An investigation of athletes’ and coaches’ perceptions of mental ill-health in elite athletes

Research suggests elite athletes have an equal, or in some circumstances possibly higher, probability of developing mental ill health as the general population, however understanding of these issues amongst athletes and coaches remains largely unknown. The perceptions of mental health problems amongst 19 elite athletes and 16 coaches were explored using two concurrent, three round Delphi surveys and the responses compared. Athletes and coaches expressed different opinions and experiences of mental ill health amongst elite athletes. However, both felt the pressure athletes place upon themselves is a significant contributing factor and that obsessional compulsive tendencies and anxiety may be particularly prevalent. Whilst associated stigma was thought to be a barrier to support seeking, both groups felt sport and clinical psychologists would provide the most appropriate support, with coaches playing an important signposting role. Implications for athletes, coaches, clinical and sport psychologists are explored and suggestions for future research are presented

Actions of Agonists, Fipronil and Ivermectin on the Predominant In Vivo Splice and Edit Variant (RDLbd, I/V) of the Drosophila GABA Receptor Expressed in Xenopus laevis Oocytes

Ionotropic GABA receptors are the targets for several classes of insecticides. One of the most widely-studied insect GABA receptors is RDL (resistance to dieldrin), originally isolated from Drosophila melanogaster. RDL undergoes alternative splicing and RNA editing, which influence the potency of GABA. Most work has focussed on minority isoforms. Here, we report the first characterisation of the predominant native splice variant and RNA edit, combining functional characterisation with molecular modelling of the agonist-binding region. The relative order of agonist potency is GABA> muscimol> TACA> β-alanine. The I/V edit does not alter the potency of GABA compared to RDLbd. Docking calculations suggest that these agonists bind and activate RDLbdI/V through a similar binding mode. TACA and β-alanine are predicted to bind with lower affinity than GABA, potentially explaining their lower potency, whereas the lower potency of muscimol and isoguvacine cannot be explained structurally from the docking calculations. The A301S (resistance to dieldrin) mutation reduced the potency of antagonists picrotoxin, fipronil and pyrafluprole but the I/V edit had no measurable effect. Ivermectin suppressed responses to GABA of RDLbdI/V, RDLbd and RDLbdI/VA301S. The dieldrin resistant variant also showed reduced sensitivity to Ivermectin. This study of a highly abundant insect GABA receptor isoform will help the design of new insecticides

Justice for Injured Workers: The Struggle Continues

This article briefly reviews the role that community legal clinics have played in the injured worker movement. It chronicles the erosion of the basic principles of workers\u27 compensation and the shift in emphasis from compensating workers to containing costs. It exposes the myth of a debt crisis in workers\u27 compensation and explores the effect of this shift on workers\u27 benefits, on workplace health and safety, and ultimately on the viability of a no-fault, publicly-administered workers\u27 compensation system. The article also outlines the threat to the existing system in the workers\u27 compensation proposals of the current government

Justice for Injured Workers: The Struggle Continues

This article briefly reviews the role that community legal clinics have played in the injured worker movement. It chronicles the erosion of the basic principles of workers\u27 compensation and the shift in emphasis from compensating workers to containing costs. It exposes the myth of a debt crisis in workers\u27 compensation and explores the effect of this shift on workers\u27 benefits, on workplace health and safety, and ultimately on the viability of a no-fault, publicly-administered workers\u27 compensation system. The article also outlines the threat to the existing system in the workers\u27 compensation proposals of the current government

Chloride Ions in the Pore of Glycine and GABA Channels Shape the Time Course and Voltage Dependence of Agonist Currents

In the vertebrate CNS, fast synaptic inhibition is mediated by GABA and glycine receptors. We recently reported that the time course of these synaptic currents is slower when intracellular chloride is high. Here we extend these findings to measure the effects of both extracellular and intracellular chloride on the deactivation of glycine and GABA currents at both negative and positive holding potentials. Currents were elicited by fast agonist application to outside-out patches from HEK-293 cells expressing rat glycine or GABA receptors. The slowing effect of high extracellular chloride on current decay was detectable only in low intracellular chloride (4 mM). Our main finding is that glycine and GABA receptors "sense" chloride concentrations because of interactions between the M2 pore-lining domain and the permeating ions. This hypothesis is supported by the observation that the sensitivity of channel gating to intracellular chloride is abolished if the channel is engineered to become cation selective or if positive charges in the external pore vestibule are eliminated by mutagenesis. The appropriate interaction between permeating ions and channel pore is also necessary to maintain the channel voltage sensitivity of gating, which prolongs current decay at depolarized potentials. Voltage dependence is abolished by the same mutations that suppress the effect of intracellular chloride and also by replacing chloride with another permeant ion, thiocyanate. These observations suggest that permeant chloride affects gating by a foot-in-the-door effect, binding to a channel site with asymmetrical access from the intracellular and extracellular sides of the membrane

Palaeomagnetic field intensity variations suggest Mesoproterozoic inner-core nucleation

The Earth’s inner core grows by the freezing of liquid iron at its surface. The point in history at which this process initiated marks a step-change in the thermal evolution of the planet. Recent computational and experimental studies1,2,3,4,5 have presented radically differing estimates of the thermal conductivity of the Earth’s core, resulting in estimates of the timing of inner-core nucleation ranging from less than half a billion to nearly two billion years ago. Recent inner-core nucleation (high thermal conductivity) requires high outer-core temperatures in the early Earth that complicate models of thermal evolution. The nucleation of the core leads to a different convective regime6 and potentially different magnetic field structures that produce an observable signal in the palaeomagnetic record and allow the date of inner-core nucleation to be estimated directly. Previous studies searching for this signature have been hampered by the paucity of palaeomagnetic intensity measurements, by the lack of an effective means of assessing their reliability, and by shorter-timescale geomagnetic variations. Here we examine results from an expanded Precambrian database of palaeomagnetic intensity measurements7 selected using a new set of reliability criteria8. Our analysis provides intensity-based support for the dominant dipolarity of the time-averaged Precambrian field, a crucial requirement for palaeomagnetic reconstructions of continents. We also present firm evidence for the existence of very long-term variations in geomagnetic strength. The most prominent and robust transition in the record is an increase in both average field strength and variability that is observed to occur between a billion and 1.5 billion years ago. This observation is most readily explained by the nucleation of the inner core occurring during this interval9; the timing would tend to favour a modest value of core thermal conductivity and supports a simple thermal evolution model for the Earth

Актуальні проблеми розвитку виноградства та виноробства

В статті розглянуто сучасні тенденції та проблеми розвитку виноградарства та виноробства України. Надано рекомендації щодо пріоритетних напрямків розвитку виноробних підприємств.The modern tendencies and development problems of Ukraine viticulture and winemaking industry are considered in the article. The regards priority areas recommendations of winemaking enterprises development are given

Subduction flux modulates the geomagnetic polarity reversal rate

© 2018 The Authors Ascertaining the cause of variations in the frequency of geomagnetic polarity reversals through the Phanerozoic has remained a primary research question straddling paleomagnetism and geodynamics for decades. Numerical models suggest the primary control on geomagnetic reversal rates on 10 to 100 Ma timescales is the changing heat flux across the core-mantle boundary and that this is itself expected to be strongly influenced by variations in the flux of lithosphere subducted into the mantle. A positive relationship between the time-dependent global subduction flux and magnetic reversal rate is expected, with a time delay to transmit the thermal imprint into the lowermost mantle. We perform the first test of this hypothesis using subduction flux estimates and geomagnetic reversal rate data back to the early Paleozoic. Subduction area flux estimates are derived from global, full-plate tectonic models, and are evaluated against independent subduction flux proxies based on the global age distribution of detrital zircons and strontium isotopes. A continuous Phanerozoic reversal rate model is built from pre-existing compilations back to ~320 Ma plus a new reversal rate model in the data-sparse mid-to-early Paleozoic. Cross-correlation of the time-dependent subduction flux and geomagnetic reversal rate series reveals a significant correlation with a time delay of ~120 Ma (with reversals trailing the subduction flux). This time delay represents a value intermediate between the seismologically constrained time expected for a subducted slab to transit from the surface to the core-mantle boundary (~150–300 Ma), and the much shorter lag time predicted by some numerical models of mantle flow (~30–60 Ma). While the reason for this large discrepancy remains unclear, it is encouraging that our novel estimate of lag time represents a compromise between them. Although important uncertainties in our proposed relationship remain, these results cast new light on the dynamic connections between the surface and deep Earth, and will help to constrain new models linking mantle convection, the thermal evolution of the lowermost mantle and the geodynamo

Evaluation of the multispecimen parallel differential pTRM method: a test on historical lavas from Iceland and Mexico

Accepted versio