A Moral Dilemma for the Political Psychologist: Decreasing Criminal Violence as Symptom

This article describes two approaches to decreasing criminal violence and the moral dilemma in choosing between them

Genetics of human neural tube defects

Neural tube defects (NTDs) are common, severe congenital malformations whose causation involves multiple genes and environmental factors. Although more than 200 genes are known to cause NTDs in mice, there has been rather limited progress in delineating the molecular basis underlying most human NTDs. Numerous genetic studies have been carried out to investigate candidate genes in cohorts of patients, with particular reference to those that participate in folate one-carbon metabolism. Although the homocysteine remethylation gene MTHFR has emerged as a risk factor in some human populations, few other consistent findings have resulted from this approach. Similarly, attention focused on the human homologues of mouse NTD genes has contributed only limited positive findings to date, although an emerging association between genes of the non-canonical Wnt (planar cell polarity) pathway and NTDs provides candidates for future studies. Priorities for the next phase of this research include: (i) larger studies that are sufficiently powered to detect significant associations with relatively minor risk factors; (ii) analysis of multiple candidate genes in groups of well-genotyped individuals to detect possible gene–gene interactions; (iii) use of high throughput genomic technology to evaluate the role of copy number variants and to detect ‘private’ and regulatory mutations, neither of which have been studied to date; (iv) detailed analysis of patient samples stratified by phenotype to enable, for example, hypothesis-driven testing of candidates genes in groups of NTDs with specific defects of folate metabolism, or in groups of fetuses with well-defined phenotypes such as craniorachischisis

Cardio-metabolic risk factors and cortical thickness in a neurologically healthy male population: results from the psychological, social and biological determinants of ill health (pSoBid) study

<p>Introduction: Cardio-metabolic risk factors have been associated with poor physical and mental health. Epidemiological studies have shown peripheral risk markers to be associated with poor cognitive functioning in normal healthy population and in disease. The aim of the study was to explore the relationship between cardio-metabolic risk factors and cortical thickness in a neurologically healthy middle aged population-based sample.</p> <p>Methods: T1-weighted MRI was used to create models of the cortex for calculation of regional cortical thickness in 40 adult males (average age = 50.96 years), selected from the PSOBID study. The relationship between cardio-vascular risk markers and cortical thickness across the whole brain, were examined using the general linear models. The relationship with various covariates of interest was explored.</p> <p>Results: Lipid fractions with greater triglyceride content (TAG, VLDL and LDL) were associated with greater cortical thickness pertaining to a number of regions in the brain. Greater C reactive protein (CRP) and Intercellular adhesion molecule (ICAM-1) levels were associated with cortical thinning pertaining to perisylvian regions in the left hemisphere. Smoking status and education status were significant covariates in the model.</p> <p>Conclusions: This exploratory study adds to a small body of existing literature increasingly showing a relationship between cardio-metabolic risk markers and regional cortical thickness involving a number of regions in the brain in a neurologically normal middle aged sample. A focused investigation of factors determining the inter-individual variations in regional cortical thickness in the adult brain could provide further clarity in our understanding of the relationship between cardio-metabolic factors and cortical structures.</p&gt

Avaliação da aterosclerose subclínica e de níveis plasmáticos de LDL minimamente modificada em pacientes com espondilite anquilosante e sua correlação com a atividade da doença

AbstractIntroductionAccelerated atherosclerosis has been shown in some autoimmune diseases, mainly in Systemic Lupus Erythematosus and Rheumatoid Arthritis. Although high preva- lence of corticosteroids use may be a confounding factor due to their detrimental effects on several risk factors, systemic inflammation per se is supposed to play an important role in atherogenesis in these patients.MethodsWe have evaluated sub-clinical atherosclerosis and plasma levels of circulating electronegative LDL, which represents the fraction of LDL that is minimally modified, in patients with ankylosing spondylitis (AS). Fourteen patients who fulfilled the modified New York criteria for AS were compared with 13 paired controls. Carotid intimal-media thick- ness (IMT) was assessed by ultrasonography bilaterally in common carotid artery, internal carotid artery and in the bifurcation. Groups were homogeneous regarding cardiovascular risk factors. Only a single patient in AS group was in use of corticosteroid.ResultsThe presence of active inflammation was demonstrated by elevated BASDAI and higher CRP levels and in patients versus controls (12.36 vs. 3.45mg/dl, P = 0.002). No dif- ference was found in carotid IMT between both groups, in any site of artery. Averaged IMT (6 measurements, at 3 pre-specified sites bilaterally) was 0.72 ± 0.28 in AS group and 0.70 ± 0.45mm in controls (P = 0.91). Minimally modified LDL did not differ significantly either between patients and controls (14.03 ± 17.40 vs. 13.21 ± 10.21; P = 0.88).ConclusionsPatients with AS did not show increased carotid IMT in comparison to con- trols. In the same way, circulating plasma levels of LDL (-), did not differ significantly in both groups

Testing MOS precipitation downscaling for ENSEMBLES regional climate models over Spain

Model Output Statistics (MOS) has been recently proposed as an alternative to the standard perfect prognosis statistical downscaling approach for Regional Climate Model (RCM) outputs. In this case, the model output for the variable of interest (e.g. precipitation) is directly downscaled using observations. In this paper we test the performance of a MOS implementation of the popular analog methodology (referred to as MOS analog) applied to downscale daily precipitation outputs over Spain. To this aim, we consider the state‐of‐the‐art ERA40‐driven RCMs provided by the EU‐funded ENSEMBLES project and the Spain02 gridded observations data set, using the common period 1961–2000. The MOS analog method improves the representation of the mean regimes, the annual cycle, the frequency and the extremes of precipitation for all RCMs, regardless of the region and the model reliability (including relatively low‐performing models), while preserving the daily accuracy. The good performance of the method in this complex climatic region suggests its potential transferability to other regions. Furthermore, in order to test the robustness of the method in changing climate conditions, a cross‐validation in driest or wettest years was performed. The method improves the RCM results in both cases, especially in the former

When emotions matter: focusing on emotion improves working memory updating in older adults

Research indicates that emotion can affect the ability to monitor and replace content in working memory, an executive function that is usually referred to as updating. However, it is less clear if the effects of emotion on updating vary with its relevance for the task and with age. Here, 25 younger (20–34 years of age) and 25 older adults (63–80 years of age) performed a 1-back and a 2-back task, in which they responded to younger, middle-aged, and older faces showing neutral, happy or angry expressions. The relevance of emotion for the task was manipulated through instructions to make match/non-match judgments based on the emotion (i.e., emotion was task-relevant) or the age (i.e., emotion was task-irrelevant) of the face. It was found that only older adults updated emotional faces more readily compared to neutral faces as evidenced by faster RTs on non-match trials. This emotion benefit was observed under low-load conditions (1-back task) but not under high-load conditions (2-back task) and only if emotion was task-relevant. In contrast, task-irrelevant emotion did not impair updating performance in either age group. These findings suggest that older adults can benefit from task-relevant emotional information to a greater extent than younger adults when sufficient cognitive resources are available. They also highlight that emotional processing can buffer age-related decline in WM tasks that require not only maintenance but also manipulation of material

CHOLINESTERASE INHIBITORS FOR ALZHEIMER’S DISEASE AND THE HEART: AN UPDATE

Acetylcholinesterase inhibitors (AChEIs) are widely used in the symptomatic treatment of Alzheimer's disease, a disease that is afflicting a major part of our greying population. Their mechanism of action is based upon non-specific cholinergic stimulation, thereby potentially inducing cardiac beneficial or adverse effects. Data of large observational studies demonstrated a small but significant cardiac risk for all registered AChEIs (donepezil, galantamine and rivastigmine) not observed in previous clinical trials. This might be explained by a non-selective approach for prescribing AChEIs, thereby also including older persons with coexisting diseases or using several drugs, opposed to a selective patient recruitment in trials. Although there is no consensus on the management, we recommend attentiveness for cardiac symptoms and heart rhythm in every patient treated with AChEIs, and plea for a vigilant use of AChEIs in elderly patients at increased risk for cardiac adverse effects.status: publishe