16 research outputs found
Comparative Investigations of Social Context-Dependent Dominance in Captive Chimpanzees (Pan troglodytes) and Wild Tibetan Macaques (Macaca thibetana)
Theoretical definitions of dominance, how dominance is structured and organized in nature, and how dominance is measured have varied as investigators seek to classify and organize social systems in gregarious species. Given the variability in behavioral measures and statistical methods used to derive dominance rankings, we conducted a comparative analysis of dominance using existing statistical techniques to analyze dominance ranks, social context-dependent dominance structures, the reliability of statistical analyses, and rank predictability of dominance structures on other social behaviors. We investigated these topics using behavioral data from captive chimpanzees (Pan troglodytes) and wild Tibetan macaques (Macaca thibetana). We used a combination of all-occurrence, focal-animal, and instantaneous scan sampling to collect social, agonistic, and associative data from both species. We analyzed our data to derive dominance ranks, test rank reliability, and assess cross-context predictability using various statistical analyses. Our results indicate context-dependent dominance and individual social roles in the captive chimpanzee group, one broadly defined dominance structure in the Tibetan macaque group, and high within-context analysis reliability but little cross-context predictability. Overall, we suggest this approach is preferable over investigations of dominance where only a few behavioral metrics and statistical analyses are utilized with little consideration of rank reliability or cross-context predictability
IL-17 expression by breast-cancer-associated macrophages: IL-17 promotes invasiveness of breast cancer cell lines
Cyclic-di-GMP regulates lipopolysaccharide modification and contributes to Pseudomonas aeruginosa immune evasion
Pseudomonas aeruginosa is a Gram-negative bacterial pathogen associated with acute and chronic
infections. The universal c-di-GMP second messenger is instrumental in the switch from a motile
lifestyle to resilient biofilm as in the cystic fibrosis lung. The SadC diguanylate cyclase is
associated with this patho-adaptive transition. Here we identified an unrecognized SadC partner,
WarA, which we show is a methyltransferase in complex with a putative kinase WarB. We
established that WarA binds to c-di-GMP, which potentiates its methyltransferase activity.
Together, WarA and WarB have structural similarities with the bi-functional Escherichia coli LPS
O antigen regulator WbdD. Strikingly, WarA influences P. aeruginosa O antigen modal
distribution and interacts with the LPS biogenesis machinery. LPS is known to modulate the
immune response in the host, and by using a zebrafish infection model, we implicate WarA in the
ability of P. aeruginosa to evade detection by the host.BBSRC & Wellcome Trus
Human caregivers are integrated social partners for captive chimpanzees
In a captive environment, it is challenging to ensure the highest level of social and psychological well-being for species with naturally complex social organizations and structures. There is a growing need to meet the social requirements for individuals of these species, especially chimpanzees, housed in zoos, sanctuaries, rehabilitation centers, and laboratories. Complex social interactions and broader social structures can be aptly described via social network analysis. We expand on the literature regarding captive chimpanzee social networks, but uniquely consider their human caregivers as potential social partners. We observed the social interactions between one group of seven chimpanzees (Pan troglodytes) and their caregivers in six behavioral contexts (nearest neighbor, play, aggression, grooming, grooming solicitation, and social vigilance) at Chimpanzee Sanctuary Northwest (USA). By constructing multiple chimpanzee and chimpanzee-caregiver social networks, our results indicate that caregivers are integrated partners in this group’s social structure. Additionally, we observed that the type and strength of chimpanzee-caregiver relationships varied between the chimpanzees. These results support the notion that caregivers offer additional opportunities (i.e., beyond those with conspecifics) for captive chimpanzees to construct and maintain meaningful social relationships. Our results show that considerations of captive primate social dynamics should include caregivers as potentially important social partners. Our results also highlight the importance of evaluating individual chimpanzee characteristics when developing philosophies of care and adopting husbandry practices that offer fulfilling social niches. Our findings bear influence on contemporary discussions of interspecies social relationships, captive welfare, health, translocation, and husbandry protocols for captive chimpanzees and other nonhuman primates
Short-Term Survival and Effects of Transmitter Implantation Into Western Grebes Using a Modified Surgical Procedure
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A Systematic Framework to Rapidly Obtain Data on Patients with Cancer and COVID-19: CCC19 Governance, Protocol, and Quality Assurance
When the COVID-19 pandemic began, formal frameworks to collect data about affected patients were lacking. The COVID-19 and Cancer Consortium (CCC19) was formed to collect granular data on patients with cancer and COVID-19 at scale and as rapidly as possible. CCC19 has grown from five initial institutions to 125 institutions with >400 collaborators. More than 5,000 cases with complete baseline data have been accrued. Future directions include increased electronic health record integration for direct data ingestion, expansion to additional domestic and international sites, more intentional patient involvement, and granular analyses of still-unanswered questions related to cancer subtypes and treatments.
When the COVID-19 pandemic began, formal frameworks to collect data about affected patients were lacking. The COVID-19 and Cancer Consortium (CCC19) was formed to collect granular data on patients with cancer and COVID-19 at scale and as rapidly as possible. CCC19 has grown from five initial institutions to 125 institutions with >400 collaborators. More than 5,000 cases with complete baseline data have been accrued. Future directions include increased electronic health record integration for direct data ingestion, expansion to additional domestic and international sites, more intentional patient involvement, and granular analyses of still-unanswered questions related to cancer subtypes and treatments