Three photometric methods tested on ground-based data of Q 2237+0305

The Einstein Cross, Q~2237+0305, has been photometrically observed in four bands on two successive nights at NOT (La Palma, Spain) in October 1995. Three independent algorithms have been used to analyse the data: an automatic image decomposition technique, a CLEAN algorithm and the new MCS deconvolution code. The photometric and astrometric results obtained with the three methods are presented. No photometric variations were found in the four quasar images. Comparison of the photometry from the three techniques shows that both systematic and random errors affect each method. When the seeing is worse than 1.0", the errors from the automatic image decomposition technique and the Clean algorithm tend to be large (0.04-0.1 magnitudes) while the deconvolution code still gives accurate results (1{sigma} error below 0.04) even for frames with seeing as bad as 1.7". Reddening is observed in the quasar images and is found to be compatible with either extinction from the lensing galaxy or colour dependent microlensing. The photometric accuracy depends on the light distribution used to model the lensing galaxy. In particular, using a numerical galaxy model, as done with the MCS algorithm, makes the method less seeing dependent. Another advantage of using a numerical model is that eventual non-homogeneous structures in the galaxy can be modeled. Finally, we propose an observational strategy for a future photometric monitoring of the Einstein Cross.Comment: 9 pages, accepted for publication in A&

The Optical Gravitational Lensing Experiment. Monitoring of QSO 2237+0305

We present results from 2 years of monitoring of Huchra's lens (QSO 2237+0305) with the 1.3 m Warsaw telescope on Las Campanas, Chile. Photometry in the V band was done using a newly developed method for image subtraction. Reliable subtraction without Fourier division removes all complexities associated with the presence of a bright lensing galaxy. With positions of lensed images adopted from HST measurements it is relatively easy to fit the variable part of the flux in this system, as opposed to modeling of the underlying galaxy. For the first time we observed smooth light variation over a period of a few months, which can be naturally attributed to microlensing. We also describe automated software capable of real time analysis of the images of QSO 2237+0305. It is expected that starting from the next observing season in 1999 an alert system will be implemented for high amplification events (HAE) in this object. Time sampling and photometric accuracy achieved should be sufficient for early detection of caustic crossings.Comment: 8 pages (including 4 figures and table), latex, emulateapj, submitted to ApJ, revised version - minor change

Measuring the Size of Quasar Broad-Line Clouds Through Time Delay Light-Curve Anomalies of Gravitational Lenses

Intensive monitoring campaigns have recently attempted to measure the time delays between multiple images of gravitational lenses. Some of the resulting light-curves show puzzling low-level, rapid variability which is unique to individual images, superimposed on top of (and concurrent with) longer time-scale intrinsic quasar variations which repeat in all images. We demonstrate that both the amplitude and variability time-scale of the rapid light-curve anomalies, as well as the correlation observed between intrinsic and microlensed variability, are naturally explained by stellar microlensing of a smooth accretion disk which is occulted by optically-thick broad-line clouds. The rapid time-scale is caused by the high velocities of the clouds (~5x10^3 km/s), and the low amplitude results from the large number of clouds covering the magnified or demagnified parts of the disk. The observed amplitudes of variations in specific lenses implies that the number of broad-line clouds that cover ~10% of the quasar sky is ~10^5 per 4 pi steradian. This is comparable to the expected number of broad line clouds in models where the clouds originate from bloated stars.Comment: 19 pages, 9 figures. Submitted to Ap

Identifying the unmet information and support needs of women with autoimmune rheumatic diseases during pregnancy planning, pregnancy and early parenting: mixed-methods study

Background Autoimmune rheumatic diseases (ARDs) such as inflammatory arthritis and Lupus, and many of the treatments for these diseases, can have a detrimental impact on fertility and pregnancy outcomes. Disease activity and organ damage as a result of ARDs can affect maternal and foetal outcomes. The safety and acceptability of hormonal contraceptives can also be affected. The objective of this study was to identify the information and support needs of women with ARDs during pregnancy planning, pregnancy and early parenting. Methods This mixed methods study included a cross-sectional online survey and qualitative narrative interviews. The survey was completed by 128 women, aged 18–49 in the United Kingdom with an ARD who were thinking of getting pregnant in the next five years, who were pregnant, or had young children (< 5 years old). The survey assessed quality-of-life and information needs (Arthritis Impact Measurement Scale Short Form and Educational Needs Assessment Tool), support received, what women found challenging, what was helpful, and support women would have liked. From the survey participants, a maximum variation sample of 22 women were purposively recruited for qualitative interviews. Interviews used a person-centered participatory approach facilitated by visual methods, which enabled participants to reflect on their experiences. Interviews were also carried out with seven health professionals purposively sampled from primary care, secondary care, maternity, and health visiting services. Results Survey findings indicated an unmet need for information in this population (ENAT total mean 104.85, SD 30.18). Women at the pre-conception stage reported higher needs for information on pregnancy planning, fertility, giving birth, and breastfeeding, whereas those who had children already expressed a higher need for information on pain and mobility. The need for high quality information, and more holistic, multi-disciplinary, collaborative, and integrated care consistently emerged as themes in the survey open text responses and interviews with women and health professionals. Conclusions There is an urgent need to develop and evaluate interventions to better inform, support and empower women of reproductive age who have ARDs as they navigate the complex challenges that they face during pregnancy planning, pregnancy and early parenting

HST Observations of the Gravitationally Lensed Cloverleaf Broad Absorption Line QSO H1413+1143: Modeling the Lens

We investigate gravitational lens models for the quadruply-lensed Cloverleaf BAL QSO H1413+1143 based on the HST WFPC/WFPC2 astrometric and photometric data of the system by Turnshek et al. and the HST NICMOS-2 data by Falco et al. The accurate image positions and the dust-extinction-corrected relative amplifications, along with a possible detection of the lensing galaxy in the infrared, permit more accurate lens models than were previously possible. While more recent models are qualitatively consistent with the HST data, none of the previous models considered the dust-extinction-corrected relative amplifications of the image components. We use the power-law elliptical mass model to fit the HST data. We find that a single elliptical galaxy perturbed by an external shear can fit the image positions within the observational uncertainties; however, the predicted relative magnifications are only roughly consistent with the observational relative amplifications. We find that a primary galaxy combined with a secondary galaxy in the vicinity of the Cloverleaf or a cluster centered (south-)west of the Cloverleaf can fit both the image positions and relative amplifications within the observational uncertainties. We discuss future observations which could be used to test and/or further constrain lens models of the Cloverleaf.Comment: 23 pages (in aaspp.sty) including 5 tables and 3 figures, Accepted for publication in the Astrophysical Journa

Photometric Monitoring of the Gravitationally Lensed Ultraluminous BAL Quasar APM08279+5255

We report on one year of photometric monitoring of the ultraluminous BAL quasar APM 08279+5255. The temporal sampling reveals that this gravitationally lensed system has brightened by ~0.2 mag in 100 days. Two potential causes present themselves; either the variability is intrinsic to the quasar, or it is the result of microlensing by stars in a foreground system. The data is consistent with both hypotheses and further monitoring is required before either case can be conclusively confirmed. We demonstrate, however, that gravitational microlensing can not play a dominant role in explaining the phenomenal properties exhibited by APM 08279+5255. The identification of intrinsic variability, coupled with the simple gravitational lensing configuration, would suggest that APM 08279+5255 is a potential golden lens from which the cosmological parameters can be derived and is worthy of a monitoring program at high spatial resolution.Comment: 17 pages, with 2 figures. Accepted for publication in P.A.S.

Three photometric methods tested on ground-based data of Q 2237+0305

The Einstein Cross, Q 2237+0305, has been photometrically observed in four bands on two successive nights at NOT (La Palma, Spain) in October 1995. Three independent algorithms have been used to analyse the data: an automatic image decomposition technique, a CLEAN algorithm and the new MCS deconvolution code. The photometric and astrometric results obtained with the three methods are presented. No photometric variations were found in the four quasar images. Comparison of the photometry from the three techniques shows that both systematic and random errors affect each method. When the seeing is worse than 1farcs0 , the errors from the automatic image decomposition technique and the Clean algorithm tend to be large (0.04-0.1 magnitudes) while the deconvolution code still gives accurate results (1sigma error below 0.04) even for frames with seeing as bad as 1farcs7 . Reddening is observed in the quasar images and is found to be compatible with either extinction from the lensing galaxy or colour dependent microlensing. The photometric accuracy depends on the light distribution used to model the lensing galaxy. In particular, using a numerical galaxy model, as done with the MCS algorithm, makes the method less seeing dependent. Another advantage of using a numerical model is that eventual non-homogeneous structures in the galaxy can be modeled. Finally, we propose an observational strategy for a future photometric monitoring of the Einstein Cross. Based on observations obtained at NOT, La Palma

Rheumatoid arthritis and pregnancy: evolution of disease activity and pathophysiological considerations for drug use

It has long been known that pregnancy and childbirth have a profound effect on the disease activity of rheumatic diseases. For clinicians, the management of patients with RA wishing to become pregnant involves the challenge of keeping disease activity under control and adequately adapting drug therapy during pregnancy and post-partum. This article aims to summarize the current evidence on the evolution of RA disease activity during and after pregnancy and the use of anti-rheumatic drugs around this period. Of recent interest is the potential use of anti-TNF compounds in the preconception period and during pregnancy. Accumulating experience with anti-TNF therapy in other immune-mediated inflammatory diseases, such as Crohn’s disease, provides useful insights for the use of TNF blockade in pregnant women with RA, or RA patients wishing to become pregnant

Asteroseismic analysis of subdwarf B variable stars of KIC 10001893 and EPIC 220641886

KIC10001893 and EPIC220641886 are V1093Her type pulsating subdwarf-B stars, which were observed by the Kepler spacecraft during nominal and K2 mission respectively. The amplitude spectrum of both stars show similar characteristics that the majority of the pulsation frequencies lay in the gravity g-mode domain. While the g-mode region contains 248 frequencies, the p-mode region contains just 15, altogether indicating the hybrid nature of both stars. We used one of the seismic tools, asymptotic period spacing effectively to identify the modal degree of the majority of the modes. We could not find rotational multiplets for both stars which is likely due to pole-on orientation. We assigned dipole and quadrupole modes for KIC10001893, while for EPIC220641886 we defined modal degrees ranging from l=1 to l=12, apart from l=3 and l=11 modes, which are not seen