Solutions of the quasi-vector wave equation for optical waveguides in a mapped infinite domains by the Galerkin's method

Galerkin's method is employed to analyze the quasi-vector wave equation for optical waveguides with arbitrary refractive index profile in a mapped infinite domains. Results are presented for a range of waveguide structures which include rectangular core, circular core, rib, and multiple quantum well. Solutions are compared favorably to exact vector solution and numerical results using Fourier operator transform method and beam-propagation method.published_or_final_versio

Cutoff frequency of the quasi-vector mode of optical waveguide with arbitrary refractive index profile

Based on the Galerkin's method, a numerical method is developed to analysis the cutoff frequencies of guided modes of optical waveguides with arbitrary refractive index profile. Solutions are presented in the quasi-vector regime. Optical waveguide structures with single core of arbitrary shape are considered in this paper. The calculated results are compared favorably with exact vector solution and circular-harmonic expansion method.published_or_final_versio

Phase modulator defined by impurities induced disordering

Optical waveguide type phase modulators defined by impurities induced disordering (IID) are investigated. To achieve a better optical confinement, a two steps ion implantation process is carried out to introduce additional impurities with respect to depth in the cladding region. A more uniform refractive index profile in deeper lateral confined region is obtained after thermal annealing. The refractive index different between the core and cladding can be adjusted by controlling the extension of interdiffusion in the cladding. This provide tuning of single mode operating region. For present IID phase modulator with 25 period of 100 angstroms/100 angstroms Al0.3Ga0.7As/GaAs multiple quantum wells single mode operating at 0.88 μm, a normalized phase shift of 362°/Vmm, chirping parameter of 47, and absorption loss less than 120 cm-1 are achieved theoretically.published_or_final_versio

Impurity induced disordering produced lateral optical confinement in AlGaAs and InGaAs (on GaAs) quantum well waveguides

The impurity induced disordering technique is employed on an AlGaAs/GaAs quantum well optical waveguide to provide lateral optical confinement. The modal propagation constant and field profile are analysed using an improved Fourier decomposition method. The single mode operating region is given in terms of thickness of quantum well layers.published_or_final_versio

Astrometry of circumstellar masers

The circumstellar masers around evolved stars offer an interesting possibility to measure stellar parameters through VLBI astrometry. In this paper the application of this technique is discussed, including the accuracy and the uncertainties of the method. The different maser species (OH, H_2O, SiO) have slightly different characteristics and applications. This paper does not concern astrometry of maser spots to study the kinematics of the envelope, but concentrates on attempting to measure the motion of the underlying star.Comment: 8 pages, 2 figures, to appear in "Mass-losing Stars and their Circumstellar Matter", eds Y. Nakada & M. Honma, Kluwer ASSL serie

Perioperative nutritional support in patients undergoing hepatectomy for hepatocellular carcinoma

Background. Resection of hepatocellular carcinoma is associated with high rates of morbidity and mortality. Since intensive nutritional support can reduce the catabolic response and improve protein synthesis and liver regeneration, we performed a prospective study to investigate whether perioperative nutritional support could improve outcome in patients undergoing hepatectomy for hepatocellular carcinoma. Methods. We studied 124 patients undergoing resection of hepatocellular carcinoma. Sixty-four patients (39 with cirrhosis, 18 with chronic active hepatitis, and 7 with no associated liver disease) were randomly assigned to receive perioperative intravenous nutritional support in addition to their oral diet, and 60 patients (33 with cirrhosis, 12 with chronic active hepatitis, and 15 with no associated liver disease) were randomly assigned to a control group. The perioperative nutritional therapy consisted of a solution enriched with 35 percent branched-chain amino acids, dextrose, and lipid emulsion (50 percent medium-chain triglycerides) given intravenously for 14 days perioperatively. Results. There was a reduction in the overall postoperative morbidity rate in the perioperative-nutrition group as compared with the control group (34 percent vs. 55 percent; relative risk, 0.66; 95 percent confidence interval, 0.45 to 0.96), predominantly because of fewer septic complications (17 percent vs. 37 percent; relative risk, 0.57; 95 percent confidence interval, 0.34 to 0.96). There were also a reduction in the requirement for diuretic agents to control ascites (25 percent vs. 50 percent; relative risk, 0.57; 95 percent confidence interval, 0.37 to 0.87), less weight loss after hepatectomy (median loss, 0 kg vs. 1.4 kg; P = 0.01), and less deterioration of liver function as measured by the change in the rate of clearance of indocyanine green (-2.8 percent vs. -4.8 percent at 20 minutes, P = 0.05). These benefits were seen predominantly in the patients with underlying cirrhosis who underwent major hepatectomy. There were five deaths during hospitalization in the perioperative-nutrition group, and nine in the control group (P not significant). Conclusions. Perioperative nutritional support can reduce complications after major hepatectomy for hepatocellular carcinoma associated with cirrhosis.published_or_final_versio

Change in the dentist population in Hong Kong between 1981 and 2001

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An evolutionary video assignment optimization technique for VOD system in heterogeneous environment

2009-2010 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

Identification of microRNA 885-5p as a novel regulator of tumor metastasis by targeting CPEB2 in colorectal cancer

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Influenza H5N1 virus infection of polarized human alveolar epithelial cells and lung microvascular endothelial cells

Background: Highly pathogenic avian influenza (HPAI) H5N1 virus is entrenched in poultry in Asia and Africa and continues to infect humans zoonotically causing acute respiratory disease syndrome and death. There is evidence that the virus may sometimes spread beyond respiratory tract to cause disseminated infection. The primary target cell for HPAI H5N1 virus in human lung is the alveolar epithelial cell. Alveolar epithelium and its adjacent lung microvascular endothelium form host barriers to the initiation of infection and dissemination of influenza H5N1 infection in humans. These are polarized cells and the polarity of influenza virus entry and egress as well as the secretion of cytokines and chemokines from the virus infected cells are likely to be central to the pathogenesis of human H5N1 disease.Aim: To study influenza A (H5N1) virus replication and host innate immune responses in polarized primary human alveolar epithelial cells and lung microvascular endothelial cells and its relevance to the pathogenesis of human H5N1 disease.Methods: We use an in vitro model of polarized primary human alveolar epithelial cells and lung microvascular endothelial cells grown in transwell culture inserts to compare infection with influenza A subtype H1N1 and H5N1 viruses via the apical or basolateral surfaces.Results: We demonstrate that both influenza H1N1 and H5N1 viruses efficiently infect alveolar epithelial cells from both apical and basolateral surface of the epithelium but release of newly formed virus is mainly from the apical side of the epithelium. In contrast, influenza H5N1 virus, but not H1N1 virus, efficiently infected polarized microvascular endothelial cells from both apical and basolateral aspects. This provides a mechanistic explanation for how H5N1 virus may infect the lung from systemic circulation. Epidemiological evidence has implicated ingestion of virus-contaminated foods as the source of infection in some instances and our data suggests that viremia, secondary to, for example, gastro-intestinal infection, can potentially lead to infection of the lung. HPAI H5N1 virus was a more potent inducer of cytokines (e.g. IP-10, RANTES, IL-6) in comparison to H1N1 virus in alveolar epithelial cells, and these virus-induced chemokines were secreted onto both the apical and basolateral aspects of the polarized alveolar epithelium.Conclusion: The predilection of viruses for different routes of entry and egress from the infected cell is important in understanding the pathogenesis of influenza H5N1 infection and may help unravel the pathogenesis of human H5N1 disease. © 2009 Chan et al; licensee BioMed Central Ltd.published_or_final_versio