Not Your Shock Troops: Queer Artists Disrupting Gentrification in Montreal's St-Henri

This thesis develops a queer(ed) analyses of gentrification, one that troubles the current analysis of the role of artists and cultural workers in the process. It does so by drawing on critical race, queer, and feminist theory and through empirical research in St-Henri that investigates the nuances of the cultural dimensions of urban redevelopment. Without denying the importance of economic processes in driving gentrification, this research suggests there is a need to think about the way that normativity is entangled with gentrification. In doing so, the research also seeks to uncover queer resistance to these changes in urban space and investigates how certain forms of queer resistance, even when embodied in artists, might disrupt rather than propel gentrification processes

La ceramica d'impasto dal cortile D degli edifici industriali di Populonia

INDICE INTRODUZIONE………………………………………………………….....p. CAPITOLO I IL QUARTIERE INDUSTRIALE DI POPULONIA………….......p. I.1 Premessa…………………………………………………….p. I.1 Gli scavi Martelli- Cristofani………………….…………….p. I.2 Le campagne di scavo 2004-2006…………………………..p. CAPITOLO II CATALOGO DEI REPERTI MOBILI…………….........................…p. II.1 Premessa…..…………………………………………….…..p. II.2 Forme chiuse ………………………………………………..p. II.2.1 Olle con corpo ‹‹ovoide››………………………………..p. II.2.2 Olle con corpo troncoconico…………………..………..p. II.2.3 Olle apode……………………………………………….p. II.2.4 Olle con piede…………………………………………..p. II.3 Forme aperte………………………………………………..p. II.3.1. Coppe…………………………………………………p. II.3.2 Coppe- coperchio……………………………………...p. II.3.3 Coperchi………………………………………………..p. CAPITOLO III FRAMMENTI DECORATI ……………………………...……..p. III.1. Decorazioni impresse……………………………………..p. III.2 Decorazioni plastiche……………………………………..p. III.3 Contrassegni alfabetici…………………………………….p. III.3.1 Segni alfabetici isolati…………………………………p. III.3.2 Brevi iscrizioni…………………………………………p. III.4 Contrassegni non alfabetici…………………………….….p. APPENDICE 1 CATALOGO DEGLI IMPASTI ………………………………….p. I.1Premessa…………..……………………………………….p. I.2 Impasti…………… ………………………………………..p. CONCLUSIONI………………………………………………………………...p. TAVOLE………………………………………………………………………....p. ABBREVIAZIONI BIBLIOGRAFICHE………………………………………..…..p

Investigating the contribution of aberrant sphingosine 1-phosphate signalling to the pathogenesis of diffuse large B-cell lymphoma

There is an increasing body of evidence indicating an important role for the bioactive signalling lipid S1P (sphingosine 1-phosphate) in cancer. Sphingosine kinase-1 (SPHK1), one of the enzymes responsible for the synthesis of S1P, is reported to be overexpressed in many cancer types; in many cases correlating with increased tumour grade and reduced patient survival. However, the expression of SPHK1, and how it might contribute to lymphomagenesis, has not previously been explored in diffuse large B-cell lymphoma (DLBCL). In chapter 3, I show that SPHK1 overexpression in DLBCL correlates with the expression of known tumour-angiogenic genes. I also describe the characterisation of human umbilical vein endothelial cells (HUVEC) as an in vitro model with which to study the impact of S1P on the endothelial cell transcriptome and to explore the extent to which these changes can be observed in primary DLBCL. In chapter 4, I explore the effects of S1P on the transcription of endothelial cells with a focus on genes associated with leukocyte recruitment. I confirm the S1P-induced upregulation of chemokines and adhesion molecules in HUVEC and show that SPHK1 expression correlates with the expression of stromal cell gene signatures in primary DLBCL. Finally, in chapter 5, I show that I can inhibit S1P-induced signalling in HUVEC with Sphingomab, a monoclonal antibody against S1P. Additionally, I validate the A20 syngeneic model of lymphoma as a relevant system which could be used to study the potential therapeutic targeting of SPHK1-S1P signalling in DLBCL

Atualidades sobre cirurgia bariátrica.

Bariatric surgery is a procedure that brings together a set of stomach reduction techniques designed to reduce weight in patients with obesity. The procedure is done when physical activities no longer have an effect on the person, requiring a medical intervention. In addition, it is recognized by the Federal Council of Medicine. Obesity is one of the most prevalent health conditions of the 21st century. This is because, although it is associated with genetic factors, it is also a reflection of habits that are gaining more and more space: unbalanced food and sedentary lifestyle.A cirurgia bariátrica é um procedimento que reúne um conjunto de técnicas de diminuição do estômago destinada a redução de peso de pacientes com obesidade. O procedimento é feito quando as atividades físicas não causam mais efeito na pessoa, necessitando de uma intervenção médica. Além disso, é reconhecida pelo Conselho Federal de Medicina. A obesidade é uma das condições de saúde mais prevalentes do século XXI. Isso porque, embora esteja associada a fatores genéticos, ela também é reflexo de hábitos que vêm ganhando cada vez mais espaço: alimentação desequilibrada e sedentarismo

Cost-effectiveness of intravitreal therapy with both anti-VEGF and Dexamethasone implant in patients with Diabetic Macular Edema

Purpose: The aim of this study was to evaluate the cost-effectiveness of intravitreal therapy (IVT) with both anti-VEGF and Dexamethasone implant in patients with Diabetic Macular Edema (DME) during two years’ follow-up. Methods: A retrospective review of 191 patients (382 eyes) with type I and II diabetes and DME was performed. Pre-IVT and final best correct visual acuity (BCVA), central macular thickness (CMT), intraocular pressure (IOP), number and type of IVT,number of examinations, and fluorescein angiography were assessed. Based on surgery procedure other than IVT, patients were divided into 5 groups. To avoid bias, we analysed only patients who had undergone cataract surgery before (group 1) or during enrolment (group 2). Results: 41 eyes from Group 1 and 48 eyes from group 2 were evaluated. Median BCVA ranged between 20/80 and 20/63 Snellen (P = 0.008) in Group 1 and from 20/63 to 20/40 Snellen (P = 0.0035) in Group 2, while improvement up to 1 Snellen line was observed in 58.5 and 68.75% of eyes in Group 1 and 2, respectively.In terms of median CMT, a statistically reduction (P = 0.0007) was found in Group 2 (-85 μm), whereas no statistical differences were found in Group 1. The two groups showed no statistically significant difference in median IOP. The estimated cost per eye was €7803 in Group 1 and €8988 Group 2, whereas the mean cost per patient was €15190 and €16580 in Group 1 and 2, respectively. Analysis between groups did not show any statistical difference in the considered parameters. Conclusions: In this study, despite the high treatment cost, vision improvement in DME patients undergoing IVT was disappointing. Our results emphasise the need for a better understanding of the cost-effectiveness of DME treatmen

Antioxidant isoenzyme responses to nickel-induced stress in tobacco cell suspension culture

Exposure to nickel (Ni) at high concentrations can lead to production of reactive oxygen species (ROS) resulting in oxidative damage at the cellular level. We investigated the antioxidative responses of Nicotiana tabacum cv BY-2 cell suspension to Ni stress (0.075 and 0.75 mM NiCl2) over a 72 h period with special attention to potential alterations in isoenzymes of superoxide dismutase (SOD), catalase (CAT) and glutathione reductase (GR). Two main SOD isoenzymes were observed, a Mn-SOD (band I) and a Fe-SOD (band II), as well as one CAT isoenzyme and four GR isoenzymes. Activity staining analysis revealed that CAT activity plays a major role in the early response to Ni-induced oxidative stress, particularly when the Ni concentration used was low, whilst a specific GR isoenzyme appears to respond to the Ni-induced oxidative stress when a much higher Ni concentration was used to induce the stress for the same period of treatment. These results illustrate the importance and advantages of determining individual isoenzyme activities.A exposição ao níquel (Ni), em altas concentrações, pode levar à produção de espécies reativas de oxigênio (EAOs), resultando em danos oxidativos em nível celular. Foram investigadas as respostas antioxidativas de células em suspensão do cultivar BY-2 de Nicotiana tabacum submetidas ao estresse por Ni (0.075 e 0.75 mM de NiCl2) por 72 h, com atenção especial às alterações potencias em isoenzimas de superóxido dismutase (SOD), catalase (CAT) e glutatione redutase (GR). Duas principais isoenzimas de SOD foram observadas, uma Mn-SOD (banda I) e outra Fe-SOD (banda II), bem como uma isoenzima CAT e quatro isoenzimas de GR. As análises revelaram que a atividade de CAT tem papel principal no momento inicial de resposta ao estresse oxidativo induzido por Ni, particularmente, quando sua concentração foi mais baixa, enquanto uma isoenzima específica de GR parece responder a este estresse na concentração mais alta de Ni, no mesmo período de tratamento. Os resultados ilustram a importância e as vantagens de se determinar a atividade de isoenzimas individuais

Antioxidant isoenzyme responses to nickel-induced stress in tobacco cell suspension culture

Exposure to nickel (Ni) at high concentrations can lead to production of reactive oxygen species (ROS) resulting in oxidative damage at the cellular level. We investigated the antioxidative responses of Nicotiana tabacum cv BY-2 cell suspension to Ni stress (0.075 and 0.75 mM NiCl2) over a 72 h period with special attention to potential alterations in isoenzymes of superoxide dismutase (SOD), catalase (CAT) and glutathione reductase (GR). Two main SOD isoenzymes were observed, a Mn-SOD (band I) and a Fe-SOD (band II), as well as one CAT isoenzyme and four GR isoenzymes. Activity staining analysis revealed that CAT activity plays a major role in the early response to Ni-induced oxidative stress, particularly when the Ni concentration used was low, whilst a specific GR isoenzyme appears to respond to the Ni-induced oxidative stress when a much higher Ni concentration was used to induce the stress for the same period of treatment. These results illustrate the importance and advantages of determining individual isoenzyme activities.A exposição ao níquel (Ni), em altas concentrações, pode levar à produção de espécies reativas de oxigênio (EAOs), resultando em danos oxidativos em nível celular. Foram investigadas as respostas antioxidativas de células em suspensão do cultivar BY-2 de Nicotiana tabacum submetidas ao estresse por Ni (0.075 e 0.75 mM de NiCl2) por 72 h, com atenção especial às alterações potencias em isoenzimas de superóxido dismutase (SOD), catalase (CAT) e glutatione redutase (GR). Duas principais isoenzimas de SOD foram observadas, uma Mn-SOD (banda I) e outra Fe-SOD (banda II), bem como uma isoenzima CAT e quatro isoenzimas de GR. As análises revelaram que a atividade de CAT tem papel principal no momento inicial de resposta ao estresse oxidativo induzido por Ni, particularmente, quando sua concentração foi mais baixa, enquanto uma isoenzima específica de GR parece responder a este estresse na concentração mais alta de Ni, no mesmo período de tratamento. Os resultados ilustram a importância e as vantagens de se determinar a atividade de isoenzimas individuais