Partial Evaluation for Java Malware Detection

The fact that Java is platform independent gives hackers the opportunity to write exploits that can target users on any platform, which has a JVM implementation. Metasploit is a well-known source of Java exploits and to circumvent detection by Anti Virus (AV) software, obfuscation techniques are routinely applied to make an exploit more difficult to recognise. Popular obfuscation techniques for Java include string obfuscation and applying reflection to hide method calls; two techniques that can either be used together or independently. This paper shows how to apply partial evaluation to remove these obfuscations and thereby improve AV matching. The paper presents a partial evaluator for Jimple, which is a typed three-address code suitable for optimisation and program analysis, and also demonstrates how the residual Jimple code, when transformed back into Java, improves the detection rates of a number of commercial AV products

Does Dysbiosis Play a Role in Age-Related Hearing Impairment?

Age-related hearing impairment (ARHI) is prevalent in older adults, affecting at least 60% of people by the time they reach 71 to 80 years of age.1 The number of people with ARHI will necessarily increase as humans live longer and a greater proportion of the population is older.2 Hearing loss does not just impact communication; it is associated with loneliness and depression, cognitive decline and dementia, as well as reduced physical well-being.3-6 A decade ago, an international report calculated that hearing loss cost Europe £213 billion annually.7 There is currently no effective drug treatment for hearing loss. Hearing aids (average cost £2,300/pair) are the most commonly prescribed ameliorative therapy, but uptake is low; and among those who obtain hearing aids, a high proportion do not use them or are dissatisfied with them. Hearing loss prevention is therefore of compelling necessity, and genetic studies will help us understand how and why people lose their hearing ability and will inform prevention strategies

Superpotentials from variational derivatives rather than Lagrangians in relativistic theories of gravity

The prescription of Silva to derive superpotential equations from variational derivatives rather than from Lagrangian densities is applied to theories of gravity derived from Lovelock Lagrangians in the Palatini representation. Spacetimes are without torsion and isolated sources of gravity are minimally coupled. On a closed boundary of spacetime, the metric is given and the connection coefficients are those of Christoffel. We derive equations for the superpotentials in these conditions. The equations are easily integrated and we give the general expression for all superpotentials associated with Lovelock Lagrangians. We find, in particular, that in Einstein's theory, in any number of dimensions, the superpotential, valid at spatial and at null infinity, is that of Katz, Bicak and Lynden-Bell, the KBL superpotential. We also give explicitly the superpotential for Gauss-Bonnet theories of gravity. Finally, we find a simple expression for the superpotential of Einstein-Gauss-Bonnet theories with an anti-de Sitter background: it is minus the KBL superpotential, confirming, as it should, the calculation of the total mass-energy of spacetime at spatial infinity by Deser and Tekin.Comment: Scheduled to appear in Class. Quantum Grav. August 200

An analysis of quadrupole splitting of the Mössbauer spectra of ferritin and iron-dextran complexes in relation to the iron core microstructural variations

Mössbauer spectra of human liver ferritin and some pharmaceutically important iron-dextran complexes as ferritin models were measured at 87 K (frozen solutions) and at both 87 and 295 K (lyophilized forms). The Mössbauer spectra consisted of paramagnetic doublets only. However, the spectral line shapes were not Lorentzian and these Mössbauer spectra were better fitted using a superposition of two or more quadrupole doublets or using a distribution of quadrupole splittings. The differences of the maximal quantity of quadrupole doublets for better fitting of various Mössbauer spectra of ferritin and iron-dextran complexes were compared with the fitting using the distribution of quadrupole splitting for additional analysis. It is possible that variations of the quantity of quadrupole doublets for better fitting of Mössbauer spectra of ferritin and iron-dextran complexes may be related to heterogeneous iron cores in the samples. This heterogeneity is supposed to be different for various samples and changed for lyophilized samples and for frozen solutions as well as for various temperatures

Diffusive Shock Acceleration with Magnetic Amplification by Non-resonant Streaming Instability in SNRs

We investigate the diffusive shock acceleration in the presence of the non-resonant streaming instability introduced by Bell (2004). The numerical MHD simulations of the magnetic field amplification combined with the analytical treatment of cosmic ray acceleration permit us to calculate the maximum energy of particles accelerated by high-velocity supernova shocks. The estimates for Cas A, Kepler, SN1006, and Tycho historical supernova remnants are given. We also found that the amplified magnetic field is preferentially oriented perpendicular to the shock front downstream of the fast shock. This explains the origin of the radial magnetic fields observed in young supernova remnants.Comment: 18 pages, 9 figures, accepted to Ap

Thiopurine pharmacogenomics: association of SNPs with clinical response and functional validation of candidate genes

Aim: We investigated candidate genes associated with thiopurine metabolism and clinical response in childhood acute lymphoblastic leukemia. Materials & methods: We performed genome-wide SNP association studies of 6-thioguanine and 6-mercaptopurine cytotoxicity using lymphoblastoid cell lines. We then genotyped the top SNPs associated with lymphoblastoid cell line cytotoxicity, together with tagSNPs for genes in the ‘thiopurine pathway’ (686 total SNPs), in DNA from 589 Caucasian UK ALL97 patients. Functional validation studies were performed by siRNA knockdown in cancer cell lines. Results: SNPs in the thiopurine pathway genes ABCC4, ABCC5, IMPDH1, ITPA, SLC28A3 and XDH, and SNPs located within or near ATP6AP2, FRMD4B, GNG2, KCNMA1 and NME1, were associated with clinical response and measures of thiopurine metabolism. Functional validation showed shifts in cytotoxicity for these genes. Conclusion: The clinical response to thiopurines may be regulated by variation in known thiopurine pathway genes and additional novel genes outside of the thiopurine pathway

Fractional Models of Cosmic Ray Acceleration in the Galaxy

Possible formulations of the problem of cosmic rays acceleration in the interstellar galactic medium are considered with the use of fractional differential equations. The applied technique has been physically justified. A Fermi result has been generalized to the case of the acceleration of particles in shock waves in the supernovae remnants fractally distributed in the Galaxy.Comment: 10 page