Relationship between anthropometric data, element status, and nutrition in Tajik schoolchildren

The aim of the study was to investigate the association between anthropometric data. clement and nutritional status of Tajik schoolchildren within the national school feeding program. A total of 283 schoolchildren aged 7 - 10 years old (141 boys and 142 girls) attending grades 1 - 4 in schools on the territory of the Republic of Tajikistan (Ayni district) were examined. The study included physical examination, interview, and the collection of anthropometric data. Analysis of hair trace element and mineral (Al, As, B, Be, Ca, Cd, Co, Cr, Cu, Fe, Hg, I, K, Li, Mg, Mn, Na, Ni, P, Pb, Se, Si, Sn, V, Zn) content was performed using inductively-coupled plasma mass spectrometry. The obtained data showed the significant positive correlation between the anthropometric parameters. nutritional and element status of the examined schoolchildren. The higher risk of Cu deficiency is a particular problem of child nutrition in the studied region. Micronutrient-fortified nutrition (WFP program) significantly improved anthropometric data and element status of Tajik schoolchildren within the WFP program

Relationship between anthropometric data, element status, and nutrition in Tajik schoolchildren

The aim of the study was to investigate the association between anthropometric data. clement and nutritional status of Tajik schoolchildren within the national school feeding program. A total of 283 schoolchildren aged 7 - 10 years old (141 boys and 142 girls) attending grades 1 - 4 in schools on the territory of the Republic of Tajikistan (Ayni district) were examined. The study included physical examination, interview, and the collection of anthropometric data. Analysis of hair trace element and mineral (Al, As, B, Be, Ca, Cd, Co, Cr, Cu, Fe, Hg, I, K, Li, Mg, Mn, Na, Ni, P, Pb, Se, Si, Sn, V, Zn) content was performed using inductively-coupled plasma mass spectrometry. The obtained data showed the significant positive correlation between the anthropometric parameters. nutritional and element status of the examined schoolchildren. The higher risk of Cu deficiency is a particular problem of child nutrition in the studied region. Micronutrient-fortified nutrition (WFP program) significantly improved anthropometric data and element status of Tajik schoolchildren within the WFP program

Systemic Essential Metal and Metalloid Levels in Patients with Benign Breast Disease and Breast Cancer

The objective of the present study is evaluation of serum and hair levels of essential metals and metalloids in women with benign breast disease and breast cancer in order to define similar and distinct patterns that may mediate the link between these pathologies. A total of 310 adult women aged 20–80 years old were enrolled in the present study. Of those, 103 patients had benign (fibrocystic) breast disease, 107 patients had breast cancer (stage II), and 100 women were healthy and with absence of breast pathology. Trace metal and metalloid levels in hair and serum were evaluated by inductively coupled argon plasma mass-spectrometry (ICP-MS). The data demonstrate that breast cancer patients were characterized by significantly higher hair Cr and V levels, as well as reduced Cu and Mn content as compared to both benign breast disease patients and controls. In contrast, serum Cu levels in women with breast cancer exceeded those in the controls and benign breast disease cases. Patients with both benign and malignant breast tumors were characterized by lower serum Mn levels as compared to the control values. Serum Cu/Zn and especially Cu/Mn were found to be significantly increased in cancer patients. Significantly reduced hair and serum Se levels were noted only in women with fibrocystic disease. Based on the analysis of two biosamples, it is proposed that malignant breast tumor development is associated with the reduction of systemic Mn and Zn levels, and a concomitant elevation of Cu concentrations. © 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature

Serum levels of copper, iron, and manganese in women with pregnancy, miscarriage, and primary infertility

Background: Iron (Fe), copper (Cu), and manganese (Mn) play a significant role in female reproduction and fetal development. At the same time, high levels of metals may exert toxic effects. Correspondingly, both excess and deficiency of essential trace elements were shown to be associated with female infertility and adverse pregnancy outcome, although the existing data are rather contradictory. Therefore, the objective of the present study was to reveal the potential role of altered iron, copper, and manganese status in female reproductive health problems through assessment of serum metal levels in healthy non-pregnant and pregnant women, as well as patients with miscarriage and primary infertility. Methods: A total of 150 healthy controls, 169 pregnant women (II trimester of pregnancy), 75 women with miscarriage, and 91 patients with primary infertility were enrolled. Serum metal levels were assessed using ICP-MS. Results: Pregnant women are characterized by a significant increase in serum Cu an Mn levels by 40% (p < 0.001) and 16% (p = 0.043) as compared to the controls, respectively. Serum Cu levels in women with miscarriage and infertility were 30% and 35% lower than those in pregnant women (p < 0.001). No significant difference in serum iron levels were observed between the control and pregnant women. Women who had miscarriage were characterized by 13% (p = 0.042) higher serum Fe levels as compared to the pregnant ones. Multiple regression analysis demonstrated that serum copper levels was significantly associated both with pregnancy (β = 0.436; p < 0.001) and reproductive health problems in women (β = −0.272; p < 0.001). The latter was improved significant after adjustment for serum Fe and Mn levels, age, and BMI (β = −0.431; p < 0.001). The model incorporating serum Cu, Fe, Mn, and anthropometric parameters accounted for 23% of variability in reproductive status (p < 0.001). Conclusions: It is proposed that the lack of pregnancy-associated increase in metal levels in miscarriage and infertility may be indicative of at least partial role of metal insufficiency in impaired pregnancy and reproductive function in general. However, detailed clinical studies as well as experimental investigations are required for assessment of the potential causes and mechanisms of the observed associations. © 201

Elementary status evaluation of Kirov region's population by method of mass spectrometry with inductively coupled plasma [Оценка элементного статуса населения Кировской области методом масс-спектрометрии с индуктивно связанной плазмой]

Introduction. The purpose of this study was to study and assess the elemental status of residents of the Kirov region as a part of the Volga Region Federal District (VFD). Material and methods. The content of elements in the hair of 295 men and women (73 and 222, respectively, 25-50 years old) and 120 boys and girls (46 and 74, respectively, 3-15 years old) were studied using massspectrometry with inductively coupled plasma. This indicator serves an index in assessing the impact of environment on human organism. Methods of non-parametric statistics were used for the mathematical simulation of our data. Results. It was found that women, girls and boys compared with other regions of the VFD are characterized by a relative increase in the absolute content (median) in the hair of Mg, Fe, V. For people living in the territory of the Kirov region a relative increase in the Si level in the hair is characterized with exception of boys. The relatively reduced level of Cu (with the exception of women) and Se (with the exception of men) also make oneself conspicuous. Discussion of the results. The main problems associated with a decrease in the content of Cu and Se compounds, as well as an increase in the content of Si, Mg, Fe and V, most likely have a geochemical nature and, in particular, are associated with the chemical composition of drinking water. The hair of children in a greater degree than in adults is shown to be a biological substrate, the elemental composition of which indicates to ecological and social factors, the quality of products and the development of the health care system. Conclusions. The obtained data can be recommended for the use as reference values in assessing the level of chemical compounds in the hair of adults and children living in the territory of the Kirov region. © 2020 Izdatel'stvo Meditsina. All rights reserved

Serum amino acid spectrum in children with autism spectrum disorder (ASD)

Background: ASD is associated with complex metabolic alterations including amino acid metabolism. However, the existing data are contradictory. Therefore, the objective of the present study was investigation of serum amino acid levels in children with ASD. Methods: A total of 97 boys (3–14 y.o.) including 64 children with diagnosed ASD and 33 neurotypical age-matched controls were enrolled in the current study. Assessment of serum amino acid levels was performed using high-pressure liquid chromatography (HPLC) with UV-detection. ClinChek® Plasma Control was used for laboratory quality control. Statistical analysis was performed using analysis of covariance (ANCOVA) with adjustment for age and Bonferroni correction. Results. The obtained data demonstrate that the mean levels of Arg, Gln, His, Leu, Lys, Phe, Ser, Tau, Thr, and Trp in ASD were 28 %, 23 %, 20 %, 17 %, 21 %, 15 %, 21 %, 24 %, 19 %, and 22 % lower as compared to the control values, respectively. Serum Hypro and Tyr levels in children with ASD were more than 2-fold and 11 % higher as compared to the control values, respectively. Multiple regression analysis demonstrated that serum Leu and Ser (negatively), and Hypro and Tyr levels (positively) were significantly associated with ASD. Conclusions: The obtained data demonstrate that children with ASD are characterized by a trend to multiple amino acid deficiency in parallel with elevation of serum Tyr and Hypro levels. The latter may provide a link between ASD and joint hypermobility. In turn, deficiency of other amino acids may impair neurobehavior in ASD due to their role as neuromediators or their precursors. © 2020 Elsevier Lt

Interactive effects of age and gender on levels of toxic and potentially toxic metals in children hair in different urban environments

Children growth and development may be affected by metal exposure. The objective of the present study was to investigate the interactive effects of age and gender on children hair toxic metal levels in urban environment of two Russian cities. A total of 2021 children living in Moscow and Novosibirsk aged 1–18 years old were examined. Hair Al, As, Cd, Hg, Ni, Pb and Sn levels were assessed using inductively-coupled plasma mass-spectrometry in dynamic reaction cell mode. Children from Novosibirsk were characterised by higher hair Al (37%), As (385%), Cd (127%), Hg (11%), Ni (23%), Pb (72%) and Sn (25%) in comparison to Moscow values. In the general cohort, boys had higher Al (13%), As (51%), Cd (65%), Pb (63%) and Sn (18%) levels, whereas hair Ni was higher in girls (17%). Further analysis demonstrated age-specific gender differences. In particular, only hair Ni and Cd levels were higher in male toddlers and pre-schoolers from Novosibirsk as compared to females. No gender difference was detected in Moscow. Maximal gender differences in hair metal levels were detected in adolescents for both locations. International Union of Pure and Applied Chemistry (IUPAC) reference values for all groups were also calculated. The overall reference limits for the studied children population were Al (1.335–3.340 µg/g), As (0.021–0.384 µg/g), Cd (0.000–1.389 µg/g), Hg (0.024–0.722 µg/g), Ni (0.076–0.701 µg/g), Pb (0.050–1.490 µg/g) and Sn (0.070–1.026 µg/g). Two-way ANOVA demonstrated significant effects of age, gender and age*gender interaction on hair metals in both cities. At the same time, the age-specific changes in hair metal content were more expressed in children from Novosibirsk, being exposed to higher metal pollution. The obtained data demonstrate that age, gender as well as the particular rate of pollution in each location should be taken into account during interpretation of hair test results. © 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group

Alterations in serum amino acid profiles in children with attention deficit/hyperactivity disorder

The objective of the present study was to evaluate the circulating serum amino acid levels in children with attention deficit/hyperactivity disorder (ADHD). A total of 71 children with untreated ADHD and 31 neurotypical controls aged 7-14 years old were examined. Serum amino acid levels were evaluated using high-performance liquid chromatography (HPLC) with UV-detection. Laboratory quality control was performed with reference materials of human plasma amino acid levels. The obtained data demonstrated that children with ADHD were characterized by 29, 10 and 20% lower serum histidine (His), glutamine (Gln) and proline (Pro) levels compared with neurotypical children, respectively. In contrast, circulating aspartate (Asp), glutamate (Glu) and hydroxyproline (Hypro) levels exceeded the respective control values by 7, 7 and 42%. Correspondingly, the Gln-to-Glu and Pro-to-Hypro ratios were 28% and 49%, respectively, lower in ADHD cases compared with the controls. Total Gln/Glu levels were also significantly lower in ADHD patients. No significant group differences were observed between the groups in the other amino acids analyzed, including phenylalanine. Multiple linear regression analysis revealed significant associations between circulating serum Gln, lysine (Lys) (both negative) and Glu (positive) levels with total ADHD Rating Scale-IV scores. The observed alterations in Pro/Hypro and Gln/Glu levels and ratios are likely associated with the coexisting connective tissue pathology and alterations in glutamatergic neurotransmission in ADHD, respectively. Altered circulating levels of His, Lys and Asp may also be implicated in ADHD pathogenesis. However, further in vivo and in vitro studies are required in order to investigate the detailed mechanisms linking amino acid metabolism with ADHD pathogenesis. © 2021, Spandidos Publications. All rights reserved

Comparative analysis and the coverage intervals of hair rare metal content in two Russian industrial centres

The existing data provide information on hair essential and toxic trace element content, whereas data on ultra-trace and rare elements are scarce. Therefore, the primary aim of the current study was to estimate hair levels and reference values of hair rare metal content using IUPAC recommendations in 2593 occupationally non-exposed adults living in Moscow and Novosibirsk (1900 women and 693 men). Hair Ag, Au, Ga, Ge, La, Rb, Tl, W and Zr content was assessed by inductively coupled plasma mass spectrometry with NexION 300D. Women were characterised by significantly higher hair Ag and Au levels than men, whereas men had increased La, Rb, Tl, W and Zr content as compared to women. Moscow inhabitants were characterised by significantly higher hair Au and Ge, and lower hair Ga, La, Rb, Tl, W and Zr content as compared to the ones from Novosibirsk. The coverage intervals of Ag, Au, Ga, Ge, La, Rb, Tl, W and Zr content in hair of the general sample of examinees calculated in accordance with IUPAC recommendations were 0.0278–0.2994, 0.0159–0.1812, 0.0062–0.0348, 0.0022–0.0066, 0.0023–0.0205, 0.0226–0.2083, 0.0002–0.0008, 0.0022–0.0120 and 0.0389–0.3521 μg/g, respectively. The obtained data indicate that both gender and geographical location affect hair rare metal content in adults. © 2017 Informa UK Limited, trading as Taylor & Francis Group