Cosmological Constraints on Late-time Entropy Production

We investigate cosmological effects concerning the late-time entropy production due to the decay of non-relativistic massive particles. The thermalization process of neutrinos after the entropy production is properly solved by using the Boltzmann equation. If a large entropy production takes place at late time t$\simeq$ 1 sec, it is found that a large fraction of neutrinos cannot be thermalized. This fact loosens the tight constraint on the reheating temperature T_R from the big bang nucleosynthesis and T_R could be as low as 0.5 MeV. The influence on the large scale structure formation and cosmic microwave background anisotropies is also discussed.Comment: 4 pages, using RevTeX and five postscript figures, comments added, to appear in Phys. Rev. Let

Connecting magnetic towers with Faraday rotation gradients in active galactic nuclei jets

The idea that systematic Faraday Rotation gradients across the parsec-scale jets of active galactic nuclei (AGNs) can reveal the presence of helical magnetic (B) fields has been around since the early 1990s, although the first observation of this phenomenon was about ten years later. These gradients are taken to be due to the systematic variation of the line-of-sight B field across the jet. We present here, the parsec-scale Faraday Rotation distributions for the BL Lac objects 0716+714 and 1749+701, based on polarization data obtained with the Very Long Baseline Array at two wavelengths near each of the 2 cm, 4 cm and 6 cm bands (0716+714) and at four wavelengths in the range 18-22 cm (1749+701). The Rotation Measure (RM) maps for both these sources indicate systematic gradients across their jets, as expected if these jets have helical B fields. The significance of these transverse RM gradients is >3 sigma in all cases. We present the results of Monte Carlo simulations directly demonstrating the possibility of observing such transverse RM gradients even if the intrinsic jet structure is much narrower than the observing beam. We observe an intriguing new feature in these sources, a reversal in the direction of the gradient in the jet as compared to the gradient in the core region. This provides new evidence to support models in which field lines emerging from the central region of the accretion disc and closing in the outer region of the accretion disc are both 'wound up' by the differential rotation of the disc. The net observed RM gradient will essentially be the sum effect of two regions of helical field, one nested inside the other. The direction of the net RM gradient will be determined by whether the inner or outer helix dominates the RM integrated through the jet, and RM gradient reversals will be observed if the inner and outer helical fields dominate in different regions of the jet. This potentially provides new insights about the overall configuration of the jet B fields

String Theory and Cosmology

We discuss the main cosmological implications of considering string-loop effects and a potential for the dilaton in the lowest order string effective action. Our framework is based on the effective model arising from regarding homogeneous and isotropic dilaton, metric and Yang-Mills field configurations. The issues of inflation, entropy crisis and the Polonyi problem as well as the problem of the cosmological constant are discussed.Comment: 7 pages, plain Tex, no figure

The Cosmological Moduli Problem, Supersymmetry Breaking and Stability in Postinflationary Cosmology

A survey of solutions to the cosmological moduli problem in string theory. The only extant proposal which may work is Intermediate Scale Inflation as proposed by Randall and Thomas. Supersymmetry preserving dynamics which could give large masses to the moduli is strongly constrained by cosmology and requires the existence of string vacuum states possessing properties different from those of any known vacuuum. Such a mechanism cannot give mass to the dilaton unless there are cancellations between different exponentially small contributions to the superpotential. Our investigation also shows that stationary points of the effective potential with negative vacuum energy do not correspond to stationary solutions of the equations of postinflationary cosmology. This suggests that supersymmetry breaking is a requirement for a successful inflationary cosmology.Comment: harvma

Inflation and flat directions in modular invariant superstring effective theories

The potential during inflation must be very flat in, at least, the direction of the inflaton. In renormalizable global supersymmetry, flat directions are ubiquitous, but they are not preserved in a generic supergravity theory. It is known that at least some of them are preserved in no-scale supergravity, and simple generalizations of it. We here study a more realistic generalization, based on string-derived supergravity, using the linear supermultiplet formalism for the dilaton. We consider a general class of hybrid inflation models, where a Fayet-Illiopoulos $D$ term drives some fields to large values. The potential is dominated by the $F$ term, but flatness is preserved in some directions. This allows inflation, with the dilaton stabilized in its domain of attraction, and some moduli stabilized at their vacuum values. Another modulus may be the inflaton.Comment: 19 pages, REVTEX, further typos, refs fixe

Pro-inflammatory flagellin proteins of prevalent motile commensal bacteria are variably abundant in the intestinal microbiome of elderly humans

Peer reviewedPublisher PD

Anomalous U(1) as a mediator of Supersymmetry Breaking

We point out that an anomalous gauge U(1) symmetry is a natural candidate for being the mediator and messenger of supersymmetry breaking. It facilitates dynamical supersymmetry breaking even in the flat limit. Soft masses are induced by both gravity and the U(1) gauge interactions giving an unusual mass hierarchy in the sparticle spectrum which suppresses flavor violations. This scenario does not suffer from the Polonyi problem.Comment: 8 pages, Latex. Some comments adde

Increased platelet counts and platelet activation in early symptomatic versus asymptomatic carotid stenosis and relationship with microembolic status: Results from the Platelets And Carotid Stenosis (PACS) Study

Background: Cerebral microembolic signals (MES) may predict increased stroke risk in carotid stenosis. However, the relationship between platelet counts or platelet activation status and MES in symptomatic versus asymptomatic carotid stenosis has not been comprehensively assessed. Setting: University teaching hospitals. Methods: This prospective, pilot observational study assessed platelet counts and platelet activation status, and the relationship between platelet activation and MES in asymptomatic versus early (≤4 weeks after TIA/stroke) and late phase (≥3 months) symptomatic moderate or severe (≥50%) carotid stenosis patients. Full blood count measurements were performed, and whole blood flow cytometry was used to quantify platelet surface activation marker expression (CD62P and CD63) and circulating leucocyte-platelet complexes. Bilateral simultaneous transcranial Doppler ultrasound monitoring of the middle cerebral arteries was performed for 1 hour to classify patients as MES-positive or MES-negative. Results: Data from 31 asymptomatic patients were compared with 46 symptomatic patients in the early phase, and 35 of these patients followed up to the late phase after symptom onset. The median platelet count (211 vs. 200 x 109/L; p=0.03) and the median % lymphocyte-platelet complexes were higher in early symptomatic than asymptomatic patients (2.8 vs. 2.4%, p=0.001). The % lymphocyte-platelet complexes was higher in early symptomatic than asymptomatic patients with ≥70% carotid stenosis (p=0.0005), and in symptomatic patients recruited within 7 days of symptom onset (p=0.028). Complete TCD data were available in 25 asymptomatic and 31 early phase symptomatic, and 27 late phase symptomatic patients. 12% of asymptomatic versus 32% of early phase symptomatic (p=0.02) and 19% of late phase symptomatic patients (p=0.2) were MES-positive. Early symptomatic MES-negative patients had ahigher % lymphocyte-platelet complexes than asymptomatic MES-negative patients (2.8 vs. 2.3%; p=0.0085). Discussion: Recently symptomatic carotid stenosis patients have higher platelet counts (potentially reflecting increased platelet production, mobilisation or reduced clearance) and platelet activation status than asymptomatic patients. MES were more frequently detected in early symptomatic than asymptomatic patients, but the differences between late symptomatic and asymptomatic groups were not significant. Increased lymphocyte-platelet complex formation in recently symptomatic vs. asymptomatic MES-negative patients indicates enhanced platelet activation in this early symptomatic subgroup. Platelet biomarkers, in combination with TCD, have the potential to aid risk-stratification in asymptomatic and symptomatic carotid stenosis patients

Investigating the Solubility and Cytocompatibility of CaO-Na2O-SiO2/TiO2 Bioactive Glasses

This study aims to investigate the solubility of a series of titanium (TiO2)-containing bioactive glasses and their subsequent effect on cell viability. Five glasses were synthesized in the composition range SiO2-Na2O-CaO with 5 mol % of increments TiO2 substituted for SiO2. Glass solubility was investigated with respect to (1) exposed surface area, (2) particle size, (3) incubation time, and (4) compositional effects. Ion release profiles showed that sodium (Na+) presented high release rates after 1 day and were unchanged between 7 and 14 days. Calcium (Ca2+) release presented a significant change at each time period and was also composition dependent, where a reduction in Ca2+ release is observed with an increase in TiO2 concentration. Silica (Si4+) release did not present any clear trends while no titanium (Ti4+) was released. Cell numbers were found to increase up to 44%, compared to the growing control population, with a reduction in particle size and with the inclusion of TiO2 in the glass composition