Features-Aware DDoS Detection in Heterogeneous Smart Environments based on Fog and Cloud Computing

Nowadays, urban environments are deploying smart environments (SEs) to evolve infrastructures, resources, and services. SEs are composed of a huge amount of heterogeneous devices, i.e., the SEs have both personal devices (smartphones, notebooks, tablets, etc) and Internet of Things (IoT) devices (sensors, actuators, and others). One of the existing problems of the SEs is the detection of Distributed Denial of Service (DDoS) attacks, due to the vulnerabilities of IoT devices. In this way, it is necessary to deploy solutions that can detect DDoS in SEs, dealing with issues like scalability, adaptability, and heterogeneity (distinct protocols, hardware capacity, and running applications). Within this context, this article presents an Intelligent System for DDoS detection in SEs, applying Machine Learning (ML), Fog, and Cloud computing approaches. Additionally, the article presents a study about the most important traffic features for detecting DDoS in SEs, as well as a traffic segmentation approach to improve the accuracy of the system. The experiments performed, using real network traffic, suggest that the proposed system reaches 99% of accuracy, while reduces the volume of data exchanged and the detection time

Analysis of neuroretinal rim distribution and vascular pattern in eyes with presumed large physiological cupping: a comparative study

Background: To investigate possible differences in neuroretinal rim distribution, vascular pattern, and peripapillary region appearance between eyes with presumed large physiological optic disc cupping (pLPC) and eyes with minimal optic disc excavation.Methods: We prospectively enrolled consecutive subjects with pLPC and individuals with minimal excavation (optic disc excavation within normal limits; control group). All eyes had normal visual fields and untreated intraocular pressure (IOP) = 0.6 and >= 30 months of follow-up with no evidence of glaucomatous neuropathy. for controls, VCDR was limited to <= 0.5. We compared ocular signs and characteristics related to the neuroretinal rim distribution, vascular pattern, peripapillary region appearance and disc size between groups. Whenever both eyes were eligible, one was randomly selected for analysis.Results: A total of 74 patients (mean age, 45.6 +/- 14.9 years) with pLPC and 45 controls (mean age, 44.8 +/- 11.6 years) were enrolled (p = 0.76). Median disc size and VCDR was significantly larger in eyes with pLPC compared to controls (p < 0.01). the proportion of eyes with violation of the ISNT rule, laminar dot sign, nasal shifting of the central vessels, nasal excavation and baring of circumlinear vessel was significantly greater in the eyes with pLPC compared to controls (p < 0.01). There were no significant differences regarding the proportions of eyes with peripapillary atrophy between groups (p < 0.09). Finally, disc size was significantly associated with VCDR (r(2) = 0.47, p < 0.01), with an increase of 0.21 in VCDR for each 1 mm(2) in disc area.Conclusion: Compared to normal controls, eyes with pLPC may present a higher proportion of optic nerve head findings frequently observed in glaucomatous eyes. This seems to be explained in part by the larger discs found in these eyes. We believe care should be taken while classifying them as glaucomatous or not based solely on these characteristics.Universidade Federal de São Paulo, Dept Ophthalmol, BR-04021001 São Paulo, BrazilHosp Med Olhos, Glaucoma Unit, BR-06018180 Osasco, SP, BrazilMayo Clin, Dept Ophthalmol, Jacksonville, FL 32224 USAUniversidade Federal de São Paulo, Dept Ophthalmol, BR-04021001 São Paulo, BrazilWeb of Scienc

March1-dependent modulation of donor MHC II on CD103+ dendritic cells mitigates alloimmunity.

In transplantation, donor dendritic cells (do-DCs) initiate the alloimmune response either by direct interaction with host T cells or by transferring intact donor MHC to host DCs. However, how do-DCs can be targeted for improving allograft survival is still unclear. Here we show CD103+ DCs are the major do-DC subset involved in the acute rejection of murine skin transplants. In the absence of CD103+ do-DCs, less donor MHC-II is carried to host lymph nodes, fewer allogenic T cells are primed and allograft survival is prolonged. Incubation of skin grafts with the anti-inflammatory mycobacterial protein DnaK reduces donor MHC-II on CD103+DCs and prolongs graft survival. This effect is mediated through IL-10-induced March1, which ubiquitinates and decreases MHC-II levels. Importantly, in vitro pre-treatment of human DCs with DnaK reduces their ability to prime alloreactive T cells. Our findings demonstrate a novel therapeutic approach to dampen alloimmunity by targeting donor MHC-II on CD103+DCs

Type 2 diabetes mellitus alters cardiac mitochondrial content and function in a non-obese mice model

Type 2 diabetes mellitus (T2DM) is associated with an increase of premature appearance of several disorders such as cardiac complications. Thus, we test the hypothesis that a combination of a high fat diet (HFD) and low doses of streptozotocin (STZ) recapitulate a suitable mice model of T2DM to study the cardiac mitochondrial disturbances induced by this disease. Animals were divided in 2 groups: the T2DM group was given a HFD and injected with 2 low doses of STZ, while the CNTRL group was given a standard chow and a buffer solution. The combination of HFD and STZ recapitulate the T2DM metabolic profile showing higher blood glucose levels in T2DM mice when compared to CNTRL, and also, insulin resistance. The kidney structure/function was preserved. Regarding cardiac mitochondrial function, in all phosphorylative states, the cardiac mitochondria from T2DM mice presented reduced oxygen fluxes when compared to CNTRL mice. Also, mitochondria from T2DM mice showed decreased citrate synthase activity and lower protein content of mitochondrial complexes. Our results show that in this non-obese T2DM model, which recapitulates the classical metabolic alterations, mitochondrial function is impaired and provides a useful model to deepen study the mechanisms underlying these alterations.This study was supported by Coordenacao de aperfeicoamento de pessoal de nivel superior (CAPES), Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) and Fundacao de Amparo a Pesquisa do Estado do Rio de Janeiro (FAPERJ)

Participation in the International Judo Federation World Tour competitions and performance in Tokyo Olympic Games

IntroductionThe International Judo Federation introduced a ranking system in 2009 that determines top athletes for the Olympic Games and seeds them in competitions. Previous research indicated that this ranking list and past performances predicted 19%–27% of performance in the Olympic Games and World Championships. However, due to the COVID-19 pandemic, the relationship between Judo World Tour competitions and Olympic Games performance may have been affected. This study aimed to examine the relationship between athletes' performance in Judo World Tour competitions and their competitive performance at the Olympic Games.MethodsData from 393 athletes who participated in the Tokyo Olympics were analyzed considering both long and short-term performance measures. Pearson correlation was used to determine the relationship between variables and multiple linear regressions were used to predict performance for each sex and the entire sample.ResultsThe results revealed a range of magnitudes in the correlation between variables, varying from small to large. In terms of regression analyses, it was observed that, for females, the percentage of matches won during the classification period and competition in the year prior to the Olympic Games predicted 37% of their performance. For males, the percentage of matches won during the classification period and competition in the six months before the Olympic Games predicted 36% of their performance.DiscussionThus, athletes’ quality and reduced exposure to competition near the Olympic Games appear to be important factors in their performance at the event

On the general one-dimensional XY Model: positive and zero temperature, selection and non-selection

We consider $(M,d)$ a connected and compact manifold and we denote by $\mathcal{B}_i$ the Bernoulli space $M^{\Z}$ of sequences represented by $$x=(... x_{-3},x_{-2},x_{-1},x_0,x_1,x_2,x_3,...),$$ where $x_i$ belongs to the space (alphabet) $M$. The case where $M=\mathbb{S}^1$, the unit circle, is of particular interest here. The analogous problem in the one-dimensional lattice $\mathbb{N}$ is also considered. %In this case we consider the potential $A: {\cal B}=M^\mathbb{N} \to \mathbb{R}.$ Let A: \mathcal{B}_i \rar \R be an {\it observable} or {\it potential} defined in the Bernoulli space $\mathcal{B}_i$. The potential $A$ describes an interaction between sites in the one-dimensional lattice $M^\mathbb{Z}$. Given a temperature $T$, we analyze the main properties of the Gibbs state $\hat{\mu}_{\frac{1}{T} A}$ which is a certain probability measure over ${\cal B}_i$. We denote this setting "the general XY model". In order to do our analysis we consider the Ruelle operator associated to $\frac{1}{T} A$, and, we get in this procedure the main eigenfunction $\psi_{\frac{1}{T} A}$. Later, we analyze selection problems when temperature goes to zero: a) existence, or not, of the limit (on the uniform convergence) $$V:=\lim_{T\to 0} T\, \log(\psi_{\frac{1}{T} A}),\,\,\,\,\text{a question about selection of subaction},$$ and, b) existence, or not, of the limit (on the weak$^*$ sense) $$\tilde{\mu}:=\lim_{T\to 0} \hat{\mu}_{\frac{1}{T}\, A},\,\,\,\,\text{a question about selection of measure}.$$ The existence of subactions and other properties of Ergodic Optimization are also considered

Rarity of monodominance in hyperdiverse Amazonian forests.

Tropical forests are known for their high diversity. Yet, forest patches do occur in the tropics where a single tree species is dominant. Such "monodominant" forests are known from all of the main tropical regions. For Amazonia, we sampled the occurrence of monodominance in a massive, basin-wide database of forest-inventory plots from the Amazon Tree Diversity Network (ATDN). Utilizing a simple defining metric of at least half of the trees ≥ 10 cm diameter belonging to one species, we found only a few occurrences of monodominance in Amazonia, and the phenomenon was not significantly linked to previously hypothesized life history traits such wood density, seed mass, ectomycorrhizal associations, or Rhizobium nodulation. In our analysis, coppicing (the formation of sprouts at the base of the tree or on roots) was the only trait significantly linked to monodominance. While at specific locales coppicing or ectomycorrhizal associations may confer a considerable advantage to a tree species and lead to its monodominance, very few species have these traits. Mining of the ATDN dataset suggests that monodominance is quite rare in Amazonia, and may be linked primarily to edaphic factors