El practicant "Doctor Holgado"

S’ofereix un breu resum biogràfic d’un personatge conegut com a “Doctor Holgado” al que s’hi han referit diversos autors, i que actuà a la ciutat vella de Barcelona  dels anys quaranta del segle passat.Se ofrece un breve resumen biográfico de un personaje conocido como “Doctor Holgado”, al que se han referido diversos autores, y que actuó en el barrio “chino” de la Barcelona de los años cuarenta

Personal sanitari a la província de Girona el 1851

S’ofereix la llista dels càrrecs professionals de la medicina i cirurgia que exercien a la província de Girona el 1851

Discourse and Configurations of Gender

My research paper is an investigation of the discourse of gender in relation to the work of Michel Foucault, Susan Bordo, Judith Butler and the artists Louise Bourgeois, Fiona Hall, Jo Spence and Neil Emmerson. I have applied Foucault's notion of the formation, necessity and operations of discourses as the basis from which ideas can be articulated, and the context within which notions of gender are formulated and challenged. I examine the processes in discourses, such as the imposition of disciplines to control the subject, which in turn are inscribed in the body of the subject by the subject, as they begin to perceive and define themselves in terms of the disciplines. I use this theory on the relationship between discourse-power-knowledge to analyse my work and that of the artists mentioned. The work of each artist is discussed in terms of the discourse of gender and the basis from which they critique its power, its effects on bodies and forms of representation through a marginal discourse. For the purposes of my work, the conclusion reached is that to disrupt the discourse of gender entails a continual questioning and awareness of its 'truths,' processes and effects. Description of Studio Work: The three major works examine the power and operations of the discourse of gender on bodies and how marginal discourses subvert these constructions. My works in paper, printmedia and metal, in two dimensions and three, reflect the effects through forms that seek to question limitations and extend our conception of male and female bodies. The wall piece, Out of Order, re-configures symbols and signs from the discourse of gender as a means of disrupting notions that gender is immutable. A swirling red line is woven through a densely layered mass of horizontal broken lines. The addition of symbols, X and Y chromosomes, numbers and other tokens of gender, appear at various points in this marginal discourse on conception of 'bodies.' Mammaphone, which accompanies Out of Order and Bullrushes, consists of an enlarged breast LP playing on a turntable. The 'tracks' are a litany of terms for the breast from slang and maternal discourses. The turntable that 'hosts' the LP sits on top of a stylised 'flight recorder's black box,' which suggests the hidden discourse on gender. Bullrushes, is an arrangement of 20 phallic-like forms each on a flexible metal rod that sways with the passage of air around the work. The work presents male bodies as durable, delicate and vulnerable despite the norms of the masculine discourse. The intention is to put into process an interrogation of the effects of gender on bodies and the possibilities for re-thinking the discourse of gender

Evolució de la demografia mèdica de les comarques gironines, 1851-2010

S’aporten dades sobre l’evolució de la demografia mèdica a les comarques de Girona entre 1851 i 2010. Es troba que ha millorat significativament la relació entre el nombre de metges i la població atesa, ha augmentat la concentració en zones urbanes i la presència de les dones metgesses, especialment als darrers anys. S’hi identifiquen dues professionals que abans no s’havien assenyalat com les primeres metgesses de Girona

Micrometric control of the optics of the human eye: environment or genes?

Purpose: The human eye has typically more optical aberrations than conventional artificial optical systems. While the lower order modes (defocus and astigmatism) are well studied, our purpose is to explore the influence of genes versus the environment on the higher order aberrations of the optical components of the eye. Methods: We have performed a classical twin study in a sample from the Region of Murcia (Spain). Optical aberrations using a Hartmann-Shack sensor (AOnEye Voptica SL, Murcia, Spain) and corneal aberrations (using corneal topography data) were measured in 138 eyes corresponding to 69 twins; 36 monozygotic (MZ) and 33 dizygotic (DZ) pairs (age 55 years, SD 7 years). Intraclass correlation coefficients (ICCs) were used to estimate how strongly aberrations of twins resemble each other, and genetic models were fitted to quantify heritability in the selected phenotypes. Results: Genes had a significant influence in the variance of most of the higher order aberration terms (heritability from 40% to 70%). This genetic influence was observed similarly in both cornea and complete eye aberrations. Additionally, the compensation factor of spherical aberration in the eye (i.e., how much corneal spherical aberration was compensated by internal spherical aberration) was found under genetic influence (heritability of 68%). Conclusions: There is a significant genetic contribution to the variance of aberrations of the eye, not only at macroscopic levels, as in myopia or astigmatism, but also at microscopic levels, where a few micrometers changes in surface topography can produce a large difference in the value of the optical aberrations

The Loss of Functional Caspase-12 in Europe Is a Pre-Neolithic Event

Contains fulltext : 109878.pdf (publisher's version ) (Open Access)BACKGROUND: Caspase-12 (CASP12) modulates the susceptibility to sepsis. In humans, the "C" allele at CASP12 rs497116 has been associated with an increased risk of sepsis. Instead, the derived "T" allele encodes for an inactive caspase-12. Interestingly, Eurasians are practically fixed for the inactive variant, whereas in Sub-Saharan Africa the active variant is still common (~24%). This marked structure has been explained as a function of the selective advantage that the inactive caspase-12 confers by increasing resistance to infection. As regards to both when positive selection started acting and as to the speed with which fixation was achieved in Eurasia, estimates depend on the method and assumptions used, and can vary substantially. Using experimental evidence, we propose that, least in Eurasia, the increase in the frequency of the T allele might be related to the selective pressure exerted by the increase in zoonotic diseases transmission caused by the interplay between increased human population densities and a closer contact with animals during the Neolithic. METHODOLOG/PRINCIPAL FINDINGS: We genotyped CASP12 rs497116 in prehistoric individuals from 6 archaeological sites from the North of the Iberian Peninsula that date from Late Upper Paleolithic to Late Neolithic. DNA extraction was done from teeth lacking cavities or breakages using standard anti-contamination procedures, including processing of the samples in a positive pressure, ancient DNA-only chamber, quantitation of DNAs by qPCR, duplication, replication, genotyping of associated animals, or cloning of PCR products. Out of 50, 24 prehistoric individuals could finally be genotyped for rs497116. Only the inactive form of CASP12 was found. CONCLUSIONS/SIGNIFICANCE: We demonstrate that the loss of caspase-12 in Europe predates animal domestication and that consequently CASP12 loss is unlikely to be related to the impact of zoonotic infections transmitted by livestock

Sustained blood glutamate scavenging enhances protection in ischemic stroke

Stroke is a major cause of morbidity, mortality, and disability. During ischemic stroke, a marked and prolonged rise of glutamate concentration in the brain causes neuronal cell death. This study explores the protective effect of a bioconjugate form of glutamate oxaloacetate transaminase (hrGOT), which catalyzes the depletion of blood glutamate in the bloodstream for ~6 days following a single administration. When treated with this bioconjugate, a significant reduction of the infarct volume and a better retention of sensorimotor function was observed for ischemic rats compared to those treated with saline. Moreover, the equivalent dose of native hrGOT yielded similar results to the saline treated group for some tests. Targeting the bioconjugate to the blood-brain-barrier did not improve its performance. The data suggest that the bioconjugates draw glutamate out of the brain by displacing homeostasis between the different glutamate pools of the body

Plasma fibrinogen and risk of vascular recurrence after ischaemic stroke:An individual participant and summary-level data meta-analysis of 11 prospective studies

INTRODUCTION: Inflammation is an emerging target for secondary prevention after stroke and randomised trials of anti-inflammatory therapies are ongoing. Fibrinogen, a putative pro-inflammatory marker, is associated with first stroke, but its association with major adverse cardiovascular events (MACE) after stroke is unclear.MATERIALS AND METHODS: We did a systematic review investigating the association between fibrinogen and post-stroke vascular recurrence. Authors were invited to provide individual-participant data (IPD) and where available we did within-study multivariable analyses with adjustment for cardiovascular risk factors and medications. Adjusted summary-level data was extracted from published reports from studies that did not provide IPD. We pooled risk ratios (RR) by random-effects meta-analysis by comparing supra-median with sub-median fibrinogen levels and performed pre-specified subgroup analysis according to timing of phlebotomy after the index event.RESULTS: Eleven studies were included (14,002 patients, 42,800 follow-up years), of which seven provided IPD. Fibrinogen was associated with recurrent MACE on unadjusted (RR 1.35, 95% CI 1.17-1.57, supra-median vs sub-median) and adjusted models (RR 1.21, 95% CI 1.06-1.38). Fibrinogen was associated with recurrent stroke on univariate analysis (RR 1.19, 95% CI 1.03-1.39), but not after adjustment (RR 1.11, 95% CI 0.94-1.31). The association with recurrent MACE was consistently observed in patients with post-acute (⩾14 days) fibrinogen measures (RR 1.29, 95% CI 1.16-1.45), but not in those with early phlebotomy (&lt;14 days) (RR 0.98, 95% CI 0.82-1.18) ( P interaction  = 0.01). Similar associations were observed for recurrent stroke. DISCUSSION AND CONCLUSION: Fibrinogen was independently associated with recurrence after stroke, but the association was modified by timing of phlebotomy. Fibrinogen measurements might be useful to identify patients who are more likely to derive benefit from anti-inflammatory therapies after stroke.</p