory Potency

A series of N α-acyl (alkyl)- and N α-alkoxycarbonyl-derivatives of l- and d-ornithine were prepared, characterized, and analyzed for their potency toward the bacterial enzyme N α-acetyl-l-ornithine deacetylase (ArgE). ArgE catalyzes the conversion of N α-acetyl-l-ornithine to l-ornithine in the fifth step of the biosynthetic pathway for arginine, a necessary step for bacterial growth. Most of the compounds tested provided IC50 values in the μM range toward ArgE, indicating that they are moderately strong inhibitors. N α-chloroacetyl-l-ornithine (1g) was the best inhibitor tested toward ArgE providing an IC50 value of 85 μM while N α-trifluoroacetyl-l-ornithine (1f), N α-ethoxycarbonyl-l-ornithine (2b), and N α-acetyl-d-ornithine (1a) weakly inhibited ArgE activity providing IC50 values between 200 and 410 μM. Weak inhibitory potency toward Bacillus subtilis-168 for N α-acetyl-d-ornithine (1a) and N α-fluoro- (1f), N α-chloro- (1g), N α-dichloro- (1h), and N α-trichloroacetyl-ornithine (1i) was also observed. These data correlate well with the IC50 values determined for ArgE, suggesting that these compounds might be capable of getting across the cell membrane and that ArgE is likely the bacterial enzymatic target

Visitors' preferences of renewable energy options in 'green' hotels.

Tourism belongs to the industries with significant energy consumption. Visitors as well as hotel managers have, however, a positive attitude towards the responsible use of energy resources. The level of research on visitors’ preferences of using different types of renewable energy is low, unlike findings on factual characteristics of conventional and renewable energies. That is why our aim was to assess visitors’ preferences of environmentally friendly energy sources in hotels. Preferences of six types of renewable energy - “green” tariff energy, solar panels on the rooftops, solar panels on the ground, heat pumps, AD, wind turbine, were measured at four tourist destinations in the Czech Republic. The positive attitude of tourists towards the selected types of energy sources was confirmed. The highest preferences were found for solar panels installed on the rooftops. A typology of preferences was revealed by cluster analysis and differences between clusters were tested for independent variables. Clusters of visitors with a high and low interest in any type of renewable energy were identified as well as a cluster of visitors with interest in all types apart from solar panels installed on the ground - the visitor’s origin was found as the main differentiation factor

Transverse momentum and collision energy dependence of high pTp_{T} hadron suppression in Au+Au collisions at ultrarelativistic energies

We report high statistics measurements of inclusive charged hadron production in Au+Au and p+p collisions at \sqrtsNN=200 GeV. A large, approximately constant hadron suppression is observed in central Au+Au collisions for 5\lt\pT\lt12 GeV/c. The collision energy dependence of the yields and the centrality and \pT dependence of the suppression provide stringent constraints on theoretical models of suppression. Models incorporating initial-state gluon saturation or partonic energy loss in dense matter are largely consistent with observations. We observe no evidence of \pT-dependent suppression, which may be expected from models incorporating jet attentuation in cold nuclear matter or scattering of fragmentation hadrons.Comment: Final journal version. Data tables for figures may be downloaded from the STAR home page: http://www.star.bnl.gov --> Publications --> Access to STAR published dat

Rapidity and centrality dependence of proton and antiproton production from 197Au + 197Au collisions at √SNN = 130 GeV

We report on the rapidity and centrality dependence of proton and antiproton transverse mass distributions from 197Au + 197Au collisions at sqrt[sNN ]=130 GeV as measured by the STAR experiment at the Relativistic Heavy Ion Collider (RHIC). Our results are from the rapidity and transverse momentum range of |y| <0.5 and 0.35< pt <1.00 GeV/c . For both protons and antiprotons, transverse mass distributions become more convex from peripheral to central collisions demonstrating characteristics of collective expansion. The measured rapidity distributions and the mean transverse momenta versus rapidity are flat within |y| <0.5 . Comparisons of our data with results from model calculations indicate that in order to obtain a consistent picture of the proton (antiproton) yields and transverse mass distributions the possibility of prehadronic collective expansion may have to be taken into account

Particle-type dependence of azimuthal anisotropy and nuclear modification of particle production in Au+Au collisions at s(NN)**(1/2) = 200-GeV

We present STAR measurements of the azimuthal anisotropy parameter $v_2$ and the binary-collision scaled centrality ratio $R_{CP}$ for kaons and lambdas ($\Lambda+\bar{\Lambda}$) at mid-rapidity in Au+Au collisions at $\sqrt{s_{_{NN}}}=200$ GeV. In combination, the $v_2$ and $R_{CP}$ particle-type dependencies contradict expectations from partonic energy loss followed by standard fragmentation in vacuum. We establish $p_T \approx 5$ GeV/c as the value where the centrality dependent baryon enhancement ends. The $K_S^0$ and $\Lambda+\bar{\Lambda}$ $v_2$ values are consistent with expectations of constituent-quark-number scaling from models of hadron fromation by parton coalescence or recombination.Comment: 6 pages, 4 figures, 1 table. As published in PRL on Feb. 2, 2004; Significant revisions have been made to the text and color has been added to plot

Correlations in STAR: interferometry and event structure

STAR observes a complex picture of RHIC collisions where correlation effects of different origins -- initial state geometry, semi-hard scattering, hadronization, as well as final state interactions such as quantum intensity interference -- coexist. Presenting the measurements of flow, mini-jet deformation, modified hadronization, and the Hanbury Brown and Twiss effect, we trace the history of the system from the initial to the final state. The resulting picture is discussed in the context of identifying the relevant degrees of freedom and the likely equilibration mechanism.Comment: 8 pages, 6 figures, plenary talk at the 5th International Conference on Physics and Astrophysics of Quark Gluon Plasma, to appear in Journal of Physics G (http://www.iop.org

Identified baryon and meson distributions at large transverse momenta from Au+Au collisions at sNN=200\sqrt{s_{_{NN}}} = 200 GeV

Transverse momentum spectra of $\pi^{\pm}$, $p$ and $\bar{p}$ up to 12 GeV/c at mid-rapidity in centrality selected Au+Au collisions at $\sqrt{s_{_{NN}}} = 200$ GeV are presented. In central Au+Au collisions, both $\pi^{\pm}$ and $p(\bar{p})$ show significant suppression with respect to binary scaling at $p_T >$ 4 GeV/c. Protons and anti-protons are less suppressed than $\pi^{\pm}$, in the range 1.5 $< p_{T} <$6 GeV/c. The $\pi^-/\pi^+$ and $\bar{p}/p$ ratios show at most a weak $p_T$ dependence and no significant centrality dependence. The $p/\pi$ ratios in central Au+Au collisions approach the values in p+p and d+Au collisions at $p_T >$ 5 GeV/c. The results at high $p_T$ indicate that the partonic sources of $\pi^{\pm}$, $p$ and $\bar{p}$ have similar energy loss when traversing the nuclear medium.Comment: 6 pages, 4 figure

Longitudinal double-spin asymmetry and cross section for inclusive jet production in polarized proton collisions at sqrt(s) = 200 GeV

We report a measurement of the longitudinal double-spin asymmetry A_LL and the differential cross section for inclusive midrapidity jet production in polarized proton collisions at sqrt(s)=200 GeV. The cross section data cover transverse momenta 5 < pT < 50 GeV/c and agree with next-to-leading order perturbative QCD evaluations. The A_LL data cover 5 < pT < 17 GeV/c and disfavor at 98% C.L. maximal positive gluon polarization in the polarized nucleon.Comment: 6 pages, 3 figures. Minor changes from review process in Phys. Rev. Lett. Plain text tables of data in STAR publications may be found at http://www.star.bnl.gov/central/publications

Evidence from d+Au measurements for final-state suppression of high pTp_T hadrons in Au+Au collisions at RHIC

We report measurements of single-particle inclusive spectra and two-particle azimuthal distributions of charged hadrons at high transverse momentum (high $p_T$) in minimum bias and central d+Au collisions at $\sqrt{s_{NN}}$=200 GeV. The inclusive yield is enhanced in d+Au collisions relative to binary-scaled p+p collisions, while the two-particle azimuthal distributions are very similar to those observed in p+p collisions. These results demonstrate that the strong suppression of the inclusive yield and back-to-back correlations at high $p_T$ previously observed in central Au+Au collisions are due to final-state interactions with the dense medium generated in such collisions.Comment: Final journal version. Data tables for figures may be downloaded from the STAR home page: http://www.star.bnl.gov --> Publications --> Access to STAR published dat

Pion-Xi correlations in Au-Au collisions at STAR

We present pion-Xi correlation analysis in Au-Au collisions at sqrt(s_NN)= 200 GeV and sqrt(s_NN) = 62.4 GeV, performed using the STAR detector at RHIC. A Xi*(1530) resonance signal is observed for the first time in Au-Au collisions. Experimental data are compared with theoretical predictions. The strength of the Xi* peak is reproduced in the correlation function assuming that pions and Xis emerge from a system in collective expansion.Comment: To appear in the proceedings of 18th Nuclear Physics Division Conference of the EPS (NPDC18),Prague, 23.8.-29.8. 200