10 research outputs found
News from Academy Bay
- Author
- Publication venue
- Publication date
- 01/06/2005
- Field of study
CDRS Research Highlights, 2004. Plants. Social Sciences. Vertebrates. Invasive Species Total Control Plan. Terrestrial Invertebrates. Project Isabela. Marine Sciences
Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity.
- Author
- Aanensen David M
- Abudahab Khalil
- Acheson Erwan
- Adams Alexander
- Adams Helen
- Adriaenssens Evelien M
- Afifi Safiah
- Aggarwal Dinesh
- Ahmad Shazaad SY
- Alam Mohammad T
- Alcolea-Medina Adela
- Alderton Alex
- Alikhan Nabil-Fareed
- Allan John
- Allara Elias
- Amato Roberto
- Andersson Monique
- Angyal Adrienn
- Aranday-Cortes Elihu
- Ariani Cristina
- Asad Hibo
- Asamaphan Patawee
- Ashworth Jordan
- Atkinson Laura
- Attwood Stephen
- Auckland Cressida
- Awan Ali R
- Aydin Alp
- Baker David J
- Baker Paul
- Balcazar Carlos E
- Ball Jonathan
- Barton Edward
- Bashton Matthew
- Batra Rahul
- Baxter Laura
- Beale Mathew A
- Beaver Charlotte
- Beckett Angela
- Beer Robert
- Beggs Andrew
- Bell Andrew
- Bellis Katherine L
- Berger Duncan J
- Berriman Matt
- Berry Lisa
- Berry Louise
- Betancor Gilberto
- Betteridge Emma
- Bewshea Claire M
- Bibby David
- Bicknell Kelly
- Birchley Alec
- Bird Paul
- Bishop Chloe
- Blane Beth
- Bolt Frances
- Bonsall David
- Boswell Tim
- Bosworth Andrew
- Bourgeois Yann
- Boyd Olivia
- Boyes John
- Bradley Declan T
- Bradshaw Daniel
- Breen Cassie
- Bresner Catherine
- Breuer Judith
- Bridgewater Hannah E
- Brooks Tony T
- Broos Alice
- Brown Julianne Rose
- Brown Paul E
- Brown Rebecca
- Brunker Kirstyn
- Bucca Giselda
- Buck David
- Buddenborg Sarah K
- Bull Matthew
- Bull Matthew
- Burton-Fanning Shirelle
- Butcher Ethan
- Caddy Sarah L
- Caller Laura G
- Campbell Sharon
- Carlile Matthew
- Carmichael Stephen N
- Casey Anna
- Castellano Sergi
- Chalker Vicki
- Chand Meera
- Chapman Michael R
- Chappell Joseph G
- Charalampous Themoula
- Charles Ian G
- Chaudhry Yasmin
- Chauhan Anoop J
- Cheng Jeffrey KJ
- Churcher Carol M
- Clark Gemma
- Coll Francesc
- Collins Jennifer
- Colquhoun Rachel
- Colquhoun Rachel M
- Connor Thomas R
- Connor Thomas R
- Constantinidou Chrystala
- Coombes Jason
- Corden Sally
- Cormie Claire
- Cortes Nicholas
- Cortes Nick
- Cottrell Simon
- Coupland Lindsay J
- Cowell Angela
- Cox Alison
- Craine Noel
- Cronin Michelle
- Crooke Derrick
- Curran Martin D
- Curran Tanya
- da Silva Filipe Ana
- da Silva Filipe Ana
- Dabrera Gavin
- Danesh John
- Darby Alistair C
- Davidson Rose K
- Davies Alisha
- Davis Thomas
- de Cesare Mariateresa
- De Lacy Elen
- de Oliveira Martins Leonardo
- de Silva Thushan I
- Debebe Johnny
- Dervisevic Samir
- Dewar Rebecca
- Dias Joana
- Diaz Maria
- Dibling Thomas
- Dorman Matthew J
- Downing Fatima
- Drury Eleanor
- du Plessis Louis
- Duckworth Nichola
- Dyal Patricia L
- Eccles Richard
- Edgeworth Jonathan
- Edwards Sue
- Eldirdiri Sahar
- Ellaby Nicholas
- Ellard Sian
- Elliott Scott
- Eltringham Gary
- Elumogo Ngozi
- Essex Sarah
- Evans Cariad
- Evans Johnathan M
- Eyre David
- Fairley Derek J
- Fallon Karlie
- Farbos Audrey
- Farr Ben
- Feltwell Theresa
- Fina Laia
- Findlay Jacqueline
- Fisher Chloe L
- Fleming Vicki M
- Forrest Leysa M
- Forrest Sally
- Foulser Luke
- Francois Sarah
- Fraser Christophe
- Freeman Timothy M
- Frost Lucy R
- Fuller William
- Gallagher Eileen
- Gallagher Michael D
- Garcia-Casado Maria V
- Gaskin Amy
- Gatica-Wilcox Bree
- Gavriil Artemis
- Geidelberg Lily
- Geidelberg Lily
- Gemmell Matthew
- Georgana Iliana
- George Ryan P
- Gifford Laura
- Gilbert Lauren
- Gill Harmeet K
- Gilroy Rachel AJ
- Girgis Sophia T
- Glaysher Sharon
- Golubchik Tanya
- Goncalves Sonia
- Goodfellow Ian
- Goodfellow Ian G
- Goodwin Scott
- Graham Clive
- Graham Lee
- Grammatopoulos Dimitris
- Green Angie
- Green Luke R
- Greenaway Jane
- Gregory Richard
- Griffith Luke
- Groves Danielle C
- Groves Natalie
- Guest Martyn
- Gulliver Huw
- Gutierrez Ana Victoria
- Hadjirin Nazreen F
- Haldenby Sam T
- Hale Antony D
- Hall Grant
- Halstead Fenella
- Hamilton William L
- Haque Tanzina
- Harper Katherine L
- Harris Kathryn Ann
- Harrison Ewan M
- Harrison Ian
- Harrison James W
- Hartman Hassan
- Hattersley Andrew
- Heaney Judith
- Helmer Thomas
- Hesketh Andrew R
- Heyburn David
- Higginson Ellen E
- Hill Verity
- Hill Verity
- Hilvers Ember
- Hiscox Julian A
- Holden Matthew TG
- Holmes Alison
- Holmes Christopher
- Holmes Nadine
- Hoosdally Sarah
- Hopes Richard
- Hosmillo Myra
- Houldcroft Charlotte J
- Howe Robin
- Howson-Wells Hannah C
- Hubb Jonathan
- Hughes Joseph
- Hughes Margaret
- Hunter Adam D
- Hutchings Stephanie
- Impey Robert
- Irish-Tavares Dianne
- Iturriza-Gomara Miren
- Jackson Ben
- Jackson Ben
- Jackson David A
- Jackson David K
- Jackson Kathryn A
- Jahun Aminu S
- James Keith
- Jamrozy Dorota
- Jarrett Ruth
- Jeffries Aaron R
- Jesudason Natasha
- Jesudason Natasha G
- John Michaela
- Johnson Kate
- Johnson Natasha
- Johnson Rob
- Johnson Robert
- Johnston Ian
- Jones Hannah
- Jones Katie
- Jones Rachel
- Jones Sophie
- Jorgensen David
- Jorgensen David
- Joseph Amelia
- Justice Anita
- Kane Leanne
- Kay Gemma L
- Kay Sally
- Keatley Jon-Paul
- Keeley Alexander J
- Kenyon Anita
- Kermack Leanne M
- Khakh Manjinder
- Khokhar Fahad A
- Kidd Stephen
- Kingsley Robert A
- Kitchen Christine
- Knight Bridget A
- Kolyva Anastasia
- Koshy Cherian
- Kraemer Moritz
- Kristiansen Mark
- Kumziene-Summerhayes Sara
- Kwiatkowski Dominic
- Lackenby Angie
- Langford Cordelia
- Lawniczak Mara
- Le-Viet Thanh
- Lee David
- Lee Jack CD
- Letchford Laura
- Levene Nick
- Levett Lisa J
- Li Kathy
- Li Kathy K
- Liggett Steven
- Lindsey Benjamin B
- Lister Michelle M
- Livett Rich
- Lloyd Allyson
- Lo Stephanie
- Loh Joshua
- Loman Nicholas J
- Loman Nicholas J
- Loose Matthew W
- Loveson Katie F
- Lowe Hannah
- Lucaci Anita O
- Ludden Catherine
- Lynch Jessica
- Lyons Ronan A
- Macfarlane-Smith Louissa R
- Machin Nicholas W
- MacIntyre-Cockett George
- Madona Pinglawathee
- Maes Mailis
- Mahungu Tabitha W
- Mair Daniel
- Maksimovic Joshua
- Manesis Nikos
- Manley Robin
- Manso Carmen
- Marchbank Angela
- Martincorena Inigo
- Martinez-Nunez Rocio T
- Masoli Jane AH
- Mason Jenifer
- Mather Alison E
- Mbisa Tamyo
- McCluggage Kathryn
- McClure Patrick C
- McCrone John T
- McCrone JT
- McGuigan Samantha
- McHugh Martin P
- McKenna James P
- McKerr Caoimhe
- McMinn Liz
- McMurray Claire
- Meader Emma J
- Meadows Lizzie
- Menegazzo Mirko
- Meredith Luke W
- Merrick Ian
- Mestek-Boukhibar Lamia
- Miah Shahjahan
- Michell Stephen L
- Michelsen Michelle L
- Molnar Zoltan
- Monaghan Lynn
- Mookerjee Siddharth
- Moore Catherine
- Moore Catrin
- Moore Christopher
- Moore Nathan
- Morgan Mari
- Morgan Sian
- Mori Matilde
- Moses Samuel
- Muir Peter
- Munn Robert
- Myers Richard
- Nascimento Fabricia F
- Nascimento Fabricia F
- Naydenova Plamena
- Neaverson Alexandra S
- Nebbia Gaia
- Nelson Andrew
- Nelson Charlotte
- Nelson Rachel
- Nicholls Sam
- Nicholls Samuel M
- Nichols Jenna
- Niebel Marc O
- Niola Paola
- Nomikou Kyriaki
- O'Toole Elaine
- O'Toole Áine
- Orton Richard J
- Osman Husam
- Ott Sascha
- O’Grady Justin
- O’Toole Áine
- Pacchiarini Nicole
- Pacchiarini Nicole
- Padgett Debra
- Page Andrew J
- Palmer Sophie
- Palmer Steve
- Panchbhaya Yasmin N
- Pandey Sarojini
- Park Naomi
- Parker Matthew D
- Parmar Surendra
- Parr Yasmin A
- Parsons Paul J
- Partridge David G
- Pascall David J
- Patel Gaurang
- Patel Minal
- Patel Vineet
- Paterson Steve
- Payne Brendan AI
- Peacock Sharon J
- Pearson Clare
- Perry Malorie
- Peto Timothy
- Pinckert Malte L
- Platt Steven
- Plimmer Amy
- Poplawski Radoslaw
- Potter Will
- Prakash Reenesh
- Prestwood Liam
- Price Anna
- Price Anna
- Price James
- Puethe Christoph
- Pybus Oliver
- Pybus Oliver G
- Pymont Hannah M
- Quail Mike
- Quick Joshua
- Raghwani Jayna
- Ragonnet-Cronin Manon
- Rainbow Lucille
- Rajatileka Shavanthi
- Rambaut Andrew
- Rambaut Andrew
- Ramsay Mary
- Randell Paul A
- Raviprakash Veena
- Raza Mohammad
- Resende Silva Paola C
- Rey Sara
- Rey Sara M
- Reynolds Nicola
- Richter Alex
- Robertson David L
- Robertson David L
- Robinson Esther
- Robinson Trevor I
- Robson Samuel C
- Rogers Hazel A
- Rooke Stefan
- Rowan Aileen
- Rowe Will
- Roy Sunando
- Rudder Steven
- Ruis Chris
- Ryan Felicity
- Sambles Christine M
- Sang Fei
- Scarlett Garry P
- Schaefer Ulf
- Scher Emily
- Scott Carol
- Scott Garren
- Sethi Dheeraj K
- Shaaban Sharif
- Shah Divya
- Shah Rajiv
- Shah Rajiv N
- Shankar Giri
- Shaw Robert
- Shepherd James
- Shepherd James G
- Sheriff Nicola
- Shirley Lesley
- Signell Adrian W
- Sillitoe John
- Simpson David A
- Singer Joshua B
- Sivaprakasam Venkat
- Siveroni Igor
- Siveroni Igor
- Sloan Tim J
- Sluga Graciela
- Smith Christen
- Smith Colin P
- Smith Darren L
- Smith Nikki
- Smith Wendy
- Smollett Katherine L
- Snell Luke B
- Souster Emily
- Southgate Joel
- Southgate Joel
- Spellman Karla
- Spencer-Chapman Michael
- Sridhar Sushmita
- Stanley Rachael
- Stanton Thomas D
- Starinskij Igor
- Stark Richard
- Stockton Joanne
- Stuart Claire
- Studholme David J
- Swindells Emma
- Swingler Tracey
- Taha Yusri
- Tang Julian
- Taylor Ben EW
- Taylor Graham P
- Taylor Sarah
- Taylor-Joyce Grace
- Tedim Ana P
- Temperton Ben
- Templeton Kate E
- Thompson Thomas
- Thomson Emma C
- Thomson Emma C
- Thomson Nicholas M
- Thornton Alicia
- Thurston Scott
- Todd John A
- Tong Lily
- Tonkin-Hill Gerry
- Torok M Estee
- Trebes Amy
- Trotter Alexander J
- Tsoleridis Theocharis
- Tucker Rachel M
- Turtle Lance
- Tutill Helena J
- Underwood Anthony P
- Unnikrishnan Meera
- Vamos Edith E
- Vasylyeva Tetyana
- Vattipally Sreenu
- Vipond Ian B
- Volz Erik
- Volz Erik M
- Wain John
- Walsh Sarah
- Wang Dennis
- Wantoch Michelle
- Warne Ben
- Warwick-Dugdale Joanna
- Wastenge Elizabeth
- Watkins Joanne
- Watts Joanne
- Waugh Sheila
- Webber Mark A
- Weeks Sam
- Weldon Danni
- Whitehead Mark
- Williams Charlotte A
- Williams Chris
- Williams David
- Williams Rachel J
- Williams Rebecca
- Williams Thomas
- Williamson Kathleen A
- Willingham Iona
- Wilson Harry D
- Wise Emma
- Workman Trudy
- Wright Victoria
- Wyles Matthew
- Wyllie Sarah
- Yakovleva Anna
- Yasir Muhammad
- Yeats Corin A
- Yew Wen C
- Young Gregory R
- Young Jamie
- Yu Xiaoyu
- Zarebski Alex
- Publication venue
- Cell
- Publication date
- 01/09/2020
- Field of study
Global dispersal and increasing frequency of the SARS-CoV-2 spike protein variant D614G are suggestive of a selective advantage but may also be due to a random founder effect. We investigate the hypothesis for positive selection of spike D614G in the United Kingdom using more than 25,000 whole genome SARS-CoV-2 sequences. Despite the availability of a large dataset, well represented by both spike 614 variants, not all approaches showed a conclusive signal of positive selection. Population genetic analysis indicates that 614G increases in frequency relative to 614D in a manner consistent with a selective advantage. We do not find any indication that patients infected with the spike 614G variant have higher COVID-19 mortality or clinical severity, but 614G is associated with higher viral load and younger age of patients. Significant differences in growth and size of 614G phylogenetic clusters indicate a need for continued study of this variant
Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity
- Author
- Aanensen David M.
- Abudahab Khalil
- Acheson Erwan
- Adams Alexander
- Adams Helen
- Adriaenssens Evelien M.
- Afifi Safiah
- Aggarwal Dinesh
- Ahmad Shazaad S.Y.
- Alam Mohammad T.
- Alcolea-Medina Adela
- Alderton Alex
- Alikhan Nabil-Fareed
- Allan John
- Allara Elias
- Amato Roberto
- Andersson Monique
- Angyal Adrienn
- Aranday-Cortes Elihu
- Ariani Cristina
- Asad Hibo
- Asamaphan Patawee
- Ashworth Jordan
- Atkinson Laura
- Attwood Stephen
- Auckland Cressida
- Awan Ali R.
- Aydin Alp
- Baker David J.
- Baker Paul
- Balcazar Carlos E.
- Ball Jonathan
- Barton Edward
- Bashton Matthew
- Batra Rahul
- Baxter Laura
- Beale Mathew A.
- Beaver Charlotte
- Beckett Angela
- Beer Robert
- Beggs Andrew
- Bell Andrew
- Bellis Katherine L.
- Berger Duncan J.
- Berriman Matt
- Berry Lisa
- Berry Louise
- Betancor Gilberto
- Betteridge Emma
- Bewshea Claire M.
- Bibby David
- Bicknell Kelly
- Birchley Alec
- Bird Paul
- Bishop Chloe
- Blane Beth
- Bolt Frances
- Bonsall David
- Boswell Tim
- Bosworth Andrew
- Bourgeois Yann
- Boyd Olivia
- Boyes John
- Bradley Declan T.
- Bradshaw Daniel
- Breen Cassie
- Bresner Catherine
- Breuer Judith
- Bridgewater Hannah E.
- Brooks Tony T.
- Broos Alice
- Brown Julianne Rose
- Brown Paul E.
- Brown Rebecca
- Brunker Kirstyn
- Bucca Giselda
- Buck David
- Buddenborg Sarah K.
- Bull Matthew
- Bull Matthew
- Burton-Fanning Shirelle
- Butcher Ethan
- Caddy Sarah L.
- Caller Laura G.
- Campbell Sharon
- Carlile Matthew
- Carmichael Stephen N.
- Casey Anna
- Castellano Sergi
- Chalker Vicki
- Chand Meera
- Chapman Michael R.
- Chappell Joseph G.
- Charalampous Themoula
- Charles Ian G.
- Chaudhry Yasmin
- Chauhan Anoop J.
- Cheng Jeffrey K.J.
- Churcher Carol M.
- Clark Gemma
- Coll Francesc
- Collins Jennifer
- Colquhoun Rachel
- Colquhoun Rachel M.
- Connor Thomas R.
- Connor Thomas R.
- Constantinidou Chrystala
- Coombes Jason
- Corden Sally
- Cormie Claire
- Cortes Nicholas
- Cortes Nick
- Cottrell Simon
- Coupland Lindsay J.
- Cowell Angela
- Cox Alison
- Craine Noel
- Cronin Michelle
- Crooke Derrick
- Curran Martin D.
- Curran Tanya
- da Silva Filipe Ana
- da Silva Filipe Ana
- Dabrera Gavin
- Danesh John
- Darby Alistair C.
- Davidson Rose K.
- Davies Alisha
- Davis Thomas
- de Cesare Mariateresa
- De Lacy Elen
- de Oliveira Martins Leonardo
- de Silva Thushan I.
- Debebe Johnny
- Dervisevic Samir
- Dewar Rebecca
- Dias Joana
- Diaz Maria
- Dibling Thomas
- Dorman Matthew J.
- Downing Fatima
- Drury Eleanor
- du Plessis Louis
- Duckworth Nichola
- Dyal Patricia L.
- Eccles Richard
- Edgeworth Jonathan
- Edwards Sue
- Eldirdiri Sahar
- Ellaby Nicholas
- Ellard Sian
- Elliott Scott
- Eltringham Gary
- Elumogo Ngozi
- Essex Sarah
- Evans Cariad
- Evans Johnathan M.
- Eyre David
- Fairley Derek J.
- Fallon Karlie
- Farbos Audrey
- Farr Ben
- Feltwell Theresa
- Fina Laia
- Findlay Jacqueline
- Fisher Chloe L.
- Fleming Vicki M.
- Forrest Leysa M.
- Forrest Sally
- Foulser Luke
- Francois Sarah
- Fraser Christophe
- Freeman Timothy M.
- Frost Lucy R.
- Fuller William
- Gallagher Eileen
- Gallagher Michael D.
- Garcia-Casado Maria V.
- Gaskin Amy
- Gatica-Wilcox Bree
- Gavriil Artemis
- Geidelberg Lily
- Geidelberg Lily
- Gemmell Matthew
- Georgana Iliana
- George Ryan P.
- Gifford Laura
- Gilbert Lauren
- Gill Harmeet K.
- Gilroy Rachel A.J.
- Girgis Sophia T.
- Glaysher Sharon
- Golubchik Tanya
- Goncalves Sonia
- Goodfellow Ian
- Goodfellow Ian G.
- Goodwin Scott
- Graham Clive
- Graham Lee
- Gramatopoulos Dimitris
- Green Angie
- Green Luke R.
- Greenaway Jane
- Gregory Richard
- Griffith Luke
- Groves Danielle C.
- Groves Natalie
- Guest Martyn
- Gulliver Huw
- Gutierrez Ana Victoria
- Hadjirin Nazreen F.
- Haldenby Sam T.
- Hale Antony D.
- Hall Grant
- Halstead Fenella
- Hamilton William L.
- Haque Tanzina
- Harper Katherine L.
- Harris Kathryn Ann
- Harrison Ewan M.
- Harrison Ian
- Harrison James W.
- Hartman Hassan
- Hattersley Andrew
- Heaney Judith
- Helmer Thomas
- Hesketh Andrew R.
- Heyburn David
- Higginson Ellen E.
- Hill Verity
- Hill Verity
- Hilvers Ember
- Hiscox Julian A.
- Holden Matthew T.G.
- Holmes Alison
- Holmes Christopher
- Holmes Nadine
- Hoosdally Sarah
- Hopes Richard
- Hosmillo Myra
- Houldcroft Charlotte J.
- Howe Robin
- Howson-Wells Hannah C.
- Hubb Jonathan
- Hughes Joseph
- Hughes Margaret
- Hunter Adam D.
- Hutchings Stephanie
- Impey Robert
- Irish-Tavares Dianne
- Iturriza-Gomara Miren
- Jackson Ben
- Jackson Ben
- Jackson David A.
- Jackson David K.
- Jackson Kathryn A.
- Jahun Aminu S.
- James Keith
- Jamrozy Dorota
- Jarrett Ruth
- Jeffries Aaron R.
- Jesudason Natasha
- Jesudason Natasha G.
- John Michaela
- Johnson Kate
- Johnson Natasha
- Johnson Rob
- Johnson Robert
- Johnston Ian
- Jones Hannah
- Jones Katie
- Jones Rachel
- Jones Sophie
- Jorgensen David
- Jorgensen David
- Joseph Amelia
- Justice Anita
- Kane Leanne
- Kay Gemma L.
- Kay Sally
- Keatley Jon-Paul
- Keeley Alexander J.
- Kenyon Anita
- Kermack Leanne M.
- Khakh Manjinder
- Khokhar Fahad A.
- Kidd Stephen
- Kingsley Robert A.
- Kitchen Christine
- Knight Bridget A.
- Kolyva Anastasia
- Koshy Cherian
- Kraemer Moritz
- Kristiansen Mark
- Kumziene-Summerhayes Sara
- Kwiatkowski Dominic
- Lackenby Angie
- Langford Cordelia
- Lawniczak Mara
- Le-Viet Thanh
- Lee David
- Lee Jack C.D.
- Letchford Laura
- Levene Nick
- Levett Lisa J.
- Li Kathy
- Li Kathy K.
- Liggett Steven
- Lindsey Benjamin B.
- Lister Michelle M.
- Livett Rich
- Lloyd Allyson
- Lo Stephanie
- Loh Joshua
- Loman Nicholas J.
- Loman Nicholas J.
- Loose Matthew W.
- Loveson Katie F.
- Lowe Hannah
- Lucaci Anita O.
- Ludden Catherine
- Lynch Jessica
- Lyons Ronan A.
- Macfarlane-Smith Louissa R.
- Machin Nicholas W.
- MacIntyre-Cockett George
- Madona Pinglawathee
- Maes Mailis
- Mahungu Tabitha W.
- Mair Daniel
- Maksimovic Joshua
- Manesis Nikos
- Manley Robin
- Manso Carmen
- Marchbank Angela
- Martincorena Inigo
- Martinez-Nunez Rocio T.
- Masoli Jane A.H.
- Mason Jenifer
- Mather Alison E.
- Mbisa Tamyo
- McCluggage Kathryn
- McClure Patrick C.
- McCrone J.T.
- McCrone John T.
- McGuigan Samantha
- McHugh Martin P.
- McKenna James P.
- McKerr Caoimhe
- McMinn Liz
- McMurray Claire
- Meader Emma J.
- Meadows Lizzie
- Menegazzo Mirko
- Meredith Luke W.
- Merrick Ian
- Mestek-Boukhibar Lamia
- Miah Shahjahan
- Michell Stephen L.
- Michelsen Michelle L.
- Molnar Zoltan
- Monaghan Lynn
- Mookerjee Siddharth
- Moore Catherine
- Moore Catrin
- Moore Christopher
- Moore Nathan
- Morgan Mari
- Morgan Sian
- Mori Matilde
- Moses Samuel
- Muir Peter
- Munn Robert
- Myers Richard
- Nascimento Fabricia F.
- Nascimento Fabricia F.
- Naydenova Plamena
- Neaverson Alexandra S.
- Nebbia Gaia
- Nelson Andrew
- Nelson Charlotte
- Nelson Rachel
- Nicholls Sam
- Nicholls Samuel M.
- Nichols Jenna
- Niebel Marc O.
- Niola Paola
- Nomikou Kyriaki
- O'Toole Elaine
- O'Toole Áine
- Orton Richard J.
- Osman Husam
- Ott Sascha
- O’Grady Justin
- O’Toole Áine
- Pacchiarini Nicole
- Pacchiarini Nicole
- Padgett Debra
- Page Andrew J.
- Palmer Sophie
- Palmer Steve
- Panchbhaya Yasmin N.
- Pandey Sarojini
- Park Naomi
- Parker Matthew D.
- Parmar Surendra
- Parr Yasmin A.
- Parsons Paul J.
- Partridge David G.
- Pascall David J.
- Patel Gaurang
- Patel Minal
- Patel Vineet
- Paterson Steve
- Payne Brendan A.I.
- Peacock Sharon J.
- Pearson Clare
- Perry Malorie
- Peto Timothy
- Pinckert Malte L.
- Platt Steven
- Plimmer Amy
- Poplawski Radoslaw
- Potter Will
- Prakash Reenesh
- Prestwood Liam
- Price Anna
- Price Anna
- Price James
- Puethe Christoph
- Pybus Oliver
- Pybus Oliver G.
- Pymont Hannah M.
- Quail Mike
- Quick Joshua
- Raghwani Jayna
- Ragonnet-Cronin Manon
- Rainbow Lucille
- Rajatileka Shavanthi
- Rambaut Andrew
- Rambaut Andrew
- Ramsay Mary
- Randell Paul A.
- Raviprakash Veena
- Raza Mohammad
- Resende Silva Paola C.
- Rey Sara
- Rey Sara M.
- Reynolds Nicola
- Richter Alex
- Robertson David L.
- Robertson David L.
- Robinson Esther
- Robinson Trevor I.
- Robson Samuel C.
- Rogers Hazel A.
- Rooke Stefan
- Rowan Aileen
- Rowe Will
- Roy Sunando
- Rudder Steven
- Ruis Chris
- Ryan Felicity
- Sambles Christine M.
- Sang Fei
- Scarlett Garry P.
- Schaefer Ulf
- Scher Emily
- Scott Carol
- Scott Garren
- Sethi Dheeraj K.
- Shaaban Sharif
- Shah Divya
- Shah Rajiv
- Shah Rajiv N.
- Shankar Giri
- Shaw Robert
- Shepherd James
- Shepherd James G.
- Sheriff Nicola
- Shirley Lesley
- Signell Adrian W.
- Sillitoe John
- Simpson David A.
- Singer Joshua B.
- Sivaprakasam Venkat
- Siveroni Igor
- Siveroni Igor
- Sloan Tim J.
- Sluga Graciela
- Smith Christen
- Smith Colin P.
- Smith Darren
- Smith Nikki
- Smith Wendy
- Smollett Katherine L.
- Snell Luke B.
- Souster Emily
- Southgate Joel
- Southgate Joel
- Spellman Karla
- Spencer-Chapman Michael
- Sridhar Sushmita
- Stanley Rachael
- Stanton Thomas D.
- Starinskij Igor
- Stark Richard
- Stockton Joanne
- Stuart Claire
- Studholme David J.
- Swindells Emma
- Swingler Tracey
- Taha Yusri
- Tang Julian
- Taylor Ben E.W.
- Taylor Graham P.
- Taylor Sarah
- Taylor-Joyce Grace
- Tedim Ana P.
- Temperton Ben
- Templeton Kate E.
- Thompson Thomas
- Thomson Emma C.
- Thomson Emma C.
- Thomson Nicholas M.
- Thornton Alicia
- Thurston Scott
- Todd John A.
- Tong Lily
- Tonkin-Hill Gerry
- Torok M. Estee
- Trebes Amy
- Trotter Alexander J.
- Tsoleridis Theocharis
- Tucker Rachel M.
- Turtle Lance
- Tutill Helena J.
- Underwood Anthony P.
- Unnikrishnan Meera
- Vamos Edith E.
- Vasylyeva Tetyana
- Vattipally Sreenu
- Vipond Ian B.
- Volz Erik
- Volz Erik M.
- Wain John
- Walsh Sarah
- Wang Dennis
- Wantoch Michelle
- Warne Ben
- Warwick-Dugdale Joanna
- Wastenge Elizabeth
- Watkins Joanne
- Watts Joanne
- Waugh Sheila
- Webber Mark A.
- Weeks Sam
- Weldon Danni
- Whitehead Mark
- Williams Charlotte A.
- Williams Chris
- Williams David
- Williams Rachel J.
- Williams Rebecca
- Williams Thomas
- Williamson Kathleen A.
- Willingham Iona
- Wilson Harry D.
- Wise Emma
- Workman Trudy
- Wright Victoria
- Wyles Matthew
- Wyllie Sarah
- Yakovleva Anna
- Yasir Muhammad
- Yeats Corin A.
- Yew Wen C.
- Young Gregory R.
- Young Jamie
- Yu Xiaoyu
- Zarebski Alex
- Publication venue
- Elsevier
- Publication date
- 07/01/2021
- Field of study
Global dispersal and increasing frequency of the SARS-CoV-2 spike protein variant D614G are suggestive of a selective advantage but may also be due to a random founder effect. We investigate the hypothesis for positive selection of spike D614G in the United Kingdom using more than 25,000 whole genome SARS-CoV-2 sequences. Despite the availability of a large dataset, well represented by both spike 614 variants, not all approaches showed a conclusive signal of positive selection. Population genetic analysis indicates that 614G increases in frequency relative to 614D in a manner consistent with a selective advantage. We do not find any indication that patients infected with the spike 614G variant have higher COVID-19 mortality or clinical severity, but 614G is associated with higher viral load and younger age of patients. Significant differences in growth and size of 614G phylogenetic clusters indicate a need for continued study of this variant
SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway
- Author
- Aanensen David M.
- Abraham Priyanka
- Abudahab Khalil
- Adams Alexander
- Adams Helen
- Adele Sandra
- Afifi Safiah
- Aggarwal Dinesh
- Ahmad Shazaad S. Y.
- Aigrain Louise
- Alcolea-Medina Adela
- Alikhan Nabil-Fareed
- Allara Elias
- Amato Roberto
- Angyal Adrienn
- Annett Tara
- Ansari M. Azim
- Aplin Stephen
- Ariani Cristina V.
- Asad Hibo
- Asamaphan Patawee
- Ash Amy
- Ashfield Paula
- Ashford Fiona
- Ashraf Shirin
- Atkinson Laura
- Attwood Stephen W.
- Auckland Cressida
- Austin James
- Aydin Alp
- Baker David J.
- Baker Paul
- Balcazar Carlos E.
- Ball Jonathan
- Barnes Eleanor
- Barrett Jeffrey C.
- Barrow Magdalena
- Barton Edward
- Bashton Matthew
- Bassett Andrew R.
- Batra Rahul
- Baxter Chris
- Bayzid Nadua
- Beaver Charlotte
- Beckett Angela H.
- Beckwith Shaun M.
- Bedford Luke
- Beer Robert
- Beggs Andrew
- Bellis Katherine L.
- Berry Louise
- Bertolusso Beatrice
- Best Angus
- Betteridge Emma
- Bibby David
- Bicknell Kelly
- Binns Debbie
- Birchley Alec
- Bird Paul W.
- Bishop Chloe
- Blacow Rachel
- Blakey Victoria
- Blane Beth
- Bolt Frances
- Bonfield James
- Bonner Stephen
- Bonsall David
- Boswell Tim
- Bosworth Andrew
- Bourgeois Yann
- Bouzidi Kate El
- Boyd Olivia
- Bradley Declan T.
- Breen Cassie
- Bresner Catherine
- Breuer Judith
- Bridgett Stephen
- Bronner Iraad F.
- Brooks Ellena
- Broos Alice
- Brown Anthony
- Brown Julianne R.
- Bucca Giselda
- Buchan Sarah L.
- Buck David
- Bull Matthew
- Burns Phillipa J.
- Burton-Fanning Shirelle
- Byaruhanga Timothy
- Byott Matthew
- Campbell Sharon
- Cantoni Diego
- Carabelli Alessandro M.
- Cargill James S.
- Carlile Matthew
- Carvalho Sílvia F.
- Casey Anna
- Castigador Anibolina
- Catalan Jana
- Chalker Vicki
- Chaloner Nicola J.
- Chand Meera
- Chappell Joseph G.
- Charalampous Themoula
- Chatterton Wendy
- Chaudhry Yasmin
- Churcher Carol M.
- Clark Gemma
- Clarke Phillip
- Cogger Benjamin J.
- Cole Kevin
- Collins Jennifer
- Colquhoun Rachel
- Connor Thomas R.
- Cook Kate F.
- Coombes Jason
- Corden Sally
- Cormie Claire
- Cortes Nicholas
- Cotic Marius
- Cotton Seb
- Cottrell Simon
- Coupland Lindsay
- Cowton Vanessa
- Cox Alison
- Cox MacGregor
- Craine Noel
- Crawford Liam
- Cross Aidan
- Crown Matthew R.
- Crudgington Dorian
- Cumley Nicola
- Curran Martin D.
- Curran Tanya
- Cutino-Moguel Teresa
- da Silva Filipe Ana
- da Silva Filipe Ana
- Dabrera Gavin
- Darby Alistair C.
- Davidson Rose K.
- Davies Alisha
- Davies Robert M.
- Davis Chris
- Davis Thomas
- de Angelis Daniela
- De Lacy Elen
- De Lorenzo Giuditta
- de Oliveira Martins Leonardo
- de Silva Thushan
- de Silva Thushan I.
- Debebe Johnny
- Deeks Alexandra
- Denton-Smith Rebecca
- Dervisevic Samir
- Dewar Rebecca
- Dey Jayasree
- Dias Joana
- Dobie Donald
- Dorman Matthew J.
- Downing Fatima
- Driscoll Megan
- du Plessis Louis
- Duckworth Nichola
- Dunachie Susanna
- Dunachie Susanna
- Duncan Christopher
- Durham Jillian
- Eastick Kirstine
- Easton Lisa J.
- Eccles Richard
- Edgeworth Jonathan
- Edwards Sue
- Eldirdiri Sahar
- Ellaby Nicholas
- Elliott Scott
- Eltringham Gary
- Ensell Leah
- Erkiert Michelle J.
- Essex Sarah
- Evans Cariad
- Evans Johnathan M.
- Everson William
- Fairley Derek J.
- Fallon Karlie
- Fanaie Arezou
- Farr Ben W.
- Fearn Christopher
- Feltwell Theresa
- Ferguson Lynne
- Fina Laia
- Flaviani Flavia
- Fleming Vicki M.
- Forrest Sally
- Foster-Nyarko Ebenezer
- Foulkes Benjamin H.
- Foulser Luke
- Fragakis Mireille
- Frampton Dan
- Francois Sarah
- Fraser Christophe
- Freeman Timothy M.
- Fryer Helen
- Fuchs Marc
- Fuller William
- Furnon Wilhelm
- Gajee Kavitha
- Galai Katerina
- Gallagher Abbie
- Gallagher Eileen
- Gallagher Michael D.
- Gallis Marta
- Gaskin Amy
- Gatica-Wilcox Bree
- Geidelberg Lily
- Gemmell Matthew
- Georgana Iliana
- George Ryan P.
- Gifford Laura
- Gilbert Lauren
- Girgis Sophia T.
- Glaysher Sharon
- Goldstein Emily J.
- Golubchik Tanya
- Gomes Andrea N.
- Gonçalves Sónia
- Goodfellow Ian G.
- Goodwin Scott
- Goudarzi Salman
- Gourtovaia Marina
- Graham Clive
- Graham Lee
- Grant Paul R.
- Green Angie
- Green Luke R.
- Greenaway Jane
- Gregory Richard
- Grove Joe
- Guest Martyn
- Gunson Rory
- Gunson Rory N.
- Gupta Ravi K.
- Gutierrez Bernardo
- Haldenby Sam T.
- Hamilton William L.
- Hansford Samantha E.
- Haque Tanzina
- Harris Kathryn A.
- Harrison Ewan M.
- Harrison Ian
- Hart Jennifer
- Hartley John A.
- Harvey Matthew
- Harvey William T.
- Harvey William T.
- Hassan-Ibrahim Mohammed O.
- Haughney John
- Heaney Judith
- Helmer Thomas
- Henderson John H.
- Hesketh Andrew R.
- Hey Jessica
- Heyburn David
- Higginson Ellen E.
- Hill Jack D.
- Hill Verity
- Hilson Rachel A.
- Hilvers Ember
- Holden Matthew T. G.
- Holden Matthew T. G.
- Holland Poppy
- Hollis Amy
- Holmes Alison H.
- Holmes Christopher W.
- Holmes Nadine
- Hopes Richard
- Hornsby Hailey R.
- Hosmillo Myra
- Houlihan Catherine
- Howson-Wells Hannah C.
- Hsu Sharon N.
- Hubb Jonathan
- Huckson Hannah
- Hughes Joseph
- Hughes Joseph
- Hughes Margaret
- Hughes Warwick
- Hutchings Stephanie
- Idle Giles
- Illingworth Chris J.
- Impey Robert
- Irish-Tavares Dianne
- Iturriza-Gomara Miren
- Izuagbe Rhys
- Jackson Ben
- Jackson Chris
- Jackson David K.
- Jackson Kathryn A.
- Jackson Leigh M.
- Jahun Aminu S.
- James Keith
- James Victoria
- Jeanes Christopher
- Jeffries Aaron R.
- Jeremiah Sarah
- Jermy Andrew
- John Michaela
- Johnson Kate
- Johnson Rob
- Johnston Ian
- Jones Christopher R.
- Jones Hannah
- Jones Neil
- Jones Owen
- Jones Sophie
- Joseph Amelia
- Judges Sarah
- Kay Gemma L.
- Kay Sally
- Keatley Jon-Paul
- Keeley Alexander J.
- Kele Beatrix
- Kenyon Anita
- Kermack Leanne M.
- Khakh Manjinder
- Kidd Stephen P.
- Killough Nicholas F.
- Kimuli Maimuna
- Kirk Stuart
- Kitchen Christine
- Kitchman Katie
- Klenerman Paul
- Klenerman Paul
- Knight Bridget A.
- Koshy Cherian
- Kraemer Moritz U. G.
- Kronsteiner Barbara
- Kumziene-Summerhayes Sara
- Kwiatkowski Dominic
- Lackenby Angie
- Laing Kenneth G.
- Lampejo Temi
- Langford Cordelia F.
- Lavin Deborah
- Lawton Andrew I.
- Le-Viet Thanh
- Lee David
- Lee Jack C. D.
- Lensing Stefanie V.
- Leonard Steven
- Levett Lisa J.
- Lewis Jonathan
- Lewis Kevin
- Liddle Jennifier
- Liggett Steven
- Lillie Patrick J.
- Lindsey Benjamin B.
- Lister Michelle M.
- Livett Rich
- Lo Stephanie
- Logan Nicola
- Loman Nicholas J.
- Loose Matthew W.
- Louka Stavroula F.
- Loveson Katie F.
- Lowdon Sarah
- Lowe Hannah
- Lowe Helen L.
- Lucaci Anita O.
- Ludden Catherine
- Lynch Jessica
- Lyons Ronan A.
- Lythgoe Katrina
- Machin Nicholas W.
- MacIntyre-Cockett George
- Mack Andrew
- Macklin Ben
- Maclean Alasdair
- MacLean Oscar A.
- Macnaughton Emily
- Madona Pinglawathee
- Maes Mailis
- Maftei Laurentiu
- Mahanama Adhyana I. K.
- Mahungu Tabitha W.
- Mair Daniel
- Maksimovic Joshua
- Malone Cassandra S.
- Maloney Daniel
- Manali Maria
- Manesis Nikos
- Manley Robin
- Mantzouratou Anna
- Marchbank Angela
- Mariappan Arun
- Martincorena Inigo
- Martinez Nunez Rocio T.
- Mather Alison E.
- Maxwell Patrick
- Mayhew Megan
- Mbisa Tamyo
- McCann Clare M.
- McCarthy Shane A.
- McCluggage Kathryn
- McClure Patrick C.
- McCrone J. T.
- McHugh Martin P.
- McKenna James P.
- McKerr Caoimhe
- McManus Georgina M.
- McMurray Claire
- McMurray Claire L.
- McNally Alan
- Meadows Lizzie
- Medd Nathan
- Megram Oliver
- Menegazzo Mirko
- Merrick Ian
- Michell Stephen L.
- Michelsen Michelle L.
- Mirfenderesky Mariyam
- Mirza Jeremy
- Miskelly Julia
- Moles-Garcia Emma
- Moll Robin J.
- Molnar Zoltan
- Monahan Irene M.
- Mondani Matteo
- Mookerjee Siddharth
- Moore Catherine
- Moore Christopher
- Moore Jonathan
- Moore Nathan
- Moore Shona
- Morcrette Helen
- Morgan Mari
- Morgan Sian
- Mori Matilde
- Morriss Arthur
- Moses Samuel
- Mower Craig
- Muir Peter
- Mukaddas Afrida
- Munemo Florence
- Munn Robert
- Murcia Pablo R.
- Murray Abigail
- Murray Darren R.
- Murray Leanne J.
- Murray Sam M.
- Mutingwende Manasa
- Myers Richard
- Nastouli Eleni
- Nebbia Gaia
- Nelson Andrew
- Nelson Charlotte
- Nicholls Sam
- Nichols Jenna
- Nicodemi Roberto
- Nomikou Kyriaki
- O?Brien Sarah
- O?Grady Justin
- O?Toole Áine
- Odedra Mina
- Ohemeng-Kumi Natasha
- Oliver Karen
- Orton Richard
- Orton Richard J.
- Osman Husam
- Pacchiarini Nicole
- Padgett Debra
- Page Andrew J.
- Palmarini Massimo
- Park Emily J.
- Park Naomi R.
- Parker Matthew D.
- Parmar Surendra
- Partridge David G.
- Pascall David
- Pascall David J.
- Patel Amita
- Patel Arvind H.
- Patel Bindi
- Paterson Steve
- Payne Brendan A. I.
- Payne Rebecca
- Peacock Sharon J.
- Pearson Clare
- Pelosi Emanuela
- Percival Benita
- Perkins Jon
- Perry Malorie
- Pinckert Malte L.
- Pinto Rute Maria
- Platt Steven
- Podplomyk Olga
- Pohare Manoj
- Pond Marcus
- Pope Cassie F.
- Poplawski Radoslaw
- Powell Jessica
- Poyner Jennifer
- Prestwood Liam
- Price Anna
- Price James R.
- Prieto Jacqui A.
- Pritchard David T.
- Prosolek Sophie J.
- Pugh Georgia
- Pusok Monika
- Puxty Kathryn
- Pybus Oliver G.
- Pymont Hannah M.
- Quail Michael A.
- Quick Joshua
- Radulescu Clara
- Raghwani Jayna
- Ragonnet-Cronin Manon
- Rainbow Lucille
- Rajan Diana
- Rajatileka Shavanthi
- Ramadan Newara A.
- Rambaut Andrew
- Ramble John
- Randell Paul
- Randell Paul A.
- Ratcliffe Liz
- Raviprakash Veena
- Ray Surajit
- Raza Mohammad
- Redshaw Nicholas M.
- Rey Sara
- Reynolds Nicola
- Richter Alex
- Richter Alex
- Robertson David L.
- Robertson David L.
- Robinson Esther
- Robson Samuel C.
- Rogan Fiona
- Rooke Stefan
- Rowe Will
- Roy Sunando
- Rudder Steven
- Ruis Chris
- Rushton Steven
- Ryan Felicity
- Saeed Kordo
- Samaraweera Buddhini
- Sambles Christine M.
- Sanderson Roy
- Sanderson Theo
- Sang Fei
- Sass Thea
- Scher Emily
- Scott Carol
- Scott Garren
- Scott Sam
- Sehmi Jasveen
- Shaaban Sharif
- Shaaban Sharif
- Shah Divya
- Shaw Jessica
- Shelest Ekaterina
- Shepherd James G.
- Sheridan Liz A.
- Sheriff Nicola
- Shirley Lesley
- Sillitoe John
- Silva Vanessa
- Silviera Siona
- Simpson David A.
- Singh Aditi
- Singleton Dawn
- Skvortsov Timofey
- Sloan Tim J.
- Sluga Graciela
- Smith Colin P.
- Smith Darren L.
- Smith Ken
- Smith Kim S.
- Smith Louise
- Smith Nikki
- Smith Perminder
- Smollett Katherine
- Smollett Katherine L.
- Snell Luke B.
- Somassa Thomas
- Southgate Joel
- Spellman Karla
- Spencer Chapman Michael H.
- Spurgin Lewis G.
- Spyer Moira J.
- Stanley Rachael
- Stanley William
- Stanton Thomas D.
- Starinskij Igor
- Stockton Joanne
- Stonehouse Susanne
- Storey Nathaniel
- Studholme David J.
- Sudhanva Malur
- Swindells Emma
- Szemiel Agnieszka
- Taha Yusri
- Tan Ngee Keong
- Tang Julian W.
- Tang Miao
- Taylor Ben E. W.
- Taylor Joshua F.
- Taylor Sarah
- Temperton Ben
- Templeton Kate
- Templeton Kate E.
- Thomas Claire
- Thomson Emma C.
- Thomson Emma C.
- Thomson Laura
- Thornton Alicia
- Thurston Scott A. J.
- Todd John A.
- Tomb Rachael
- Tong Lily
- Tong Lily
- Tonkin-Hill Gerry
- Torok M. Estee
- Tovar-Corona Jaime M.
- Trebes Amy
- Trotter Alexander J.
- Tsatsani Ioulia
- Turnbull Robyn
- Turtle Lance
- Twohig Katherine A.
- Umpleby Helen
- Underwood Anthony P.
- Vamos Edith E.
- Vasylyeva Tetyana I.
- Vattipally Sreenu
- Vernet Gabrielle
- Vink Elen
- Vipond Barry B.
- Volz Erik M.
- Walsh Sarah
- Wang Dennis
- Warne Ben
- Warwick-Dugdale Joanna
- Wastnedge Elizabeth
- Watkins Joanne
- Watson Louisa K.
- Waugh Sheila
- Webster Hermione J.
- Weldon Danni
- Westwick Elaine
- Whalley Thomas
- Wheeler Helen
- Whitehead Mark
- Whiteley Max
- Whitwham Andrew
- Wierzbicki Claudia
- Wilkie Craig
- Willett Brian J.
- Willford Nicholas J.
- Williams Catryn
- Williams Charlotte A.
- Williams Cheryl
- Williams Chris
- Williams Lesley-Anne
- Williams Rachel J.
- Williams Rebecca
- Williams Thomas
- Williamson Kathleen A.
- Wilson-Davies Eleri
- Witele Eric
- Withell Karen T.
- Witney Adam A.
- Wolverson Paige
- Wong Nick
- Workman Trudy
- Wright Derek W.
- Wright Victoria
- Wyatt Tim
- Wyllie Sarah
- Xu-McCrae Li
- Yavus Mehmet
- Yaze Geraldine
- Yeats Corin A.
- Yebra Gonzalo
- Yebra Gonzalo
- Yew Wen C.
- Young Gregory R.
- Young Jamie
- Zarebski Alex E.
- Zhang Peijun
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 31/08/2022
- Field of study
Vaccines based on the spike protein of SARS-CoV-2 are a cornerstone of the public health response to COVID-19. The emergence of hypermutated, increasingly transmissible variants of concern (VOCs) threaten this strategy. Omicron (B.1.1.529), the fifth VOC to be described, harbours multiple amino acid mutations in spike, half of which lie within the receptor-binding domain. Here we demonstrate substantial evasion of neutralization by Omicron BA.1 and BA.2 variants in vitro using sera from individuals vaccinated with ChAdOx1, BNT162b2 and mRNA-1273. These data were mirrored by a substantial reduction in real-world vaccine effectiveness that was partially restored by booster vaccination. The Omicron variants BA.1 and BA.2 did not induce cell syncytia in vitro and favoured a TMPRSS2-independent endosomal entry pathway, these phenotypes mapping to distinct regions of the spike protein. Impaired cell fusion was determined by the receptor-binding domain, while endosomal entry mapped to the S2 domain. Such marked changes in antigenicity and replicative biology may underlie the rapid global spread and altered pathogenicity of the Omicron variant
Causas físicas e genéticas dos nevoeiros na região central do Rio Grande do Sul
- Publication venue
- 'Universidad Federal de Santa Maria'
- Publication date
- 13/09/2016
- Field of study
Causas físicas e genéticas dos nevoeiros na região central do Rio Grande do Su
Chromatin Shapes the Mitotic Spindle
- Author
- Ana Dinarina
- Antonio
- Athale
- Bird
- Bornens
- Bringmann
- Brown
- Burbank
- Clausen
- Céline Pugieux
- Desai
- Desai
- Dogterom
- Echeverri
- Eric Karsenti
- François Nédélec
- Gaetz
- Gatlin
- Gehmlich
- Glotzer
- Goshima
- Hannak
- Heald
- Joachim Spatz
- Kapitein
- Karsenti
- Khodjakov
- Lloyd
- Mahoney
- Maresca
- Maria Mora Corral
- Martin Loose
- Matthies
- Mayer
- Mitchison
- Miyamoto
- Murray
- Schuh
- Thiébaud
- Tokai-Nishizumi
- Valentine
- Walczak
- Walczak
- Waterman-Storer
- Wickstead
- Winey
- Wittmann
- Wühr
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
Oxidoreductases on their way to industrial biotransformations
- Author
- Acebes
- Acebes
- Alcalde
- Alessandra Piscitelli
- Ana Gutiérrez
- Ana Serrano
- Angel T. Martínez
- Babot
- Babot
- Baratto
- Barrasa
- Barrasa
- Bormann
- Büttner
- Carro
- Carro
- Christiane Liers
- Cinzia Pezzella
- Courtade
- Couturier
- Craig B. Faulds
- Daou
- de Salas
- Dolores Linde
- Elena Fernández-Fueyo
- Eric Record
- Ewing
- Fernández-Fueyo
- Fernández-Fueyo
- Fernández-Fueyo
- Fernández-Fueyo
- Fernández-Fueyo
- Fernández-Fueyo
- Fernández-Fueyo
- Fernández-Fueyo
- Ferreira
- Ferreira
- Francisco J. Ruiz-Dueñas
- Frank Hollmann
- Garajova
- García-Ruiz
- Giacobelli
- Giovanni Sannia
- González-Pérez
- González-Pérez
- González-Pérez
- González-Pérez
- González-Pérez
- Gygli
- Gygli
- Harris
- Henrik Lund
- Hofrichter
- Hofrichter
- Hori
- Ib Winckelmann
- Isaksen
- Jesper Vind
- Jo-Anne Rasmussen
- Jorge Rencoret
- José C. del Río
- Karich
- Katrin Scheibner
- Kellner
- Kiebist
- Kracher
- Kracher
- Lettera
- Linde
- Linde
- Linde
- Linde
- Loose
- Lucas
- Maria Fátima Lucas
- Marta Tortajada
- Martin Hofrichter
- Martínez
- Martínez
- Mathieu
- Maté
- Maté
- Maté
- Maté
- Mehmet E. Sener
- Miguel Alcalde
- Mirjana Gelo-Pujic
- Molina-Espeja
- Molina-Espeja
- Molina-Espeja
- Molina-Espeja
- Monza
- Morten Tovborg
- Ni
- Olmedo
- Owik M. Herold-Majumdar
- Pardo
- Pardo
- Pardo
- Patel
- Pezzella
- Pezzella
- Pham
- Piumi
- Poraj-Kobielska
- Poraj-Kobielska
- Ralf Zuhse
- Rencoret
- René Ullrich
- Rico
- Roland Ludwig
- Salvachúa
- Santiago
- Sibel Kılıç
- Strittmatter
- Susana Camarero
- Sáez-Jiménez
- Sáez-Jiménez
- Sáez-Jiménez
- Sáez-Jiménez
- Sáez-Jiménez
- Tan
- Vaaje-Kolstad
- van Kuijk
- Vicente
- Victor Guallar
- Viña-González
- Viña-González
- Wang
- Willem J.H. van Berkel
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
Exacerbation of Autoimmune Neuro-Inflammation in Mice Cured from Blood-Stage Plasmodium berghei Infection
- Author
- Alexandre Leite Rodrigues Oliveira
- AM Clemente
- Ana Leda Figueiredo Longhini
- André Luis Bombeiro
- AS Farias
- BC Urban
- BC Urban
- BN Dittel
- BS Franklin
- C Francelin
- Catarina Rapôso
- CF Andrade
- Claudio Romero Farias Marinho
- CM Lloyd
- CQ Chu
- CT Daniel-Ribeiro
- CT Daniel-Ribeiro
- D Adu
- D Capalbo
- DA Mendes-da-Cruz
- DH Gilden
- DO Willenborg
- E Bettiol
- E Mix
- EF Lind
- FC Hartgers
- Fábio Trindade Maranhão Costa
- G Anderson
- G Butcher
- G Das
- GA Butcher
- HS Domingues
- I Herrmann
- IA Cockburn
- Isadora Tassinari Ferreira
- J Gameiro
- J Gameiro
- JM Fletcher
- JP Peron
- K Bang
- KA Hogquist
- LD Loose
- LG Poels
- Liana Verinaud
- LR Sardinha
- Luidy Kazuo Issayama
- M Asano
- M Itoh
- M Tutaj
- MA Ataide
- Maria Alice da Cruz Höfling
- MB McCall
- MN Wykes
- OA Skorokhod
- P Giusti
- P Phanuphak
- PB Falanga
- PT Fawcett
- R Thome
- R Thome
- RA O'Connor
- RM Goncalves
- Rodolfo Thomé
- Rosária Di Gangi
- S Bhaumik
- S Kawakita
- S Sotgiu
- SE Read
- SM Muxel
- Stefanie Costa Pinto Lopes
- Thiago Alves da Costa
- TK Starr
- W Jarra
- W Savino
- W Savino
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- Field of study
Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity
- Author
- Aanensen David M
- Abudahab Khalil
- Acheson Erwan
- Adams Alexander
- Adams Helen
- Adriaenssens Evelien M
- Afifi Safiah
- Aggarwal Dinesh
- Ahmad Shazaad SY
- Alam Mohammad T
- Alcolea-Medina Adela
- Alderton Alex
- Alikhan Nabil-Fareed
- Allan John
- Allara Elias
- Amato Roberto
- Andersson Monique
- Angyal Adrienn
- Aranday-Cortes Elihu
- Ariani Cristina
- Asad Hibo
- Asamaphan Patawee
- Ashworth Jordan
- Atkinson Laura
- Attwood Stephen
- Auckland Cressida
- Awan Ali R
- Aydin Alp
- Baker David J
- Baker Paul
- Balcazar Carlos E
- Ball Jonathan
- Barton Edward
- Bashton Matthew
- Batra Rahul
- Baxter Laura
- Beale Mathew A
- Beaver Charlotte
- Beckett Angela
- Beer Robert
- Beggs Andrew
- Bell Andrew
- Bellis Katherine L
- Berger Duncan J
- Berriman Matt
- Berry Lisa
- Berry Louise
- Betancor Gilberto
- Betteridge Emma
- Bewshea Claire M
- Bibby David
- Bicknell Kelly
- Birchley Alec
- Bird Paul
- Bishop Chloe
- Blane Beth
- Bolt Frances
- Bonsall David
- Boswell Tim
- Bosworth Andrew
- Bourgeois Yann
- Boyd Olivia
- Boyes John
- Bradley Declan T
- Bradshaw Daniel
- Breen Cassie
- Bresner Catherine
- Breuer Judith
- Bridgewater Hannah E
- Brooks Tony T
- Broos Alice
- Brown Julianne Rose
- Brown Paul E
- Brown Rebecca
- Brunker Kirstyn
- Bucca Giselda
- Buck David
- Buddenborg Sarah K
- Bull Matthew
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- Burton-Fanning Shirelle
- Butcher Ethan
- Caddy Sarah L
- Caller Laura G
- Campbell Sharon
- Carlile Matthew
- Carmichael Stephen N
- Casey Anna
- Castellano Sergi
- Chalker Vicki
- Chand Meera
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- Chappell Joseph G
- Charalampous Themoula
- Charles Ian G
- Chaudhry Yasmin
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- Churcher Carol M
- Clark Gemma
- Coll Francesc
- Collins Jennifer
- Colquhoun Rachel
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- Connor Thomas R
- Connor Thomas R
- Constantinidou Chrystala
- Coombes Jason
- Corden Sally
- Cormie Claire
- Cortes Nicholas
- Cortes Nick
- Cottrell Simon
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- Cowell Angela
- Cox Alison
- Craine Noel
- Cronin Michelle
- Crooke Derrick
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- Curran Tanya
- da Silva Filipe Ana
- da Silva Filipe Ana
- Dabrera Gavin
- Danesh John
- Darby Alistair C
- Davidson Rose K
- Davies Alisha
- Davis Thomas
- de Cesare Mariateresa
- De Lacy Elen
- de Oliveira Martins Leonardo
- de Silva Thushan I
- Debebe Johnny
- Dervisevic Samir
- Dewar Rebecca
- Dias Joana
- Diaz Maria
- Dibling Thomas
- Dorman Matthew J
- Downing Fatima
- Drury Eleanor
- du Plessis Louis
- Duckworth Nichola
- Dyal Patricia L
- Eccles Richard
- Edgeworth Jonathan
- Edwards Sue
- Eldirdiri Sahar
- Ellaby Nicholas
- Ellard Sian
- Elliott Scott
- Eltringham Gary
- Elumogo Ngozi
- Essex Sarah
- Evans Cariad
- Evans Johnathan M
- Eyre David
- Fairley Derek J
- Fallon Karlie
- Farbos Audrey
- Farr Ben
- Feltwell Theresa
- Fina Laia
- Findlay Jacqueline
- Fisher Chloe L
- Fleming Vicki M
- Forrest Leysa M
- Forrest Sally
- Foulser Luke
- Francois Sarah
- Fraser Christophe
- Freeman Timothy M
- Frost Lucy R
- Fuller William
- Gallagher Eileen
- Gallagher Michael D
- Garcia-Casado Maria V
- Gaskin Amy
- Gatica-Wilcox Bree
- Gavriil Artemis
- Geidelberg Lily
- Geidelberg Lily
- Gemmell Matthew
- Georgana Iliana
- George Ryan P
- Gifford Laura
- Gilbert Lauren
- Gill Harmeet K
- Gilroy Rachel AJ
- Girgis Sophia T
- Glaysher Sharon
- Golubchik Tanya
- Goncalves Sonia
- Goodfellow Ian
- Goodfellow Ian G
- Goodwin Scott
- Graham Clive
- Graham Lee
- Gramatopoulos Dimitris
- Green Angie
- Green Luke R
- Greenaway Jane
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- Groves Natalie
- Guest Martyn
- Gulliver Huw
- Gutierrez Ana Victoria
- Hadjirin Nazreen F
- Haldenby Sam T
- Hale Antony D
- Hall Grant
- Halstead Fenella
- Hamilton William L
- Haque Tanzina
- Harper Katherine L
- Harris Kathryn Ann
- Harrison Ewan M
- Harrison Ian
- Harrison James W
- Hartman Hassan
- Hattersley Andrew
- Heaney Judith
- Helmer Thomas
- Hesketh Andrew R
- Heyburn David
- Higginson Ellen E
- Hill Verity
- Hill Verity
- Hilvers Ember
- Hiscox Julian A
- Holden Matthew TG
- Holmes Alison
- Holmes Christopher
- Holmes Nadine
- Hoosdally Sarah
- Hopes Richard
- Hosmillo Myra
- Houldcroft Charlotte J
- Howe Robin
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- Hubb Jonathan
- Hughes Joseph
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- Hutchings Stephanie
- Impey Robert
- Irish-Tavares Dianne
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- Jackson Ben
- Jackson Ben
- Jackson David A
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- Jackson Kathryn A
- Jahun Aminu S
- James Keith
- Jamrozy Dorota
- Jarrett Ruth
- Jeffries Aaron R
- Jesudason Natasha
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- John Michaela
- Johnson Kate
- Johnson Natasha
- Johnson Rob
- Johnson Robert
- Johnston Ian
- Jones Hannah
- Jones Katie
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- Keeley Alexander J
- Kenyon Anita
- Kermack Leanne M
- Khakh Manjinder
- Khokhar Fahad A
- Kidd Stephen
- Kingsley Robert A
- Kitchen Christine
- Knight Bridget A
- Kolyva Anastasia
- Koshy Cherian
- Kraemer Moritz
- Kristiansen Mark
- Kumziene-Summerhayes Sara
- Kwiatkowski Dominic
- Lackenby Angie
- Langford Cordelia
- Lawniczak Mara
- Le-Viet Thanh
- Lee David
- Lee Jack CD
- Letchford Laura
- Levene Nick
- Levett Lisa J
- Li Kathy
- Li Kathy K
- Liggett Steven
- Lindsey Benjamin B
- Lister Michelle M
- Livett Rich
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- Loose Matthew W
- Loveson Katie F
- Lowe Hannah
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- Ludden Catherine
- Lynch Jessica
- Lyons Ronan A
- Macfarlane-Smith Louissa R
- Machin Nicholas W
- MacIntyre-Cockett George
- Madona Pinglawathee
- Maes Mailis
- Mahungu Tabitha W
- Mair Daniel
- Maksimovic Joshua
- Manesis Nikos
- Manley Robin
- Manso Carmen
- Marchbank Angela
- Martincorena Inigo
- Martinez-Nunez Rocio T
- Masoli Jane AH
- Mason Jenifer
- Mather Alison E
- Mbisa Tamyo
- McCluggage Kathryn
- McClure Patrick C
- McCrone John T
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- Michelsen Michelle L
- Molnar Zoltan
- Monaghan Lynn
- Mookerjee Siddharth
- Moore Catherine
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- Morgan Sian
- Mori Matilde
- Moses Samuel
- Muir Peter
- Munn Robert
- Myers Richard
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- O'Toole Elaine
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- Pacchiarini Nicole
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- Ramsay Mary
- Randell Paul A
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- Rey Sara M
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- Shepherd James G
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- Siveroni Igor
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- Smith Wendy
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- Souster Emily
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- Southgate Joel
- Spellman Karla
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- Starinskij Igor
- Stark Richard
- Stockton Joanne
- Stuart Claire
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- Swingler Tracey
- Taha Yusri
- Tang Julian
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- Thomson Emma C
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- Torok M Estee
- Trebes Amy
- Trotter Alexander J
- Tsoleridis Theocharis
- Tucker Rachel M
- Turtle Lance
- Tutill Helena J
- Underwood Anthony P
- Unnikrishnan Meera
- Vamos Edith E
- Vasylyeva Tetyana
- Vattipally Sreenu
- Vipond Ian B
- Volz Erik
- Volz Erik M
- Wain John
- Walsh Sarah
- Wang Dennis
- Wantoch Michelle
- Warne Ben
- Warwick-Dugdale Joanna
- Wastenge Elizabeth
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- Watts Joanne
- Waugh Sheila
- Webber Mark A
- Weeks Sam
- Weldon Danni
- Whitehead Mark
- Williams Charlotte A
- Williams Chris
- Williams David
- Williams Rachel J
- Williams Rebecca
- Williams Thomas
- Williamson Kathleen A
- Willingham Iona
- Wilson Harry D
- Wise Emma
- Workman Trudy
- Wright Victoria
- Wyles Matthew
- Wyllie Sarah
- Yakovleva Anna
- Yasir Muhammad
- Yeats Corin A
- Yew Wen C
- Young Gregory R
- Young Jamie
- Yu Xiaoyu
- Zarebski Alex
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2021
- Field of study
Global dispersal and increasing frequency of the SARS-CoV-2 spike protein variant D614G are suggestive of a selective advantage but may also be due to a random founder effect. We investigate the hypothesis for positive selection of spike D614G in the United Kingdom using more than 25,000 whole genome SARS-CoV-2 sequences. Despite the availability of a large dataset, well represented by both spike 614 variants, not all approaches showed a conclusive signal of positive selection. Population genetic analysis indicates that 614G increases in frequency relative to 614D in a manner consistent with a selective advantage. We do not find any indication that patients infected with the spike 614G variant have higher COVID-19 mortality or clinical severity, but 614G is associated with higher viral load and younger age of patients. Significant differences in growth and size of 614G phylogenetic clusters indicate a need for continued study of this variant
Genomic reconstruction of the SARS-CoV-2 epidemic in England
- Author
- Aanensen David M
- Abnizova Irina
- Abudahab Khalil
- Adams Alexander
- Adams Helen
- Afifi Safiah
- Aggarwal Dinesh
- Ahmad Shazaad SY
- Aigrain Louise
- Alcolea Adela
- Alderton Alex
- Ali Mozam
- Alikhan Nabil-Fareed
- Allara Elias
- Allen Laura
- Amato Roberto
- Anderson Ralph
- Angyal Adrienn
- Annett Tara
- Aplin Stephen
- Ariani Cristina
- Ariani Cristina V
- Asad Hibo
- Ash Amy
- Ashfield Paula
- Ashford Fiona
- Atkinson Laura
- Attwood Stephen W
- Auckland Cressida
- Austin-Guest Siobhan
- Aydin Alp
- Baker David J
- Baker Paul
- Bala Sendu
- Balcazar Carlos E
- Ball Jonathan
- Barrett Jeffrey
- Barrett Jeffrey C
- Barrow Magdalena
- Barton Edward
- Bashton Matthew
- Bassett Andrew
- Bassett Andrew R
- Batra Rahul
- Battleday Kristina
- Baxter Chris
- Bayzid Nadua
- Beal James
- Beale Mathew
- Beaver Charlotte
- Beckett Angela H
- Beckwith Shaun M
- Bedford Luke
- Beer Robert
- Beggs Andrew
- Bellany Sam
- Bellerby Tristram
- Bellis Katherine L
- Bellis Katie
- Berger Duncan
- Berriman Matt
- Berry Louise
- Bertolusso Beatrice
- Best Angus
- Betteridge Emma
- Bevan Paul
- Bibby David
- Bicknell Kelly
- Binley Simon
- Binns Debbie
- Birchley Alec
- Bird Paul W
- Birney Ewan
- Bishop Chloe
- Bishop Jason
- Blackburn Kirsty
- Blacow Rachel
- Blakey Victoria
- Blane Beth
- Bolt Frances
- Bonfield James
- Bonner Stephen
- Bonsall David
- Boswell Tim
- Bosworth Andrew
- Boughton Nick
- Bourgeois Yann
- Bowker Sam
- Boyd Olivia
- Bradley Declan T
- Breen Cassie
- Brendler-Spaeth Timothy
- Bresner Catherine
- Breuer Judith
- Bridgett Stephen
- Bronner Iraad
- Bronner Iraad F
- Brooklyn Tanya
- Brooks Ellena
- Broos Alice
- Brown Julianne R
- Bucca Giselda
- Buchan Sarah L
- Buck David
- Buddenborg Sarah Kay
- Bull Matthew
- Burns Phillipa J
- Burton-Fanning Shirelle
- Bush Robert
- Byaruhanga Timothy
- Byott Matthew
- Caetano Catarina
- Cagan Alex
- Campbell Sharon
- Carabelli Alessandro M
- Cargill James S
- Carlile Matthew
- Carter Nicola
- Cartwright Joanna
- Carvalho Sílvia F
- Casey Anna
- Castigador Anibolina
- Catalan Jana
- Chalker Vicki
- Chaloner Nicola J
- Chand Meera
- Chand Meera
- Chapman Liz
- Chappell Joseph G
- Charalampous Themoula
- Chatterton Wendy
- Chaudhry Yasmin
- Chillingworth Tracey-Jane
- Churcher Carol M
- Clapham Peter
- Clark Gemma
- Clark Richard
- Clarke Adrian
- Clarke Catriona
- Clarke Phillip
- Cogger Benjamin J
- Cole Daryl
- Cole Kevin
- Collins Jennifer
- Colquhoun Rachel
- Connor Thomas R
- Cook Elizabeth
- Cook Kate F
- Coombes Jason
- Coppola Maria
- Corden Sally
- Cormie Claire
- Cornell Linda
- Cornwell Clare
- Cortes Nicholas
- Corton Craig
- Cotic Marius
- Cotton Seb
- Cottrell Simon
- Coupland Lindsay
- Cox Alison
- Cox MacGregor
- Crackett Abby
- Craine Noel
- Cranage Alison
- Craven Harriet
- Craw Sarah
- Crawford Liam
- Crawford Mark
- Cross Aidan
- Crown Matthew R
- Crudgington Dorian
- Cumley Nicola
- Curran Martin D
- Curran Tanya
- Cutts Tim
- da Silva Filipe Ana
- Dabrera Gavin
- Dabrowska Monika
- Darby Alistair C
- Davidson Rose K
- Davies Alisha
- Davies Matt
- Davies Robert
- Davies Robert M
- Davis Thomas
- Dawson Joseph
- Day Callum
- de Angelis Daniela
- De Lacy Elen
- De Maio Nicola
- de Oliveira Martins Leonardo
- de Silva Thushan I
- Debebe Johnny
- Densem Aiden
- Denton-Smith Rebecca
- Dervisevic Samir
- Dewar Rebecca
- Dey Jayasree
- Dias Joana
- Dibling Thomas
- Dobie Donald
- Dockree Cat
- Dodd David
- Dogga Sunil
- Dorman Matthew
- Dorman Matthew J
- Dougan Gordon
- Dougherty Martin
- Dove Alexander
- Downing Fatima
- Drummond Lucy
- Drury Eleanor
- du Plessis Louis
- Duckworth Nichola
- Dudek Monika
- Durham Jillian
- Durrant Laura
- Easthope Elizabeth
- Eastick Kirstine
- Easton Lisa J
- Eccles Richard
- Eckert Sabine
- Edgeworth Jonathan
- Edwards Sue
- El Bouzidi Kate
- Eldirdiri Sahar
- Ellaby Nicholas
- Elliott Scott
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- Eltringham Gary
- Ensell Leah
- Erkiert Michelle J
- Essex Sarah
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- Evans Johnathan M
- Everson William
- Fairley Derek J
- Fallon Karlie
- Fanaie Arezou
- Farr Ben
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- Fearn Christopher
- Feltwell Theresa
- Fenton Michael
- Ferguson Lynne
- Ferrero Marcella
- Fina Laia
- Flack Neil
- Flaviani Flavia
- Fleming Vicki M
- Fordham Howerd
- Forrest Sally
- Forsythe Grace
- Foster-Nyarko Ebenezer
- Foulkes Benjamin H
- Foulser Luke
- Fragakis Mireille
- Frampton Dan
- Francis Matt
- Francois Sarah
- Fraser Audrey
- Fraser Christophe
- Freeman Adam
- Freeman Timothy M
- Fryer Helen
- Fuchs Marc
- Fuller William
- Funk Sebastian
- Gajee Kavitha
- Galai Katerina
- Gallagher Abbie
- Gallagher Eileen
- Gallagher Michael D
- Gallis Marta
- Galvin Anastasia
- Garcia-Casado Maria
- Gaskin Amy
- Gatica-Wilcox Bree
- Gedny Alex
- Geidelberg Lily
- Gemmell Matthew
- Georgana Iliana
- George Ryan P
- Gerstung Moritz
- Gifford Laura
- Gilbert Lauren
- Girgis Sophia
- Girgis Sophia T
- Glaysher Sharon
- Glover James
- Goater Richard
- Goldman Nick
- Goldstein Emily J
- Golubchik Tanya
- Gomes Andrea N
- Goncalves Sonia
- Gonçalves Sonia
- Gonçalves Sónia
- Goodfellow Ian G
- Goodwin Scott
- Goudarzi Salman
- Gould Oliver
- Gourtovaia Marina
- Graham Clive
- Graham Lee
- Grant Paul R
- Gray Andy
- Gray Emma
- Green Angie
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- Greenaway Jane
- Gregory Richard
- Griffiths Coline
- Gu Yong
- Guerin Florence
- Guest Martyn
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- Gutierrez Bernardo
- Haldenby Sam T
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- Hansford Samantha E
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- Harris Kathryn A
- Harrison Ewan
- Harrison Ewan M
- Harrison Ian
- Harrott Alexandria
- Harry Edward
- Hart Jennifer
- Hartley John A
- Harvey Matthew
- Harvey William T
- Harvison Julia
- Hassan-Ibrahim Mohammed O
- Heaney Judith
- Heath Paul
- Hellewell Joel
- Helmer Thomas
- Henderson John H
- Hernandez-Koutoucheva Anastasia
- Hesketh Andrew R
- Hey Jessica
- Heyburn David
- Higginson Ellen E
- Hill Jack D
- Hill Verity
- Hilson Rachel A
- Hilvers Ember
- Hobbs Rhiannon
- Holden Matthew TG
- Holland Dave
- Hollis Amy
- Holmes Alison H
- Holmes Christopher W
- Holmes Nadine
- Holmes Sarah
- Hopes Richard
- Hornett Gary
- Hornsby Hailey R
- Hosmillo Myra
- Hough Nicholas
- Houlihan Catherine
- Howson-Wells Hannah C
- Hsu Sharon N
- Hubb Jonathan
- Huckle Liz
- Huckson Hannah
- Hughes Joseph
- Hughes Margaret
- Hughes Warwick
- Hughes-Hallet Lena
- Hunter Adam
- Hutchings Stephanie
- Idle Giles
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- Impey Robert
- Inglis Stephen
- Iqbal Sameena
- Irish-Tavares Dianne
- Iturriza-Gomara Miren
- Izuagbe Rhys
- Jackson Adam
- Jackson Ben
- Jackson Chris
- Jackson David
- Jackson David K
- Jackson Kathryn A
- Jackson Leigh M
- Jahun Aminu S
- James Keith
- James Victoria
- Jamrozy Dorota
- Jeanes Christopher
- Jeffries Aaron R
- Jeremiah Sarah
- Jermy Andrew
- John Michaela
- Johnson Kate
- Johnson Rob
- Johnston Ian
- Jones Christopher R
- Jones Hannah
- Jones Matthew
- Jones Neil
- Jones Owen
- Jones Sophie
- Joseph Amelia
- Judges Sarah
- Jung Alexander W
- Kallepally Kalyan
- Kane Leanne
- Kay Gemma L
- Kay Keely
- Kay Sally
- Keatley Jon
- Keatley Jon-Paul
- Keeley Alexander J
- Keith Alan
- Kenyon Anita
- Kermack Leanne M
- Khakh Manjinder
- Kidd Stephen P
- Kimuli Maimuna
- King Alison
- Kirk Stuart
- Kitchen Christine
- Kitchin Lucy
- Kitchman Katie
- Kleanthous Matt
- Klimekova Martina
- Knight Bridget A
- Korlevic Petra
- Koshy Cherian
- Kraemer Moritz UG
- Krasheninnkova Ksenia
- Kumziene-Summerhayes Sara
- Kwiatkowski Dominic
- Kwiatkowski Dominic
- Lackenby Angie
- Laing Kenneth G
- Lampejo Temi
- Lane Greg
- Langford Cordelia
- Langford Cordelia F
- Laverack Adam
- Lavin Deborah
- Law Katharine
- Lawniczak Mara
- Lawton Andrew I
- Le-Viet Thanh
- Lee David
- Lee Jack CD
- Lensing Stefanie
- Lensing Stefanie V
- Leonard Steven
- Letchford Laura
- Levett Lisa J
- Lewis Jonathan
- Lewis Kevin
- Lewis-Wade Amanah
- Liddle Jennifer
- Liddle Jennifier
- Liggett Steven
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- Lin Quan
- Lindsay Sarah
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- Lister Michelle M
- Livett Rich
- Lo Stephanie
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- Louka Stavroula F
- Lovell Jamie
- Lovell Jon
- Loveson Katie F
- Lowdon Sarah
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- Lythgoe Katrina
- Machin Nicholas W
- MacIntyre-Cockett George
- Mack Andrew
- Mack James
- Macklin Ben
- Maclean Alasdair
- Macnaughton Emily
- Maddison Mark
- Madona Pinglawathee
- Maes Mailis
- Maftei Laurentiu
- Mahanama Adhyana IK
- Mahungu Tabitha W
- Mair Daniel
- Maksimovic Joshua
- Makunin Aleksei
- Malone Cassandra S
- Maloney Daniel
- Mamun Irfan
- Manesis Nikos
- Manley Robin
- Mansfield Jenny
- Mantzouratou Anna
- Marchbank Angela
- Mariappan Arun
- Marriott Neil
- Martin Matt
- Martincorena Inigo
- Martinez Nunez Rocio T
- Masters Kathryn McCluggage
- Mather Alison E
- Maxwell Patrick
- Mayhew Megan
- Mayho Matthew
- Mbisa Tamyo
- McCann Clare M
- McCarthy Shane
- McCarthy Shane A
- McClintock Jo
- McClure Patrick C
- McCrone JT
- McGuigan Samantha
- McHugh Martin P
- McHugh Sandra
- McKenna James P
- McKerr Caoimhe
- McManus Georgina M
- McMinn Liz
- McMurray Claire
- McMurray Claire L
- McNally Alan
- Meadows Carl
- Meadows Lizzie
- Medd Nathan
- Megram Oliver
- Menegazzo Mirko
- Merrick Ian
- Michell Stephen L
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- Mirfenderesky Mariyam
- Mirza Jeremy
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- Mondani Matteo
- Monteiro Tiago Carvalho
- Mookerjee Siddharth
- Moore Catherine
- Moore Christopher
- Moore Jonathan
- Moore Nathan
- Morcrette Helen
- Morgan Mari
- Morgan Sian
- Mori Matilde
- Morra Maria
- Morriss Arthur
- Morrow Leanne
- Moses Samuel
- Mower Craig
- Muir Peter
- Mukaddas Afrida
- Munemo Florence
- Munn Robert
- Murie Kathryn
- Murray Abigail
- Murray Darren R
- Murray Leanne J
- Mutingwende Manasa
- Myers Richard
- Nash Sian
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- Nathwani Claire
- Naydenova Plamena
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- Nebbia Gaia
- Nelson Andrew
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- Ormond Doug
- Orton Richard J
- Osman Husam
- Oszlanczi Agnes
- O’Brien Sarah
- O’Grady Justin
- O’Meara Sarah
- O’Toole Áine
- Pacchiarini Nicole
- Padgett Debra
- Page Andrew J
- Palmer Steve
- Pang Yoke Fei
- Panovska-Griffiths Jasmina
- Pardubska Barbora
- Park Emily J
- Park Naomi
- Park Naomi R
- Parker Matthew D
- Parmar Aaron
- Parmar Surendra
- Partridge David G
- Pascall David
- Patel Amita
- Patel Bindi
- Patel Gaurang
- Patel Minal
- Paterson Steve
- Payne Brendan AI
- Payne Maggie
- Peacock Sharon
- Peacock Sharon J
- Pearson Clare
- Pelosi Emanuela
- Percival Benita
- Perkins Jon
- Perry Malorie
- Petersen Arabella
- Pinckert Malte L
- Platt Steven
- Plowman Deborah
- Podplomyk Olga
- Pohare Manoj
- Pond Marcus
- Pope Cassie F
- Poplawski Radoslaw
- Powell Jessica
- Poyner Jennifer
- Preston Tom
- Prestwood Liam
- Price Anna
- Price James R
- Prieto Jacqui A
- Pritchard David T
- Prosolek Sophie J
- Puethe Christoph
- Pugh Georgia
- Pusok Monika
- Pybus Oliver G
- Pymont Hannah M
- Quail Michael
- Quail Michael A
- Quick Joshua
- Radulescu Clara
- Raghwani Jayna
- Ragonnet-Cronin Manon
- Rainbow Lucille
- Rajan Diana
- Rajatileka Shavanthi
- Ramadan Newara A
- Rambaut Andrew
- Ramble John
- Rance Richard
- Randell Paul
- Randell Paul A
- Ratcliffe Liz
- Raviprakash Veena
- Rawlings Suzannah
- Raza Mohammad
- Redshaw Nicholas
- Redshaw Nicholas M
- Rey Sara
- Reynolds Joe
- Reynolds Mark
- Reynolds Nicola
- Rice Simon
- Richardson Matt
- Richter Alex
- Roberts Connor
- Robertson David L
- Robinson David
- Robinson Esther
- Robinson Katrina
- Robinson Melanie
- Robson Samuel C
- Rogan Fiona
- Rogers Hazel
- Rojo Eduardo Martin
- Rooke Stefan
- Roopra Daljit
- Rose Mark
- Rowe Will
- Roy Sunando
- Rudd Luke
- Rudder Steven
- Ruis Chris
- Rushton Steven
- Sadri Ramin
- Saeed Kordo
- Saint Callum
- Salmon Nicholas
- Samaraweera Buddhini
- Sambles Christine M
- Sanderson Roy
- Sanderson Theo
- Sanderson Theo
- Sang Fei
- Sass Thea
- Saul David
- Scher Emily
- Schwach Frank
- Schwach Frank
- Scott Carol
- Scott Garren
- Seekings Phil
- Sehmi Jasveen
- Shaaban Sharif
- Shah Divya
- Shaw Jessica
- Shelest Ekaterina
- Shepherd James G
- Sheridan Liz A
- Sheriff Nicola
- Shirley Lesley
- Sillitoe John
- Silviera Siona
- Simms Alison
- Simpson David A
- Singh Aditi
- Singleton Dawn
- Sinnott Matthew
- Sinnott Matthew
- Sivadasan Shanthi
- Siwek Bart
- Sizer Dale
- Skeldon Kenneth
- Skelton Jason
- Skvortsov Timofey
- Slater-Tunstill Joanna
- Sloan Tim J
- Sloper Lisa
- Sluga Graciela
- Smerdon Nathalie
- Smith Chris
- Smith Christen
- Smith Colin P
- Smith Darren L
- Smith James
- Smith Katie
- Smith Ken
- Smith Kim S
- Smith Louise
- Smith Michelle
- Smith Nikki
- Smith Perminder
- Smith Sean
- Smith Tina
- Smollett Katherine L
- Sneade Leighton
- Snell Luke B
- Somassa Thomas
- Soria Carmen Diaz
- Sousa Catarina
- Souster Emily
- Southgate Joel
- Sparkes Andrew
- Spellman Karla
- Spencer Chapman Michael H
- Spencer-Chapman Michael
- Spurgin Lewis G
- Spyer Moira J
- Squares Janet
- Stanley Rachael
- Stanley Robert
- Stanley William
- Stanton Thomas D
- Starinskij Igor
- Steed Claire
- Stickland Tim
- Still Ian
- Stockton Joanne
- Stonehouse Susanne
- Storey Nathaniel
- Stratton Michael R
- Strickland Michelle
- Studholme David J
- Suciu Maria
- Sudhanva Malur
- Swann Allen
- Swiatkowska Agnieszka
- Swift Emma
- Swindells Emma
- Sycamore Neil
- Symons Edward
- Szluha Suzanne
- Taha Yusri
- Taluy Emma
- Tan Ngee Keong
- Tang Julian W
- Tang Miao
- Tao Nunu
- Taylor Ben EW
- Taylor Joshua F
- Taylor Katy
- Taylor Sam
- Taylor Sarah
- Temperton Ben
- Templeton Kate E
- Thomas Claire
- Thompson Mark
- Thompson Stacey
- Thomson Emma C
- Thomson Laura
- Thomson Mark
- Thomson Nicholas
- Thornton Alicia
- Thurston Scott
- Thurston Scott AJ
- Todd John A
- Tomb Rachael
- Tong Lily
- Tonkin-Hill Gerry
- Toombs Dee
- Topping Benjamin
- Torok M Estee
- Tovar-Corona Jaime
- Tovar-Corona Jaime M
- Trebes Amy
- Trotter Alexander J
- Tsatsani Ioulia
- Turnbull Robyn
- Turtle Lance
- Twohig Katherine A
- Umpleby Helen
- Underwood Anthony P
- Ungureanu Daniel
- Uphill James
- Urbanova Jana
- Vamos Edith E
- Van Vuuren Philip Jansen
- Vancollie Valerie
- Vasylyeva Tetyana I
- Vattipally Sreenu
- Verdejo Carlos Jimenez
- Vernet Gabrielle
- Vipond Barry B
- Voak Paul
- Volz Erik
- Volz Erik M
- Vöhringer Harald S
- Walker Danielle
- Walker Matthew
- Waller Matt
- Walsh Sarah
- Wang Dennis
- Ward Gary
- Warne Ben
- Warwick-Dugdale Joanna
- Wastnedge Elizabeth
- Watkins Joanne
- Watson Louisa K
- Waugh Sheila
- Weatherhogg Charlie
- Webb Niki
- Webster Hermione J
- Weldon Danni
- Wells Alan
- Wells Eloise
- Westwick Elaine
- Westwood Luke
- Whalley Thomas
- Wheeler Helen
- Whipp Theo
- Whitehead Mark
- Whiteley Max
- Whiteley Thomas
- Whitton Georgia
- Whitwham Andrew
- Widaa Sara
- Wierzbicki Claudia
- Willford Nicholas J
- Williams Catryn
- Williams Charlotte A
- Williams Cheryl
- Williams Chris
- Williams Lesley-Anne
- Williams Mia
- Williams Rachel J
- Williams Rebecca
- Williams Thomas
- Williamson Kathleen A
- Wilson Mark
- Wilson-Davies Eleri
- Witele Eric
- Withell Karen T
- Witney Adam A
- Wolverson Paige
- Wong Nick
- Workman Trudy
- Wright Derek W
- Wright Sean
- Wright Victoria
- Wyatt Tim
- Wyllie Sarah
- Xu-McCrae Li
- Yavus Mehmet
- Yaze Geraldine
- Yeats Corin A
- Yebra Gonzalo
- Yew Wen C
- Young Gregory R
- Young Jamie
- Zamudio Marina Escalera
- Zarebski Alex E
- Zhang Peijun
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 14/10/2021
- Field of study
AbstractThe evolution of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus leads to new variants that warrant timely epidemiological characterization. Here we use the dense genomic surveillance data generated by the COVID-19 Genomics UK Consortium to reconstruct the dynamics of 71 different lineages in each of 315 English local authorities between September 2020 and June 2021. This analysis reveals a series of subepidemics that peaked in early autumn 2020, followed by a jump in transmissibility of the B.1.1.7/Alpha lineage. The Alpha variant grew when other lineages declined during the second national lockdown and regionally tiered restrictions between November and December 2020. A third more stringent national lockdown suppressed the Alpha variant and eliminated nearly all other lineages in early 2021. Yet a series of variants (most of which contained the spike E484K mutation) defied these trends and persisted at moderately increasing proportions. However, by accounting for sustained introductions, we found that the transmissibility of these variants is unlikely to have exceeded the transmissibility of the Alpha variant. Finally, B.1.617.2/Delta was repeatedly introduced in England and grew rapidly in early summer 2021, constituting approximately 98% of sampled SARS-CoV-2 genomes on 26 June 2021.</jats:p