Non-equilibrium ionization around clouds evaporating in the interstellar medium

It is of prime importance for global models of the interstellar medium to know whether dense clouds do or do not evaporate in the hot coronal gas. The rate of mass exchanges between phases depends very much on that. McKee and Ostriker's model, for instance, assumes that evaporation is important enough to control the expansion of supernova remnants, and that mass loss obeys the law derived by Cowie and McKee. In fact, the geometry of the magnetic field is nearly unknown, and it might totally inhibit evaporation, if the clouds are not regularly connected to the hot gas. Up to now, the only test of the theory is the U.V. observation (by the Copernicus and IUE satellites) of absorption lines of ions such as OVI or NV, that exist at temperatures of a few 100,000 K typical of transition layers around evaporating clouds. Other means of testing the theory are discussed

Can be gravitational waves markers for an extra-dimension?

The main issue of the present letter is to fix specific features (which turn out being independent of extradimension size) of gravitational waves generated before a dimensional compactification process. Valuable is the possibility to detect our prediction from gravitational wave experiment without high energy laboratory investigation. In particular we show how gravitational waves can bring information on the number of Universe dimensions. Within the framework of Kaluza-Klein hypotheses, a different morphology arises between waves generated before than the compactification process settled down and ordinary 4-dimensional waves. In the former case the scalar and tensor degrees of freedom can not be resolved. As a consequence if were detected gravitational waves having the feature here predicted (anomalous polarization amplitudes), then they would be reliable markers for the existence of an extra dimension.Comment: 5 pages, two figure, to appear on Int. Journ. Mod. Phys.

Rainfall thresholds for the possible occurrence of landslides in Italy

Abstract. In Italy, rainfall is the primary trigger of landslides that frequently cause fatalities and large economic damage. Using a variety of information sources, we have compiled a catalogue listing 753 rainfall events that have resulted in landslides in Italy. For each event in the catalogue, the exact or approximate location of the landslide and the time or period of initiation of the slope failure is known, together with information on the rainfall duration D, and the rainfall mean intensity I, that have resulted in the slope failure. The catalogue represents the single largest collection of information on rainfall-induced landslides in Italy, and was exploited to determine the minimum rainfall conditions necessary for landslide occurrence in Italy, and in the Abruzzo Region, central Italy. For the purpose, new national rainfall thresholds for Italy and new regional rainfall thresholds for the Abruzzo Region were established, using two independent statistical methods, including a Bayesian inference method and a new Frequentist approach. The two methods proved complementary, with the Bayesian method more suited to analyze small data sets, and the Frequentist method performing better when applied to large data sets. The new regional thresholds for the Abruzzo Region are lower than the new national thresholds for Italy, and lower than the regional thresholds proposed in the literature for the Piedmont and Lombardy Regions in northern Italy, and for the Campania Region in southern Italy. This is important, because it shows that landslides in Italy can be triggered by less severe rainfall conditions than previously recognized. The Frequentist method experimented in this work allows for the definition of multiple minimum rainfall thresholds, each based on a different exceedance probability level. This makes the thresholds suited for the design of probabilistic schemes for the prediction of rainfall-induced landslides. A scheme based on four probabilistic thresholds is proposed. The four thresholds separate five fields, each characterized by different rainfall intensity-duration conditions, and corresponding different probability of possible landslide occurrence. The scheme can be implemented in landslide warning systems that operate on rainfall thresholds, and on precipitation measurements or forecasts

Verifica degli impatti socioeconomici ed ambientali conseguenza dei mutamenti climatici in atto nel bacino del Mediterraneo, attraverso l’uso del telerilevamento satellitare

Oggi l’uomo è pericolosamente prossimo ad un punto di non ritorno, in cui può decidere di cambiare rotta od accettare di vedere avverarsi ciò che più temeva l'economista statunitense Premio Nobel Paul Robin Krugmani, il quale sosteneva che le future generazioni non avrebbero più potuto contare, come avevano sempre fatto le precedenti, su di un tenore di vita migliore rispetto a quello di padri e nonni. Questo potrebbe avvenire perché è stato ormai sollevato il problema dell’assoluta carenza di risorse naturali, questione che per lungo tempo è stata risolta dai paesi più industrializzati con l’esclusione della maggioranza della popolazione mondiale dai consumi di massa propri dell’Occidente. Ma la problematica riguardante questa scarsità segue, ogni giorno di più, quella altrettanto drammatica che investe il clima e per la comunità scientifica è ormai ovvio che entrambi sono due facce di una stessa medaglia. Sempre più spesso, dunque, siamo chiamati a confrontarci non solo con la miseria, in preoccupante aumento in ogni Paese dopo la crisi economica globale iniziata nel 2008 e non ancora conclusasi, ma, anche, con tematiche come calamità naturali, eventi estremi, squilibri ecologici, avvenimenti pure essi in apparente, decisa crescita. Privazioni e mutamenti climatici hanno un costo economico e sociale altissimo e l’unico metodo per risolvere queste difficoltà parrebbe quello di ricondurre la dottrina al significato primigenio della parola economia, “oikos nomos”, che circa 2700 anni fa significava gestione della casa comune, ovvero la Terra, pianeta in cui viviamo. In questo contesto è da inquadrare il programma di studio interministeriale che ha per titolo “Modello integrato per l’evoluzione degli ecosistemi naturali ed agricoli in relazione ai cambiamenti climatici nell’area mediterranea (FISR-MICENA)”; il lavoro che qui si presenta è parte integrante dell’attività di ricerca n.19 di questo progetto

Ion diffusion modelling of Fricke-agarose dosemeter gels

In Fricke-agarose gels, an accurate determination of the spatial dose distribution is hindered by the diffusion of ferric ions. In this work, a model was developed to describe the diffusion process within gel samples of finite length and, thus, permit the reconstruction of the initial spatial distribution of the ferric ions. The temporal evolution of the ion concentration as a function of the initial concentration is derived by solving Fick's second law of diffusion in two dimensions with boundary reflections. The model was applied to magnetic resonance imaging data acquired at high spatial resolution (0.3 mm) and was found to describe accurately the observed diffusion effect

Implementing quality by design for biotech products: are regulators on track?

Quality by design (QbD) is an innovative approach to drug development that has started to be implemented into the regulatory framework, but currently mainly for chemical drugs. The recent marketing authorization of the first monoclonal antibody developed using extensive QbD concepts in the European Union paves the way for future further regulatory approvals of complex products employing this cutting-edge technological concept. In this paper, we report and comment on insights and lessons learnt from the non-public discussions in the European Medicines Agency's Biologicals Working Party and Committee for Medicinal Products for Human Use on the key issues during evaluation related to the implementation of an extensive QbD approach for biotechnology-derived medicinal products. Sharing these insights could prove useful for future developments in QbD for biotech products in general and monoclonal antibodies in particular

Mean Arterial Pressure (MAP) Trial: study protocol for a multicentre, randomized, controlled trial to compare three different strategies of mean arterial pressure management during cardiopulmonary bypass.

Background: One of the main goals of cardiopulmonary bypass (CPB) is targeting an adequate mean arterial pressure (MAP) during heart surgery, in order to maintain appropriate perfusion pressures in all end-organs. As inheritance of early studies, a value of 50-60 mmHg has been historically accepted as the "gold standard" MAP. However, in the last decades, the CPB management has remarkably changed, thanks to the evolution of technology and the availability of new biomaterials. Therefore, as highlighted by the latest European Guidelines, the current management of CPB can no longer refer to those pioneering studies. To date, only few single-centre studies have compared different strategies of MAP management during CPB, but with contradictory findings and without achieving a real consensus. Therefore, what should be the ideal strategy of MAP management during CPB is still on debate. This trial is the first multicentre, randomized, controlled study which compares three different strategies of MAP management during the CPB. Methods: We described herein the methodology of a multicentre, randomized, controlled trial comparing three different approaches to MAP management during CPB in patients undergoing elective cardiac surgery: the historically accepted "standard MAP" (50-60 mmHg), the "high MAP" (70-80 mmHg) and the "patient-tailored MAP" (comparable to the patient's preoperative MAP). It is the aim of the study to find the most suitable management in order to obtain the most adequate perfusion of end-organs during cardiac surgery. For this purpose, the primary endpoint will be the peak of serum lactate (Lmax) released during CPB, as index of tissue hypoxia. The secondary outcomes will include all the intraoperative parameters of tissue oxygenation and major postoperative complications related to organ malperfusion. Discussion: This trial will assess the best strategy to target the MAP during CPB, thus further improving the outcomes of cardiac surgery

Detection of serum allergen-specific IgE in atopic dogs tested in northern Italy: Preliminary study

Canine atopic dermatitis (CAD) is a pruritic allergic skin disease associated with IgE-mediated hypersensitivity. IgE is detected using Serum Allergen-Specific IgE test (SAT) in order to identify allergens. The present study aims to identify the environmental allergens in atopic dogs living in Northern Italy using SAT. The screening SAT (sSAT), using a monoclonal antibody cocktail-based ELISA to identify indoor and outdoor allergens, was performed. In all positive samples, an anti-IgE monoclonal antibody ELISA test was performed to extend panel of allergens. Out of 117 selected dogs, 69 were included in the study; 71% were positive and 29% were negative to sSAT. Among the 49 positive sSAT, 53% were positive for both indoor and outdoor, 38.8% only for indoor, and 8.2% only for outdoor allergens. This is the first study on the frequency of allergens involved in CAD in Italy using SAT. IgE hypersensitivity in atopic dogs of Northern Italy is usually associated with indoor allergens, primarily house dust mites. Among the outdoor allergens, an important role was played by Rumex acetosa. Polysensitization also commonly occurs. Therefore, since the numerous factors affect the IgE positivity in CAD, specific panels for geographical areas should be considered and re-evaluated at time intervals