Patient Safety and the COVID-19 Pandemic in Germany: A Repeated Population-Based Cross-Sectional Survey.

The coronavirus (COVID-19) has presented Germany with major challenges and has led to concerns about patient safety. We conducted an observational, population-based, nationwide, repeated cross-sectional survey on patient safety in Germany in 2019, 2020, and 2021. Each of the three samples consisted of 1000 randomly recruited adults. Self-reported data via computer-assisted telephone interviews were taken from TK Monitor of Patient Safety. Perceptions, experience, and knowledge relating to patient safety were assessed. The majority of respondents considered medical treatment to involve risks to patient safety. This proportion decreased during the pandemic. The majority also had a high degree of self-efficacy regarding the prevention of medical errors, whereby the percentage that felt well informed with regard to patient safety rose throughout the pandemic. The proportion of persons that suspected they had in the past experienced an error in their treatment remained steady at one third as well as the reported errors. In 2020, 65% of respondents thought health communication with service providers (e.g., extent and comprehensibility of information) remained unchanged during the pandemic, while 35% reported that medical appointments had been cancelled or postponed. This study is the first to assess patient safety from a general population perspective during the coronavirus pandemic in Germany. COVID-19 had a positive impact on perceived patient safety but no impact on suspected and reported errors. Self-efficacy with regard to medical error prevention steadily increased in the general population, and people considered themselves well informed

Does entanglement depend on the timing of the impacts at the beam-splitters?

A new nonlocality experiment with moving beam-splitters is proposed. The experiment is analysed according to conventional quantum mechanics, and to an alternative nonlocal description in which superposition depends not only on indistinguishability but also on the timing of the impacts at the beam-splitters.Comment: 5 pages of Latex and 2 eps figures. Submitted to Phys. Lett.

Aptamer BC 007’s Affinity to Specific and Less-Specific Anti-SARS-CoV-2 Neutralizing Antibodies

COVID-19 is a pandemic respiratory disease that is caused by the highly infectious severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Anti-SARS-CoV-2 antibodies are essential weapons that a patient with COVID-19 has to combat the disease. When now repurposing a drug, namely an aptamer that interacts with SARS-CoV-2 proteins for COVID-19 treatment (BC 007), which is, however, a neutralizer of pathogenic autoantibodies in its original indication, the possibility of also binding and neutralizing anti-SARS-CoV-2 antibodies must be considered. Here, the highly specific virus-neutralizing antibodies have to be distinguished from the ones that also show cross-reactivity to tissues. The last-mentioned could be the origin of the widely reported SARS-CoV-2-induced autoimmunity, which should also become a target of therapy. We, therefore, used enzyme-linked immunosorbent assay (ELISA) technology to assess the binding of well-characterized publicly accessible anti-SARS-CoV-2 antibodies (CV07-209 and CV07-270) with BC 007. Nuclear magnetic resonance spectroscopy, isothermal calorimetric titration, and circular dichroism spectroscopy were additionally used to test the binding of BC 007 to DNA-binding sequence segments of these antibodies. BC 007 did not bind to the highly specific neutralizing anti-SARS-CoV-2 antibody but did bind to the less specific one. This, however, was a lot less compared to an autoantibody of its original indication (14.2%, range 11.0–21.5%). It was also interesting to see that the less-specific anti-SARS-CoV-2 antibody also showed a high background signal in the ELISA (binding on NeutrAvidin-coated or activated but noncoated plastic plate). These initial experiments suggest that the risk of binding and neutralizing highly specific anti-SARS CoV-2 antibodies by BC 007 should be low.Transfer-BonunsPeer Reviewe

From classical to modern ether-drift experiments: the narrow window for a preferred frame

Modern ether-drift experiments look for a preferred frame by measuring the difference \Delta \nu in the relative frequencies of two cavity-stabilized lasers, upon local rotations of the apparatus or under the Earth's rotation. If the small deviations observed in the classical ether-drift experiments were not mere instrumental artifacts, by replacing the high vacuum in the resonating cavities with a dielectric gaseous medium (e.g. air), the typical measured \Delta\nu\sim 1 Hz should increase by orders of magnitude. This prediction is consistent with the characteristic modulation of a few kHz observed in the original experiment with He-Ne masers. However, if such enhancement would not be confirmed by new and more precise data, the existence of a preferred frame can be definitely ruled out.Comment: 15 pages, Latex fil

Neutron beta decay in effective field theory

Radiative corrections to the lifetime and angular correlation coefficients of neutron beta-decay are evaluated in effecitive field theory. We also evaluate the lowest order nucleon recoil corrections, including weak-magnetism. Our results agree with those of the long-range and model-independent part of previous calculations. In an effective theory the model-dependent radiative corrections are replaced by well-defined low-energy constants. The effective field theory allows a systematic evaluation of higher order corrections to our results to the extent that the relevant low-energy constants are known.Comment: 13 pages, 1 figure; two references added, minor correctio

A derivation of quantum theory from physical requirements

Quantum theory is usually formulated in terms of abstract mathematical postulates, involving Hilbert spaces, state vectors, and unitary operators. In this work, we show that the full formalism of quantum theory can instead be derived from five simple physical requirements, based on elementary assumptions about preparation, transformations and measurements. This is more similar to the usual formulation of special relativity, where two simple physical requirements -- the principles of relativity and light speed invariance -- are used to derive the mathematical structure of Minkowski space-time. Our derivation provides insights into the physical origin of the structure of quantum state spaces (including a group-theoretic explanation of the Bloch ball and its three-dimensionality), and it suggests several natural possibilities to construct consistent modifications of quantum theory.Comment: 16 pages, 2 figures. V3: added alternative formulation of Requirement 5, extended abstract, some minor modification

Quantum measurement occurrence is undecidable

In this work, we show that very natural, apparently simple problems in quantum measurement theory can be undecidable even if their classical analogues are decidable. Undecidability hence appears as a genuine quantum property here. Formally, an undecidable problem is a decision problem for which one cannot construct a single algorithm that will always provide a correct answer in finite time. The problem we consider is to determine whether sequentially used identical Stern-Gerlach-type measurement devices, giving rise to a tree of possible outcomes, have outcomes that never occur. Finally, we point out implications for measurement-based quantum computing and studies of quantum many-body models and suggest that a plethora of problems may indeed be undecidable.Comment: 4+ pages, 1 figure, added a proof that the QMOP is still undecidable for exponentially small but nonzero probabilit

Three-dimensionality of space and the quantum bit: an information-theoretic approach

It is sometimes pointed out as a curiosity that the state space of quantum two-level systems, i.e. the qubit, and actual physical space are both three-dimensional and Euclidean. In this paper, we suggest an information-theoretic analysis of this relationship, by proving a particular mathematical result: suppose that physics takes place in d spatial dimensions, and that some events happen probabilistically (not assuming quantum theory in any way). Furthermore, suppose there are systems that carry "minimal amounts of direction information", interacting via some continuous reversible time evolution. We prove that this uniquely determines spatial dimension d=3 and quantum theory on two qubits (including entanglement and unitary time evolution), and that it allows observers to infer local spatial geometry from probability measurements.Comment: 13 + 22 pages, 9 figures. v4: some clarifications, in particular in Section V / Appendix C (added Example 39