2,219 research outputs found
Spherically Symmetric Gravitational Collapse of Perfect Fluids
Formulating a perfect fluid filled spherically symmetric metric utilizing the
3+1 formalism for general relativity, we show that the metric coefficients are
completely determined by the mass-energy distribution, and its time rate of
change on an initial spacelike hypersurface. Rather than specifying
Schwarzschild coordinates for the exterior of the collapsing region, we let the
interior dictate the form of the solution in the exterior, and thus both
regions are found to be written in one coordinate patch. This not only
alleviates the need for complicated matching schemes at the interface, but also
finds a new coordinate system for the Schwarzschild spacetime expressed in
generalized Painleve-Gullstrand coordinates.Comment: 3 pages, To appear in the proceedings of the eleventh Marcel
Grossmann meeting on general relativity (MGXI), 23-29 July, 2006, Berli
High temperature expansion applied to fermions near Feshbach resonance
We show that, apart from a difference in scale, all of the surprising
recently observed properties of a degenerate Fermi gas near a Feshbach
resonance persist in the high temperature Boltzmann regime. In this regime, the
Feshbach resonance is unshifted. By sweeping across the resonance, a thermal
distribution of bound states (molecules) can be reversibly generated.
Throughout this process, the interaction energy is negative and continuous. We
also show that this behavior must persist at lower temperatures unless there is
a phase transition as the temperature is lowered. We rigorously demonstrate
universal behavior near the resonance.Comment: 4 pages, 4 figures (3 color, 1 BW), RevTeX4; ver4 -- updated
references, changed title -- version accepted for publication in Physical
Review Letter
Fermion Superfluids of Non-Zero Orbital Angular Momentum near Resonance
We study the pairing of Fermi gases near the scattering resonance of the
partial wave. Using a model potential which reproduces the actual
two-body low energy scattering amplitude, we have obtained an analytic solution
of the gap equation. We show that the ground state of and
superfluid are orbital ferromagnets with pairing wavefunctions and
respectively. For , there is a degeneracy between and
a "cyclic state". Dipole energy will orient the angular momentum axis. The gap
function can be determined by the angular dependence of the momentum
distribution of the fermions.Comment: 4 pages, 1 figur
Human African trypanosomiasis : the current situation in endemic regions and the risks for non-endemic regions from imported cases
Human African trypanosomiasis (HAT) is caused by Trypanosoma brucei
gambiense and T. b. rhodesiense and caused devastating epidemics during the 20th
century. Due to effective control programs implemented in the last two decades, the
number of reported cases has fallen to a historically low level. Although fewer than
977 cases were reported in 2018 in endemic countries, HAT is still a public health
problem in endemic regions until it is completely eliminated. In addition, almost 150
confirmed HAT cases were reported in non-endemic countries in the last three
decades. The majority of non-endemic HAT cases were reported in Europe, United
States and South Africa, due to historical alliances, economic links or geographic
proximity to disease endemic countries. Furthermore, with the implementation of the
“Belt and Road” project, sporadic imported HAT cases have been reported in China
as a warning sign of tropical diseases prevention. In this paper, we explore and
interpret the data on HAT incidence and find no positive correlation between the
number of HAT cases from endemic and non-endemic countries.This data will
provide useful information for better understanding the imported cases of HAT
globally in the post-elimination phase
Vacuolar ATPase depletion contributes to dysregulation of endocytosis in bloodstream forms of Trypanosoma brucei
BACKGROUND
Vacuolar H-ATPase (V-ATPase) is a highly conserved protein complex which hydrolyzes ATP and pumps protons to acidify vacuolar vesicles. Beyond its role in pH maintenance, the involvement of V-ATPase in endocytosis is well documented in mammals and plants but is less clear in Trypanosoma brucei.
METHODS
In this study, the subcellular localization of V-ATPase subunit B (TbVAB) of T. brucei was assessed via in situ N-terminal YFP-tagging and immunofluorescence assays. Transgenic bloodstream forms (BSF) of T. brucei were generated which comprised either a V-ATPase subunit B (TbVAB) conditional knockout or a V-ATPase subunit A (TbVAA) knockdown. Acridine orange and BCECF-AM were employed to assess the roles of V-ATPase in the pH regulation of BSF T. brucei. The endocytic activities of three markers were also characterized by flow cytometry analyses. Furthermore, trypanosomes were counted from trypanolysis treatment groups (either containing 1% or 5% NHS) and endocytosed trypanosome lytic factor (TLF) was also analyzed by an immunoblotting assay.
RESULTS
TbVAB was found to localize to acidocalcisomes, lysosomes and probably also to endosomes of BSF of T. brucei and was demonstrated to be essential for cell growth. TbVAB depletion neutralized acidic organelles at 24 hours post-tetracycline depletion (hpd), meanwhile the steady state intracellular pH increased from 7.016 ± 0.013 to 7.422 ± 0.058. Trypanosomes with TbVAB depletion at 24 hpd were found to take up more transferrin (2.068 ± 0.277 fold) but less tomato lectin (49.31 ± 22.57%) by endocytosis, while no significant change was detected in dextran uptake. Similar endocytic dysregulated phenotypes were also observed in TbVAA knockdown cells. In addition, TbVAB depleted trypanosomes showed a low uptake of TLF and exhibited less sensitive to lysis in both 1% and 5% NHS treatments.
CONCLUSIONS
TbVAB is a key component of V-ATPase and was found to play a key function in endocytosis as well as exhibiting different effects in a receptor/cargo dependent manner in BSF of T. brucei. Besides vacuolar alkalinization, the dysregulation of endocytosis in TbVAB depleted T. brucei is considered to contribute to the reduced sensitivity to lysis by normal human serum
Rapidly Rotating Fermi Gases
We show that the density profile of a Fermi gas in rapidly rotating potential
will develop prominent features reflecting the underlying Landau level like
energy spectrum. Depending on the aspect ratio of the trap, these features can
be a sequence of ellipsoidal volumes or a sequence of quantized steps.Comment: 4 pages, 1 postscript fil
Universal velocity distributions in an experimental granular fluid
We present experimental results on the velocity statistics of a uniformly
heated granular fluid, in a quasi-2D configuration. We find the base state, as
measured by the single particle velocity distribution , to be universal
over a wide range of filling fractions and only weakly dependent on all other
system parameters. There is a consistent overpopulation in the distribution's
tails, which scale as . More
importantly, the high probability central region of , at low velocities,
deviates from a Maxwell-Boltzmann by a second order Sonine polynomial with a
single adjustable parameter, in agreement with recent theoretical analysis of
inelastic hard spheres driven by a stochastic thermostat. To our knowledge,
this is the first time that Sonine deviations have been measured in an
experimental system.Comment: 13 pages, 15 figures, with minor corrections, submitted to Phys. Rev.
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