1 research outputs found
Assosation of the XRCC1 gene polymorhism with breast cancer risk in Kashmiri patients
X ray repair cross-complementing group 1 (XRCC1) plays an important role in base
excision and single-strand break repair, as a scaffold protein that brings together proteins
of the DNA repair complex, and appears to be a candidate for cancer risk. A common
polymorphism (Arg→Gln) at codon 399 of the XRCC1 gene has been previously linked
to functional changes of the gene product and risk of cancers. However, studies on the
association between polymorphisms in this protein and cancer have yielded conflicting
results. We evaluated the association between XRCC1 Arg399Gln polymorphism and
breast cancer risk in the Kashmiri patients. Our study included total of 142 female
subjects. In our case control study we genotyped 70 breast cancer (BC) patients and 72
controls for XRCC1 Arg399Gln polymorphisms by PCR RLFP technique.. It was found
22.8%of cases and 37.5%were homozygous for variant genotype with odd ratio OR 0.48
CI (0.18-1.25); P = 0.13 for Gln/Gln and OR=1.01 CI = (0.42-1.49); P= 0.985 for
Arg/Gln. However OR was insignificant. It was observed that OR associated with
Gln/Gln genotype are not modified for either above or below 45 years age (OR=0.72; CI
= 0.18-2.74), (OR=0.28; 95% CI=0.06-1.20), however these results were statistically
insignificant. Similar observation was found with respect to menopausal status
(postmenopausal women OR=0.85; CI=0.19-3.72), (premenopausal women OR=0.35;
CI= 0.09-0.29) as none of association reached statistical significance. Thus we did not
find any association between Arg399Gln polymorphism and breast cancer risk among
both pre-and post menopausal women