Using multiple criteria decision analysis to aid the selection of enterprise resource planning software : a case study

BHC Ltd is a family owned SME which specialises in steel fabrication for the construction industry. Due to rapid growth over the past decade the company’s current business software has evolved from a collection of semi-integrated individual packages and Excel spreadsheets. To help the company become more efficient during the current financial downturn and to ensure they are capable of future growth, BHC Ltd initiated a project with the University of Strathclyde to select and implement an Enterprise Resource Planning (ERP) solution. This paper will provide a case study of BHC’s ERP selection process. In particular it will discuss how steel specific business requirements and organisational culture led us to use multiple criteria decision analysis (MCDA) when making a final software selection. The MCDA process that was followed is further discussed and includes the success that was achieved by using this approach

Evaluation of phylogenetic reconstruction methods using bacterial whole genomes: a simulation based study

Background: Phylogenetic reconstruction is a necessary first step in many analyses which use whole genome sequence data from bacterial populations. There are many available methods to infer phylogenies, and these have various advantages and disadvantages, but few unbiased comparisons of the range of approaches have been made. Methods: We simulated data from a defined "true tree" using a realistic evolutionary model. We built phylogenies from this data using a range of methods, and compared reconstructed trees to the true tree using two measures, noting the computational time needed for different phylogenetic reconstructions. We also used real data from Streptococcus pneumoniae alignments to compare individual core gene trees to a core genome tree. Results: We found that, as expected, maximum likelihood trees from good quality alignments were the most accurate, but also the most computationally intensive. Using less accurate phylogenetic reconstruction methods, we were able to obtain results of comparable accuracy; we found that approximate results can rapidly be obtained using genetic distance based methods. In real data we found that highly conserved core genes, such as those involved in translation, gave an inaccurate tree topology, whereas genes involved in recombination events gave inaccurate branch lengths. We also show a tree-of-trees, relating the results of different phylogenetic reconstructions to each other. Conclusions: We recommend three approaches, depending on requirements for accuracy and computational time. Quicker approaches that do not perform full maximum likelihood optimisation may be useful for many analyses requiring a phylogeny, as generating a high quality input alignment is likely to be the major limiting factor of accurate tree topology. We have publicly released our simulated data and code to enable further comparisons

Draft genome sequence of the Streptococcus pneumoniae Avery strain A66

We have used HiSeq 2000 technology to generate a draft genome sequence of Streptococcus pneumoniae strain A66. This is a common study strain used in investigations of pneumococcal bacterium-host interactions and was used in the seminal genetic studies of Avery et al

Exciton coherence lifetimes from electronic structure

We model the coherent energy transfer of an electronic excitation within covalently linked aromatic homodimers from first-principles, to answer whether the usual models of the bath calculated via detailed electronic structure calculations can reproduce the key dynamics. For these systems the timescales of coherent transport are experimentally known from time-dependent polarization anisotropy measurements, and so we can directly assess the whether current techniques might be predictive for this phenomenon. Two choices of electronic basis states are investigated, and their relative merits discussed regarding the predictions of the perturbative model. The coupling of the electronic degrees of freedom to the nuclear degrees of freedom is calculated rather than assumed, and the fluorescence anisotropy decay is directly reproduced. Surprisingly we find that although TDDFT absolute energies are routinely in error by orders of magnitude more than the coupling energy, the coherent transport properties of these dimers can be semi-quantitatively reproduced from first-principles. The directions which must be pursued to yield predictive and reliable prediction of coherent transport are suggested.Comment: 22 pages, 7 figure

Course-Level Curriculum Map Pilot Program

Objective: To pilot a newly developed course level curriculum map that documents course learning outcomes, corresponding teaching activities, assessments, student achievement on assessments, and evidence-based changes made subsequently at the course level. Method: The newly developed course level curriculum map was piloted in twelve courses involving nine faculty members. Faculty either retroactively recorded data or utilized the map during the semester. At the conclusion of the pilot period, a focus group was conducted during which seven of the faculty members shared experiences and recommendations. Focus group comments were recorded by three people. Recorders’ notes were compared for accuracy and completeness. Notes were analyzed using ATLAS.ti, a qualitative research program. Results: Qualitative analysis of focus group notes yielded four principal comment codes: learning outcomes, changing activities, documenting changes, and changing assessments. These four main codes document that faculty believe work is needed on writing better course learning outcomes, creating more appropriately matched course activities, better documenting data-driven changes that occur at the course level, and developing appropriate assessments. Implications: Faculty comments support school-wide adoption of course level curriculum mapping. They also suggest a need to provide faculty development on writing precise learning outcomes and mapping them to specific classroom activities to support outcomes achievement. Additionally, curricular changes made at the course level need to be carefully documented and linked to appropriate evidence derived from assessments. The value of the map for inclusion in the dossier for promotion and tenure was also noted

Low genomic diversity of Legionella pneumophila within clinical specimens.

OBJECTIVES: Legionella pneumophila is the leading cause of Legionnaires' disease, a severe form of pneumonia acquired from environmental sources. Investigations of both sporadic cases and outbreaks rely mostly on analysis of a single to a few colony pick(s) isolated from each patient. However, because of the lack of data describing diversity within single patients, the optimal number of picks is unknown. Here, we investigated diversity within individual patients using sequence-based typing (SBT) and whole-genome sequencing (WGS). METHODS: Ten isolates of L. pneumophila were obtained from each of ten epidemiologically unrelated patients. SBT and WGS were undertaken, and single-nucleotide polymorphisms (SNPs) were identified between isolates from the same patient. RESULTS: The same sequence type (ST) was obtained for each set of ten isolates. Using genomic analysis, zero SNPs were identified between isolates from seven patients, a maximum of one SNP was found between isolates from two patients, and a maximum of two SNPs was found amongst isolates from one patient. Assuming that the full within-host diversity has been captured with ten isolates, statistical analyses showed that, on average, analysis of one isolate would yield a 70% chance of capturing all observed genotypes, and seven isolates would yield a 90% chance. CONCLUSIONS: SBT and WGS analyses of multiple colony picks obtained from ten patients showed no, or very low, within-host genomic diversity in L. pneumophila, suggesting that analysis of one colony pick per patient will often be sufficient to obtain reliable typing data to aid investigation of cases of Legionnaires' disease

An Interpretation of Late Quaternary Glacial Flow Indicators in the Baie des Chaleurs Region, Northern New Brunswick

A sequence of late Quaternary geologic events in northern New Brunswick is determined from striation analysis derived from published data, open file reports, and field research conducted by the authors since 1985. These data are integrated with clast provenance and clast fabric trend analysis, as well as information from other studies in the surrounding area. South of the Baie des Chaleurs, a complicated Late Wisconsinan glacial history is preserved in the form of erosive features including nailhead striae, miniature crag-and-tails, and various scars, striations, and fractures. The rarity of sedimentary deposits and datable materials precludes simple stratigraphie interpretation. Based on over 1,000 striation sites, we conclude four major phases of glacial flow affected the area during the Late Wisconsinan: 1) an early flow to the southeast which reflects local Appalachian ice; 2) a second phase of glacial flow to the east indicating a Laurentide ice influence in western New Brunswick; 3) a third phase of glacial flow to the north-northeast, which may represent ice response to drawdown in the Baie des Chaleurs; and 4) a final multidirectional flow indicating localized ice response during the last stages of Late Wisconsinan glaciation. The absence of Canadian Shield erratics in northern New Brunswick is explained in terms of ice streaming along the St. Lawrence channel beneath a southward-flowing Laurentide Ice Sheet. Basal ice debris (including Shield erratics) was apparently truncated and removed by the obliquely flowing ice stream, leaving relatively clean ice in the Ice Sheet as it entered Gaspésie and ultimately New Brunswick.On a déterminé la séquence des événements géologiques du Quaternaire supérieur survenus dans le nord du Nouveau-Brunswick à partir de l'analyse des stries tirée de diverses sources. Au sud de la baie des Chaleurs, l'évolution glaciaire complexe du Wisconsinien supérieur peut être retracée à partir des formes d'érosion glaciaire dont les clouures, les crag-and-tails miniatures, les cicatrices de toutes sortes, les stries et les fractures. La rareté des sédiments et des matériaux pouvant être datés excluent toute interprétation fondée sur la stratigraphie. En s'appuyant sur plus de 1000 sites de stries, on croit que la région a connu quatre épisodes glaciaires pendant le Wisconsinien supérieur: 1 ) le premier mouvement, de faible importance, s'est fait vers le SE en provenance des Appalaches; 2) le deuxième écoulement glaciaire vers PE démontre la force des glaces laurentidiennes au nord du Nouveau-Brunswick; 3) le troisième mouvement glaciaire vers le NNE pourrait être une réaction à l'affaissement qui s'est produit dans la baie des Chaleurs; 4) le dernier mouvement multidirectionnel s'est fait à partir de calottes localisées pendant les derniers stades de la glaciation wisconsinienne. On explique l'absence des blocs erratiques dans le nord du Nouveau-Brunswick par un écoulement des glaces le long du chenal laurentien interrompant l'Inlandsis laurentidien s'écoulant vers le sud. Les débris glaciaires de fond (y compris les blocs erratiques du Bouclier) ont apparemment été tronqués et enlevés par un courant glaciaire oblique, épurant ainsi la glace qui pénétrait en Gaspésie, puis au Nouveau-Brunswick.Een Interpretatie van Laat-glaciale Ijsbewegingsindicaties in de Chaleur Bay Regio, Noord New Brunswick. De Kwartair geologische kartering van noord New Brunswick begon met de studies van Robert Chalmers aan het einde van de 19e eeuw. Sindsdien zijn verschillende pogingen gedaan om de glaciale geschiedenis van dit gebied te ontravelen en uiteindelijk zijn Chalmers ideeen herontdekt en aangepast aan moderne theorien en modellen van glaciale processen en isostasie. De afwezigheid van stratigrafische secties en de aanwezigheid van vêle glaciale erosieve en morphologische vormen heeft geleid tot de ontwikkeling van een "erosie-stratigrafie ". Deze informatie wordt gesteund door till lithologische en ges-teente orientatie studies. Het resultaat van dit gedetailleerde karterings project is de her-kenning van 4 verschillende ijs-bewegingen. Datering van deze gebeurtenissen is een probleem vanwege een gebrek aan dateer-bare materialen. Een eerste zuidoostelijke ijsbeweging is geregistreerd in het oostelijke deel van het gebied en in de Chaleur Coastal Plain. De tweede en sterkste gebeurtenis geeft een oostwaartse ijsbeweging te zien, die waarschijnlijk gedurende het gehele Wisconsinan (Weichselien) en mogelijk het gehele Pleistoceen van belang kan zijn geweest. Een derde ijsbeweging is in noord-oostelijke richt-ing in de Baie des Chaleurs. In een latere fase, lokale ijsbewegingen vonden plaats in verschillende richtingen vanaf de hooglanden en mogelijk vanuit Baie des Chaleurs. Er is een poging gedaan deze gebeurtenissen in een régionale context te plaatsen, waarin de interactie van de Laurentide Ice Sheet met het Appalachian Ice Complex en het concept van een Laurentian ijsstroomkanaal centraal staan

When People Evaluate Others, the Level of Others’ Narcissism Matters Less to Evaluators Who are Narcissistic

Prior studies have documented how people in general respond to others’ narcissism, but existing research offers few clues about whether and how evaluator narcissism influences judgments of traits associated with narcissism. Participants completed the Narcissistic Personality Inventory and then evaluated hypothetical target persons. Target narcissism was conveyed through a single trait description (Study 1), a list of traits (Study 2), or Facebook content (Study 3). Narcissistic qualities were reliably viewed unfavorably, but narcissistic participants were comparatively less bothered by target narcissism and less positive in their judgments of targets without narcissistic qualities. In each study, symptoms of the presence or absence of narcissism had less impact on the social judgments of participants who were narcissistic