Effect of potassium application rate and timing on alfalfa yield and potassium concentration and removal in Tennessee

Received: December 1st, 2022 ; Accepted: March 15th, 2023 ; Published: April 13th, 2023 ; Correspondence: [email protected] (Medicago sativa L.) is the most important forage crop in the world and potassium plays a significant role in achieving high yields. A field experiment was conducted during the 2012–2014 growing seasons at the University of Tennessee in Springfield. The experimental design was a split-split plot that included four levels of potassium (K) application rates (0, 67.25, 134.50, and 269.00 kg K2O ha-1 ) as the main plots and two K application times (green-up and split) as the subplots, and harvest dates as sub-subplots. The results demonstrated that the dry matter yield (DM) increased significantly with each increment in K application rate up to 134.50 kg K2O ha-1 ; however, the highest K fertilizer application (269 kg K2O ha-1 ) did not result in a significant yield increase relative to 134.50 kg K2O ha-1 , because some luxury consumption of K occurred at the highest rate due to yield leveling off while K2O uptake continued to rise. Potassium concentration and K removal increased with K fertilizer at rates beyond those that maximized yield, indicating luxury consumption of K. The greatest K concentration and removal were recorded at 269 kg K2O ha-1 in all harvest months. The split application was more beneficial than applying full K at the time of green-up due to higher dry matter, K concentration, and K removal in alfalfa. In conclusion, 134.50 kg K2O ha-1 is adequate for maximizing alfalfa yield; split application of K is sometimes superior to the single dose of K fertilizer in alfalfa production

Notes on feasibility and optimality conditions of small-scale multifunction robotic cell scheduling problems with pickup restrictions

Optimization of robotic workcells is a growing concern in automated manufacturing systems. This study develops a methodology to maximize the production rate of a multifunction robot (MFR) operating within a rotationally arranged robotic cell. An MFR is able to perform additional special operations while in transit between transferring parts from adjacent processing stages. Considering the free-pickup scenario, the cycle time formulas are initially developed for small-scale cells where an MFR interacts with either two or three machines. A methodology for finding the optimality regions of all possible permutations is presented. The results are then extended to the no-wait pickup scenario in which all parts must be processed from the input hopper to the output hopper, without any interruption either on or between machines. This analysis enables insightful evaluation of the productivity improvements of MFRs in real-life robotized workcells.Mehdi Foumani, Indra Gunawan, Kate Smith-Miles, M. Yousef Ibrahi

Candidate gene association study of esophageal squamous cell carcinoma in a high-risk region in Iran

There is a region with a high risk for esophageal squamous cell carcinoma (ESCC) in the northeast of Iran. Previous studies suggest that hereditary factors play a role in the high incidence of cancer in the region. We selected 22 functional variants (and 130 related tagSNPs) from 15 genes that have been associated previously with the risk of ESCC. We genotyped a primary set of samples from 451 Turkmens (197 cases and 254 controls). Seven of 152 variants were associated with ESCC at the P = 0.05 level; these single nucleotide polymorphisms were then studied in a validation set of 549 cases and 1,119 controls, which included both Turkmens and non-Turkmens. The association observed for a functional variant in ADH1B was confirmed in the validation set, and that of a tagSNP in MGMT, the association was borderline significant in the validation set, after correcting for multiple testing. The other 5 variants that were associated in the primary set were not significantly associated in the validation set. The histidine allele at codon 48 of ADH1B gene was associated with a significantly decreased risk of ESCC in the joint data set (primary and validation set) under a recessive model (odds ratio, 0.41; 95 confidence interval, 0.29-0.76; P = 4 × 10⁻⁴). The A allele of the rs7087131 variant of MGMT gene was associated with a decreased risk of ESCC under a dominant model (odds ratio, 0.79; 95 confidence interval, 0.64-0.96; P = 0.02). These results support the hypothesis that genetic predisposition plays a role in the high incidence of ESSC in Iran. ©2009 American Association for Cancer Research

Evaluation of lymphocyte transformation test results in patients with delayed hypersensitivity reactions following the use of anticonvulsant drugs

Background/Aim: Administration of the anticonvulsant drugs phenobarbital, phenytoin, carbamazepine and lamotrigine can be associated with severe hypersensitivity reactions. The lymphocyte transformation test (LTT) is a method to determine which drug has caused the hypersensitivity reaction. This study was done to evaluate the results of LTT in patients with delayed hypersensitivity reactions following the administration of anticonvulsants. Methods: Twenty-four patients with hypersensitivity reactions, e.g. drug-induced hypersensitivity syndrome/drug rash and eosinophilia with systemic symptoms (DIHS/DRESS), Stevens-Johnson syndrome (SJS) and toxic epidermal necrosis (TEN), following the administration of anticonvulsant drugs, and 24 patients who had used anticonvulsant drugs but did not have hypersensitivity reactions (the control group) were included in this study. Peripheral blood mononuclear cells were isolated. The cells were stimulated with the drugs, phytohemagglutinin as a mitogen and Candida as an antigen (positive controls). Lymphocyte proliferation was measured using the BrdU proliferation assay kit (Roche, Germany). The stimulation index was calculated as the mean ratio of the OD of stimulated cells divided by the OD of unstimulated cells. The results in the case and control groups were compared. Results: Of 24 patients in the test group, 14 (58.3) had positive LTT results and 10 (41.7) had negative results. Among patients in the control group, 1 (4.2) had a positive LTT result and 23 (95.8) had negative results. Among the patients who had received carbamazepine and phenytoin, there was a significant difference between the results of LTT in the case and control groups (p = 0.002 and p = 0.028, respectively). Although patients receiving lamotrigine and phenobarbital had more positive LTT results in the case group than in the control group, these differences were not statistically significant. The sensitivity, specificity, positive predictive value and negative predictive value of LTT were 58.4, 95.8, 93.3 and 69.9, respectively. Conclusions: Considering the significant difference in LTT results between the case and control groups in patients receiving carbamazepine and phenytoin, and not observing such a difference in patients receiving phenobarbital and lamotrigine, LTT results are more valuable for the diagnosis of hypersensitivity reactions following the administration of carbamazepine and phenytoin. The LTT has good specificity but low sensitivity for the diagnosis of drug hypersensitivity reactions. © 2016 S. Karger AG, Basel

Treatments for people who use anabolic androgenic steroids: a scoping review.

BACKGROUND: A growing body of evidence suggests that anabolic androgenic steroids (AAS) are used globally by a diverse population with varying motivations. Evidence has increased greatly in recent years to support understanding of this form of substance use and the associated health harms, but there remains little evidence regarding interventions to support cessation and treat the consequences of use. In this scoping review, we identify and describe what is known about interventions that aim to support and achieve cessation of AAS, and treat and prevent associated health problems. METHODS: A comprehensive search strategy was developed in four bibliographic databases, supported by an iterative citation searching process to identify eligible studies. Studies of any psychological or medical treatment interventions delivered in response to non-prescribed use of AAS or an associated harm in any setting were eligible. RESULTS: In total, 109 eligible studies were identified, which included case reports representing a diverse range of disciplines and sources. Studies predominantly focussed on treatments for harms associated with AAS use, with scant evidence on interventions to support cessation of AAS use or responding to dependence. The types of conditions requiring treatment included psychiatric, neuroendocrine, hepatic, kidney, cardiovascular, musculoskeletal and infectious. There was limited evidence of engagement with users or delivery of psychosocial interventions as part of treatment for any condition, and of harm reduction interventions initiated alongside, or following, treatment. Findings were limited throughout by the case report study designs and limited information was provided. CONCLUSION: This scoping review indicates that while a range of case reports describe treatments provided to AAS users, there is scarce evidence on treating dependence, managing withdrawal, or initiating behaviour change in users in any settings. Evidence is urgently required to support the development of effective services for users and of evidence-based guidance and interventions to respond to users in a range of healthcare settings. More consistent reporting in articles of whether engagement or assessment relating to AAS was initiated, and publication within broader health- or drug-related journals, will support development of the evidence base

Diagnostic accuracy of a clinical diagnosis of idiopathic pulmonary fibrosis: An international case-cohort study

We conducted an international study of idiopathic pulmonary fibrosis (IPF) diagnosis among a large group of physicians and compared their diagnostic performance to a panel of IPF experts. A total of 1141 respiratory physicians and 34 IPF experts participated. Participants evaluated 60 cases of interstitial lung disease (ILD) without interdisciplinary consultation. Diagnostic agreement was measured using the weighted kappa coefficient (\u3baw). Prognostic discrimination between IPF and other ILDs was used to validate diagnostic accuracy for first-choice diagnoses of IPF and were compared using the Cindex. A total of 404 physicians completed the study. Agreement for IPF diagnosis was higher among expert physicians (\u3baw=0.65, IQR 0.53-0.72, p20 years of experience (C-index=0.72, IQR 0.0-0.73, p=0.229) and non-university hospital physicians with more than 20 years of experience, attending weekly MDT meetings (C-index=0.72, IQR 0.70-0.72, p=0.052), did not differ significantly (p=0.229 and p=0.052 respectively) from the expert panel (C-index=0.74 IQR 0.72-0.75). Experienced respiratory physicians at university-based institutions diagnose IPF with similar prognostic accuracy to IPF experts. Regular MDT meeting attendance improves the prognostic accuracy of experienced non-university practitioners to levels achieved by IPF experts

Dynamic 3-Dimensional kinematics of the wrist joint and radiocarpal articular contact

Wrist complaints are responsible for the longest absence period from work of employees, with substantial financial consequences due to workers’ compensation, medical expenses, and productivity losses with an annually cost of approximately €600 million in the Netherlands. Therefore, it is of great importance to recognize and properly diagnose problems in the wrist at an early stage to prevent irreversible degenerative pathologies of the wrist. Currently, quantification of wrist instabilities is not possible by commonly available clinical diagnostic modalities. Ligament injuries frequently go undiagnosed and untreated, often being passed off as a simple sprain. If left untreated, such injuries often leads to damage of the cartilage layers that cannot be treated without residual problems in joint function. In these cases, the problem has progressed to such extent that the chances for success after surgical reconstruction are strongly reduced. Unfortunately this is a frequently observed situation for many patients seen in the clinic. The main objective of this thesis is to introduce novel methods for assessment and quantification of in-vivo carpal kinematics and joint space thickness measurements during wrist motion for diagnostic and prognostic purposes

Increasing throughput for a class of two-machine robotic cells served by a multifunction robot

The multifunction robotic cell scheduling problem has been recently studied in the literature. The main assumption in the pertaining literature is that a multifunction robot performs an operation on the part during any loaded move between two adjacent processing stages. For a two-machine cell, these stages are the input hopper, the first machine, the second machine and the output hopper. Consequently, the multifunction robot performs three operations with fixed processing times. In contrast, we assume a class of two-machine cells where none of the processing times of three operations are fixed. However, their summation is fixed and equivalent to the processing time of the unique operation. The processing mode of the unique operation performed by the multifunction robot is “stop resume.” Thus, regardless of the gap interrupts during operations by two machines, the robot continues performing the unique operation of the part when it is reloaded to the robot without any loss of time. The focus lies on n -unit cycles due to their popularity. It is proven one-unit cycles have better performance for the problem under study. The cycle time of one-unit cycles are obtained and optimality conditions are determined for different pickup criteria: free, interval, and no-wait.Mehdi Foumani, Indra Gunawan, Kate Smith-Mile