7 research outputs found
A comprehensive mechanistic basis of prostate cancer advancement & its personalized implementation-bridging the gap: present state and future prospect
Despite significant achievements in prostate cancer mechanistic understanding
and its targeted therapies, currently there exists several major challenges that
mainly arises during the therapy of advanced prostate cancer. Present prostate
cancer precision medicine strategy principally suffers from several practical
concerns, particularly in point of therapeutic resistance, tumor heterogeneity,
complex clinical & pathological behavior and an extensive genomic perturbation
landscape.
Prostate Cancer Systems-Medicine Initiative is a global
trans-disciplinary movement taken from corresponding scientific domains to
critically determine the nature of this major existing challenges and its
corresponding most possible solutions by systematically accumulating the present
existing knowledge. Basically, it explains the importance of broad spectrum
cancer hallmark based integrative approaches for development of combination
therapy associated strategic measures for metastatic castration resistant
prostate cancer. The major findings of this initiative can be summarized by
identification of 136 therapeutic resistance mediators, 103 prostate cancer
driver oncogenes and 8 progression pathways along with 5 terrain factors which
centrally drives the basic events in prostate cancer pathogenesis, its further
metastatic propagation and ultimate therapeutic resistance. In addition, it also
attempts to summarize the critical features and basic challenging aspects of
current therapeutic options