2,884 research outputs found
Directional optical switching and transistor functionality using optical parametric oscillation in a spinor polariton fluid
Over the past decade, spontaneously emerging patterns in the density of
polaritons in semiconductor microcavities were found to be a promising
candidate for all-optical switching. But recent approaches were mostly
restricted to scalar fields, did not benefit from the polariton's unique
spin-dependent properties, and utilized switching based on hexagon far-field
patterns with 60{\deg} beam switching (i.e. in the far field the beam
propagation direction is switched by 60{\deg}). Since hexagon far-field
patterns are challenging, we present here an approach for a linearly polarized
spinor field, that allows for a transistor-like (e.g., crucial for
cascadability) orthogonal beam switching, i.e. in the far field the beam is
switched by 90{\deg}. We show that switching specifications such as
amplification and speed can be adjusted using only optical means
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Selective cell death of latently HIV-infected CD4+ T cells mediated by autosis inducing nanopeptides.
Despite significant advances in the treatment of human immunodeficiency virus type-1 (HIV) infection, antiretroviral therapy only suppresses viral replication but is unable to eliminate infection. Thus, discontinuation of antiretrovirals results in viral reactivation and disease progression. A major reservoir of HIV latent infection resides in resting central memory CD4+ T cells (TCM) that escape clearance by current therapeutic regimens and will require novel strategies for elimination. Here, we evaluated the therapeutic potential of autophagy-inducing peptides, Tat-Beclin 1 and Tat-vFLIP-α2, which can induce a novel Na+/K+-ATPase dependent form of cell death (autosis), to kill latently HIV-infected TCM while preventing virologic rebound. In this study, we encapsulated autophagy inducing peptides into biodegradable lipid-coated hybrid PLGA (poly lactic-co-glycolic acid) nanoparticles for controlled intracellular delivery. A single dose of nanopeptides was found to eliminate latent HIV infection in an in vitro primary model of HIV latency and ex vivo using resting CD4+ T cells obtained from peripheral blood mononuclear cells of HIV-infected patients on antiretroviral with fully suppressed virus for greater than 12 months. Notably, increased LC3B lipidation, SQSTM1/p62 degradation and Na+/K+-ATPase activity characteristic of autosis, were detected in nanopeptide treated latently HIV-infected cells compared to untreated uninfected or infected cells. Nanopeptide-induced cell death could be reversed by knockdown of autophagy proteins, ATG5 and ATG7, and inhibition or knockdown of Na+/K+-ATPase. Importantly, viral rebound was not detected following the induction of the Na+/K+-ATPase dependent form of cell death induced by the Tat-Beclin 1 and Tat-vFLIP-α2 nanopeptides. These findings provide a novel strategy to eradicate HIV latently infected resting memory CD4+ T cells, the major reservoir of HIV latency, through the induction of Na+/K+-ATPase dependent autophagy, while preventing reactivation of virus and new infection of uninfected bystander cells
Sampling Distributions of Random Electromagnetic Fields in Mesoscopic or Dynamical Systems
We derive the sampling probability density function (pdf) of an ideal
localized random electromagnetic field, its amplitude and intensity in an
electromagnetic environment that is quasi-statically time-varying statistically
homogeneous or static statistically inhomogeneous. The results allow for the
estimation of field statistics and confidence intervals when a single spatial
or temporal stochastic process produces randomization of the field. Results for
both coherent and incoherent detection techniques are derived, for Cartesian,
planar and full-vectorial fields. We show that the functional form of the
sampling pdf depends on whether the random variable is dimensioned (e.g., the
sampled electric field proper) or is expressed in dimensionless standardized or
normalized form (e.g., the sampled electric field divided by its sampled
standard deviation). For dimensioned quantities, the electric field, its
amplitude and intensity exhibit different types of
Bessel sampling pdfs, which differ significantly from the asymptotic
Gauss normal and ensemble pdfs when is relatively
small. By contrast, for the corresponding standardized quantities, Student ,
Fisher-Snedecor and root- sampling pdfs are obtained that exhibit
heavier tails than comparable Bessel pdfs. Statistical uncertainties
obtained from classical small-sample theory for dimensionless quantities are
shown to be overestimated compared to dimensioned quantities. Differences in
the sampling pdfs arising from de-normalization versus de-standardization are
obtained.Comment: 12 pages, 15 figures, accepted for publication in Phys. Rev. E, minor
typos correcte
Kaluza-Klein towers for real vector fields in flat space
We consider a free real vector field propagating in a five dimensional flat
space with its fifth dimension compactified either on a strip or on a circle
and perform a Kalaza Klein reduction which breaks SO(4,1) invariance while
reserving SO(3,1) invariance. Taking into account the Lorenz gauge condition,
we obtain from the most general hermiticity conditions for the relevant
operators all the allowed boundary conditions which have to be imposed on the
fields in the extra-dimension. The physical Kaluza-Klein mass towers, which
result in a four-dimensional brane, are determined in the different distinct
allowed cases. They depend on the bulk mass, on the parameters of the boundary
conditions and on the extra parameter present in the Lagrangian. In general,
they involve vector states together with accompanying scalar states.Comment: 28 pages, 4 independent table
Algorithmic fault tolerance using the Lanczos method
We consider the problem of algorithm-based fault tolerance, and make two major contributions. First, we show how very general sequences of polynomials can be used to generate the checksums, so as to reduce the chance of numerical overows. Second, we show how the Lanczos process can be applied in the error location and correction steps, so as to save on the amount of work and to facilitate actual hardware implementation
The Stability of Biological Apatite in the Presence of Strontium
Poster no. 646published_or_final_versio
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