Workshop Overview

Workshop Overview Lovell Allan Jones, Ph.D., received his doctorate in 1977 in the field of zoology with an emphasis in endocrinology and tumor biology from the University of California, Berkeley. During his training Dr. Jones was a National Institutes of Health (NIH) pre-doctoral trainee and a Ford Foundation Fellow at the UC Berkeley\u27s Cancer Research Laboratory. After receiving his doctorate, Dr. Jones joined the Reproductive Endocrinology Center at the University of California San Francisco (UCSF) as an NIH Postdoctoral Fellow under the mentorship of Dr. Pentti Siiteri. Before joining the Department of Gynecologic Oncology at University of Texas M. D. Anderson Cancer Center (UTMDACC) in 1980, Dr. Jones served as an Instructor in the Departments of Physiology and Obstetrics, Gynecology & Reproductive Sciences at UCSF. Dr. Jones is presently the director of the Congressionally mandated Center for Research on Minority Health in the Department of Health Disparities Research in the division of Cancer Prevention and Population Sciences at The University of Texas M. D. Anderson Cancer Center. He is also the Founding Co-Chair of the Intercultural Cancer Council, the nation\u27s largest multicultural health policy group focused on minorities, the medically underserved and cancer

Community-Based Participatory Research and Gene-Environment Interaction Methodologies Addressing Environmental Justice among Migrant and Seasonal Farmworker Women and Children in Texas: "From Mother to Child Project"

The “From Mother to Child Project” is a molecular epidemiological study that employs a communitybased participatory research (CBPR) approach and gene-environment interaction research to address environmental justice in migrant and seasonal farmworker (MSF) women and children of Mexican origin home-based in Baytown and La Joya, Texas. This paper presents the background and rationale for the study and describes the study design and methodology. Preliminary data showed that MSF women and children in Texas have measurable levels of pesticides in their blood and urine, some of which were banned in the United States decades ago and are possible human carcinogens. Polymorphisms in genes involved in chemical detoxification and DNA repair have been associated with susceptibility to genetic damage and cancer development in populations exposed to environmental toxins. The “From Mother to Child Project” is testing three hypotheses: (1) MSF women and children who are occupationally exposed to pesticides are at higher risk for DNA damage than are non-exposed women and children. (2) Both, the extent of pesticide exposure and type of polymorphisms in chemical detoxification and DNA repair genes contribute to the extent of DNA damage observed in study participants. (3) The mutagenic potency levels measured in the organic compounds extracted from the urine and serum of study participants will correlate with the total concentrations of pesticides and with the measured DNA damage in study participants. The study will enroll 800 participants: 200 MSF mother-child pairs; 200 children (one per family) whose parents have never worked in agriculture, matched with the MSF children by ethnicity, age ± 2 years, gender, and city of residence; and these children’s mothers. Personal interviews with the mothers are used to gather data for both mothers and children on sociodemographic characteristics; pesticide exposure at work and home; medical and reproductive history; dietary assessment, and lifestyle factors. Blood and urine samples are collected from each participant and analyzed for (1) organochlorine and organophosphate pesticide levels, (2) genetic polymorphisms of chemical detoxification and DNA repair genes, (3) DNA damage (chromosomal aberrations), and (4) the mutagenic potential of pesticides in the serum and urine. Recruitment and data collection in Baytown is near completion, and over one third of the target population for the La Joya study site

Initial Assessment of a Forgotten Minority Community: Key Informant's Perceptions of Environmental Health in Fresno, Texas

Background. Environmental hazards are increasingly being detected in minority and low-income communities. The Fresno, Texas community is located near Houston, Texas, and many of its residents are ethnic minorities and of low socioeconomic status. While Fresno residents have voiced concerns about long-standing undocumented environmental hazards, the extent to which the concerns were accurate was unclear. As an initial assessment of environmental exposure hazards, key informant interviews of residents and officials were conducted to examine the perceptions of environmental exposures and associated health effects in the Fresno community. Results. The responses about perceived environmental exposures and the extent of access to primary healthcare were similar between residents and officials. The key informants identified inadequate public water supply and possible groundwater contamination as sources of potential environmental exposures and agreed that access to primary healthcare was a major problem in the Fresno area. However, Fresno residents and officials had contrasting perceptions about the overall health of the community, the existence of community-based organizations, strengths and barriers of the community, and how well environmental concerns were addressed. Methods. Qualitative methodology was used to conduct key informant interviews of seven residents and five elected or assigned officials who serve residents of Fresno. An interview guide designed to obtain information on potential environmental hazards and associated health effects was utilized to collect qualitative data that were then utilized to identify recurrent themes and dissimilarities of responses. Conclusions. The responses obtained in this study suggest that potential environmental exposures may be present in this community. However, although residents and officials identified access to primary healthcare as a barrier to residing in Fresno, residents and officials had differing perceptions of the overall heath status of the Fresno community. These findings must be further investigated to develop additional qualitative and quantitative studies that will validate the preliminary findings of this study and begin to accurately measure contaminant levels and health status in Fresno residents

Working Toward Social Justice: Center for Research on Minority Health Summer Workshop on Health Disparities

Health disparities research encompasses a complex web of areas of cross-disciplinary expertise from fields such as health policy, public health, economics, sociology, psychology, anthropology, communications, genetics, biology, environmental science, ethics, and law. Dissemination of health disparities research is paramount to educating and training professionals, academics, community leaders, students and others about the subject area, and providing them with the necessary tools to affect change and eliminate health disparities. This paper chronicles the development of a unique health disparities and social justice research educational program held annually by The University of Texas M. D. Anderson Cancer Center, Center for Research on Minority Health. The program is composed of a college semester course and summer workshop, which in the past five years, has become a preeminent program in the United States. The program's impetus, premise, evaluation, and future directions are discussed

Cancer Screening Practices Among Chinese and Vietnamese in the Greater Houston Area

National data on Asian Americans indicate that compared to other groups in the US, cancer incidence and prevalence is relatively lower (Miller, Kolonel et al. 1996; American Cancer Society 2006). However, when the data is examined further based on specific Asian subgroups and for specific cancers, Asian Americans bear a disproportionate burden for cancers of infectious origin, such as cervical, liver, and stomach cancer (Chen 2005). Furthermore, Asian Americans are also experiencing increasing rates of cancers associated with “Westernization,” such as breast and prostate cancer (Kolonel, Yoshizawa et al. 1988; Whittemore, Kolonel et al. 1995; Ziegler, Hoover et al. 1996). Early detection and screening are among the frontline strategies in cancer control, yet Asian American and Pacific Islanders have the lowest cancer screening rates of all ethnic groups in the US (American Cancer Society 2006). The Asian American Health Needs Assessment (AsANA) project was designed to collect data on the rapidly growing Asian American community in the Greater Houston area. The AsANA project included a telephone survey to over 800 randomly selected households in the Chinese and Vietnamese communities, two of the largest Asian American subgroups in Texas. Included in the telephone interview were questions regarding cancer screening practices. This article describes the reported screening practices among the surveyed populations and discusses the implications for developing targeted programs that can address cancer screening disparities in this community

Residential Perceptions of Environmental Exposures and Associated Health Effects in the Fresno, Texas Community

Background: Environmental contaminants are often located in areas heavily populated by African Americans, Hispanics/Latinos, and the poor. In many communities, the discovery of environmental hazards occurs following concern and investigation by its constituents. The residents of Fresno, Texas, which is a predominantly minority community located near Houston, Texas, have long-standing undocumented concerns related to potential environmental exposures and associated health effects. To begin to document the concerns of the members of the Fresno community, we used focus group methodology to examine the resident’s perceptions of the environment in the Fresno community, potential routes and sources of environmental exposures, and how Fresno residents perceived that these environmental hazards could affect their health. Methods: Focus group methodology was used to assess the Fresno communities’ perceptions of environmental exposure, perceived routes of exposure, and perceived adverse health affects. Nineteen Fresno residents took part in four focus group discussions that were recorded, transcribed, and analyzed using content analysis. Results: The residential participants overwhelmingly described poor water quality in the Fresno community. While some residents perceived that the air quality was good or clear, others described the air as poor or potentially dangerous. Some residents identified the local chemical companies, a landfill, chlorination, and a lack of public water supply as potential sources of contamination in the Fresno community. The residents perceived that environmental exposures could potentially affect their health status, in particular the drinking water. Conclusions: The findings of our study convey the concerns of the members of the Fresno community. Potential environmental exposures were identified along with sources of environmental hazards. Although there were differing perceptions of air quality, the perceptions of water quality and sources of contamination were consistent. These findings should be used in developing a larger-scale environmental health assessment in the Fresno community to examine self-reported health status and measure contaminant levels in the residential drinking water

Lifestyle factors and ovarian cancer outcomes

Purpose: Few studies have reported on the lifestyle characteristics of ovarian cancer survivors. The objectives of this study were to characterize the associations between physical activity (PA) and body size (BS) with health-related quality of life (HRQOL) and ovarian cancer recurrence in a sample of regional and distal stage ovarian cancer survivors. Methods: Epithelial ovarian cancer survivors in their first clinical remission, with no evidence of recurrent disease were identified from The University of Texas MD Anderson Cancer Center tumor registry. A total of 51 survivors consented to participate in a battery of self-reported questionnaires. Trained staff collected data on anthropometric and recurrence data were collected from the tumor registry. Generalized linear models were used to assess the relationship between PA, BS, and HRQOL. Cox proportional hazard models were used to assess the associations between PA, BS, and recurrence-free survival. Results: Most (59%) women were overweight or obese (BMI \u3c 25 kg/m2) , 49% met current guidelines for PA (150 minutes of moderate to vigorous PA/week), and 29% displayed characteristics of abdominal obesity (\u3e88 centimeters). Women who were not obese reported significantly higher (better) overall HRQOL (point difference = 10.8, P \u3c 0.05) and mental health (point difference = 12.4, P \u3c 0.05) scores than women who were obese. Elevated waist circumference and physical activity were not significantly associated with HRQOL outcomes and we did not find any associations between lifestyle behaviors and recurrence free survival (all P \u3e 0.05). Conclusions: Ovarian cancer survivors with characteristics of overall and abdominal obesity may be at risk for deficits in HRQOL and could benefit from interventions designed to reduce weight. More research is needed to determine whether meeting guidelines for physical activity is associated with improvements in health outcomes this population

Helical Jet in the Gravitationally Lensed Blazar PKS1830-211

Recent radio VLBI observations of the complex gravitationally lensed system PKS1830-211 have thrown up some questions with regard to the processes occuring at the heart of the blazar source at a redshift of 2.51, which is viewed almost straight down the jet axis. This work links, by a model of a helical jet tracked by ballistically ejected plasmons from a precessing nozzle, observations on the scale of tens of microarcseconds to those on the scale of milliarcseconds. An observed jet precession period of 1.08 years is inferred from the model, translating to an intrinsic period of 30.8 years for a source at redshift 2.51 and an assumed jet bulk velocity of 0.99 c. This fits well with the picture of an active galactic nucleus hosting a binary black hole system at its centre, with the jet emitted by one member of the system, and the precession as being due to its orbital motion around its companion.Comment: Accepted for publication in the MNRA

The stealth episome: suppression of gene expression on the excised genomic island PPHGI-1 from Pseudomonas syringae pv. phaseolicola

Pseudomonas syringae pv. phaseolicola is the causative agent of halo blight in the common bean, Phaseolus vulgaris. P. syringae pv. phaseolicola race 4 strain 1302A contains the avirulence gene avrPphB (syn. hopAR1), which resides on PPHGI-1, a 106 kb genomic island. Loss of PPHGI-1 from P. syringae pv. phaseolicola 1302A following exposure to the hypersensitive resistance response (HR) leads to the evolution of strains with altered virulence. Here we have used fluorescent protein reporter systems to gain insight into the mobility of PPHGI-1. Confocal imaging of dual-labelled P. syringae pv. phaseolicola 1302A strain, F532 (dsRFP in chromosome and eGFP in PPHGI-1), revealed loss of PPHGI-1::eGFP encoded fluorescence during plant infection and when grown in vitro on extracted leaf apoplastic fluids. Fluorescence-activated cell sorting (FACS) of fluorescent and non-fluorescent PPHGI-1::eGFP F532 populations showed that cells lost fluorescence not only when the GI was deleted, but also when it had excised and was present as a circular episome. In addition to reduced expression of eGFP, quantitative PCR on sub-populations separated by FACS showed that transcription of other genes on PPHGI-1 (avrPphB and xerC) was also greatly reduced in F532 cells harbouring the excised PPHGI-1::eGFP episome. Our results show how virulence determinants located on mobile pathogenicity islands may be hidden from detection by host surveillance systems through the suppression of gene expression in the episomal state