1,517 research outputs found
Circumventing antivector immunity: potential use of nonhuman adenoviral vectors
Adenoviruses are efficient gene delivery vectors based on their ability to transduce a wide variety of cell types and drive high-level transient transgene expression. While there have been advances in modifying human adenoviral (HAdV) vectors to increase their safety profile, there are still pitfalls that need to be further addressed. Preexisting humoral and cellular immunity against common HAdV serotypes limits the efficacy of gene transfer and duration of transgene expression. As an alternative, nonhuman AdV (NHAdV) vectors can circumvent neutralizing antibodies against HAdVs in immunized mice and monkeys and in human sera, suggesting that NHAdV vectors could circumvent preexisting humoral immunity against HAdVs in a clinical setting. Consequently, there has been an increased interest in developing NHAdV vectors for gene delivery in humans. In this review, we outline the recent advances and limitations of HAdV vectors for gene therapy and describe examples of NHAdV vectors focusing on their immunogenicity, tropism, and potential as effective gene therapy vehicles
Phantom-Like Behavior of a DGP-Inspired Scalar-Gauss-Bonnet Gravity
We study the phantom-like behavior of a DGP-inspired braneworld scenario
where curvature correction on the brane is taken into account. We include a
possible modification of the induced gravity on the brane by incorporating
higher order curvature terms of Gauss-Bonnet type. We investigate the
cosmological implications of the model and we show that the normal branch of
the scenario self-accelerates in this modified scenario without introducing any
dark energy component. Also, a phantom-like behavior can be realized in this
model without introducing any phantom field that suffers from serious
difficulties such as violation of the null energy condition.Comment: 20 pages, revised version, typos fixed, new references, to appear in
JCA
Charge and spin configurations in the coupled quantum dots with Coulomb correlations induced by tunneling current
We investigated the peculiarities of non-equilibrium charge states and spin
configurations in the system of two strongly coupled quantum dots (QDs) weakly
connected to the electrodes in the presence of Coulomb correlations. We
analyzed the modification of non-equilibrium charge states and different spin
configurations of the system in a wide range of applied bias voltage and
revealed well pronounced ranges of system parameters where negative tunneling
conductivity appears due to the Coulomb correlations.Comment: 10 pages, 6 figure
Cranked Relativistic Hartree-Bogoliubov Theory: Superdeformed Bands in the Region
Cranked Relativistic Hartree-Bogoliubov (CRHB) theory is presented as an
extension of Relativistic Mean Field theory with pairing correlations to the
rotating frame. Pairing correlations are taken into account by a finite range
two-body force of Gogny type and approximate particle number projection is
performed by Lipkin-Nogami method. This theory is applied to the description of
yrast superdeformed rotational bands observed in even-even nuclei of the mass region. Using the well established parameter sets NL1 for the
Lagrangian and D1S for the pairing force one obtains a very successful
description of data such as kinematic () and dynamic ()
moments of inertia without any adjustment of new parameters. Within the present
experimental accuracy the calculated transition quadrupole moments agree
reasonably well with the observed data.Comment: 6 pages including 4 PostScript figures, uses RevTex, revised version,
Phys.Rev. C, Rapid Communications, in pres
QED Effects in Heavy Few-Electron Ions
Accurate calculations of the binding energies, the hyperfine splitting, the
bound-electron g-factor, and the parity nonconservation effects in heavy
few-electron ions are considered. The calculations include the relativistic,
quantum electrodynamic (QED), electron-correlation, and nuclear effects. The
theoretical results are compared with available experimental data. A special
attention is focused on tests of QED in a strong Coulomb field.Comment: 28 pages, 6 tables, 5 figure
Relative spins and excitation energies of superdeformed bands in 190Hg: Further evidence for octupole vibration
An experiment using the Eurogam Phase II gamma-ray spectrometer confirms the
existence of an excited superdeformed (SD) band in 190Hg and its very unusual
decay into the lowest SD band over 3-4 transitions. The energies and dipole
character of the transitions linking the two SD bands have been firmly
established. Comparisons with RPA calculations indicate that the excited SD
band can be interpreted as an octupole-vibrational structure.Comment: 12 pages, latex, 4 figures available via WWW at
http://www.phy.anl.gov/bgo/bc/hg190_nucl_ex.htm
Tri-meson-mixing of -- and -- in the light-cone quark model
The radiative transition form factors of the pseudoscalar mesons {,
, } and the vector mesons {, , } are restudied
with -- and -- in tri-meson-mixing
pattern, which is described by tri-mixing matrices in the light-cone
constituent quark model. The experimental transition decay widths are better
reproduced with tri-meson-mixing than previous results in a two-mixing-angle
scenario of only two-meson - mixing and - mixing.Comment: 8 pages, 6 figures, final version to appear in EPJ
Non-Minimal Warm Inflation and Perturbations on the Warped DGP Brane with Modified Induced Gravity
We construct a warm inflation model with inflaton field non-minimally coupled
to induced gravity on a warped DGP brane. We incorporate possible modification
of the induced gravity on the brane in the spirit of -gravity. We study
cosmological perturbations in this setup. In the case of two field inflation
such as warm inflation, usually entropy perturbations are generated. While it
is expected that in the case of one field inflation these perturbations to be
removed, we show that even in the absence of the radiation field, entropy
perturbations are generated in our setup due to non-minimal coupling and
modification of the induced gravity.Comment: 29 pages, 7 figures, Accepted by Gen. Rel Gravi
Pion, kaon, proton and anti-proton transverse momentum distributions from p+p and d+Au collisions at GeV
Identified mid-rapidity particle spectra of , , and
from 200 GeV p+p and d+Au collisions are reported. A
time-of-flight detector based on multi-gap resistive plate chamber technology
is used for particle identification. The particle-species dependence of the
Cronin effect is observed to be significantly smaller than that at lower
energies. The ratio of the nuclear modification factor () between
protons and charged hadrons () in the transverse momentum
range GeV/c is measured to be
(stat)(syst) in minimum-bias collisions and shows little
centrality dependence. The yield ratio of in minimum-bias d+Au
collisions is found to be a factor of 2 lower than that in Au+Au collisions,
indicating that the Cronin effect alone is not enough to account for the
relative baryon enhancement observed in heavy ion collisions at RHIC.Comment: 6 pages, 4 figures, 1 table. We extended the pion spectra from
transverse momentum 1.8 GeV/c to 3. GeV/
Modified GBIG Scenario as an Alternative for Dark Energy
We construct a DGP-inspired braneworld model where induced gravity on the
brane is modified in the spirit of gravity and stringy effects are taken
into account by incorporation of the Gauss-Bonnet term in the bulk action. We
explore cosmological dynamics of this model and we show that this scenario is a
successful alternative for dark energy proposal. Interestingly, it realizes the
phantom-like behavior without introduction of any phantom field on the brane
and the effective equation of state parameter crosses the cosmological constant
line naturally in the same way as observational data suggest.Comment: 16 pages, 6 figures, Accepted for publication in JCA
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