91 research outputs found
The Effectiveness of Cognitive – Behavioral Group Therapy On Pain Perception And Pain Severity Among Patients With Chronic Neuropathic Pain
Get PDFBACKGROUND AND OBJECTIVE: The experience of pain consists of two sensory and emotional dimensions. The sensory dimension of pain indicates pain severity and the emotional dimension indicates pain perception. Since cognitive–behavioral therapy is an evidence-based treatment and emphasizes on the correction of dysfunctional thought processes and changing the maladaptive behaviors, this study was designed to investigate the effectiveness of cognitive – behavioral group therapy on pain perception and pain severity among patients with chronic neuropathic pain.
METHODS: This quasi-randomized trial was performed among 30 patients with chronic neuropathy referring to Rouhani Hospital in Babol in two groups of case and control (15 patients in each group). Cognitive – behavioral group therapy was performed in ten 120-minute sessions, held once a week for the experimental group. Participants were examined before the experiment and 45 days after the sessions, and the perception of pain was evaluated by the components of belief in pain permanence, self-blame, belief in pain constancy, mysteriousness of pain, and pain severity. The attainable score in The Pain Beliefs and Perceptions Inventory was 30 to -30, and in The West Haven-Yale Multidimensional Pain Inventory was 0 to 6.
FINDINGS: The results showed that there was a statistically significant difference between the two groups in the total score of pain perception (-8.87±7.40 vs. 1.6±93.30) (p=0.001), and the subscales of belief in pain permanence
(-4.13±1.76 vs. 0.93±3.30) (p=0.04), belief in pain constancy (0.80±3.16 vs. -2.13±3.50) (p=0.04), mysteriousness of pain (-2.73±3.67 vs. 1.33±3.95) (p=0.003), and pain severity (2.19±1.28 vs. 3.64±1.27) (p=0.003).
CONCLUSION: The present study showed that cognitive–behavioral group therapy could be an effective intervention for reducing the pain perception and pain severity in patients with chronic neuropathic pain
Damage Detection Using Measurement Response Data of Beam Structure Subject to a Moving Mass
Full text linkPolygenic Resilience Modulates the Penetrance of Parkinson Disease Genetic Risk Factors
Get PDFpeer reviewedObjective: The aim of the current study is to understand why some individuals avoid developing Parkinson disease (PD) despite being at relatively high genetic risk, using the largest datasets of individual-level genetic data available. Methods: We calculated polygenic risk score to identify controls and matched PD cases with the highest burden of genetic risk for PD in the discovery cohort (International Parkinson's Disease Genomics Consortium, 7,204 PD cases and 9,412 controls) and validation cohorts (Comprehensive Unbiased Risk Factor Assessment for Genetics and Environment in Parkinson's Disease, 8,968 cases and 7,598 controls; UK Biobank, 2,639 PD cases and 14,301 controls; Accelerating Medicines Partnership–Parkinson's Disease Initiative, 2,248 cases and 2,817 controls). A genome-wide association study meta-analysis was performed on these individuals to understand genetic variation associated with resistance to disease. We further constructed a polygenic resilience score, and performed multimarker analysis of genomic annotation (MAGMA) gene-based analyses and functional enrichment analyses. Results: A higher polygenic resilience score was associated with a lower risk for PD (β = −0.054, standard error [SE] = 0.022, p = 0.013). Although no single locus reached genome-wide significance, MAGMA gene-based analyses nominated TBCA as a putative gene. Furthermore, we estimated the narrow-sense heritability associated with resilience to PD (h2 = 0.081, SE = 0.035, p = 0.0003). Subsequent functional enrichment analysis highlighted histone methylation as a potential pathway harboring resilience alleles that could mitigate the effects of PD risk loci. Interpretation: The present study represents a novel and comprehensive assessment of heritable genetic variation contributing to PD resistance. We show that a genetic resilience score can modify the penetrance of PD genetic risk factors and therefore protect individuals carrying a high-risk genetic burden from developing PD. ANN NEUROL 202
SENSITIVITY ANALYSIS ON THE EFFECTIVE PARAMETERS OF GROUND DEFORMATION VALUE BY MICRO TUNNELING METHOD WHILE PIPE JACKING OPERATES
No full textIn recent years, micro tunneling method has been developed quickly in comparison to other open excavation methods. Micro tunneling is a method for installing the pipelines, channels and underground conduits.In recent years, micro tunneling method has been developed quickly compared to other open excavation methods. In this method, hydraulic jacks are used for pipe driving with a special design. The pipes are placed behind the excavation drill, driven into the ground along with the ground excavation simultaneously. The result of this method is a flexible, impermeable and resistant structure construction pipelines. The micro tunneling method reduces the requirement number of transporting materials for operation activities and the machines traffic and devices. Too As a result, its events are reduced. According to this method, almost all the activities are performed underground. Hence, the negligible interferences are occurred with environment. Thus, the amount of environmental deterioration is very low. In some cases, performing the operation, increases the negative effects of vibrations from pipe driving and causes the problems such as settlements or swelling (heaving) of the ground surface. Upon analysis, some parameters have more influences rather than others, and some of them could be ignored due to low importance in the model. Therefore, investigating the effect of various independent parameters is important, i.e. sensitive analysis. The aim of this study is to compare the actual deformations occurred in ground surface due to behavior survey with the values of numerical modeling. In addition, this study aims to investigate the effect of various parameters on soil settlement values
Enhancing the bioactivity of zirconia and zirconia composites by surface modification
No full textAmong bioceramics, zirconia (ZrO2) and alumina (Al2O3) possess exceptional mechanical properties suitable for load-bearing and wear-resistant applications but the poor bioactivity of these materials is the major concern when bonding and integration to the living bone are desired. This article investigates two different approaches and their underlying mechanisms to improve the bioactivity of zirconia (3Y-TZP) and a zirconia composite with alumina (10Ce-TZP/Al2O3). Chemical treatment approach applied on 3Y-TZP where the substrates were soaked in 5M H3PO4 to create chemically functional groups on the surface for inducing apatite nucleation. X-ray photoelectron spectroscopy (XPS) was used to detect chemical changes and X-ray diffraction (XRD) to monitor phase changes on the surface before and after acid treatment. Alternate soaking approach applied on 10Ce-TZP/Al2O3 consisted of soaking the composite substrates in CaCl2 and Na2HPO4 solutions alternately to make a precursor for apatite formation. The bioactivity was evaluated by apatite-forming ability of surface-treated materials in simulated body fluid (SBF). Both methods resulted in the formation of hydroxyapatite on the surface of materials; however, alternate soaking approach showed to be a simpler, faster, and more effective method than the chemical treatment approach for enhancing the bioactivity of zirconia materials
The Effectiveness of Marlaat’s Cognitive Behavior Intervention and Group Treatment Based on Change Stages for Recovery and Relapse Prevention Rates in Male Heroin Crack Addicts
No full textObjective: The aim of this study was the Study of effectiveness of Marlaat’s cognitive behavior intervention and group treatment based on change stages for recovery and relapse rates in male heroin crack addictions. Method: In a experimental research design, 45 men addictions, who were diagnosed as the dependence of the heroin crack on the basis of DSM-IV-TR criteria, were chosen after successfully detoxified. They were divided two experimental groups (30 participants) and a control group (15 participants) that have been selected by random sampling. The first experimental group was undergone group treatment based on change stages underwent 16 sessions of 1.5 hours, totally 24 hours and the second experimental groups who were undergone Marlaat’s cognitive behavior intervention has been held 15 sessions of 2 hours, totally 24 hours. The control group were just received MMT without any psychotherapy. All participants were assessed by structured interview, urine test, before treatment, after treatment and after 3 months follow up. Results: Results showed that both psychotherapy treatments were affected on recovery and relapse rates. Conclusion: It seems that psychological problems and conflicts before addiction and after addiction could be caused for individuals’ tendency to narcotics consumption. Therefore, applying of psychotherapy could be useful in relapse prevention
Density Functional Theory Calculation on Improving the Photocatalytic Properties of Zinc Oxide and Cadmium Sulfide by Hybridization with Metal-Organic Framework
No full textIn this study, energy and chemical interaction of ZnO and CdS surfaces interfaced with metal-organic framework (MOF), to improve their properties, have been investigated using density functional theory (DFT). Results show that reformation of structures by hybridation with MOF can increase their stability and improve their properties. Comparison of ZnO and CdS structures predict that deposition of MOF on ZnO substrate can be more effective
Colon Lipoma: A Case Report And Review Of The Literature
No full textColon lipomas are rare. They are almost always asymptomatic; only when
their diameter is more than 3 cm do they become symptomatic. They tend
to occur in an older population and most of the cases are located at
the right side of the large bowel. Usually the diagnosis is not made
until operation is performed. We describe a 67-year-old woman with a
large colonic submucosal lipoma causing left-sided abdominal pain and
altered bowel habit. Abdominal sonography, CT scan and colonoscopy
showed a mass 5 cm x 4.5cm x 4 cm located 90cm from the anal verge.
Left hemicolectomy was performed, and histologic examination revealed
the mass to be a benign colonic lipoma. We also reviewed the literature
on the subject to examine the main characteristics of lipoma of the
colon
Exogenous potassium phosphite application improved PR-protein expression and associated physio-biochemical events in cucumber challenged by Pseudoperonospora cubensis
No full textIn the present study, the effect of potassium phosphite on Pseudoperonospora cubensis-inoculated cucumber plants was investigated. Different defense-related enzymes including laccase, polyphenoloxidase and glucanase as well as total protein and lignin contents were analyzed. Anatomical alterations in plant tissues were analyzed using a light microscope. Expression changes in major pathogenesis-related genes were studied at different time courses. The highest expression of glucanase was observed in pre-inoculated plants (97 higher than control) at 24 h with 97 increase compared to the control plants, while Chitinase transcripts were accumulated at a maximum level in potassium phosphite-treated plants 96 h after inoculation with 93 increase over control plants. Analysis of polygalacturonase inhibitor proteins gene expression revealed a transcription peak (96 increase over control plants) 48 h after inoculation. The potassium phosphite-treated plants exhibited an increase in β-1,3-glucanase (82) enzymatic activity as well as total protein (53), polyphenoloxidase (21), laccase (11) and lignin contents (15) in comparison to the control. The results of the anatomical assay showed an increase in the vascular bundle diameter in potassium phosphite-treated plants (174 μm) and a decrease in pathogen-treated leaves (66 μm) compared with the control (100 μm). It can be suggested that potassium phosphite treatment induced higher expression of plant defense genes and increased laccase and polyphenoloxidase activities which in turn enhanced lignin deposition in plant tissues. The findings of the present study would be implemented for designing a controlling program to decrease the adverse effect of Pseudoperonospora cubensis on cucumber plants. © 2018 Elsevier B.V
Colon Lipoma: a Case Report and Review of the Literature
No full textABSTRACT Colon lipomas are rare.They are almost always asymptomatic;only when their diameter is more than 3 cm do they become symptomatic.They tend to occur in an older population and most of the cases are located at the right side of the large bowel. Usually the diagnosis is not made until operation is performed.We describe a 67-year-old woman with a large colonic submucosal lipoma causing left-sided abdominal pain and altered bowel habit.Abdominal sonography,CT scan and colonoscopy showed a mass 5 c
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