La correlazione tra CMB e struttura su larga scala dell'Universo, come test dell'accelerazione cosmologica

Una conseguenza osservativa dell'espansione accelerata dell'Universo è la produzione di correlazioni statistiche tra la distribuzione in temperatura del fondo cosmico di microonde e la distribuzione su grande scala delle strutture cosmiche. Scopo di questa tesi è lo studio approfondito di tale correlazione, e delle sue applicazioni nello studio dell'energia oscura o della gravità modificata.ope

The regulation of fat metabolism during aerobic exercise

Since the lipid profile is altered by physical activity, the study of lipid metabolism is a remarkable element in understanding if and how physical activity affects the health of both professional athletes and sedentary subjects. Although not fully defined, it has become clear that resistance exercise uses fat as an energy source. The fatty acid oxidation rate is the result of the following processes: (a) triglycerides lipolysis, most abundant in fat adipocytes and intramuscular triacylglycerol (IMTG) stores, (b) fatty acid transport from blood plasma to muscle sarcoplasm, (c) availability and hydrolysis rate of intramuscular triglycerides, and (d) transport of fatty acids through the mitochondrial membrane. In this review, we report some studies concerning the relationship between exercise and the aforementioned processes also in light of hormonal controls and molecular regulations within fat and skeletal muscle cells

Perceived parental self-efficacy and adolescents' self-efficacy during the transition to middle school

The transition from elementary to middle school represents an important challenge for students, whose lives undergo several changes in different areas of development. In fact, with the passage to middle school, for the first time students can exercise their autonomy as they navigate an environment that is less attentive to their individual needs unlike in the elementary school (Smetana, 1988). This school transition is generally associated with changes that can affect the students’ academic adjustment. Specifically, a first difference between elementary and middle school is in the educational programs, which become more complex and require higher academic goals than those of elementary school. The number of subjects to handle also goes up. A next change concerns students’ relationship with their teachers, which in elementary school was informal and focused on individual progress, whereas in middle school becomes more formal and detached, characterized by normative valuation criteria. A further challenge is in terms of learning. Students must now master new concepts that are more sophisticated and complex. In addition, with the transition to middle school students are exposed to new classmates and are faced with the loss of some friendships previously cultivated during their elementary school years. Therefore, the passage to middle school represents a great challenge for both students and parents. Students must cope with all the changes described above, and parents must exercise an important role in supporting their children in successfully managing the new challenges and new academic goals (Hoover-Dempsey et al., 1992; Hoover-Dempsey et al., 2001; Bogenschneider, 1997). In this regard, some scholars (Eccles & Midgley, 1989; Eccles, Midgley, & Adler, 1984) have highlighted the importance of parents’ and adolescents’ self-efficacy beliefs during this transitional period, suggesting that high perceived parental efficacy in their ability to positively affect their children’s academic development, and high perceived students’ efficacy in their ability to plan and 5 organize their academic activities, predict higher levels of academic adjustment and achievement. However, few studies (Bandura, Barbaranelli, Caprara & Pastorelli, 1996; Ardelt & Eccles, 2001) have analyzed how parental academic self-efficacy can support their children’s sense of efficacy, necessary for developmental success during this school transition. Accordingly, the overall aim of this dissertation was to analyze the relations among parental self-efficacy in the scholastic domain, children’s academic self-efficacy beliefs and academic functioning during the transition to middle school. Specifically, the first aim of the present dissertation was to investigate the psychometric characteristics of both Perceived Parental Self-Efficacy in School-Related Performance and Adolescents’ Perceived Efficacy for Self-Regulated Learning during the transition from elementary to middle school. The second aim was to identify the normative developmental trajectory of Perceived Parental Self-Efficacy in School-Related Performance, and its relations to concurrent and later students’ academic achievement (at the end of middle school). Finally, the third aim was to investigate, during the transition to middle school, the longitudinal bidirectional associations between Perceived Parental Self-Efficacy and Adolescents’ Perceived Efficacy for Self-Regulated Learning, and their associations with adolescents’ academic achievement. In this introductory chapter the theoretical framework of the Social Cognitive Theory and an outline of the dissertation will be presented

Bullying and cyberbullying: Do personality profiles matter in adolescence?

Bullying and cyberbullying represent pervasive issues in adolescence because they are very common situations with significant implications for concurrent and later adjustment. It is crucial to investigate the extent to which youths’ personality characteristics may represent a vulnerability to becoming (cyber)bullies or (cyber)victims. However, research mostly has focused on associations with single personality dimensions rather than overall functioning patterns, studies on personality profiles in relation to bullying are limited and under-examined, and no evidence for cyberbullying is available. Within Latent Profile Analysis (i.e., LPA), the present study aimed to identify personality profiles in a sample of 426 Italian early adolescents (Mage = 12; 51 % female), according to the Big Five Model (i.e., Extraversion-E, Agreeableness-A, Conscientiousness-C, Emotional Stability-ES, Openness-O), in connection with traditional bullying and cyberbullying roles (i.e., uninvolved, victims, bullies, bullies/victims). Three profiles emerged with specific associations with (cyber)bullying roles: (1) Resilient (with high scores in all traits) which tended to be uninvolved; (2) Undercontrolled (with low C, average-to-high E, and average-to-low ES, and O), which was more likely to be both bullies and victims, both offline and online; and (3) Overcontrolled (with very low E, average C, and average-to-low ES and O), which was more likely to be associated with traditional (but not online) victimization. The results fill a research gap, demonstrating that specific youths’ personality configurations may be associated with different roles in traditional and online bullying

An Overview of Mitochondrial Protein Defects in Neuromuscular Diseases

none8noNeuromuscular diseases (NMDs) are dysfunctions that involve skeletal muscle and cause incorrect communication between the nerves and muscles. The specific causes of NMDs are not well known, but most of them are caused by genetic mutations. NMDs are generally progressive and entail muscle weakness and fatigue. Muscular impairments can differ in onset, severity, prognosis, and phenotype. A multitude of possible injury sites can make diagnosis of NMDs difficult. Mitochondria are crucial for cellular homeostasis and are involved in various metabolic pathways; for this reason, their dysfunction can lead to the development of different pathologies, including NMDs. Most NMDs due to mitochondrial dysfunction have been associated with mutations of genes involved in mitochondrial biogenesis and metabolism. This review is focused on some mitochondrial routes such as the TCA cycle, OXPHOS, and β-oxidation, recently found to be altered in NMDs. Particular attention is given to the alterations found in some genes encoding mitochondrial carriers, proteins of the inner mitochondrial membrane able to exchange metabolites between mitochondria and the cytosol. Briefly, we discuss possible strategies used to diagnose NMDs and therapies able to promote patient outcomeopenMarra Federica, Lunetti Paola, Curcio Rosita, Lasorsa Francesco Massimo, Capobianco Loredana, Porcelli Vito, Dolce Vincenza, Fiermonte Giuseppe and Scarcia PasqualeMarra, Federica; Lunetti, Paola; Curcio, Rosita; Lasorsa Francesco, Massimo; Capobianco, Loredana; Porcelli, Vito; Dolce, Vincenza; Fiermonte Giuseppe and Scarcia, Pasqual

Exploring the protective function of positivity and regulatory emotional self-efficacy in time of pandemic covid-19

Despite several empirical studies on the 2019 coronavirus disease (COVID-19) pandemic that have highlighted its detrimental effect on individuals’ mental health, the identification of psychological factors that may moderate its impact on individuals’ behavior and well-being remains partly unexplored. The present study was conceived to examine the mediation role of regulatory emotional self-efficacy in the relationship between positivity and anxiety, depression, and perceived self-efficacy in complying with the containment measures to contrast the COVID-19 spread. Furthermore, the moderation role of age was tested. A sample of 1258 participants (64.2% women; Mage = 42.09, SD = 13.62) enrolled from the Italian general population answered an online survey aimed at investigating the role of individual differences in facing the COVID-19 pandemic. We opted for a snowball recruiting procedure to find participants. The online survey was disseminated through email invitation and using social media platforms (i.e., Facebook, Instagram). A multi-group path analysis model was performed using Mplus 8.4 to explore the hypothesized relations among variables. The following criteria were employed to evaluate the goodness of fit: χ2 likelihood ratio statistic, CFI and TLI > 0.95, RMSEA < 0.06 and SRMR < 0.08. The findings corroborated the protective role of both positivity and regulatory emotional self-efficacy in reducing individuals’ anxiety and depressive symptoms, as well as in fostering individuals’ capabilities in complying with the containment measures imposed by the government to reduce the risk of illness and to contain the spread of the virus COVID-19. Specifically, regulatory emotional self-efficacy beliefs partially mediated the relations between positivity and anxiety and depressive symptoms and fully mediated the effect of positivity on perceived self-efficacy beliefs in complying with the containment measures. These paths were equal across ages. The results of the present study appear relevant to implementing psychological interventions aimed to reduce the deleterious effects of the COVID-19 pandemic on mental health through the promotion of individuals’ optimistic orientation and emotion regulation

Platinated Nucleotides are Substrates for the Human Mitochondrial Deoxynucleotide Carrier (DNC) and DNA Polymerase g: Relevance for the Development of New Platinum-Based Drugs.

cis-[PtCl2(NH3)2] (cisplatin) is among the highest effective antitumor drugs used for the chemotherapeutic treatment of a broad range of malignancies. Recently, alongside with the classical direct bond to DNA, an alternative mechanism of action mediated by N7 platinated nucleotides has been suggested for cisplatin. Considering that mitochondria play an important role in cell death activation and in a significant portion of the clinical activity and pharmacological properties associated with cisplatin, aim of this research was to evaluate the possibility that platinated deoxynucleotides, as the model complex [Pt(dien)(N7-5’-dGTP)] (1), dien=diethylenetriamine, could be transported into mitochondria and then incorporated into mtDNA. The kinetic characterization has revealed that the mitochondrial deoxynucleotide carrier (DNC) transports complex 1 with high affinity. Finally, a highly efficient in organello DNA synthesis system, followed by ICP-AES, has demonstrated that [Pt(dien)(N7-5’-dGTP)] is incorporated in the mitochondrial DNA by DNA polymerase g. These results may have critical implications in the development of new generations of anticancer and/or antiviral nucleotide analogues with more specific cellular targets and fewer side effects

Drosophila melanogaster Uncoupling Protein-4A (UCP4A) Catalyzes a Unidirectional Transport of Aspartate

Uncoupling proteins (UCPs) form a distinct subfamily of the mitochondrial carrier family (MCF) SLC25. Four UCPs, DmUCP4A-C and DmUCP5, have been identified in Drosophila melanogaster on the basis of their sequence homology with mammalian UCP4 and UCP5. In a Parkinson’s disease model, DmUCP4A showed a protective role against mitochondrial dysfunction, by increasing mitochondrial membrane potential and ATP synthesis. To date, DmUCP4A is still an orphan of a biochemical function, although its possible involvement in mitochondrial uncoupling has been ruled out. Here, we show that DmUCP4A expressed in bacteria and reconstituted in phospholipid vesicles catalyzes a unidirectional transport of aspartate, which is saturable and inhibited by mercurials and other mitochondrial carrier inhibitors to various degrees. Swelling experiments carried out in yeast mitochondria have demonstrated that the unidirectional transport of aspartate catalyzed by DmUCP4 is not proton-coupled. The biochemical function of DmUCP4A has been further confirmed in a yeast cell model, in which growth has required an efflux of aspartate from mitochondria. Notably, DmUCP4A is the first UCP4 homolog from any species to be biochemically characterized. In Drosophila melanogaster, DmUCP4A could be involved in the transport of aspartate from mitochondria to the cytosol, in which it could be used for protein and nucleotide synthesis, as well as in the biosynthesis of ß-alanine and N-acetylaspartate, which play key roles in signal transmission in the central nervous system

Longitudinal associations between positive parenting and youths’ engagement in sexting behaviors: the mediating role of filial self-efficacy beliefs

Youths who enter emerging adulthood with a background of familial relations grounded in positive parent-child interactions are better equipped to cope with transitional stressors, to voice effectively their opinions with parents, and to resist engaging in risky activities. However, little is known about the longitudinal associations between positive parenting, filial self-efficacy beliefs and youths’ engagement in sexting behaviors. This study examined if positive parenting (mothers’ and fathers’ reports at child ages 13, 14, and 15) were related to youths’ engagement in sexting behaviors (child’s reports at age 19) both directly and indirectly, through adolescents perceived filial self-efficacy beliefs (child’s reports at age 18). Participants included 194 Italian children (MAgeAtTime1 = 13.54, 52.6% girls), their mothers (n = 193), and fathers (n = 150), who provided data across five waves over seven years. The mediation model was tested through a path analysis. Overall, results showed that, controlling for child gender and family SES, the effect of positive parenting on sexting behaviors was fully mediated by higher levels of perceived filial self-efficacy beliefs. The study reveals filial self-efficacy beliefs as central to the benefits conveyed to teens by parents in reducing their sexting behaviors

Maternal and paternal psychological control and adolescents’ negative adjustment: a dyadic longitudinal study in three countries

Psychological Control (PC) interferes with autonomy-related processes in adolescence and has a negative impact on adolescents’ development related to internalizing and externalizing problems. Several scholars suggested that PC can be used differently by mothers and fathers. However, these differences are still understudied and mainly grounded on maternal and/or adolescents’ perspectives, leading to potentially incomplete inferences on the effects of PC. The present study extends previous research on PC in two directions. First, we tested the dyadic and cumulative effects of maternal and paternal PC on adolescents’ antisocial behaviors and anxious-depressive symptoms. Secondly, we explored the cross-cultural generalizability of these associations in three countries: Italy, Colombia, and USA. Participants included 376 families with data from three consecutive years (T1, adolescents’ age=13.70). Mothers’ and fathers’ reports of PC and youth’s reports of antisocial and internalizing behaviors were assessed. Using the Actor-Partner Interdependence Model (APIM) we found that maternal PC predicted adolescents’ reported antisocial behaviors whereas paternal PC predicted lower anxious-depressed symptoms. Comparisons across countries evidenced the cross-cultural invariance of the longitudinal APIM across Italy, Colombia, and USA. The practical implications of these results are discussed