Trades in complex Hadamard matrices

A trade in a complex Hadamard matrix is a set of entries which can be changed to obtain a different complex Hadamard matrix. We show that in a real Hadamard matrix of order $n$ all trades contain at least $n$ entries. We call a trade rectangular if it consists of a submatrix that can be multiplied by some scalar $c \neq 1$ to obtain another complex Hadamard matrix. We give a characterisation of rectangular trades in complex Hadamard matrices of order $n$ and show that they all contain at least $n$ entries. We conjecture that all trades in complex Hadamard matrices contain at least $n$ entries.Comment: 9 pages, no figure

The Value and Importance of International Service Learning Programs: A Model for Human Service Education

Given our growing globalized society, students are studying abroad at increasing rates. While different formats of study abroad programs exist, there is a surge in the number of short-term international service learning programs. This manuscript defines service learning and discusses the benefits of international service learning programs, specifically for human service students. The manuscript will conclude with a model of a successful study abroad program in San Jose, Costa Rica for undergraduate human service students led by two faculty members

Secondary Traumatic Stress and the Role of the Human Service Practitioner: Working Effectively With Veterans\u27 Families

Posttraumatic Stress disorder (PTSD) is an increasing mental health concern in the military veteran population. It is important to note that PTSD is a systemic diagnosis, meaning that the well-being and emotional health of family members is impacted by living with a veteran suffering from PTSD. Some family members may develop secondary traumatic stress (STS) symptoms. This manuscript will describe secondary traumatic stress and will explore the role of the human service practitioner in working with family members with STS. Future research in this area will also be explored

Self-Injury and the Role of the Human Service Professional

Given the broad field of human services, human service professionals are likely to encounter self-injury. Thus it is critical that they become knowledgeable about self-injury and understand how to best intervene with clients who self-injure. Through case studies the readers will learn about helpful ways to respond to a client who harms him/her self through the use of a non-judgmental and supportive stance. This manuscript has direct implications for direct human service providers, human service educators, human service students, and supervisors by demonstrating the wide continuum of services humans service professionals can provide to clients who self-injure including: utilizing basic helping skills, educating oneself, issues of confidentiality, how to make referrals, and the importance of creating self-injury protocols

Online Relationships and the Role of the Human Service Practitioner

Online relationships are an increasing phenomenon in our contemporary society. While many individuals experience successful online relationships, there are clear physical, emotional, and financial risks to meeting a partner online. This manuscript addresses the nature of online relationships and the potential consequences of engaging in an online relationship. Given the large number of individuals who seek out the internet for a potential partner, human service practitioners are in an ideal position to work with clients engaging in relationships online. This manuscript also discusses different strategies and interventions that human service practitioners can employ when working with clients involved in online relationships. These interventions align with the Human Services Professional Standards, namely the Skills Standards and the National Organization for Human Services (NOHS) Ethical Standards. Recommendations for future research are also included in this manuscript

Preassociative aggregation functions

The classical property of associativity is very often considered in aggregation function theory and fuzzy logic. In this paper we provide axiomatizations of various classes of preassociative functions, where preassociativity is a generalization of associativity recently introduced by the authors. These axiomatizations are based on existing characterizations of some noteworthy classes of associative operations, such as the class of Acz\'elian semigroups and the class of t-norms.Comment: arXiv admin note: text overlap with arXiv:1309.730

Cloning and expression of a mammalian peptide chain release factor with sequence similarity to tryptophanyl-tRNA synthetases

The termination of protein synthesis is encoded by in-frame nonsense (stop) codons. Most organisms use three nonsense codons: UGA, UAG, and UAA. In contrast to sense codons, which are decoded by specific tRNAs, nonsense codons are decoded by proteins called release factors (RFs). Here we report the cloning of a mammalian RF cDNA by the use of monoclonal antibodies specific for rabbit RF. Functional studies showed that, when expressed in Escherichia coli, the protein encoded by this cDNA has in vitro biochemical characteristics similar to those of previously characterized mammalian RFs. DNA sequencing of this eukaryotic RF cDNA revealed a remarkable sequence similarity to bacterial and mitochondrial tryptophanyl-tRNA synthetases, with the greatest similarity confined to the synthetase active site, and no obvious similarity to bacterial RFs

On quaternary complex Hadamard matrices of small orders

One of the main goals of design theory is to classify, characterize and count various combinatorial objects with some prescribed properties. In most cases, however, one quickly encounters a combinatorial explosion and even if the complete enumeration of the objects is possible, there is no apparent way how to study them in details, store them efficiently, or generate a particular one rapidly. In this paper we propose a novel method to deal with these difficulties, and illustrate it by presenting the classification of quaternary complex Hadamard matrices up to order 8. The obtained matrices are members of only a handful of parametric families, and each inequivalent matrix, up to transposition, can be identified through its fingerprint.Comment: 7 page

TSPO interacts with VDAC1 and triggers a ROS-mediated inhibition of mitochondrial quality control

The 18-kDa TSPO (translocator protein) localizes on the outer mitochondrial membrane (OMM) and participates in cholesterol transport. Here, we report that TSPO inhibits mitochondrial autophagy downstream of the PINK1-PARK2 pathway, preventing essential ubiquitination of proteins. TSPO abolishes mitochondrial relocation of SQSTM1/p62 (sequestosome 1), and consequently that of the autophagic marker LC3 (microtubule-associated protein 1 light chain 3), thus leading to an accumulation of dysfunctional mitochondria, altering the appearance of the network. Independent of cholesterol regulation, the modulation of mitophagy by TSPO is instead dependent on VDAC1 (voltage-dependent anion channel 1), to which TSPO binds, reducing mitochondrial coupling and promoting an overproduction of reactive oxygen species (ROS) that counteracts PARK2-mediated ubiquitination of proteins. These data identify TSPO as a novel element in the regulation of mitochondrial quality control by autophagy, and demonstrate the importance for cell homeostasis of its expression ratio with VDAC1

AntiFam: a tool to help identify spurious ORFs in protein annotation

As the deluge of genomic DNA sequence grows the fraction of protein sequences that have been manually curated falls. In turn, as the number of laboratories with the ability to sequence genomes in a high-throughput manner grows, the informatics capability of those labs to accurately identify and annotate all genes within a genome may often be lacking. These issues have led to fears about transitive annotation errors making sequence databases less reliable. During the lifetime of the Pfam protein families database a number of protein families have been built, which were later identified as composed solely of spurious open reading frames (ORFs) either on the opposite strand or in a different, overlapping reading frame with respect to the true protein-coding or non-coding RNA gene. These families were deleted and are no longer available in Pfam. However, we realized that these may perform a useful function to identify new spurious ORFs. We have collected these families together in AntiFam along with additional custom-made families of spurious ORFs. This resource currently contains 23 families that identified 1310 spurious proteins in UniProtKB and a further 4119 spurious proteins in a collection of metagenomic sequences. UniProt has adopted AntiFam as a part of the UniProtKB quality control process and will investigate these spurious proteins for exclusion