Compressibility effects on the scalar mixing in reacting homogeneous turbulence

The compressibility and heat of reaction influence on the scalar mixing in decaying isotropic turbulence and homogeneous shear flow are examined via data generated by direct numerical simulations (DNS). The reaction is modeled as one-step, exothermic, irreversible and Arrhenius type. For the shear flow simulations, the scalar dissipation rate, as well as the time scale ratio of mechanical to scalar dissipation, are affected by compressibility and reaction. This effect is explained by considering the transport equation for the normalized mixture fraction gradient variance and the relative orientation between the mixture fraction gradient and the eigenvectors of the solenoidal strain rate tensor.Comment: In Turbulent Mixing and Combustion, eds. A. Pollard and S. Candel, Kluwer, 200

Statistics of pressure and of pressure-velocity correlations in isotropic turbulence

Some pressure and pressure-velocity correlation in a direct numerical simulations of a three-dimensional turbulent flow at moderate Reynolds numbers have been analyzed. We have identified a set of pressure-velocity correlations which posseses a good scaling behaviour. Such a class of pressure-velocity correlations are determined by looking at the energy-balance across any sub-volume of the flow. According to our analysis, pressure scaling is determined by the dimensional assumption that pressure behaves as a ``velocity squared'', unless finite-Reynolds effects are overwhelming. The SO(3) decompositions of pressure structure functions has also been applied in order to investigate anisotropic effects on the pressure scaling.Comment: 21 pages, 8 figur

COVID-19 and hereditary spherocytosis: A recipe for hemolysis

We describe a patient infected with COVID-19 in the setting of a known chronic illness, HS, and the resulting presentation and medical complications

Identification of a murine CD45-F4/80lo HSC-derived marrow endosteal cell associated with donor stem cell engraftment

Hematopoietic stem cells (HSCs) reside in specialized microenvironments within the marrow designated as stem cell niches, which function to support HSCs at homeostasis and promote HSC engraftment after radioablation. We previously identified marrow space remodeling after hematopoietic ablation, including osteoblast thickening, osteoblast proliferation, and megakaryocyte migration to the endosteum, which is critical for effective engraftment of donor HSCs. To further evaluate the impact of hematopoietic cells on marrow remodeling, we used a transgenic mouse model (CD45Cre/iDTR) to selectively deplete hematopoietic cells in situ. Depletion of hematopoietic cells immediately before radioablation and hematopoietic stem cell transplantation abrogated donor HSC engraftment and was associated with strikingly flattened endosteal osteoblasts with preserved osteoblast proliferation and megakaryocyte migration. Depletion of monocytes, macrophages, or megakaryocytes (the predominant hematopoietic cell populations that survive short-term after irradiation) did not lead to an alteration of osteoblast morphology, suggesting that a hematopoietic-derived cell outside these lineages regulates osteoblast morphologic adaptation after irradiation. Using 2 lineage-tracing strategies, we identified a novel CD45-F4/80lo HSC-derived cell that resides among osteoblasts along the endosteal marrow surface and, at least transiently, survives radioablation. This newly identified marrow cell may be an important regulator of HSC engraftment, possibly by influencing the shape and function of endosteal osteoblasts

Cryopreserved homograft valves in the pulmonary position: Risk analysis for intermediate-term failure

AbstractObjective: The purpose of this study was to examine the durability of cryopreserved homografts used to replace the “pulmonary” valve and to identify factors associated with their late deterioration. Methods: We reviewed our entire experience (1985-1997) with 331 survivors in whom cryopreserved homograft valves (pulmonary, n = 304; aortic, n = 27) were used to reconstruct the pulmonary outflow tract. Median age was 14 years (range, 2 days–62 years). Operations included Ross operation (n = 259), tetralogy of Fallot (n = 41), truncus arteriosus (n = 14), Rastelli operation (n = 11), and others (n = 6). Median follow-up was 3.8 years (range, 0.2–11.2 years); late echographic follow-up was complete for 97% of patients. Homograft failure was defined as the need for explantation and valve-related death; homograft dysfunction was defined as a pulmonary insufficiency grade 3/4 or greater and a transvalvular gradient of 40 mm Hg or greater. Results: Homograft failure occurred in 9% (30 of 331 patients; Kaplan-Meier); freedom from failure was 82% ± 4% at 8 years. Homograft dysfunction occurred in 12% (39 of 331 patients), although freedom from dysfunction was 76% ± 4% at 8 years. For aortic homografts, this was 56% ± 11%, compared to 80% ± 4% for pulmonary homografts (P = .003). For patients aged less than 3 years (n = 38), this was 51% ± 12%, compared with 87% ± 4% for older patients (P = .0001). By multivariable analysis, younger age of homograft donors, non-Ross operation, and later year of operation were associated with homograft failure; younger age of homograft donors, later year of operation, and use of an aortic homograft were associated with homograft dysfunction. Conclusions: Homograft valves function satisfactorily in the pulmonary position at mid-term follow-up. The pulmonary homograft valve appears to be more durable than the aortic homograft valve in the pulmonary position. (J Thorac Cardiovasc Surg 1999;117:141-7

Terrestrial Effects Of Nearby Supernovae In The Early Pleistocene

Recent results have strongly confirmed that multiple supernovae happened at distances ~100 pc consisting of two main events: one at 1.7 to 3.2 million years ago, and the other at 6.5 to 8.7 million years ago. These events are said to be responsible for excavating the Local Bubble in the interstellar medium and depositing 60Fe on Earth and the Moon. Other events are indicated by effects in the local cosmic ray (CR) spectrum. Given this updated and refined picture, we ask whether such supernovae are expected to have had substantial effects on the terrestrial atmosphere and biota. In a first cut at the most probable cases, combining photon and cosmic ray effects, we find that a supernova at 100 pc can have only a small effect on terrestrial organisms from visible light and that chemical changes such as ozone depletion are weak. However, tropospheric ionization right down to the ground due to the penetration of $\geq$TeV cosmic rays will increase by nearly an order of magnitude for thousands of years, and irradiation by muons on the ground and in the upper ocean will increase 20-fold, which will approximately triple the overall radiation load on terrestrial organisms. Such irradiation has been linked to possible changes in climate and increased cancer and mutation rates. This may be related to a minor mass extinction around the Pliocene-Pleistocene boundary, and further research on the effects is needed.Comment: Revised version accepted at ApJ

The economical lifestyle of CPR bacteria in groundwater allows little preference for environmental drivers

Background: The highly diverse Cand. Patescibacteria are predicted to have minimal biosynthetic and metabolic pathways, which hinders understanding of how their populations differentiate in response to environmental drivers or host organisms. Their mechanisms employed to cope with oxidative stress are largely unknown. Here, we utilized genome‑resolved metagenomics to investigate the adaptive genome repertoire of Patescibacteria in oxic and anoxic groundwaters, and to infer putative host ranges. Results: Within six groundwater wells, Cand. Patescibacteria was the most dominant (up to 79%) super‑phylum across 32 metagenomes sequenced from DNA retained on 0.2 and 0.1 μm filters after sequential filtration. Of the reconstructed 1275 metagenome‑assembled genomes (MAGs), 291 high‑quality MAGs were classified as Cand. Patescibacteria. Cand. Paceibacteria and Cand. Microgenomates were enriched exclusively in the 0.1 μm fractions, whereas candidate division ABY1 and Cand. Gracilibacteria were enriched in the 0.2 μm fractions. On average, Patescibacteria enriched in the smaller 0.1 μm filter fractions had 22% smaller genomes, 13.4% lower replication measures, higher proportion of rod‑shape determining proteins, and of genomic features suggesting type IV pili mediated cell–cell attachments. Near‑surface wells harbored Patescibacteria with higher replication rates than anoxic downstream wells characterized by longer water residence time. Except prevalence of superoxide dismutase genes in Patescibacteria MAGs enriched in oxic groundwaters (83%), no major metabolic or phylogenetic differences were observed. The most abundant Patescibacteria MAG in oxic groundwater encoded a nitrate transporter, nitrite reductase, and F‑type ATPase, suggesting an alternative energy conservation mechanism. Patescibacteria consistently co‑occurred with one another or with members of phyla Nanoarchaeota, Bacteroidota, Nitrospirota, and Omnitrophota. Among the MAGs enriched in 0.2 μm fractions,, only 8% Patescibacteria showed highly significant one‑to‑one correlation, mostly with Omnitrophota. Motility and transport related genes in certain Patescibacteria were highly similar to genes from other phyla (Omnitrophota, Proteobacteria and Nanoarchaeota). Conclusion: Other than genes to cope with oxidative stress, we found little genomic evidence for niche adaptation of Patescibacteria to oxic or anoxic groundwaters. Given that we could detect specific host preference only for a few MAGs, we speculate that the majority of Patescibacteria is able to attach multiple hosts just long enough to loot or exchange suppliesPeer Reviewe

Why growth equals power - and why it shouldn't : constructing visions of China

When discussing the success of China's transition from socialism, there is a tendency to focus on growth figures as an indication of performance. Whilst these figures are indeed impressive, we should not confuse growth with development and assume that the former necessarily automatically generates the latter. Much has been done to reduce poverty in China, but the task is not as complete as some observers would suggest; particularly in terms of access to health, education and welfare, and also in dealing with relative (rather than absolute) depravation and poverty. Visions of China have been constructed that exaggerate Chinese development and power in the global system partly to serve political interests, but partly due to the failure to consider the relationship between growth and development, partly due to the failure to disaggregate who gets what in China, and partly due to the persistence of inter-national conceptions of globalised production, trade, and financial flows