Long Duration Exposure Facility (LDEF) structural verification test report

Structural load tests on the Long Duration Exposure Facility's (LDEF) primary structure were conducted. These tests had three purposes: (1) demonstrate structural adequacy of the assembled LDEF primary structure when subjected to anticipated flight loads; (2) verify analytical models and methods used in loads and stress analysis; and (3) perform tests to comply with the Space Transportation System (STS) requirements. Test loads were based on predicted limit loads which consider all flight events. Good agreement is shown between predicted and observed load, strain, and deflection data. Test data show that the LDEF structure was subjected to 1.2 times limit load to meet the STS requirements. The structural adequacy of the LDEF is demonstrated

Dealing with the deluge of historical weather data: the example of the TEMPEST database

People have long been interested in the history of weather, particularly extremes, and chronologies of past events drawing on information from written records, have been compiled and published throughout history. In recent years, concern over current and future weather and climate has triggered a new level of interest in past weather events and their impacts. This interest, alongside the development of digital humanities research methods has resulted in a rapid growth in the number of online databases relating to historic weather and climate around the world. This paper reviews this expansion with reference to a range of examples, before documenting the design and creation of one such database, TEMPEST, an online repository for extreme weather history in the UK. TEMPEST has been created as the major output of the AHRC funded project ?Spaces of Experience and Horizons of Expectation: Extreme Weather in the UK, Past, Present and Future? (2013-2016). Unlike the majority of existing databases that rely on published materials, TEMPEST?s records are drawn from primary research into original documentary sources held in archives around the UK. The c. 18,000 records that TEMPEST currently contains offer personalised and geo-referenced insights into the relationship between society and extreme weather in the UK spanning a period of over 400 years. We conclude this paper by outlining some potential applications for TEMPEST, and suggesting directions for future research and resources in historical weather. We also consider broader issues for the digital humanities.publishersversionPeer reviewe

Functional plasticity of antibacterial EndoU toxins.

Bacteria use several different secretion systems to deliver toxic EndoU ribonucleases into neighboring cells. Here, we present the first structure of a prokaryotic EndoU toxin in complex with its cognate immunity protein. The contact-dependent growth inhibition toxin CdiA-CTSTECO31 from Escherichia coli STEC_O31 adopts the eukaryotic EndoU fold and shares greatest structural homology with the nuclease domain of coronavirus Nsp15. The toxin contains a canonical His-His-Lys catalytic triad in the same arrangement as eukaryotic EndoU domains, but lacks the uridylate-specific ribonuclease activity that characterizes the superfamily. Comparative sequence analysis indicates that bacterial EndoU domains segregate into at least three major clades based on structural variations in the N-terminal subdomain. Representative EndoU nucleases from clades I and II degrade tRNA molecules with little specificity. In contrast, CdiA-CTSTECO31 and other clade III toxins are specific anticodon nucleases that cleave tRNAGlu between nucleotides C37 and m2 A38. These findings suggest that the EndoU fold is a versatile scaffold for the evolution of novel substrate specificities. Such functional plasticity may account for the widespread use of EndoU effectors by diverse inter-bacterial toxin delivery systems

Case report: Severe mercuric sulphate poisoning treated with 2,3-dimercaptopropane-1-sulphonate and haemodiafiltration

INTRODUCTION: Inorganic mercury poisoning is uncommon, but when it occurs it can result in severe, life-threatening features and acute renal failure. Previous reports on the use of extracorporeal procedures such as haemodialysis and haemoperfusion have shown no significant removal of mercury. We report here the successful use of the chelating agent 2,3-dimercaptopropane-1-sulphonate (DMPS), together with continuous veno-venous haemodiafiltration (CVVHDF), in a patient with severe inorganic mercury poisoning. CASE REPORT: A 40-year-old man presented with haematemesis after ingestion of 1 g mercuric sulphate and rapidly deteriorated in the emergency department, requiring intubation and ventilation. His initial blood mercury was 15 580 μg/l. At 4.5 hours after ingestion he was started on DMPS. He rapidly developed acute renal failure and so he was started on CVVHDF for renal support and in an attempt to improve mercury clearance; CVVHDF was continued for 14 days. METHODS: Regular ultradialysate and pre- and post-filtrate blood samples were taken and in addition all ultradialysate generated was collected to determine its mercury content. RESULTS: The total amount of mercury in the ultrafiltrate was 127 mg (12.7% of the ingested dose). The sieving coefficient ranged from 0.13 at 30-hours to 0.02 at 210-hours after ingestion. He developed no neurological features and was discharged from hospital on day 50. Five months after discharge from hospital he remained asymptomatic, with normal creatinine clearance. DISCUSSION: We describe a patient with severe inorganic mercury poisoning in whom full recovery occurred with the early use of the chelating agent DMPS and CVVHDF. There was removal of a significant amount of mercury by CVVHDF. CONCLUSION: We feel that CVVHDF should be considered in patients with inorganic mercury poisoning, particularly those who develop acute renal failure, together with meticulous supportive care and adequate doses of chelation therapy with DMPS

Long Term Displacement Data of Woven Fabric Webbings Under Constant Load for Inflatable Structures

Inflatable modules for space applications offer weight and launch volume savings relative to current metallic modules. Limited data exist on the creep behavior of the restraint layer of inflatable modules. Long-term displacement and strain data of two high strength woven fabric webbings, Kevlar and Vectran, under constant load is presented. The creep behavior of webbings is required by designers to help determine service life parameters of inflatable modules. Four groups of different webbings with different loads were defined for this study. Group 1 consisted of 4K Kevlar webbings loaded to 33% ultimate tensile strength and 6K Vectran webbings loaded to 27% ultimate tensile strength, group 2 consisted of 6K Kevlar webbings loaded to 40% and 43% ultimate tensile strength, and 6K Vectran webbings loaded to 50% ultimate tensile strength, group 3 consisted of 6K Kevlar webbings loaded to 52% ultimate tensile strength and 6K Vectran webbings loaded to 60% ultimate tensile strength, and group 4 consisted of 12.5K Kevlar webbings loaded to 22% ultimate tensile strength, and 12.5K Vectran webbings loaded to 22% ultimate tensile strength. The uniquely designed test facility, hardware, displacement measuring devices, and test data are presented. Test data indicate that immediately after loading all webbings stretch an inch or more, however as time increases displacement values significantly decrease to fall within a range of several hundredth of an inch over the remainder of test period. Webbings in group 1 exhibit near constant displacements and strains over a 17-month period. Data acquisition was suspended after the 17th month, however webbings continue to sustain load without any local webbing damage as of the 21st month of testing. Webbings in group 2 exhibit a combination of initial constant displacement and subsequent increases in displacement rates over a 16-month period. Webbings in group 3 exhibit steady increases in displacement rates leading to webbing failure over a 3-month period. Five of six webbings experienced local damage and subsequent failure in group 3. Data from group 4 indicates increasing webbing displacements over a 7-month period. All webbings in groups 1, 2, and 4 remain suspended without any local damage as of the writing of this paper. Variations in facility temperatures over test period seem to have had limited effect on long-term webbing displacement data

The potential of research drawing on clinical free text to bring benefits to patients in the United Kingdom: a systematic review of the literature

Background: The analysis of clinical free text from patient records for research has potential to contribute to the medical evidence base but access to clinical free text is frequently denied by data custodians who perceive that the privacy risks of data-sharing are too high. Engagement activities with patients and regulators, where views on the sharing of clinical free text data for research have been discussed, have identified that stakeholders would like to understand the potential clinical benefits that could be achieved if access to free text for clinical research were improved. We aimed to systematically review all UK research studies which used clinical free text and report direct or potential benefits to patients, synthesizing possible benefits into an easy to communicate taxonomy for public engagement and policy discussions. Methods: We conducted a systematic search for articles which reported primary research using clinical free text, drawn from UK health record databases, which reported a benefit or potential benefit for patients, actionable in a clinical environment or health service, and not solely methods development or data quality improvement. We screened eligible papers and thematically analyzed information about clinical benefits reported in the paper to create a taxonomy of benefits. Results: We identified 43 papers and derived five themes of benefits: health-care quality or services improvement, observational risk factor-outcome research, drug prescribing safety, case-finding for clinical trials, and development of clinical decision support. Five papers compared study quality with and without free text and found an improvement of accuracy when free text was included in analytical models. Conclusions: Findings will help stakeholders weigh the potential benefits of free text research against perceived risks to patient privacy. The taxonomy can be used to aid public and policy discussions, and identified studies could form a public-facing repository which will help the health-care text analysis research community better communicate the impact of their work

The fundamental links between climate change and marine plastic pollution

Plastic pollution and climate change have commonly been treated as two separate issues and sometimes are even seen as competing. Here we present an alternative view that these two issues are fundamentally linked. Primarily, we explore how plastic contributes to greenhouse gas (GHG) emissions from the beginning to the end of its life cycle. Secondly, we show that more extreme weather and floods associated with climate change, will exacerbate the spread of plastic in the natural environment. Finally, both issues occur throughout the marine environment, and we show that ecosystems and species can be particularly vulnerable to both, such as coral reefs that face disease spread through plastic pollution and climate-driven increased global bleaching events. A Web of Science search showed climate change and plastic pollution studies in the ocean are often siloed, with only 0.4% of the articles examining both stressors simultaneously. We also identified a lack of regional and industry-specific life cycle analysis data for comparisons in relative GHG contributions by materials and products. Overall, we suggest that rather than debate over the relative importance of climate change or marine plastic pollution, a more productive course would be to determine the linking factors between the two and identify solutions to combat both crises

Towards a fully consistent Milky Way disc model: Part 1 The local model based on kinematic and photometric data

We present a fully consistent evolutionary disc model of the solar cylinder. The model is based on a sequence of stellar sub-populations described by the star formation history (SFR) and the dynamical heating law (given by the age-velocity dispersion relation AVR). The combination of kinematic data from Hipparcos and the finite lifetimes of main sequence (MS) stars enables us to determine the detailed vertical disc structure independent of individual stellar ages and only weakly dependent on the IMF. The disc parameters are determined by applying a sophisticated best fit algorithm to the MS star velocity distribution functions in magnitude bins. We find that the AVR is well constrained by the local kinematics, whereas for the SFR the allowed range is larger. A simple chemical enrichment model is included in order to fit the local metallicity distribution of G dwarfs. In our favoured model A the power law index of the AVR is 0.375 with a minimum and maximum velocity dispersion of 5.1 km/s and 25.0 km/s, respectively. The SFR shows a maximum 10 Gyr ago and declines by a factor of four to the present day value of 1.5 M_sun/pc^2/Gyr. A best fit of the IMF leads to power-law indices of -1.46 below and -4.16 above 1.72 M_sun avoiding a kink at 1 M_sun. An isothermal thick disc component with local density of ~6% of the stellar density is included. A thick disc containing more than 10% of local stellar mass is inconsistent with the local kinematics of K and M dwarfs.Comment: 20 pages, 18 figs., accepted by MNRA

The CORALIE survey for southern extra-solar planets IX. A 1.3-day period brown dwarf disguised as a planet

In this article we present the case of HD 41004 AB, a system composed of a K0V star and a 3.7-magnitude fainter M-dwarf companion separated by only 0.5 arcsec. An analysis of CORALIE radial-velocity measurements has revealed a variation with an amplitude of about 50m/s and a periodicity of 1.3days. This radial-velocity signal is consistent with the expected variation induced by the presence a very low mass giant planetary companion to HD 41004 A, whose light dominates the spectra. The radial-velocity measurements were then complemented with a photometric campaign and with the analysis of the bisector of the CORALIE Cross-Correlation Function (CCF). While the former revealed no significant variations within the observational precision of 0.003-0.004 mag (except for an observed flare event), the bisector analysis showed that the line profiles are varying in phase with the radial-velocity. This latter result, complemented with a series of simulations, has shown that we can explain the observations by considering that HD 41004 B has a brown-dwarf companion orbiting with the observed 1.3-day period. If confirmed, this detection represents the first discovery of a brown dwarf in a very short period (1.3-day) orbit around an M dwarf. Finally, this case should be taken as a serious warning about the importance of analyzing the bisector when looking for planets using radial-velocity techniques.Comment: 16 pages, 17 eps figures, A&A in press (Figure 11 not as in original version due to size